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Original Research

Amorphous silica nanoparticles aggregate human platelets: potential implications for vascular homeostasis

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Pages 631-639 | Published online: 07 Feb 2012

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Read on this site (11)

Ghada E Ali, Marwa A Ibrahim, Ayman H El-Deeb, Hassan Amer & Said M Zaki. (2019) Pulmonary deregulation of expression of miR-155 and two of its putative target genes; PROS1 and TP53INP1 associated with gold nanoparticles (AuNPs) administration in rat. International Journal of Nanomedicine 14, pages 5569-5579.
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Lin Feng, Xiaozhe Yang, Yanfeng Shi, Shuang Liang, Tong Zhao, Junchao Duan & Zhiwei Sun. (2018) Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system. International Journal of Nanomedicine 13, pages 7819-7834.
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Pejman Mohammadi, Marzieh Abbasinia, Mohammad Javad Assari & Mohammad Oliaei. (2018) The Toxicology of Silica Nanoparticles: A Review. Toxicological & Environmental Chemistry 100:3, pages 285-316.
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Wai-Tao Chan, Cheng-Che Liu, Jen-Shiu Chiang Chiau, Shang-Ting Tsai, Chih-Kai Liang, Mei-Lien Cheng, Hung-Chang Lee, Chun-Yun Yeung & Shao-Yi Hou. (2017) In vivo toxicologic study of larger silica nanoparticles in mice. International Journal of Nanomedicine 12, pages 3421-3432.
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Abderrahim Nemmar, Priya Yuvaraju, Sumaya Beegam, Javed Yasin, Elsadig E Kazzam & Badreldin H Ali. (2016) Oxidative stress, inflammation, and DNA damage in multiple organs of mice acutely exposed to amorphous silica nanoparticles. International Journal of Nanomedicine 11, pages 919-928.
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James Clark, Clive C. Gregory, Ian P. Matthews & Bastiaan Hoogendoorn. (2016) The biological effects upon the cardiovascular system consequent to exposure to particulates of less than 500 nm in size. Biomarkers 21:1, pages 1-47.
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Maria J Santos-Martinez, Krzysztof A Tomaszewski, Carlos Medina, Despina Bazou, John F Gilmer & Marek W Radomski. (2015) Pharmacological characterization of nanoparticle-induced platelet microaggregation using quartz crystal microbalance with dissipation: comparison with light aggregometry. International Journal of Nanomedicine 10, pages 5107-5119.
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Stephen P Samuel, Maria J Santos-Martinez, Carlos Medina, Namrata Jain, Marek W Radomski, Adriele Prina-Mello & Yuri Volkov. (2015) CdTe quantum dots induce activation of human platelets: implications for nanoparticle hemocompatibility. International Journal of Nanomedicine 10, pages 2723-2734.
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Caixia Guo, Yinye Xia, Piye Niu, Lizhen Jiang, Junchao Duan, Yang Yu, Xianqing Zhou, Yanbo Li & Zhiwei Sun. (2015) Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling. International Journal of Nanomedicine 10, pages 1463-1477.
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Abderrahim Nemmar, Sulayma Albarwani, Sumaya Beegam, Priya Yuvaraju, Javed Yasin, Samir Attoub & Badreldin H Ali. (2014) Amorphous silica nanoparticles impair vascular homeostasis and induce systemic inflammation. International Journal of Nanomedicine 9, pages 2779-2789.
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Yan-rong Jiang, Zhen-hai Zhang, Qi-yuan Liu, Shao-ying Hu, Xiao-yun Chen & Xiao-bin Jia. (2013) Preparation, characterization, and in vivo evaluation of tanshinone IIA solid dispersions with silica nanoparticles. International Journal of Nanomedicine 8, pages 2285-2293.
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Jun-ichiro Jo, Tsubasa Emi & Yasuhiko Tabata. (2021) Design of a Platelet-Mediated Delivery System for Drug-Incorporated Nanospheres to Enhance Anti-Tumor Therapeutic Effect. Pharmaceutics 13:10, pages 1724.
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Raphaël Michel, Maïlie Roquart, Elodie Llusar, Fabrice Gaslain, Sophie Norvez, Jae Seon Baik, Gi-Ra Yi, Mathieu Manassero & Laurent Corté. (2020) Hydrogel-Tissue Adhesion Using Blood Coagulation Induced by Silica Nanoparticle Coatings. ACS Applied Bio Materials 3:12, pages 8808-8819.
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Rana Bakhaidar, Sarah O’Neill & Zebunnissa Ramtoola. (2020) PLGA-PEG Nanoparticles Show Minimal Risks of Interference with Platelet Function of Human Platelet-Rich Plasma. International Journal of Molecular Sciences 21:24, pages 9716.
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Ivan V. Gmoshinski, Vladimir A. Shipelin, Antonina A. Shumakova, Eleonora N. Trushina, Oksana K. Mustafina, Irina V. Safenkova, Sergey A. Khotimchenko, Dmitry B. Nikityuk & Viktor A. Tutelyan. (2020) Toxicity Evaluation of Nanostructured Silica Orally Administered to Rats: Influence on Immune System Function. Nanomaterials 10:11, pages 2126.
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Ludovica Soddu, Duong N Trinh, Eimear Dunne, Dermot Kenny, Giorgia Bernardini, Ida Kokalari, Arianna Marucco, Marco P Monopoli & Ivana Fenoglio. (2020) Identification of physicochemical properties that modulate nanoparticle aggregation in blood. Beilstein Journal of Nanotechnology 11, pages 550-567.
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Sivakumar Murugadoss, Dominique Lison, Lode Godderis, Sybille Van Den Brule, Jan Mast, Frederic Brassinne, Noham Sebaihi & Peter H. Hoet. (2017) Toxicology of silica nanoparticles: an update. Archives of Toxicology 91:9, pages 2967-3010.
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Volodymyr Gryshchuk & Natalya Galagan. (2016) Silica Nanoparticles Effects on Blood Coagulation Proteins and Platelets. Biochemistry Research International 2016, pages 1-6.
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