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International Journal of Nanomedicine Volume 9, 2014 - Issue
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Original Research

Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer

Armando Lucero-Acuña1 Department of Chemical and Environmental Engineering, University of Arizona, Tucson, AZ, USA
,
Justin J Jeffery2 Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA
,
Edward R Abril3 University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;4 Department of Pathology, University of Arizona, Tucson, AZ, USA
,
Raymond B Nagle3 University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;4 Department of Pathology, University of Arizona, Tucson, AZ, USA
,
Roberto Guzman1 Department of Chemical and Environmental Engineering, University of Arizona, Tucson, AZ, USA
,
Mark D Pagel2 Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA;3 University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;5 Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA;6 Department of Medical Imaging, University of Arizona, Tucson, AZ, USA
&
Emmanuelle J Meuillet3 University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;7 Department of Molecular and Cell Biology, University of Arizona, Tucson, AZ, USA;8 Department of Nutritional Sciences, University of Arizona, Tucson, AZ, USACorrespondence[email protected]
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Pages 5653-5665 | Published online: 03 Dec 2014

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Benedito A Carneiro, Jason B Kaplan, Jessica K Altman, Francis J Giles & Leonidas C Platanias. (2015) Targeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia. Cancer Biology & Therapy 16:5, pages 648-656.
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Articles from other publishers (4)

Abdullah K. Alshememry, Nasser B. Alsaleh, Nora Alkhudair, Rami Alzhrani & Aws Alshamsan. (2022) Recent nanotechnology advancements to treat multidrug-resistance pancreatic cancer: Pre-clinical and clinical overview. Frontiers in Pharmacology 13.
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Joaquín Yanes-Díaz, Raquel Palao-Suay, María Rosa Aguilar, Juan Ignacio Riestra-Ayora, Antonio Ferruelo-Alonso, Luis Rojo del Olmo, Blanca Vázquez-Lasa, Ricardo Sanz-Fernández & Carolina Sánchez-Rodríguez. (2021) Antitumor Activity of Nanoparticles Loaded with PHT-427, a Novel AKT/PDK1 Inhibitor, for the Treatment of Head and Neck Squamous Cell Carcinoma. Pharmaceutics 13:8, pages 1242.
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Wenpeng Cao, Zhirui Zeng, Runsang Pan, Hao Wu, Xiangyan Zhang, Hui Chen, Yingjie Nie, Zijiang Yu & Shan Lei. (2021) Hypoxia-Related Gene FUT11 Promotes Pancreatic Cancer Progression by Maintaining the Stability of PDK1. Frontiers in Oncology 11.
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Tania Maffucci & Marco Falasca. (2020) Inositol Polyphosphate-Based Compounds as Inhibitors of Phosphoinositide 3-Kinase-Dependent Signaling. International Journal of Molecular Sciences 21:19, pages 7198.
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