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Original Research

Parthenolide suppresses pancreatic cell growth by autophagy-mediated apoptosis

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Pages 453-461 | Published online: 23 Jan 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Tao An, Huanhuan Yin, Yanting Lu & Feng Liu. (2022) The Emerging Potential of Parthenolide Nanoformulations in Tumor Therapy. Drug Design, Development and Therapy 16, pages 1255-1272.
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Jingbo Li, Xin Chen, Rui Kang, Herbert Zeh, Daniel J. Klionsky & Daolin Tang. (2021) Regulation and function of autophagy in pancreatic cancer. Autophagy 17:11, pages 3275-3296.
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Bo Tian, Yuhang Xiao, Junliang Ma, Wei Ou, Hui Wang, Jie Wu, Jinming Tang, Baihua Zhang, Xiaojuan Liao, Desong Yang, Zhining Wu, Xu Li, Yong Zhou, Min Su & Wenxiang Wang. (2020) Parthenolide Inhibits Angiogenesis in Esophageal Squamous Cell Carcinoma Through Suppression of VEGF. OncoTargets and Therapy 13, pages 7447-7458.
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Yanshan Zheng, Jiawei Tu, Xinxin Wang, Yue Yu, Jiajia Li, Yin Jin & Jiansheng Wu. (2019) The Therapeutic Effect of Melatonin on GC by Inducing Cell Apoptosis and Autophagy Induced by Endoplasmic Reticulum Stress. OncoTargets and Therapy 12, pages 10187-10198.
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Xin Jin, Jianping Zhou, Zhenhai Zhang & Huixia Lv. (2018) The combined administration of parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 931-942.
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Xiao Yu, Hongyan Lin, Yu Wang, Wenwen Lv, Shuo Zhang, Ying Qian, Xiaobei Deng, Nannan Feng, Herbert Yu & Biyun Qian. (2018) d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer. OncoTargets and Therapy 11, pages 1833-1847.
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Articles from other publishers (21)

Joana Jorge, Joana Neves, Raquel Alves, Catarina Geraldes, Ana Cristina Gonçalves & Ana Bela Sarmento-Ribeiro. (2023) Parthenolide Induces ROS-Mediated Apoptosis in Lymphoid Malignancies. International Journal of Molecular Sciences 24:11, pages 9167.
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Sipin Zhu, Ping Sun, Samuel Bennett, Oscar Charlesworth, Renxiang Tan, Xing Peng, Qiang Gu, Omar Kujan & Jiake Xu. (2023) The therapeutic effect and mechanism of parthenolide in skeletal disease, cancers, and cytokine storm. Frontiers in Pharmacology 14.
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Yonghao Chen, Jialin Meng, Xiaofan Lu, Xiao Li & Chunhui Wang. (2022) Clustering analysis revealed the autophagy classification and potential autophagy regulators' sensitivity of pancreatic cancer based on multi‐omics data. Cancer Medicine 12:1, pages 733-746.
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Francesca V. LoBianco, Kimberly J. Krager, Erica Johnson, Christopher O. Godwin, Antino R. Allen, Peter A. Crooks, Cesar M. Compadre, Michael J. Borrelli & Nukhet Aykin-Burns. (2022) Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells. Frontiers in Toxicology 4.
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Wamidh H. Talib, Safa Daoud, Asma Ismail Mahmod, Reem Ali Hamed, Dima Awajan, Sara Feras Abuarab, Lena Hisham Odeh, Samar Khater & Lina T. Al Kury. (2022) Plants as a Source of Anticancer Agents: From Bench to Bedside. Molecules 27:15, pages 4818.
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Yubo Dong, Xuanjin Qian & Jian Li. (2022) Sesquiterpene Lactones and Cancer: New Insight into Antitumor and Anti-inflammatory Effects of Parthenolide-Derived Dimethylaminomicheliolide and Micheliolide. Computational and Mathematical Methods in Medicine 2022, pages 1-8.
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Laura Cecilia Laurella, Nadia Talin Mirakian, Maria Noé Garcia, Daniel Héctor Grasso, Valeria Patricia Sülsen & Daniela Laura Papademetrio. (2022) Sesquiterpene Lactones as Promising Candidates for Cancer Therapy: Focus on Pancreatic Cancer. Molecules 27:11, pages 3492.
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James A. McCubrey, Akshaya K. Meher, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Michelle M. LaHair, Richard A. Franklin, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Fulvio Barbaro, Przemysław Duda & Agnieszka Gizak. (2022) Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties. Aging 14:8, pages 3365-3386.
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Daniela Trisciuoglio & Francesca Degrassi. (2021) The Tubulin Code and Tubulin-Modifying Enzymes in Autophagy and Cancer. Cancers 14:1, pages 6.
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Arezoo Fathalizadeh Alamdari, Sama Rahnemayan, Hadi Rajabi, Nafiseh Vahed, Hamid Reza Khayat Kashani, Aysa Rezabakhsh & Sarvin Sanaie. (2021) Melatonin as a promising modulator of aging related neurodegenerative disorders: Role of microRNAs. Pharmacological Research 173, pages 105839.
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Chirine El-Baba, Amro Baassiri, Georges Kiriako, Batoul Dia, Sukayna Fadlallah, Sara Moodad & Nadine Darwiche. (2021) Terpenoids’ anti-cancer effects: focus on autophagy. Apoptosis 26:9-10, pages 491-511.
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Yulin Ren & A. Douglas Kinghorn. (2020) Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones. Journal of Medicinal Chemistry 63:24, pages 15410-15448.
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Ce Shi, Wenjia Lan, Zhenkun Wang, Dongguang Yang, Jia Wei, Zhiyu Liu, Yueqiu Teng, Mengmeng Gu, Tian Yuan, Fenglin Cao, Jin Zhou & Yang Li. (2020) Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia. Cancer Cell International 20:1.
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Thaise Gonçalves Araújo, Lara Vecchi, Paula Marynella Alves Pereira Lima, Everton Allan Ferreira, Igor Moreira Campos, Douglas Cardoso Brandão, Gabriela Silva Guimarães, Matheus Alves Ribeiro & Ademar Alves da Silva Filho. (2020) Parthenolide and its Analogues: A New Potential Strategy for the Treatment of Triple-Negative Breast Tumors. Current Medicinal Chemistry 27:39, pages 6628-6642.
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Tareq Abu-Izneid, Abdur Rauf, Mohammad Ali Shariati, Anees Ahmed Khalil, Muhammad Imran, Maksim Rebezov, Md. Sahab Uddin, Mohamad Fawzi Mahomoodally & Kannan R.R. Rengasamy. (2020) Sesquiterpenes and their derivatives-natural anticancer compounds: An update. Pharmacological Research 161, pages 105165.
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Youcheng Bian, Hui Zeng, Hong Tao, Lulin Huang, Zhenyun Du, Jiao Wang & Kan Ding. (2020) A pectin-like polysaccharide from Polygala tenuifolia inhibits pancreatic cancer cell growth in vitro and in vivo by inducing apoptosis and suppressing autophagy. International Journal of Biological Macromolecules 162, pages 107-115.
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Charles A. Berdan, Raymond Ho, Haley S. Lehtola, Milton To, Xirui Hu, Tucker R. Huffman, Yana Petri, Chad R. Altobelli, Sasha G. Demeulenaere, James A. Olzmann, Thomas J. Maimone & Daniel K. Nomura. (2019) Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells. Cell Chemical Biology 26:7, pages 1027-1035.e22.
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Amlan Das, Maruthi Kumar Narayanam, Santanu Paul, Pritha Mukhnerjee, Suvranil Ghosh, Debabrata Ghosh Dastidar, Subhendu Chakrabarty, Arnab Ganguli, Biswarup Basu, Mahadeb Pal, Urmi Chatterji, Sushanta K. Banerjee, Parimal Karmakar, Dalip Kumar & Gopal Chakrabarti. (2019) A novel triazole, NMK-T-057, induces autophagic cell death in breast cancer cells by inhibiting γ-secretase–mediated activation of Notch signaling. Journal of Biological Chemistry 294:17, pages 6733-6750.
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Yulin Ren, Esperanza J. Carcache de Blanco, James R. Fuchs, Djaja D. Soejarto, Joanna E. Burdette, Steven M. Swanson & A. Douglas Kinghorn. (2019) Potential Anticancer Agents Characterized from Selected Tropical Plants. Journal of Natural Products 82:3, pages 657-679.
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Jiabin Zhu, Jun Zhao, Zhenlong Yu, Sandeep Shrestha, Jing Song, Wenwen Liu, Wen Lan, Jinshan Xing, Shuang Liu, Chen Chen, Momo Cao, Xiuzhen Sun, Qi Wang & Xishuang Song. (2018) Epoxymicheliolide, a novelguaiane-type sesquiterpene lactone, inhibits NF‑κB/COX‑2 signaling pathways by targeting leucine�281 and leucine�25 in IKKβ in renal cell carcinoma. International Journal of Oncology.
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Claudia A. Anesini, María Rosario Alonso & Renzo F. Martino. 2018. Sesquiterpene Lactones. Sesquiterpene Lactones 303 323 .