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Original Article

Active Immunotherapy of Human Melanoma Exploiting the Immunopotentiating Effects of Cyclophosphamide

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Pages 337-349 | Published online: 11 Jun 2009

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David Berd. (2023) Portrait of an autologous cancer vaccine: Then and now. Human Vaccines & Immunotherapeutics 19:1.
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Ioannis M. Koukourakis & Michael I. Koukourakis. (2023) Combining the past and present to advance immuno-radiotherapy of cancer. International Reviews of Immunology 42:1, pages 26-42.
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Sabry A. El-Naggar, Ibrahim B. Abdel-Farid, Mousa O. Germoush, Hassan A. Elgebaly & Abeer A. Alm-Eldeen. (2016) Efficacy of Rosmarinus officinalis leaves extract against cyclophosphamide-induced hepatotoxicity. Pharmaceutical Biology 54:10, pages 2007-2016.
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Leona A Holmberg & Brenda M Sandmaier. (2001) Theratope® vaccine (STn-KLH). Expert Opinion on Biological Therapy 1:5, pages 881-891.
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Malcolm S. Mitchell. (1991) Attempts to Optimize Active Specific Immunotherapy for Melanoma. International Reviews of Immunology 7:4, pages 331-347.
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Joseph G. Sinkovics. (1991) Viral Oncolysates as Human Tumor Vaccines. International Reviews of Immunology 7:4, pages 259-287.
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Mitesh Dwivedi, Sanjay Tiwari, E. Helen Kemp & Rasheedunnisa Begum. (2022) Implications of regulatory T cells in anti-cancer immunity: from pathogenesis to therapeutics. Heliyon 8:8, pages e10450.
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Antonella Sistigu, Sophie Viaud, Nathalie Chaput, Laura Bracci, Enrico Proietti & Laurence Zitvogel. (2011) Immunomodulatory effects of cyclophosphamide and implementations for vaccine design. Seminars in Immunopathology 33:4, pages 369-383.
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Lana E. Kandalaft, Nathan Singh, John B. Liao, Andrea Facciabene, Jonathan S. Berek, Daniel J. PowellJr.Jr. & George Coukos. (2010) The emergence of immunomodulation: Combinatorial immunochemotherapy opportunities for the next decade. Gynecologic Oncology 116:2, pages 222-233.
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Joris D. Veltman, Margaretha E. H. Lambers, Menno van Nimwegen, Sanne de Jong, Rudi W. Hendriks, Henk C. Hoogsteden, Joachim G. J. V. Aerts & Joost P. J. J. Hegmans. (2010) Low-Dose Cyclophosphamide Synergizes with Dendritic Cell-Based Immunotherapy in Antitumor Activity. Journal of Biomedicine and Biotechnology 2010, pages 1-10.
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Giuseppe Valentino Masucci, Eva Månsson-Brahme, Boel Ragnarsson-Olding, Bo Nilsson, Gunnar Wagenius & Johan Hansson. (2006) Alternating chemo-immunotherapy with temozolomide and low-dose interleukin-2 in patients with metastatic melanoma. Melanoma Research 16:4, pages 357-363.
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Margalit B. Mokyr, Aaron T. Place, James E. Artwohl & VE Ted Valli. (2005) Importance of signaling via the IFN-α/β receptor on host cells for the realization of the therapeutic benefits of cyclophosphamide for mice bearing a large MOPC-315 tumor. Cancer Immunology, Immunotherapy 55:4, pages 459-468.
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Nuhad K. Ibrahim & James Lee Murray. (2003) Clinical Development of the STn-KLH Vaccine (Theratope®). Clinical Breast Cancer 3, pages S139-S143.
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Kwang-Mi Kim, Ho Won Kim, Jae-Ouk Kim, Kyoung-Min Baek, Joong Gon Kim & Chang-Yuil Kang. (2002) Induction of 4-1BB (CD137) expression by DNA damaging agents in human T lymphocytes. Immunology 107:4, pages 472-479.
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Vladimir M. Jovasevic & Margalit B. Mokyr. (2001) Melphalan-Induced Expression of IFN-β in MOPC-315 Tumor-Bearing Mice and Its Importance for the Up-Regulation of TNF-α Expression. The Journal of Immunology 167:9, pages 4895-4901.
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Manjula Donepudi, Pradip Raychaudhuri, Jeffrey A. Bluestone & Margalit B. Mokyr. (2001) Mechanism of Melphalan-Induced B7-1 Gene Expression in P815 Tumor Cells. The Journal of Immunology 166:11, pages 6491-6499.
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