1,559
Views
102
CrossRef citations to date
0
Altmetric
Articles

Second AKT: The rise of SGK in cancer signalling

, , &
Pages 394-408 | Received 23 Jun 2010, Accepted 23 Aug 2010, Published online: 05 Oct 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Abhishek Kumar Verma, Sk. Faisal Ahmed, Md.Shahadat Hossain, Ali Asger Bhojiya, Sudhir K. Upadhyay, Abhishek K. Srivastava, Nripendra Singh, Harina Harina, Md. Mizanur Rahaman & Newaz Mohammed Bahadur. (2022) Unlocking SGK1 inhibitor potential of bis-[1-N,7-N, pyrazolo tetraethoxyphthalimido{-4-(3,5-Dimethyl-4-(spiro-3-methylpyazolo)-1,7-dihydro-1H-dipyrazolo[3,4-b;4',3'-e]pyridin-8-yl)}]p-disubstituted phenyl compounds: a computational study. Journal of Biomolecular Structure and Dynamics 40:24, pages 13412-13431.
Read now
Laura Devis-Jauregui, Núria Eritja, Meredith Leigh Davis, Xavier Matias-Guiu & David Llobet-Navàs. (2021) Autophagy in the physiological endometrium and cancer. Autophagy 17:5, pages 1077-1095.
Read now
Joshua A. Mason & Zachary T. Schafer. (2019) Ras-ling with new therapeutic targets for metastasis. Small GTPases 10:4, pages 249-253.
Read now
Maressa A Bruhn, Richard B Pearson, Ross D Hannan & Karen E Sheppard. (2013) AKT-independent PI3-K signaling in cancer – emerging role for SGK3. Cancer Management and Research 5, pages 281-292.
Read now

Articles from other publishers (98)

Min Wang, Jiannan Liu, Xingming Liao, Yasong Yi, Yijue Xue, Ling Yang, Hailing Cheng & Pixu Liu. (2023) The SGK3-Catalase antioxidant signaling axis drives cervical cancer growth and therapy resistance. Redox Biology 67, pages 102931.
Crossref
Nurul Nadirah Razali, Raja Affendi Raja Ali, Khairul Najmi Muhammad Nawawi, Azyani Yahaya, Norshafila Diana Mohd Rathi & Norfilza Mohd Mokhtar. (2023) Roles of phosphatidylinositol-3-kinases signaling pathway in inflammation-related cancer: Impact of rs10889677 variant and buparlisib in colitis-associated cancer. World Journal of Gastroenterology 29:40, pages 5543-5556.
Crossref
Li Chen, Yikai Lu, Mengmeng Zhao, Junfang Xu, Yan Wang, Qinghua Xu, Yajuan Cao & Haipeng Liu. (2023) A non‐canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT). The Journal of Gene Medicine.
Crossref
Hossein Moutabian, Usama Kadem Radi, Abdulkarem Younis Saleman, Mohaned Adil, Rahman S. Zabibah, MV N.L. Chaitanya, Mohamed J. Saadh, Mahmood Jasem Jawad, Ebrahi Hazrati, Hamed Bagheri, Rashmi Saxena Pal & Reza Akhavan-Sigari. (2023) MicroRNA-155 and cancer metastasis: Regulation of invasion, migration, and epithelial-to-mesenchymal transition. Pathology - Research and Practice 250, pages 154789.
Crossref
Ritesh P. Bhole, Payal R. Kute, Rupesh V. Chikhale, C.G. Bonde, Amit Pant & Shailendra S. Gurav. (2023) Unlocking the potential of PROTACs: A comprehensive review of protein degradation strategies in disease therapy. Bioorganic Chemistry 139, pages 106720.
Crossref
Valentin Mieville, Arjan W. Griffioen, Daniel Benamran & Patrycja Nowak-Sliwinska. (2023) Advanced in vitro models for renal cell carcinoma therapy design. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:5, pages 188942.
Crossref
Pejman Molaei, Marzieh Savari, Ali Mahdavinezhad, Rezvan Najafi, Saeid Afshar, Negin Esfandiari, Ramin Khorrami & Mehrdad Hashemi. (2023) Highlighting functions of apoptosis and circular RNAs in colorectal cancer. Pathology - Research and Practice 248, pages 154592.
Crossref
Yannis Hara, Viktor T. Lemgart, Nis Halland, Kiana Mahdaviani, Jean-Antoine Ribeil, Samuel Lessard, Alexandra Hicks & David R. Light. (2023) SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells. Blood Advances 7:11, pages 2317-2323.
Crossref
Xin Kong, Hong Peng, Peng Liu, Xiao Fu, Ni Wang & Dazhi Zhang. (2023) Programmed death ligand 1 regulates epithelial–mesenchymal transition and cancer stem cell phenotypes in hepatocellular carcinoma through the serum and glucocorticoid kinase 2/β‐catenin signaling pathway. Cancer Science 114:6, pages 2265-2276.
Crossref
Ang Qu, Yulin Bai, Jiaying Wang, Ji Zhao, Junjia Zeng, Yue Liu, Xintong Chen, Qiaozhen Ke, Pengxin Jiang, Xinyi Zhang, Xin Li, Peng Xu & Tao Zhou. (2023) Integrated mRNA and miRNA expression analyses for Cryptocaryon irritans resistance in large yellow croaker (Larimichthys crocea). Fish & Shellfish Immunology 135, pages 108650.
Crossref
Natalia Miroschnikov, Oliver Dräger, Dario Van Meenen, Klaus Metz, Bettina Budeus, Nicole Dünker & Maike Anna Busch. (2023) Tumor Suppressor Role of INPP4B in Chemoresistant Retinoblastoma. Journal of Oncology 2023, pages 1-22.
Crossref
Yanan Sun, Huihui Wang, Taiqi Qu, Junjie Luo, Peng An, Fazheng Ren, Yongting Luo & Yixuan Li. (2023) mTORC2: a multifaceted regulator of autophagy. Cell Communication and Signaling 21:1.
Crossref
Erik A. Blackwood, Lauren F. MacDonnellDonna J. ThueraufAlina S. Bilal, Victoria B. MurrayKenneth C. BediJrJr, Kenneth B. MarguliesChristopher C. Glembotski. (2023) Noncanonical Form of ERAD Regulates Cardiac Hypertrophy. Circulation 147:1, pages 66-82.
Crossref
Zi Liu, Mingxing Hu, Yu Yang, Chenghao Du, Haoxuan Zhou, Chengyali Liu, Yuanwei Chen, Lei Fan, Hongqun Ma, Youling Gong & Yongmei Xie. (2022) An overview of PROTACs: a promising drug discovery paradigm. Molecular Biomedicine 3:1.
Crossref
Suguru Kurokawa, Masato Yoneda, Yuji Ogawa, Yasushi Honda, Takaomi Kessoku, Kento Imajo, Satoru Saito, Atsushi Nakajima & Kikuko Hotta. (2022) Two differentially methylated region networks in nonalcoholic fatty liver disease, viral hepatitis, and hepatocellular carcinoma. BMC Gastroenterology 22:1.
Crossref
Julie Refardt, Tessa Brabander, Noémie S Minczeles, Richard A Feelders, Wouter W de Herder & Johannes Hofland. (2022) Prognostic value of dysnatremia for survival in neuroendocrine neoplasm patients. European Journal of Endocrinology 187:1, pages 209-217.
Crossref
Edgar del Llano, Rajan Iyyappan, Daria Aleshkina, Tomas Masek, Michal Dvoran, Zongliang Jiang, Martin Pospisek, Michal Kubelka & Andrej Susor. (2022) SGK1 is essential for meiotic resumption in mammalian oocytes. European Journal of Cell Biology 101:2, pages 151210.
Crossref
Run-qing Lu, Yin-yin Zhang, Hai-qiu Zhao, Rong-qun Guo, Zhong-xing Jiang & Rong Guo. (2022) SGK1, a Critical Regulator of Immune Modulation and Fibrosis and a Potential Therapeutic Target in Chronic Graft-Versus-Host Disease. Frontiers in Immunology 13.
Crossref
Katie L. Pennington, Colten M. McEwan, James Woods, Colin M. Muir, A.G. Pramoda Sahankumari, Riley Eastmond, Eranga R. Balasooriya, Christina M. Egbert, Sandeep Kaur, Tyler Heaton, Katherine K. McCormack, Stephen R. Piccolo, Manabu Kurokawa & Joshua L. Andersen. (2022) SGK2, 14-3-3, and HUWE1 Cooperate to Control the Localization, Stability, and Function of the Oncoprotein PTOV1. Molecular Cancer Research 20:2, pages 231-243.
Crossref
Taj Mohammad & Md. Imtaiyaz Hassan. 2022. Protein Kinase Inhibitors. Protein Kinase Inhibitors 223 238 .
Sabryn A. Hamila, Lisa M. Ooms, Samuel J. Rodgers & Christina A. Mitchell. (2021) The INPP4B paradox: Like PTEN, but different. Advances in Biological Regulation 82, pages 100817.
Crossref
Katharina Joechle, Jessica Guenzle, Claus Hellerbrand, Pavel Strnad, Thorsten Cramer, Ulf Peter Neumann & Sven Arke Lang. (2021) Role of mammalian target of rapamycin complex 2 in primary and secondary liver cancer. World Journal of Gastrointestinal Oncology 13:11, pages 1632-1647.
Crossref
Mahmood S. Mozaffari & Rafik Abdelsayed. (2021) Expression Profiles of GILZ and SGK-1 in Potentially Malignant and Malignant Human Oral Lesions. Frontiers in Oral Health 2.
Crossref
Julie Refardt, Anissa Pelouto, Laura Potasso, Ewout J. Hoorn & Mirjam Christ-Crain. (2021) Hyponatremia Intervention Trial (HIT): Study Protocol of a Randomized, Controlled, Parallel-Group Trial With Blinded Outcome Assessment. Frontiers in Medicine 8.
Crossref
Joshua A. Mason, Jordan A. Cockfield, Daniel J. Pape, Hannah Meissner, Michael T. Sokolowski, Taylor C. White, José C. Valentín López, Juan Liu, Xiaojing Liu, Inmaculada Martínez-Reyes, Navdeep S. Chandel, Jason W. Locasale & Zachary T. Schafer. (2021) SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells. Cell Reports 34:11, pages 108821.
Crossref
Raquel A. C. Machado, Dunja Stojevski, Sébastien De Landtsheer, Philippe Lucarelli, Alexandre Baron, Thomas Sauter & Elisabeth Schaffner-Reckinger. (2021) L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness. Cell Communication and Signaling 19:1.
Crossref
Anem Iftikhar, Mohammad Islam, Simon Shepherd, Sarah Jones & Ian Ellis. (2021) Cancer and Stress: Does It Make a Difference to the Patient When These Two Challenges Collide?. Cancers 13:2, pages 163.
Crossref
Pedro Martín-Acosta & Xiangshu Xiao. (2021) PROTACs to address the challenges facing small molecule inhibitors. European Journal of Medicinal Chemistry 210, pages 112993.
Crossref
Hongchang Guo, Ke Ma, Wenjing Hao, Yao Jiao, Ping Li, Jing Chen, Chen Xu, Fu‐jian Xu, Wayne Bond Lau, Jie Du, Xin‐liang Ma & Yulin Li. (2020) mir15a/mir16‐1 cluster and its novel targeting molecules negatively regulate cardiac hypertrophy. Clinical and Translational Medicine 10:8.
Crossref
Zhuoyu Gu, Liping Wang, Xiaohan Yao, Qian Long, Kaping Lee, Jieyao Li, Dongli Yue, Shuangning Yang, Yanfen Liu, Na Li & Yixin Li. (2020) ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma. Cell Death & Disease 11:10.
Crossref
Valentina Ranzuglia, Ilaria Lorenzon, Ilenia Pellarin, Maura Sonego, Alessandra Dall’Acqua, Sara D’Andrea, Sara Lovisa, Ilenia Segatto, Michela Coan, Jerry Polesel, Diego Serraino, Patrizia Sabatelli, Paola Spessotto, Barbara Belletti, Gustavo Baldassarre & Monica Schiappacassi. (2020) Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells. Oncogene 39:40, pages 6370-6386.
Crossref
Yang Liu, Junying liu, Xin Kong, Han Li, Jianying Shao & Ziting Jiang. (2020) SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition in colon cancer cells. European Journal of Surgical Oncology 46:10, pages 1912-1917.
Crossref
Vincenzo Dattilo, Rosario Amato, Nicola Perrotti & Massimo Gennarelli. (2020) The Emerging Role of SGK1 (Serum- and Glucocorticoid-Regulated Kinase 1) in Major Depressive Disorder: Hypothesis and Mechanisms. Frontiers in Genetics 11.
Crossref
Bao-yi Chen, Cheng-cui Huang, Xiao-fei Lv, Hua-qing Zheng, Ya-juan Zhang, Lu Sun, Guan-lei Wang, Ming-ming Ma & Yong-yuan Guan. (2020) SGK1 mediates the hypotonic protective effect against H2O2-induced apoptosis of rat basilar artery smooth muscle cells by inhibiting the FOXO3a/Bim signaling pathway. Acta Pharmacologica Sinica 41:8, pages 1073-1084.
Crossref
Boris Y. Shorning, Manisha S. Dass, Matthew J. Smalley & Helen B. Pearson. (2020) The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling. International Journal of Molecular Sciences 21:12, pages 4507.
Crossref
Seonghee Jung, Hyeonjeong Jeong & Seong-Woon Yu. (2020) Autophagy as a decisive process for cell death. Experimental & Molecular Medicine 52:6, pages 921-930.
Crossref
Muhammad Shahid, Muhammad Idrees, Azeem Mehmood Butt, Syed Mohsin Raza, Iram Amin, Afza Rasul & Samia Afzal. (2020) Blood-based gene expression profile of oxidative stress and antioxidant genes for identifying surrogate markers of liver tissue injury in chronic hepatitis C patients. Archives of Virology 165:4, pages 809-822.
Crossref
Miguel A. Ortega, Oscar Fraile-Martínez, Ángel Asúnsolo, Julia Buján, Natalio García-Honduvilla & Santiago Coca. (2020) Signal Transduction Pathways in Breast Cancer: The Important Role of PI3K/Akt/mTOR. Journal of Oncology 2020, pages 1-11.
Crossref
Taj Mohammad, Shiza Siddiqui, Anas Shamsi, Mohamed F. Alajmi, Afzal Hussain, Asimul Islam, Faizan Ahmad & Md. Imtaiyaz Hassan. (2020) Virtual Screening Approach to Identify High-Affinity Inhibitors of Serum and Glucocorticoid-Regulated Kinase 1 among Bioactive Natural Products: Combined Molecular Docking and Simulation Studies. Molecules 25:4, pages 823.
Crossref
Hui Cao, Zhong Xu, Jingxiao Wang, Antonio Cigliano, Maria G. Pilo, Silvia Ribback, Shu Zhang, Yu Qiao, Li Che, Rosa M. Pascale, Diego F. Calvisi & Xin Chen. (2019) Functional role of SGK3 in PI3K/Pten driven liver tumor development. BMC Cancer 19:1.
Crossref
Jing Chen, Hai Liang Li, Bo Bo Li, Wei Li, Dong Ma, Yong He Li & Tao Liu. (2019) Serum- and glucocorticoid-inducible kinase 3 is a potential oncogene in nasopharyngeal carcinoma. Brazilian Journal of Otorhinolaryngology 85:6, pages 705-715.
Crossref
Bashir A. Akhoon, Neha S. Gandhi & Rakesh Pandey. (2019) Computational insights into the active structure of SGK1 and its implication for ligand design. Biochimie 165, pages 57-66.
Crossref
Giovanni Fucà, Luigi Mariani, Salvatore Lo Vullo, Giulia Galli, Rossana Berardi, Massimo Di Nicola, Claudio Vernieri, Daniele Morelli, Katia Dotti, Ilaria Fiordoliva, Silvia Rinaldi, Cecilia Gavazzi, Filippo Pietrantonio, Marco Platania & Filippo de Braud. (2019) Weighing the prognostic role of hyponatremia in hospitalized patients with metastatic solid tumors: the HYPNOSIS study. Scientific Reports 9:1.
Crossref
Sheng Lu, Zheng-Gang Zhu & Wen-Cong Lu. (2019) Inferring novel genes related to colorectal cancer via random walk with restart algorithm. Gene Therapy 26:9, pages 373-385.
Crossref
Lucia D'Antona, Vincenzo Dattilo, Giada Catalogna, Domenica Scumaci, Claudia Vincenza Fiumara, Francesca Musumeci, Giuseppe Perrotti, Silvia Schenone, Rossana Tallerico, Cristina B. Spoleti, Nicola Costa, Rodolfo Iuliano, Giovanni Cuda, Rosario Amato & Nicola Perrotti. (2019) In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity. Translational Oncology 12:8, pages 1045-1055.
Crossref
Xiuquan Ma, Luxi Zhang, Jiangning Song, Elizabeth Nguyen, Rachel S. Lee, Samuel J. Rodgers, Fuyi Li, Cheng Huang, Ralf B. Schittenhelm, Howard Chan, Chanly Chheang, Jianmin Wu, Kristin K. Brown, Christina A. Mitchell, Kaylene J. Simpson & Roger J. Daly. (2019) Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation. Nature Communications 10:1.
Crossref
Hongjun Jin, Liyuan Yang, Lu Wang, Zailin Yang, Qian Zhan, Yao Tao, Qin Zou, Yuting Tang, Jingrong Xian, Shuaishuai Zhang, Yipei Jing & Ling Zhang. (2018) INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia. Journal of Experimental & Clinical Cancer Research 37:1.
Crossref
Grace Qun Gong, Ke Wang, Xin-Chuan Dai, Yan Zhou, Rajesh Basnet, Yi Chen, De-Hua Yang, Woo-Jeong Lee, Christina Maree Buchanan, Jack Urquhart Flanagan, Peter Robin Shepherd, Ying Chen & Ming-Wei Wang. (2018) Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds. Acta Pharmacologica Sinica 39:12, pages 1902-1912.
Crossref
Giovanni Fucà, Giulia Galli, Marta Poggi, Giuseppe Lo Russo, Claudia Proto, Martina Imbimbo, Milena Vitali, Monica Ganzinelli, Claudia Lanti, Giuliano Molino, Fabiano Stangoni, Nicoletta Zilembo, Filippo de Braud, Marina Chiara Garassino & Diego Signorelli. (2018) Low Baseline Serum Sodium Concentration Is Associated with Poor Clinical Outcomes in Metastatic Non-Small Cell Lung Cancer Patients Treated with Immunotherapy. Targeted Oncology 13:6, pages 795-800.
Crossref
Ya-Nan Du, Xiao-Feng Tang, Lian Xu, Wen-Dong Chen, Ping-Jin Gao & Wei-Qing Han. (2018) SGK1-FoxO1 Signaling Pathway Mediates Th17/Treg Imbalance and Target Organ Inflammation in Angiotensin II-Induced Hypertension. Frontiers in Physiology 9.
Crossref
Rajesh Basnet, Grace Qun Gong, Chenyao Li & Ming-Wei Wang. (2018) Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention. Acta Pharmaceutica Sinica B 8:5, pages 767-771.
Crossref
Birgit Knebel, Sonja Hartwig, Sylvia Jacob, Ulrike Kettel, Martina Schiller, Waltraud Passlack, Cornelia Koellmer, Stefan Lehr, Dirk Müller-Wieland & Jorg Kotzka. (2018) Inactivation of SREBP-1a Phosphorylation Prevents Fatty Liver Disease in Mice: Identification of Related Signaling Pathways by Gene Expression Profiles in Liver and Proteomes of Peroxisomes. International Journal of Molecular Sciences 19:4, pages 980.
Crossref
Alejandro E. Leroux, Jörg O. Schulze & Ricardo M. Biondi. (2018) AGC kinases, mechanisms of regulation ‎and innovative drug development. Seminars in Cancer Biology 48, pages 1-17.
Crossref
Nazma MalikThomas MacartneyAnnika HornbergerKaren E. AndersonHannah TovellAlan R. PrescottDario R. Alessi. (2018) Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks. Biochemical Journal 475:1, pages 117-135.
Crossref
Domenico Conza, Paola Mirra, Gaetano Calì, Teresa Tortora, Luigi Insabato, Francesca Fiory, Silvia Schenone, Rosario Amato, Francesco Beguinot, Nicola Perrotti & Luca Ulianich. (2017) The SGK1 inhibitor SI113 induces autophagy, apoptosis, and endoplasmic reticulum stress in endometrial cancer cells. Journal of Cellular Physiology 232:12, pages 3735-3743.
Crossref
Xuchun Liang, Chunling Lan, Guanming Jiao, Wencheng Fu, Xuesha Long, Yu An, Kejin Wang, Jinzhe Zhou, Ting Chen, Yongqin Li, Jiahong Xu, Qi Huang, Bin Xu & Junjie Xiao. (2017) Therapeutic inhibition of SGK1 suppresses colorectal cancer. Experimental & Molecular Medicine 49:11, pages e399-e399.
Crossref
Patricia Razquin Navas & Kathrin Thedieck. (2017) Differential control of ageing and lifespan by isoforms and splice variants across the mTOR network. Essays in Biochemistry 61:3, pages 349-368.
Crossref
Junying Liu, Guangdong Zhang, Yanping Lv, Xiaoyang Zhang, Cui Ying, Suocheng Yang, Xin Kong & Yanzhang Yu. (2017) SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3β/β-catenin signaling in HCC cells. Tumor Biology 39:6, pages 101042831770040.
Crossref
Liang Ding, Lifang Zhang, Michael Kim, Tatiana Byzova & Eugene Podrez. (2017) Akt3 kinase suppresses pinocytosis of low-density lipoprotein by macrophages via a novel WNK/SGK1/Cdc42 protein pathway. Journal of Biological Chemistry 292:22, pages 9283-9293.
Crossref
Althea N. Waldhart, Holly Dykstra, Anderson S. Peck, Elissa A. Boguslawski, Zachary B. Madaj, Jennifer Wen, Kelsey Veldkamp, Matthew Hollowell, Bin Zheng, Lewis C. Cantley, Timothy E. McGraw & Ning Wu. (2017) Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin. Cell Reports 19:10, pages 2005-2013.
Crossref
Vincenzo Dattilo, Lucia D’Antona, Cristina Talarico, Mjriam Capula, Giada Catalogna, Rodolfo Iuliano, Silvia Schenone, Sante Roperto, Cataldo Bianco, Nicola Perrotti & Rosario Amato. (2017) SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation. Scientific Reports 7:1.
Crossref
Yiyun Lou, Minhao Hu, Luna Mao, Yingming Zheng & Fan Jin. (2016) Involvement of serum glucocorticoid‐regulated kinase 1 in reproductive success. The FASEB Journal 31:2, pages 447-456.
Crossref
Xin Kong, Fengchao Liu & Jian Gao. (2016) MiR-155 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells through the activation of PI3K/SGK3/β-catenin signaling pathways. Oncotarget 7:40, pages 66051-66060.
Crossref
Ruzica Bago, Eeva Sommer, Pau Castel, Claire Crafter, Fiona P Bailey, Natalia Shpiro, José Baselga, Darren Cross, Patrick A Eyers & Dario R Alessi. (2016) The hVps34‐ SGK 3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC 1 and tumour growth . The EMBO Journal 35:17, pages 1902-1922.
Crossref
J A Mason, C A Davison-Versagli, A K Leliaert, D J Pape, C McCallister, J Zuo, S M Durbin, C L Buchheit, S Zhang & Z T Schafer. (2016) Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells. Cell Death & Differentiation 23:8, pages 1271-1282.
Crossref
Shi-qi Cheng, Heng-yi Fan, Xin Xu, Wei-wei Gao, Shi-gang Lv, Min-hua Ye, Miao-jing Wu, Xiao-li Shen, Zu-jue Cheng, Xin-gen Zhu & Yan Zhang. (2016) Over-expression of LRIG1 suppresses biological function of pituitary adenoma via attenuation of PI3K/AKT and Ras/Raf/ERK pathways in vivo and in vitro. Journal of Huazhong University of Science and Technology [Medical Sciences] 36:4, pages 558-563.
Crossref
S T Guo, M N Chi, R H Yang, X Y Guo, L K Zan, C Y Wang, Y F Xi, L Jin, A Croft, H-Y Tseng, X G Yan, M Farrelly, F H Wang, F Lai, J F Wang, Y P Li, S Ackland, R Scott, I U Agoulnik, H Hondermarck, R F Thorne, T Liu, X D Zhang & C C Jiang. (2015) INPP4B is an oncogenic regulator in human colon cancer. Oncogene 35:23, pages 3049-3061.
Crossref
Cristina Talarico, Vincenzo Dattilo, Lucia D’Antona, Agnese Barone, Nicola Amodio, Stefania Belviso, Francesca Musumeci, Claudia Abbruzzese, Cataldo Bianco, Francesco Trapasso, Silvia Schenone, Stefano Alcaro, Francesco Ortuso, Tullio Florio, Marco G. Paggi, Nicola Perrotti & Rosario Amato. (2016) SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells. Oncotarget 7:13, pages 15868-15884.
Crossref
Zhenqi Qin, Hang Zheng, Ling Zhou, Yanhua Ou, Bin Huang, Bo Yan, Zhenshu Qin, Cuilan Yang, Yongchun Su, Xiaochun Bai, Jiasong Guo & Jun Lin. (2016) Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα and cell-cycle-driving proteins. Scientific Reports 6:1.
Crossref
Yu Xiaobo, Lin Qiang, Qin Xiong, Ruan Zheng, Zhou Jianhua, Lin Zhifeng, Su Yijiang & Jian Zheng. (2016) Serum and glucocorticoid kinase 1 promoted the growth and migration of non-small cell lung cancer cells. Gene 576:1, pages 339-346.
Crossref
Meng Na Chi, Su Tang Guo, James S. Wilmott, Xiang Yun Guo, Xu Guang Yan, Chun Yan Wang, Xiao Ying Liu, Lei Jin, Hsin-Yi Tseng, Tao Liu, Amanda Croft, Hubert Hondermarck, Richard A. Scolyer, Chen Chen Jiang & Xu Dong Zhang. (2015) INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas. Oncotarget 6:37, pages 39891-39907.
Crossref
Cristina Talarico, Lucia D’Antona, Domenica Scumaci, Agnese Barone, Francesco Gigliotti, Claudia Vincenza Fiumara, Vincenzo Dattilo, Enzo Gallo, Paolo Visca, Francesco Ortuso, Claudia Abbruzzese, Lorenzo Botta, Silvia Schenone, Giovanni Cuda, Stefano Alcaro, Cataldo Bianco, Patrizia Lavia, Marco G. Paggi, Nicola Perrotti & Rosario Amato. (2015) Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy . Oncotarget 6:35, pages 37511-37525.
Crossref
Seraina Faes & Olivier Dormond. (2015) PI3K and AKT: Unfaithful Partners in Cancer. International Journal of Molecular Sciences 16:9, pages 21138-21152.
Crossref
Jennifer Jasmin Schwarz, Heike Wiese, Regine Charlotte Tölle, Mostafa Zarei, Jörn Dengjel, Bettina Warscheid & Kathrin Thedieck. (2015) Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate. Molecular & Cellular Proteomics 14:8, pages 2042-2055.
Crossref
Roberta L. Beauchamp, Marianne F. James, Patrick A. DeSouza, Vilas Wagh, Wen-Ning Zhao, Justin T. Jordan, Anat Stemmer-Rachamimov, Scott R. Plotkin, James F. Gusella, Stephen J. Haggarty & Vijaya Ramesh. (2015) A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas. Oncotarget 6:19, pages 16981-16997.
Crossref
MINZHI HOU, YINGRONG LAI, SHANYANG HE, WEILING HE, HONGWEI SHEN & ZUNFU KE. (2015) SGK3 (CISK) may induce tumor angiogenesis (Hypothesis). Oncology Letters 10:1, pages 23-26.
Crossref
Huailei Liu, Chenguang Li, Chen Shen, Fei Yin, Kaikai Wang, Yaohua Liu, Bingjie Zheng, Weiguang Zhang, Xu Hou, Xin Chen, Jianing Wu, Xiaoxiong Wang, Chen Zhong, Jiakang Zhang, Huaizhang Shi, Jing Ai & Shiguang Zhao. (2015) MiR-212-3p inhibits glioblastoma cell proliferation by targeting SGK3. Journal of Neuro-Oncology 122:3, pages 431-439.
Crossref
Marzia Scortegagna, Eric Lau, Tongwu Zhang, Yongmei Feng, Chris Sereduk, Hongwei Yin, Surya K. De, Katrina Meeth, James T. Platt, Casey G. Langdon, Ruth Halaban, Maurizio Pellecchia, Michael A. Davies, Kevin Brown, David F. Stern, Marcus Bosenberg & Ze'ev A. Ronai. (2015) PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets. Cancer Research 75:7, pages 1399-1412.
Crossref
Nis Halland, Friedemann Schmidt, Tilo Weiss, Joachim Saas, Ziyu Li, Jörg Czech, Matthias Dreyer, Armin Hofmeister, Katharina Mertsch, Uwe Dietz, Carsten Strübing & Marc Nazare. (2014) Discovery of N -[4-(1 H -Pyrazolo[3,4- b ]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors . ACS Medicinal Chemistry Letters 6:1, pages 73-78.
Crossref
Kai Xu, Pengda Liu & Wenyi Wei. (2014) mTOR signaling in tumorigenesis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1846:2, pages 638-654.
Crossref
Takamitsu Miyayama & Masato Matsuoka. (2014) Increased expression and activation of serum- and glucocorticoid-inducible kinase-1 (SGK1) by cadmium in HK-2 renal proximal tubular epithelial cells. Environmental Toxicology and Pharmacology 38:2, pages 374-378.
Crossref
Sebastian Schmidt, Guoxing Liu, Guilai Liu, Wenting Yang, Sabina Honisch, Stavros Pantelakos, Christos Stournaras, Arnd Hönig & Florian Lang. (2014) Enhanced Orai1 and STIM1 expression as well as store operated Ca2+ entry in therapy resistant ovary carcinoma cells. Oncotarget 5:13, pages 4799-4810.
Crossref
B. Baban, J. Y. Liu & M. S. Mozaffari. (2014) SGK-1 Regulates Inflammation and Cell Death in the Ischemic-Reperfused Heart: Pressure-Related Effects. American Journal of Hypertension 27:6, pages 846-856.
Crossref
Inn H. Yuk, Jitao David Zhang, Martin Ebeling, Marco Berrera, Natalia Gomez, Silke Werz, Christoph Meiringer, Zhixin Shao, Jeffrey C. Swanberg, Kelvin H. Lee, Jun Luo & Berthold Szperalski. (2014) Effects of copper on CHO cells: Insights from gene expression analyses. Biotechnology Progress 30:2, pages 429-442.
Crossref
Shunsuke Mori, Shigeyuki Nada, Hironobu Kimura, Shoji Tajima, Yusuke Takahashi, Ayaka Kitamura, Chitose Oneyama & Masato Okada. (2014) The mTOR Pathway Controls Cell Proliferation by Regulating the FoxO3a Transcription Factor via SGK1 Kinase. PLoS ONE 9:2, pages e88891.
Crossref
Yuanzhong Wang, Wanping Xu, Dujin Zhou, Len Neckers & Shiuan Chen. (2014) Coordinated Regulation of Serum- and Glucocorticoid-inducible Kinase 3 by a C-terminal Hydrophobic Motif and Hsp90-Cdc37 Chaperone Complex. Journal of Biological Chemistry 289:8, pages 4815-4826.
Crossref
Beatriz Martín-Fernández, María Valero Muñoz, Natalia de las Heras, Sandra Ballesteros & Vicente Lahera. (2014) Relevance of SGK1 in structural, functional and molecular alterations produced by aldosterone in heart. Hormone Molecular Biology and Clinical Investigation 18:2.
Crossref
Susanne Badura, Tamara Tesanovic, Heike Pfeifer, Sylvia Wystub, Bart A. Nijmeijer, Marcus Liebermann, J. H. Frederik Falkenburg, Martin Ruthardt & Oliver G. Ottmann. (2013) Differential Effects of Selective Inhibitors Targeting the PI3K/AKT/mTOR Pathway in Acute Lymphoblastic Leukemia. PLoS ONE 8:11, pages e80070.
Crossref
Albert Tzong‐Yang Chen, Chunfang Guo, Kathleen J. Dumas, Kaveh Ashrafi & Patrick J. Hu. (2013) Effects of C aenorhabditis elegans sgk‐1 mutations on lifespan, stress resistance, and DAF ‐16/ F ox O regulation . Aging Cell 12:5, pages 932-940.
Crossref
José M. Arencibia, Daniel Pastor-Flores, Angelika F. Bauer, Jörg O. Schulze & Ricardo M. Biondi. (2013) AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834:7, pages 1302-1321.
Crossref
Bridget A. O'Keeffe, Salvatore Cilia, Anita C. Maiyar, Maria Vaysberg & Gary L. Firestone. (2013) The serum- and glucocorticoid-induced protein kinase-1 (Sgk-1) mitochondria connection: Identification of the IF-1 inhibitor of the F1F0-ATPase as a mitochondria-specific binding target and the stress-induced mitochondrial localization of endogenous Sgk-1. Biochimie 95:6, pages 1258-1265.
Crossref
Steven Pennock, David Kim, Shizuo Mukai, Matthew Kuhnle, Dal W. Chun, Joanne Matsubara, Jing Cui, Patrick Ma, David Maberley, Arif Samad, Robert J. Van Geest, Sarit L. Oberstein, Reinier O. Schlingemann & Andrius Kazlauskas. (2013) Ranibizumab Is a Potential Prophylaxis for Proliferative Vitreoretinopathy, a Nonangiogenic Blinding Disease. The American Journal of Pathology 182:5, pages 1659-1670.
Crossref
John J. O'Shea & Russell G. Jones. (2013) Rubbing salt in the wound. Nature 496:7446, pages 437-439.
Crossref
Claudia Abbruzzese, Stefano Mattarocci, Laura Pizzuti, Anna M Mileo, Paolo Visca, Barbara Antoniani, Gabriele Alessandrini, Francesco Facciolo, Rosario Amato, Lucia D'Antona, Massimo Rinaldi, Armando Felsani, Nicola Perrotti & Marco G Paggi. (2012) Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas. Journal of Experimental & Clinical Cancer Research 31:1.
Crossref
Ming Liu, Leilei Chen, Tim Hon Man Chan, Jian Wang, Yan Li, Yan Li, Ting-Ting Zeng, Yun-Fei Yuan & Xin-Yuan Guan. (2012) Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma. Hepatology 55:6, pages 1754-1765.
Crossref
Lalitha Durgadoss, Prakash Nidadavolu, Rupanagudi Khader Valli, Uzma Saeed, Mamata Mishra, Pankaj Seth & Vijayalakshmi Ravindranath. (2011) Redox modification of Akt mediated by the dopaminergic neurotoxin MPTP, in mouse midbrain, leads to down‐regulation of pAkt. The FASEB Journal 26:4, pages 1473-1483.
Crossref
Piero Dalle PezzeAnnika G. SonntagAntje ThienMirja T. PrentzellMarkus GödelSven FischerElke Neumann-HaefelinTobias B. HuberRalf BaumeisterDaryl P. ShanleyKathrin Thedieck. (2012) A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation. Science Signaling 5:217.
Crossref
Shahanawaz Jiwani, Yi Wang, Georgina C. Dowd, Antonella Gianfelice, Phannipha Pichestapong, Balramakrishna Gavicherla, Neyda Vanbennekom & Keith Ireton. (2012) Identification of Components of the Host Type IA Phosphoinositide 3-Kinase Pathway That Promote Internalization of Listeria monocytogenes. Infection and Immunity 80:3, pages 1252-1266.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.