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Stress
The International Journal on the Biology of Stress
Volume 14, 2011 - Issue 4: 7th International Congress of Neuroendocrinology - stress neuroendocrinology
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PACAP centrally mediates emotional stress-induced corticosterone responses in mice

Naohiro TsukiyamaLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan
,
Yoko SaidaLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan
,
Michiya KakudaLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan
,
Norihito ShintaniLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan
,
Atsuko Hayata
,
Yoshiko MoritaLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan
,
Mamoru TanidaDepartment of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan
,
Minako TajiriLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan
,
Keisuke HazamaLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan
,
Katsuya OgataLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan
,
Hitoshi HashimotoCorrespondence[email protected]
&
Akemichi Baba
 show all
Pages 368-375 | Received 28 Jun 2010, Accepted 29 Nov 2010, Published online: 27 Mar 2011

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Teniel S. Ramikie & Kerry J. Ressler. (2016) Stress-related disorders, pituitary adenylate cyclase—activating peptide (PACAP)ergic system, and sex differences. Dialogues in Clinical Neuroscience 18:4, pages 403-413.
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Sunny Zhihong Jiang & Lee E. Eiden. (2016) Activation of the HPA axis and depression of feeding behavior induced by restraint stress are separately regulated by PACAPergic neurotransmission in the mouse. Stress 19:4, pages 374-382.
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Tomris Mustafa, Sunny Zhihong Jiang, Adrian M. Eiden, Eberhard Weihe, Ian Thistlethwaite & Lee E. Eiden. (2015) Impact of PACAP and PAC1 receptor deficiency on the neurochemical and behavioral effects of acute and chronic restraint stress in male C57BL/6 mice. Stress 18:4, pages 408-418.
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John A. Russell. (2011) Reviews on stress neuroendocrinology from the 7th International Congress of Neuroendocrinology. Stress 14:4, pages 345-347.
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Articles from other publishers (58)

Sunny Zhihong Jiang, Hai-Ying Zhang & Lee E. Eiden. (2023) PACAP Controls Endocrine and Behavioral Stress Responses via Separate Brain Circuits. Biological Psychiatry Global Open Science 3:4, pages 673-685.
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Abha K. Rajbhandari, Jessica R. Barson, Marieke R. Gilmartin, Sayamwong E. Hammack & Briana K. Chen. (2023) The functional heterogeneity of PACAP: Stress, learning, and pathology. Neurobiology of Learning and Memory 203, pages 107792.
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Keisuke Suzuki, Hiroki Yamaga, Hirokazu Ohtaki, Satoshi Hirako, Kazuyuki Miyamoto, Motoyasu Nakamura, Kaoru Yanagisawa, Takuya Shimada, Tomohiko Hosono, Hitoshi Hashimoto, Kazuho Honda & Kenji Dohi. (2023) Effect of PACAP on Heat Exposure. International Journal of Molecular Sciences 24:4, pages 3992.
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Yusuke Shintani, Atsuko Hayata-Takano, Yui Yamano, Mankato Ikuta, Rei Takeuchi, Kazuhiro Takuma, Takuya Okada, Naoki Toyooka, Ichiro Takasaki, Atsuro Miyata, Takashi Kurihara & Hitoshi Hashimoto. (2022) Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice. Biochemical and Biophysical Research Communications 631, pages 146-151.
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Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos & Balázs Gaszner. (2022) Epigenetic and Neuronal Activity Markers Suggest the Recruitment of the Prefrontal Cortex and Hippocampus in the Three-Hit Model of Depression in Male PACAP Heterozygous Mice. International Journal of Molecular Sciences 23:19, pages 11739.
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Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Gergely Berta, Valér Csernus, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos & Balázs Gaszner. (2022) Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy. Frontiers in Endocrinology 13.
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Mariel P. Seiglie, Lauren Lepeak, Clara Velázquez-Sanchez, Antonio Ferragud, Teresa Le, Pietro Cottone & Valentina Sabino. (2022) The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) System of the Central Amygdala Mediates the Detrimental Effects of Chronic Social Defeat Stress in Rats. eneuro 9:5, pages ENEURO.0260-22.2022.
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Lee E. Eiden, Vito S. Hernández, Sunny Z. Jiang & Limei Zhang. (2022) Neuropeptides and small-molecule amine transmitters: cooperative signaling in the nervous system. Cellular and Molecular Life Sciences 79:9.
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E. R. Velasco, A. Florido, Á Flores, E. Senabre, A. Gomez-Gomez, A. Torres, A. Roca, S. Norrholm, E. L. Newman, P. Das, R. A. Ross, A. Lori, O. J. Pozo, K. J. Ressler, L. L. Garcia-Esteve, T. Jovanovic & R. Andero. (2022) PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus. Nature Communications 13:1.
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Manessa Riser & Seth Davin Norrholm. (2022) Pituitary Adenylate Cyclase Activating Peptide and Post-traumatic Stress Disorder: From Bench to Bedside. Frontiers in Psychiatry 13.
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Dana Bakalar, Sean Sweat, Gunner Drossel, Sunny Z. Jiang, Babru B. Samal, Nikolas Stroth, Wenqin Xu, Limei Zhang, Haiying Zhang & Lee E. Eiden. (2022) Relationships between constitutive and acute gene regulation, and physiological and behavioral responses, mediated by the neuropeptide PACAP. Psychoneuroendocrinology 135, pages 105447.
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Keerthana Sureshkumar, Andrea Saenz, Syed M. Ahmad & Kabirullah Lutfy. (2021) The PACAP/PAC1 Receptor System and Feeding. Brain Sciences 12:1, pages 13.
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Angela E. Snyder & Yuval Silberman. (2021) Corticotropin releasing factor and norepinephrine related circuitry changes in the bed nucleus of the stria terminalis in stress and alcohol and substance use disorders. Neuropharmacology 201, pages 108814.
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Antonio Ferragud, Clara Velazquez-Sanchez, Margaret A. Minnig, Valentina Sabino & Pietro Cottone. (2020) Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates dependence-induced alcohol drinking and anxiety-like behavior in male rats. Neuropsychopharmacology 46:3, pages 509-518.
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Limei Zhang, Vito S Hernandez, Charles R Gerfen, Sunny Z Jiang, Lilian Zavala, Rafael A Barrio & Lee E Eiden. (2021) Behavioral role of PACAP signaling reflects its selective distribution in glutamatergic and GABAergic neuronal subpopulations. eLife 10.
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Lee E. Eiden, Vito Hernández, Sunny Z. Jiang & Limei Zhang. 2021. Neuroanatomy of Neuroendocrine Systems. Neuroanatomy of Neuroendocrine Systems 429 486 .
Zhiguo Lu, Tianlu Zhang, Jun Yang, Jianze Wang, Jie Shen, Xiangyu Wang, Zuobing Xiao, Yunwei Niu, Guiying Liu & Xin Zhang. (2020) Effect of mesoporous silica nanoparticles‐based nano‐fragrance on the central nervous system. Engineering in Life Sciences 20:11, pages 535-540.
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Rachel A. Ross, Susanne S. Hoeppner, Samantha N. Hellberg, Emily B. O’Day, Peter L. Rosencrans, Kerry J. Ressler, Víctor May & Naomi M. Simon. (2020) Circulating PACAP peptide and PAC1R genotype as possible transdiagnostic biomarkers for anxiety disorders in women: a preliminary study. Neuropsychopharmacology 45:7, pages 1125-1133.
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Nicole C. Ferrara & Marieke R. Gilmartin. 2020. Handbook of Amygdala Structure and Function. Handbook of Amygdala Structure and Function 227 240 .
Jorge A. Avila, Magdalena Kiprowska, Teneka Jean‐Louis, Patricia Rockwell, Maria E. Figueiredo‐Pereira & Peter A. Serrano. (2019) PACAP27 mitigates an age‐dependent hippocampal vulnerability to PGJ2‐induced spatial learning deficits and neuroinflammation in mice. Brain and Behavior 10:1.
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Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May & Jianing Li. (2019) Targeting the PAC1 Receptor for Neurological and Metabolic Disorders. Current Topics in Medicinal Chemistry 19:16, pages 1399-1417.
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Jacqueline Ojala, Katharine Tooke, Harrison Hsiang, Beatrice M. Girard, Victor May & Margaret A. Vizzard. (2018) PACAP/PAC1 Expression and Function in Micturition Pathways. Journal of Molecular Neuroscience 68:3, pages 357-367.
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Olivia W. Miles, Victor May & Sayamwong E. Hammack. (2018) Pituitary Adenylate Cyclase-Activating Peptide (PACAP) Signaling and the Dark Side of Addiction. Journal of Molecular Neuroscience 68:3, pages 453-464.
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Olivia W. Miles & Stephen Maren. (2019) Role of the Bed Nucleus of the Stria Terminalis in PTSD: Insights From Preclinical Models. Frontiers in Behavioral Neuroscience 13.
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Alessandro Castorina, Monica Vogiatzis, James W.M. Kang & Kevin A. Keay. (2019) PACAP and VIP expression in the periaqueductal grey of the rat following sciatic nerve constriction injury. Neuropeptides 74, pages 60-69.
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Edward G. Meloni, Karen T. Kaye, Archana Venkataraman & William A. CarlezonJr.Jr.. (2019) PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of Learning and Memory 157, pages 24-34.
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Kabirullah Lutfy & Gollapudi Shankar. 2019. Molecular Basis of Neuropsychiatric Disorders: from Bench to Bedside. Molecular Basis of Neuropsychiatric Disorders: from Bench to Bedside 143 157 .
Sarah L. Gray & Daemon L. Cline. 2019. Stress: Physiology, Biochemistry, and Pathology. Stress: Physiology, Biochemistry, and Pathology 279 291 .
Limei Zhang & Lee E. Eiden. (2018) Two ancient neuropeptides, PACAP and AVP, modulate motivated behavior at synapses in the extrahypothalamic brain: a study in contrast. Cell and Tissue Research 375:1, pages 103-122.
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Lee E. Eiden, Andrew C. Emery, Limei Zhang & Corey B. Smith. (2017) PACAP signaling in stress: insights from the chromaffin cell. Pflügers Archiv - European Journal of Physiology 470:1, pages 79-88.
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Robert Lalonde & Catherine Strazielle. (2017) Neuroanatomical pathways underlying the effects of hypothalamo-hypophysial-adrenal hormones on exploratory activity. Reviews in the Neurosciences 28:6, pages 617-648.
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József Farkas, László Á. Kovács, László Gáspár, Anna Nafz, Tamás Gaszner, Balázs Ujvári, Viktória Kormos, Valér Csernus, Hitoshi Hashimoto, Dóra Reglődi & Balázs Gaszner. (2017) Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background. Neuroscience 354, pages 11-29.
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Galen Missig, Linda Mei, Margaret A. Vizzard, Karen M. Braas, James A. Waschek, Kerry J. Ressler, Sayamwong E. Hammack & Victor May. (2017) Parabrachial Pituitary Adenylate Cyclase-Activating Polypeptide Activation of Amygdala Endosomal Extracellular Signal–Regulated Kinase Signaling Regulates the Emotional Component of Pain. Biological Psychiatry 81:8, pages 671-682.
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Victor May & Rodney L. Parsons. (2017) G Protein-Coupled Receptor Endosomal Signaling and Regulation of Neuronal Excitability and Stress Responses: Signaling Options and Lessons From the PAC1 Receptor. Journal of Cellular Physiology 232:4, pages 698-706.
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K B Mercer, B Dias, D Shafer, S A Maddox, J G Mulle, P Hu, J Walton & K J Ressler. (2016) Functional evaluation of a PTSD-associated genetic variant: estradiol regulation and ADCYAP1R1. Translational Psychiatry 6:12, pages e978-e978.
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Rachel J. Donahue, Archana Venkataraman, F. Ivy Carroll, Edward G. Meloni & William A. CarlezonJr.Jr.. (2016) Pituitary Adenylate Cyclase–Activating Polypeptide Disrupts Motivation, Social Interaction, and Attention in Male Sprague Dawley Rats. Biological Psychiatry 80:12, pages 955-964.
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Tando Maduna & Vincent Lelievre. (2016) Neuropeptides shaping the central nervous system development: Spatiotemporal actions of VIP and PACAP through complementary signaling pathways. Journal of Neuroscience Research 94:12, pages 1472-1487.
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Viktória Kormos, László Gáspár, László Á. Kovács, József Farkas, Tamás Gaszner, Valér Csernus, András Balogh, Hitoshi Hashimoto, Dóra Reglődi, Zsuzsanna Helyes & Balázs Gaszner. (2016) Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers. Neuroscience 330, pages 335-358.
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Jozsef Farkas, Laszlo A. Kovacs, Tamas Gaszner & Balazs Gaszner. 2016. Pituitary Adenylate Cyclase Activating Polypeptide — PACAP. Pituitary Adenylate Cyclase Activating Polypeptide — PACAP 731 741 .
Sunny Z. Jiang & Lee E. Eiden. 2016. Pituitary Adenylate Cyclase Activating Polypeptide — PACAP. Pituitary Adenylate Cyclase Activating Polypeptide — PACAP 711 729 .
Yukio Ago, Michael C. Condro, Abha K. Rajbhandari, Christina Van, Bhavaani Jayaram, Victor May & James A. Waschek. 2016. Pituitary Adenylate Cyclase Activating Polypeptide — PACAP. Pituitary Adenylate Cyclase Activating Polypeptide — PACAP 651 670 .
Kristina B. Mercer & Kerry J. Ressler. 2016. Epigenetics and Neuroendocrinology. Epigenetics and Neuroendocrinology 23 41 .
Sayamwong E. Hammack & Victor May. (2015) Pituitary Adenylate Cyclase Activating Polypeptide in Stress-Related Disorders: Data Convergence from Animal and Human Studies. Biological Psychiatry 78:3, pages 167-177.
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Yuki Ota, Yukio Ago, Tatsunori Tanaka, Shigeru Hasebe, Yui Toratani, Yusuke Onaka, Hitoshi Hashimoto, Kazuhiro Takuma & Toshio Matsuda. (2015) Anxiolytic-like effects of restraint during the dark cycle in adolescent mice. Behavioural Brain Research 284, pages 103-111.
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Katsuya Ogata, Norihito Shintani, Atsuko Hayata-Takano, Toshihiko Kamo, Shintaro Higashi, Kaoru Seiriki, Hisae Momosaki, David Vaudry, Hubert Vaudry, Ludovic Galas, Atsushi Kasai, Kazuki Nagayasu, Takanobu Nakazawa, Ryota Hashimoto, Yukio Ago, Toshio Matsuda, Akemichi Baba & Hitoshi Hashimoto. (2015) PACAP Enhances Axon Outgrowth in Cultured Hippocampal Neurons to a Comparable Extent as BDNF. PLOS ONE 10:3, pages e0120526.
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J. Megan Gray, Francis Chaouloff & Matthew N. Hill. (2015) To Stress or Not to Stress: A Question of Models. Current Protocols in Neuroscience 70:1.
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Carolyn W. Roman, Kim R. Lezak, Matthew J. Hartsock, William A. Falls, Karen M. Braas, Alan B. Howard, Sayamwong E. Hammack & Victor May. (2014) PAC1 receptor antagonism in the bed nucleus of the stria terminalis (BNST) attenuates the endocrine and behavioral consequences of chronic stress. Psychoneuroendocrinology 47, pages 151-165.
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Keisuke Hazama, Atsuko Hayata-Takano, Kazuki Uetsuki, Atsushi Kasai, Naoki Encho, Norihito Shintani, Kazuki Nagayasu, Ryota Hashimoto, Dora Reglodi, Tsuyoshi Miyakawa, Takanobu Nakazawa, Akemichi Baba & Hitoshi Hashimoto. (2014) Increased Behavioral and Neuronal Responses to a Hallucinogenic Drug in PACAP Heterozygous Mutant Mice. PLoS ONE 9:2, pages e89153.
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Elizabeth N. Madva & Richard D. Granstein. (2013) Nerve-derived transmitters including peptides influence cutaneous immunology. Brain, Behavior, and Immunity 34, pages 1-10.
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Michael L. Lehmann, Tomris Mustafa, Adrian M. Eiden, Miles Herkenham & Lee E. Eiden. (2013) PACAP-deficient mice show attenuated corticosterone secretion and fail to develop depressive behavior during chronic social defeat stress. Psychoneuroendocrinology 38:5, pages 702-715.
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Lynn M. Almli, Kristina B. Mercer, Kimberly Kerley, Hao Feng, Bekh Bradley, Karen N. Conneely & Kerry J. Ressler. (2013) ADCYAP1R1 genotype associates with post‐traumatic stress symptoms in highly traumatized African‐American females . American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162:3, pages 262-272.
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Renata L. Fleming, Mariana S. Silveira, Luís E. Santos, Isabela P. Henze, Patrícia F. Gardino, Maria Christina F. de Mello & Fernando G. de Mello. (2012) Pituitary adenylyl cyclase‐activating polypeptide receptor re‐sensitization induces plastic changes in the dopaminergic phenotype in the mature avian retina. Journal of Neurochemistry 124:5, pages 621-631.
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N. Stroth, B. A. Kuri, T. Mustafa, S.-A. Chan, C. B. Smith & L. E. Eiden. (2013) PACAP Controls Adrenomedullary Catecholamine Secretion and Expression of Catecholamine Biosynthetic Enzymes at High Splanchnic Nerve Firing Rates Characteristic of Stress Transduction in Male Mice. Endocrinology 154:1, pages 330-339.
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Aoife O’Donovan, George M. Slavich, Elissa S. Epel & Thomas C. Neylan. (2013) Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging. Neuroscience & Biobehavioral Reviews 37:1, pages 96-108.
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Tomris Mustafa. 2013. A New Era of Catecholamines in the Laboratory and Clinic. A New Era of Catecholamines in the Laboratory and Clinic 445 457 .
Anthony J Harmar, Jan Fahrenkrug, Illana Gozes, Marc Laburthe, Victor May, Joseph R Pisegna, David Vaudry, Hubert Vaudry, James A Waschek & Sami I Said. (2012) Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR Review 1. British Journal of Pharmacology 166:1, pages 4-17.
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B. Gaszner, V. Kormos, T. Kozicz, H. Hashimoto, D. Reglodi & Z. Helyes. (2012) The behavioral phenotype of pituitary adenylate-cyclase activating polypeptide-deficient mice in anxiety and depression tests is accompanied by blunted c-Fos expression in the bed nucleus of the stria terminalis, central projecting Edinger–Westphal nucleus, ventral lateral septum, and dorsal raphe nucleus. Neuroscience 202, pages 283-299.
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N. Stroth, Y. Liu, G. Aguilera & L. E. Eiden. (2011) Pituitary Adenylate Cyclase-Activating Polypeptide Controls Stimulus-Transcription Coupling in the Hypothalamic-Pituitary-Adrenal Axis to Mediate Sustained Hormone Secretion During Stress. Journal of Neuroendocrinology 23:10, pages 944-955.
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