Citations (174)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (21)
Jane Kasten-Jolly & David A. Lawrence. (2022) Perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA) modify in vitro mitogen- and antigen-induced human peripheral blood mononuclear cell (PBMC) responses. Journal of Toxicology and Environmental Health, Part A 85:17, pages 715-737.
Read now
Read now
Tomoya Yamada, Samuel M. Cohen & Brian G Lake. (2022) Response to Letter to the Editor from Drs. van Kesteren, Pronk, Heusinkveld, Luijten and Hakkert concerning Yamada et al. (2021): Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Crit. Rev. Toxicol. Vol. 51: 373-394.. Critical Reviews in Toxicology 52:5, pages 399-402.
Read now
Read now
Tomoya Yamada, Brian G. Lake & Samuel M. Cohen. (2022) Evaluation of the human hazard of the liver and lung tumors in mice treated with permethrin based on mode of action. Critical Reviews in Toxicology 52:1, pages 1-31.
Read now
Read now
Susan P. Felter, Virunya S. Bhat, Philip A. Botham, David A. Bussard, Warren Casey, A. Wallace Hayes, Gina M. Hilton, Kelly A. Magurany, Ursula G. Sauer & Edward V. Ohanian. (2021) Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop. Critical Reviews in Toxicology 51:8, pages 653-694.
Read now
Read now
M. M. Mumtaz, M. C. Buser & H.R. Pohl. (2021) Per- and polyfluoroalkyl mixtures toxicity assessment “Proof-of-Concept” illustration for the hazard index approach. Journal of Toxicology and Environmental Health, Part A 84:13, pages 553-567.
Read now
Read now
Tomoya Yamada, Samuel M. Cohen & Brian G. Lake. (2021) Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Critical Reviews in Toxicology 51:5, pages 373-394.
Read now
Read now
Styliani Fragki, Hubert Dirven, Tony Fletcher, Bettina Grasl-Kraupp, Kristine Bjerve Gützkow, Ron Hoogenboom, Sander Kersten, Birgitte Lindeman, Jochem Louisse, Ad Peijnenburg, Aldert H. Piersma, Hans M. G. Princen, Maria Uhl, Joost Westerhout, Marco J. Zeilmaker & Mirjam Luijten. (2021) Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?. Critical Reviews in Toxicology 51:2, pages 141-164.
Read now
Read now
Harm Heusinkveld, Hedwig Braakhuis, Robin Gommans, Phil Botham, Marco Corvaro, Jan Willem van der Laan, Dick Lewis, Federica Madia, Irene Manou, Frédéric Schorsch, Gerrit Wolterink, Ruud Woutersen, Raffaella Corvi, Jyotigna Mehta & Mirjam Luijten. (2020) Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals. Critical Reviews in Toxicology 50:9, pages 725-739.
Read now
Read now
Kaat Leroy, Alanah Pieters, Andrés Tabernilla, Axelle Cooreman, Raf Van Campenhout, Bruno Cogliati & Mathieu Vinken. (2020) Targeting gap junctional intercellular communication by hepatocarcinogenic compounds. Journal of Toxicology and Environmental Health, Part B 23:6, pages 255-275.
Read now
Read now
Samuel M. Cohen, Yan Zhongyu & James S. Bus. (2020) Relevance of mouse lung tumors to human risk assessment. Journal of Toxicology and Environmental Health, Part B 23:5, pages 214-241.
Read now
Read now
Hiroshi Iwata, Masatomo Goto, Norifumi Sakai, Hiroshi Suemizu & Hiroshi Yamazaki. (2019) Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver. Xenobiotica 49:11, pages 1311-1322.
Read now
Read now
Joyce S. Tsuji, Ellen T. Chang, P. Robinan Gentry, Harvey J. Clewell, Paolo Boffetta & Samuel M. Cohen. (2019) Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach. Critical Reviews in Toxicology 49:1, pages 36-84.
Read now
Read now
Brent D. Kerger, Kenneth T. Bogen, Anne E. Loccisano & James C. Lamb. (2018) Proposed reference dose for toxaphene carcinogenicity based on constitutive androstane receptor-mediated mode of action. Human and Ecological Risk Assessment: An International Journal 24:5, pages 1160-1180.
Read now
Read now
Yu-Syuan Luo, Shinji Furuya, Weihsueh Chiu & Ivan Rusyn. (2018) Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse. Journal of Toxicology and Environmental Health, Part A 81:1-3, pages 37-52.
Read now
Read now
Alan Boobis, Paul Brown, Mark Timothy David Cronin, James Edwards, Corrado Lodovico Galli, Jay Goodman, Abigail Jacobs, David Kirkland, Mirjam Luijten, Cyril Marsaux, Matthew Martin, Chihae Yang & Heli Miriam Hollnagel. (2017) Origin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their re-evaluation. Critical Reviews in Toxicology 47:8, pages 710-732.
Read now
Read now
M. K. Manibusan & L. W. Touart. (2017) A comprehensive review of regulatory test methods for endocrine adverse health effects. Critical Reviews in Toxicology 47:6, pages 440-488.
Read now
Read now
Ellen T. Chang, Hans-Olov Adami, Paolo Boffetta, H. James Wedner & Jack S. Mandel. (2016) A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and immunological health conditions in humans. Critical Reviews in Toxicology 46:4, pages 279-331.
Read now
Read now
Radhakrishna Sura, Raja S. Settivari, Matthew J. LeBaron, J. Craig Rowlands, Edward W. Carney & B. Bhaskar Gollapudi. (2015) A critical assessment of the methodologies to investigate the role of inhibition of apoptosis in rodent hepatocarcinogenesis. Toxicology Mechanisms and Methods 25:3, pages 192-200.
Read now
Read now
David Rouquié, Marjoke Heneweer, Jane Botham, Hans Ketelslegers, Lauren Markell, Thomas Pfister, Winfried Steiling, Volker Strauss & Christa Hennes. (2015) Contribution of new technologies to characterization and prediction of adverse effects. Critical Reviews in Toxicology 45:2, pages 172-183.
Read now
Read now
Ted W. Simon, S. Stoney Simons$suffix/text()$suffix/text(), R. Julian Preston, Alan R. Boobis, Samuel M. Cohen, Nancy G. Doerrer, Penelope A. Fenner-Crisp, Tami S. McMullin, Charlene A. McQueen & J. Craig Rowlands. (2014) The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events. Critical Reviews in Toxicology 44:sup3, pages 17-43.
Read now
Read now
Ellen T. Chang, Hans-Olov Adami, Paolo Boffetta, Philip Cole, Thomas B. Starr & Jack S. Mandel. (2014) A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and cancer risk in humans. Critical Reviews in Toxicology 44:sup1, pages 1-81.
Read now
Read now
Articles from other publishers (153)
Furqan Shafqat, Shafeeq Ur Rehman, Muhammad Sajjad Khan & Kamal Niaz. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology
897
913
.
Gina M. Hilton, Yadvinder Bhuller, John E. Doe, Douglas C. Wolf & Richard A. Currie. (2023) A new paradigm for regulatory sciences. Regulatory Toxicology and Pharmacology 145, pages 105524.
Crossref
Crossref
Iva Sabovic, Maria Giovanna Lupo, Ilaria Rossi, Federica Pedrucci, Andrea Di Nisio, Stefano Dall’Acqua, Nicola Ferri, Alberto Ferlin, Carlo Foresta & Luca De Toni. (2023) Legacy perfluoro-alkyl substances impair LDL-cholesterol uptake independently from PCSK9-function. Toxicology Reports 11, pages 288-294.
Crossref
Crossref
Michael Gutmann, Emily Stimpfl, Gregor Langmann, Helga Koudelka, Birgit Mir-Karner & Bettina Grasl-Kraupp. (2023) Differentiated and non-differentiated HepaRG™ cells: A possible in-vitro model system for early hepatocarcinogenesis and non-genotoxic carcinogens. Toxicology Letters 390, pages 15-24.
Crossref
Crossref
Christian Strupp, Marco Corvaro, Samuel M. Cohen, J. Christopher Corton, Kumiko Ogawa, Lysiane Richert & Miriam N. Jacobs. (2023) Increased Cell Proliferation as a Key Event in Chemical Carcinogenesis: Application in an Integrated Approach for the Testing and Assessment of Non-Genotoxic Carcinogenesis. International Journal of Molecular Sciences 24:17, pages 13246.
Crossref
Crossref
Gabriella Cancemi, Nicola Cicero, Alessandro Allegra & Sebastiano Gangemi. (2023) Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders. Antioxidants 12:9, pages 1674.
Crossref
Crossref
Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez & Jeffrey M. Peters. (2023) Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice. Metabolites 13:8, pages 936.
Crossref
Crossref
Mark Lafranconi, Janet Anderson, Robert Budinsky, Lisa Corey, Norman Forsberg, Joanna Klapacz & Matthew J. LeBaron. (2023) An integrated assessment of the 1,4-dioxane cancer mode of action and threshold response in rodents. Regulatory Toxicology and Pharmacology 142, pages 105428.
Crossref
Crossref
Tetyana Kobets & Gary M. Williams. 2003. Patty's Toxicology. Patty's Toxicology
1
22
.
Zhiru Wang, Lu Zang, Wanlan Ren, Hua Guo, Nan Sheng, Xuming Zhou, Yong Guo & Jiayin Dai. (2023) Bile acid metabolism disorder mediates hepatotoxicity of Nafion by-product 2 and perfluorooctane sulfonate in male PPARα-KO mice. Science of The Total Environment 876, pages 162579.
Crossref
Crossref
. (2023) Stoffmonographie für Diethylhexyladipat (Di(2-ethylhexyl)adipat, DEHA) – HBM-I-Werte für den Metaboliten Mono-5-carboxy-(2-ethylpentyl)adipat (5cx-MEPA) im Urin von Erwachsenen und Kindern. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 66:6, pages 702-712.
Crossref
Crossref
John M. Rogers, Melissa M. Heintz, Chad M. Thompson & Laurie C. Haws. (2023) A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per‐ and polyfluoroalkyl substances and relevance to human health. Birth Defects Research.
Crossref
Crossref
Amber M. Hall & Joseph M. Braun. (2023) Per- and Polyfluoroalkyl Substances and Outcomes Related to Metabolic Syndrome: A Review of the Literature and Current Recommendations for Clinicians. American Journal of Lifestyle Medicine, pages 155982762311628.
Crossref
Crossref
Kristin Fritsche, Andrea Ziková-Kloas, Philip Marx-Stoelting & Albert Braeuning. (2023) Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification. International Journal of Molecular Sciences 24:3, pages 2686.
Crossref
Crossref
Melissa M Heintz, Laurie C Haws, James E Klaunig, John M Cullen & Chad M Thompson. (2023) Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans. Toxicological Sciences.
Crossref
Crossref
Ozge Kose, Paride Mantecca, Anna Costa & Marie Carrière. (2023) Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review. Particle and Fibre Toxicology 20:1.
Crossref
Crossref
Gina M. Hilton, Raffaella Corvi, Mirjam Luijten, Jyotigna Mehta & Douglas C. Wolf. (2023) Towards achieving a modern science-based paradigm for agrochemical carcinogenicity assessment. Regulatory Toxicology and Pharmacology 137, pages 105301.
Crossref
Crossref
Shengde Wu, George Daston, Jane Rose, Karen Blackburn, Joan Fisher, Allison Reis, Bastian Selman & Jorge Naciff. (2023) Identifying chemicals based on receptor binding/bioactivation/mechanistic explanation associated with potential to elicit hepatotoxicity and to support structure activity relationship-based read-across. Current Research in Toxicology 5, pages 100108.
Crossref
Crossref
George Wypych. 2023. Handbook of Plasticizers. Handbook of Plasticizers
693
752
.
W. S. Baldwin, Tyler T. Davis & Jazmine A. Eccles. 2023. Biomarkers in Toxicology. Biomarkers in Toxicology
989
1016
.
W. S. Baldwin, Tyler T. Davis & Jazmine A. Eccles. 2022. Biomarkers in Toxicology. Biomarkers in Toxicology
1
28
.
Satoki Fukunaga, Keiko Ogata, Ayumi Eguchi, Kohei Matsunaga, Kengo Sakurai, Jun Abe, Samuel M. Cohen & Hiroyuki Asano. (2022) Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil. Regulatory Toxicology and Pharmacology 136, pages 105268.
Crossref
Crossref
Ivan Rusyn, Weihsueh A. Chiu & Fred A. Wright. (2022) Model systems and organisms for addressing inter- and intra-species variability in risk assessment. Regulatory Toxicology and Pharmacology 132, pages 105197.
Crossref
Crossref
Melissa M. Heintz, Grace A. Chappell, Chad M. Thompson & Laurie C. Haws. (2022) Evaluation of Transcriptomic Responses in Livers of Mice Exposed to the Short-Chain PFAS Compound HFPO-DA. Frontiers in Toxicology 4.
Crossref
Crossref
Pingwei Wang, Dongge Liu, Shuqi Yan, Jiajing Cui, Yujun Liang & Shuping Ren. (2022) Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms. Toxics 10:5, pages 265.
Crossref
Crossref
Ling-Ling Xu, Yu-Kui Chen, Qin-Yao Zhang, Li-Jian Chen, Kai-Kai Zhang, Jia-Hao Li, Jia-Li Liu, Qi Wang & Xiao-Li Xie. (2022) Gestational exposure to GenX induces hepatic alterations by the gut-liver axis in maternal mice: A similar mechanism as PFOA. Science of The Total Environment 820, pages 153281.
Crossref
Crossref
Silke Schmidt. (2022) Targeting the Macrophage: Immune Cells May Be the Key to Phthalate-Induced Liver Toxicity. Environmental Health Perspectives 130:3.
Crossref
Crossref
Stefano Palazzolo, Isabella Caligiuri, Andrea Augusto Sfriso, Matteo Mauceri, Rossella Rotondo, Davide Campagnol, Vincenzo Canzonieri & Flavio Rizzolio. (2022) Early Warnings by Liver Organoids on Short- and Long-Chain PFAS Toxicity. Toxics 10:2, pages 91.
Crossref
Crossref
Miao Xu, Yongning Li, Xiaohong Wang, Qiannan Zhang, Lei Wang, Xin Zhang, Wenming Cui, Xiaomin Han, Ning Ma, Haishan Li, Hongyun Fang, Song Tang, Jingguang Li, Zhaoping Liu, Hui Yang & Xudong Jia. (2022) Role of Hepatocyte- and Macrophage-Specific PPARγ in Hepatotoxicity Induced by Diethylhexyl Phthalate in Mice. Environmental Health Perspectives 130:1.
Crossref
Crossref
Shengzhong Su, Laura J. Billy, Sue Chang, Frank J. Gonzalez, Andrew D. Patterson & Jeffrey M. Peters. (2022) The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice. Toxicology 465, pages 153056.
Crossref
Crossref
Akhileshwar Kumar Srivastava, Dhruv Kumar, Divya Singh & Rajesh Kumar Singh. 2022. Xenobiotics in Chemical Carcinogenesis. Xenobiotics in Chemical Carcinogenesis
83
110
.
W. S. Baldwin, Tyler T. Davis, Jazmine A. Eccles & In Absentia. 2022. Biomarkers in Toxicology. Biomarkers in Toxicology
1
28
.
Franz Oesch, Daniela Fruth, Jan G. Hengstler, Eric Fabian, Franz Ingo Berger & Robert Landsiedel. (2021) Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat. Archives of Toxicology 95:12, pages 3717-3744.
Crossref
Crossref
Jennifer E Foreman, Takayuki Koga, Oksana Kosyk, Boo-Hyon Kang, Xiaoyang Zhu, Samuel M Cohen, Laura J Billy, Arun K Sharma, Shantu Amin, Frank J Gonzalez, Ivan Rusyn & Jeffrey M Peters. (2021) Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice. Toxicological Sciences 183:1, pages 81-92.
Crossref
Crossref
Jennifer E Foreman, Takayuki Koga, Oksana Kosyk, Boo-Hyon Kang, Xiaoyang Zhu, Samuel M Cohen, Laura J Billy, Arun K Sharma, Shantu Amin, Frank J Gonzalez, Ivan Rusyn & Jeffrey M Peters. (2021)
Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in
PPARA
-Humanized Mice
. Toxicological Sciences 183:1, pages 70-80.
Crossref
Crossref
Danny Orabi, Nathan A. Berger & J. Mark Brown. (2021) Abnormal Metabolism in the Progression of Nonalcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Mechanistic Insights to Chemoprevention. Cancers 13:14, pages 3473.
Crossref
Crossref
Melvin E. Andersen, Bruno Hagenbuch, Udayan Apte, J. Christopher Corton, Tony Fletcher, Christopher Lau, William L. Roth, Bart Staels, Gloria L. Vega, Harvey J. Clewell3rd3rd & Matthew P. Longnecker. (2021) Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms. Toxicology 459, pages 152845.
Crossref
Crossref
Matthew C. Hamilton, Melissa M. Heintz, Marisa Pfohl, Emily Marques, Lucie Ford, Angela L. Slitt & William S. Baldwin. (2021) Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a high-fat diet (HFD). Food and Chemical Toxicology 152, pages 112175.
Crossref
Crossref
Claire Terry, Zhongyu Yan, Marco Corvaro & Sean C. Gehen. (2021) A retrospective study on EU harmonised classifications for carcinogenicity to guide future research. Regulatory Toxicology and Pharmacology 119, pages 104800.
Crossref
Crossref
Justin M. Conley, Christy S. Lambright, Nicola Evans, James McCord, Mark J. Strynar, Donna Hill, Elizabeth Medlock-Kakaley, Vickie S. Wilson & L. Earl GrayJr.Jr.. (2021) Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat. Environment International 146, pages 106204.
Crossref
Crossref
Jenni Küblbeck, Jonna Niskanen & Paavo Honkakoski. (2020) Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR. Cells 9:10, pages 2306.
Crossref
Crossref
J. Christopher Corton, Katharine L. Korunes, Jaleh Abedini, Hisham El-Masri, Jason Brown, Katie Paul-Friedman, Ying Liu, Cari Martini, Shihan He & John Rooney. (2020) Thresholds Derived From Common Measures in Rat Studies Are Predictive of Liver Tumorigenic Chemicals. Toxicologic Pathology 48:7, pages 857-874.
Crossref
Crossref
J.J. Schlezinger, H. Puckett, J. Oliver, G. Nielsen, W. Heiger-Bernays & T.F. Webster. (2020) Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet. Toxicology and Applied Pharmacology 405, pages 115204.
Crossref
Crossref
Luísa Camacho, John R. Latendresse, Levan Muskhelishvili, Charles D. Law & K. Barry Delclos. (2020) Effects of intravenous and oral di(2-ethylhexyl) phthalate (DEHP) and 20% Intralipid vehicle on neonatal rat testis, lung, liver, and kidney. Food and Chemical Toxicology 144, pages 111497.
Crossref
Crossref
J Christopher Corton, Thomas HillIIIIIIJeffrey J Sutherland, James L Stevens & John Rooney. (2020) A Set of Six Gene Expression Biomarkers Identify Rat Liver Tumorigens in Short-term Assays. Toxicological Sciences 177:1, pages 11-26.
Crossref
Crossref
Zemin Wang, Qiangen Wu, Xilin Li & James E. Klaunig. (2020) Constitutive androstane receptor (CAR) mediates dieldrin-induced liver tumorigenesis in mouse. Archives of Toxicology 94:8, pages 2873-2884.
Crossref
Crossref
Brian G. Lake, Roger J. Price, Mary P. Scott, Lynsey R. Chatham, Audrey Vardy & Thomas G. Osimitz. (2020) Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance. Toxicology 439, pages 152465.
Crossref
Crossref
Miwa Kondo, Hiroko Kikumoto, Thomas G Osimitz, Samuel M Cohen, Brian G Lake & Tomoya Yamada. (2020) An Evaluation of the Human Relevance of the Liver Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action. Toxicological Sciences 175:1, pages 50-63.
Crossref
Crossref
Grace A. Chappell, Chad M. Thompson, Jeffrey C. Wolf, John M. Cullen, James E. Klaunig & Laurie C. Haws. (2020) Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks. Toxicologic Pathology 48:3, pages 494-508.
Crossref
Crossref
Patrick D. McMullen, Sudin Bhattacharya, Courtney G. Woods, Salil N. Pendse, Mary T. McBride, Valerie Y. Soldatow, Chad Deisenroth, Edward L. LeCluyse, Rebecca A. Clewell & Melvin E. Andersen. (2020) Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods. Toxicology in Vitro 64, pages 104463.
Crossref
Crossref
Yaping Wang, Takero Nakajima, Frank J. Gonzalez & Naoki Tanaka. (2020) PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice. International Journal of Molecular Sciences 21:6, pages 2061.
Crossref
Crossref
Rance Nault, Bryan Bals, Farzaneh Teymouri, Michael B. Black, Melvin E. Andersen, Patrick D. McMullen, Seetha Krishnan, Nagesh Kuravadi, Neetha Paul, Santhosh Kumar, Kamala Kannan, K.C. Jayachandra, Lakshmanan Alagappan, Bhavesh Dhirajlal Patel, Kenneth T. Bogen, Bhaskar B. Gollapudi, James E. Klaunig, Tim R. Zacharewski & Venkataraman Bringi. (2020) A toxicogenomic approach for the risk assessment of the food contaminant acetamide. Toxicology and Applied Pharmacology 388, pages 114872.
Crossref
Crossref
James E. Klaunig, Luma Melo & Karen Tilmant. (2020) Mechanisms of hepatic cancer by persistent organic pollutants. Current Opinion in Toxicology 19, pages 105-111.
Crossref
Crossref
Brian N. Chorley, Gleta K. Carswell, Gail Nelson, Virunya S. Bhat & Charles E. Wood. (2020) Early microRNA indicators of PPARα pathway activation in the liver. Toxicology Reports 7, pages 805-815.
Crossref
Crossref
James E. Sidaway, Terry C. Orton, Kassiani Kalaitzi, Huw B. Jones, Alison Foster & Brian G. Lake. (2020) Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital. Toxicology 430, pages 152343.
Crossref
Crossref
Karen Tilmant & James E. Klaunig. 2020. Information Resources in Toxicology. Information Resources in Toxicology
133
151
.
Wolfgang Dekant. (2019) Tetrahydrofuran-induced tumors in rodents are not relevant to humans: Quantitative weight of evidence analysis of mode of action information does not support classification of tetrahydrofuran as a possible human carcinogen. Regulatory Toxicology and Pharmacology 109, pages 104499.
Crossref
Crossref
Jonathan M. Ali, Stephen M. Roberts, David S. Gordon & Leah D. Stuchal. (2019) Derivation of a chronic reference dose for perfluorohexane sulfonate (PFHxS) for reproductive toxicity in mice. Regulatory Toxicology and Pharmacology 108, pages 104452.
Crossref
Crossref
Roberta Attanasio. (2019) Sex differences in the association between perfluoroalkyl acids and liver function in US adolescents: Analyses of NHANES 2013–2016. Environmental Pollution 254, pages 113061.
Crossref
Crossref
Christiane Wiemann, Manuela Goettel, Audrey Vardy, Barbara M. Elcombe, Clifford R. Elcombe, Lynsey R. Chatham, Hongbing Wang, Linhao Li, Roland Buesen, Naveed Honarvar, Silke Treumann, Heike Marxfeld, Sibylle Groeters & Brian G. Lake. (2019) Metazachlor: Mode of action analysis for rat liver tumour formation and human relevance. Toxicology 426, pages 152282.
Crossref
Crossref
Chad M. Thompson, Seneca E. Fitch, Caroline Ring, William Rish, John M. Cullen & Laurie C. Haws. (2019) Development of an oral reference dose for the perfluorinated compound GenX. Journal of Applied Toxicology 39:9, pages 1267-1282.
Crossref
Crossref
Ivan Notardonato, Carmela Protano, Matteo Vitali, Badal Bhattacharya & Pasquale Avino. (2019) A Method Validation for Simultaneous Determination of Phthalates and Bisphenol A Released from Plastic Water Containers. Applied Sciences 9:14, pages 2945.
Crossref
Crossref
Miwa Kondo, Kaori Miyata, Hirohisa Nagahori, Kayo Sumida, Thomas G Osimitz, Samuel M Cohen, Brian G Lake & Tomoya Yamada. (2019) Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse. Toxicological Sciences 168:2, pages 572-596.
Crossref
Crossref
Tetyana Kobets, Michael J. Iatropoulos & Gary M. Williams. (2019) Mechanisms of DNA-reactive and epigenetic chemical carcinogens: applications to carcinogenicity testing and risk assessment. Toxicology Research 8:2, pages 123-145.
Crossref
Crossref
Xia Wen, Angela A. Baker, Curtis D. Klaassen, J. Christopher Corton, Jason R. Richardson & Lauren M. Aleksunes. (2019) Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid. Toxicology 416, pages 15-22.
Crossref
Crossref
Tetyana Kobets & Gary M. Williams. (2019) Review of the evidence for thresholds for DNA-Reactive and epigenetic experimental chemical carcinogens. Chemico-Biological Interactions 301, pages 88-111.
Crossref
Crossref
XiaoZhi Lim. (2019) Tainted water: the scientists tracing thousands of fluorinated chemicals in our environment. Nature 566:7742, pages 26-29.
Crossref
Crossref
Samuel M. Cohen, Gerhard Eisenbrand, Shoji Fukushima, Nigel J. Gooderham, F. Peter Guengerich, Stephen S. Hecht, Ivonne M.C.M. Rietjens, Maria Bastaki, Jeanne M. Davidsen, Christie L. Harman, Margaret McGowen & Sean V. Taylor. (2019) FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients. Food and Chemical Toxicology 124, pages 192-218.
Crossref
Crossref
Erin M. Quist, Gary A. Boorman, John M. Cullen, Robert R. Maronpot, Amera K. Remick, James A. Swenberg, Les Freshwater & Jerry F. Hardisty. (2018) Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin. Toxicologic Pathology 47:1, pages 11-17.
Crossref
Crossref
John P Rooney, Keiyu Oshida, Ramiya Kumar, William S Baldwin & J Christopher Corton. (2019) Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced Nrf2. Toxicological Sciences 167:1, pages 172-189.
Crossref
Crossref
Zhiying Ji, Raja S. Settivari & Matthew J. LeBaron. (2018)
Pilot studies evaluating the nongenotoxic rodent carcinogens phenobarbital and clofibrate in the rat
Pig‐a
assay
. Environmental and Molecular Mutagenesis 60:1, pages 42-46.
Crossref
Crossref
Helle Katrine Knutsen, Jan Alexander, Lars Barregård, Margherita Bignami, Beat Brüschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Lutz Edler, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Carlo Stefano Nebbia, Isabelle P Oswald, Annette Petersen, Martin Rose, Alain‐Claude Roudot, Christiane Vleminckx, Günter Vollmer, Heather Wallace, Laurent Bodin, Jean‐Pierre Cravedi, Thorhallur Ingi Halldorsson, Line Småstuen Haug, Niklas Johansson, Henk van Loveren, Petra Gergelova, Karen Mackay, Sara Levorato, Mathijs van Manen & Tanja Schwerdtle. (2018) Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food. EFSA Journal 16:12.
Crossref
Crossref
Montserrat A. de la Rosa Rodriguez, Go Sugahara, Guido J. E. J. Hooiveld, Yuji Ishida, Chise Tateno & Sander Kersten. (2018) The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice. BMC Genomics 19:1.
Crossref
Crossref
Xilin Li, Zemin Wang & James E. Klaunig. (2018) Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease. Toxicology 410, pages 199-213.
Crossref
Crossref
Constanze Knebel, Juliane Kebben, Ivano Eberini, Luca Palazzolo, Helen S. Hammer, Roderich D. Süssmuth, Tanja Heise, Stefanie Hessel-Pras, Alfonso Lampen, Albert Braeuning & Philip Marx-Stoelting. (2018) Propiconazole is an activator of AHR and causes concentration additive effects with an established AHR ligand. Archives of Toxicology 92:12, pages 3471-3486.
Crossref
Crossref
Chin‐Hsiao Tseng. (2018) Metformin and risk of hepatocellular carcinoma in patients with type 2 diabetes. Liver International 38:11, pages 2018-2027.
Crossref
Crossref
Harm J. Heusinkveld, Paul F.K. Wackers, Willem G. Schoonen, Leo van der Ven, Jeroen L.A. Pennings & Mirjam Luijten. (2018) Application of the comparison approach to open TG-GATEs: A useful toxicogenomics tool for detecting modes of action in chemical risk assessment. Food and Chemical Toxicology 121, pages 115-123.
Crossref
Crossref
Yangshun Tang, Michelle M. Vanlandingham, Yuanfeng Wu, Frederick A. Beland, Greg R. Olson & Jia-Long Fang. (2018) Role of peroxisome proliferator-activated receptor alpha (PPARα) and PPARα-mediated species differences in triclosan-induced liver toxicity. Archives of Toxicology 92:11, pages 3391-3402.
Crossref
Crossref
John Rooney, Thomas HillIIIIII, Chunhua Qin, Frank D. Sistare & J. Christopher Corton. (2018) Adverse outcome pathway-driven identification of rat liver tumorigens in short-term assays. Toxicology and Applied Pharmacology 356, pages 99-113.
Crossref
Crossref
Brian G. Lake. (2018) Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators. Toxicology Research 7:4, pages 697-717.
Crossref
Crossref
James E. Klaunig, Xilin Li & Zemin Wang. (2018) Role of xenobiotics in the induction and progression of fatty liver disease. Toxicology Research 7:4, pages 664-680.
Crossref
Crossref
Tomoya Yamada. (2018) Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action. Toxicology Research 7:4, pages 681-696.
Crossref
Crossref
Robert L. Smith, Samuel M. Cohen, Shoji Fukushima, Nigel J. Gooderham, Stephen S. Hecht, F. Peter Guengerich, Ivonne M. C. M. Rietjens, Maria Bastaki, Christie L. Harman, Margaret M. McGowen & Sean V. Taylor. (2018) The safety evaluation of food flavouring substances: the role of metabolic studies. Toxicology Research 7:4, pages 618-646.
Crossref
Crossref
Melvin E. Andersen, George Cruzan, Michael B. Black, Salil N. Pendse, Darol E. Dodd, James S. Bus, Satinder S. Sarang, Marcy I. Banton, Robbie Waites, Debra B. Layko & Patrick D. McMullen. (2018) Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment. Regulatory Toxicology and Pharmacology 96, pages 153-166.
Crossref
Crossref
Richard C. Peffer, Matthew J. LeBaron, Michael Battalora, Werner H. Bomann, Christoph Werner, Manoj Aggarwal, Rocky R. Rowe & Helen Tinwell. (2018) Minimum datasets to establish a CAR-mediated mode of action for rodent liver tumors. Regulatory Toxicology and Pharmacology 96, pages 106-120.
Crossref
Crossref
Christian Strupp, Werner H. Bomann, François Spézia, Frédéric Gervais, Roy Forster, Lysiane Richert & Pramila Singh. (2018) A human relevance investigation of PPARα-mediated key events in the hepatocarcinogenic mode of action of propaquizafop in rats. Regulatory Toxicology and Pharmacology 95, pages 348-361.
Crossref
Crossref
Sue Chang, John L. Butenhoff, George A. Parker, Prägati S. Coder, Jeremiah D. Zitzow, Ryan M. Krisko, James A. Bjork, Kendall B. Wallace & Jennifer G. Seed. (2018) Reproductive and developmental toxicity of potassium perfluorohexanesulfonate in CD-1 mice. Reproductive Toxicology 78, pages 150-168.
Crossref
Crossref
Changqing Tang, Yuxin Deng, Hongyu Duan, Yi Zhang, Yifei Li, Dajian Qiu, Kaiyu Zhou, Yimin Hua & Chuan Wang. (2018) The effect of maternal exposure to di‐(2‐ethylhexyl)‐phthalate on fetal cardiac development in mice. Journal of Applied Toxicology 38:6, pages 834-842.
Crossref
Crossref
Matteo Convertino, Timothy R Church, Geary W Olsen, Yang Liu, Eddie Doyle, Clifford R Elcombe, Anna L Barnett, Leslie M Samuel, Iain R MacPherson & Thomas R J Evans. (2018) Stochastic Pharmacokinetic-Pharmacodynamic Modeling for Assessing the Systemic Health Risk of Perfluorooctanoate (PFOA). Toxicological Sciences 163:1, pages 293-306.
Crossref
Crossref
Uros Midic, Benjamin Goheen, Kailey A. Vincent, Catherine A. VandeVoort & Keith E. Latham. (2018) Changes in gene expression following long-term in vitro exposure of Macaca mulatta trophoblast stem cells to biologically relevant levels of endocrine disruptors. Reproductive Toxicology 77, pages 154-165.
Crossref
Crossref
Chuan-Hai Li, Xiao-Min Ren, Ting Ruan, Lin-Ying Cao, Yan Xin, Liang-Hong Guo & Guibin Jiang. (2018) Chlorinated Polyfluorinated Ether Sulfonates Exhibit Higher Activity toward Peroxisome Proliferator-Activated Receptors Signaling Pathways than Perfluorooctanesulfonate. Environmental Science & Technology 52:5, pages 3232-3239.
Crossref
Crossref
Aparajita Chowdhury, Lora L. Arnold, Zemin Wang, Karen L. Pennington, Puttappa Dodmane, Ana Paula Farragut-Cardoso, James E. Klaunig, Daniel Cros, Edmond E. Creppy & Samuel M. Cohen. (2018) Effect of polyhexamethylene biguanide on rat liver. Toxicology Letters 285, pages 94-103.
Crossref
Crossref
Susan P. Felter, Jennifer E. Foreman, Alan Boobis, J. Christopher Corton, Adriana M. Doi, Lynn Flowers, Jay Goodman, Lynne T. Haber, Abigail Jacobs, James E. Klaunig, Angela M. Lynch, Jonathan Moggs & Arun Pandiri. (2018) Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action. Regulatory Toxicology and Pharmacology 92, pages 1-7.
Crossref
Crossref
Hanne Friis Berntsen, Anette Kocbach Bølling, Cesilie Granum Bjørklund, Karin Zimmer, Erik Ropstad, Shanbeh Zienolddiny, Rune Becher, Jørn A. Holme, Hubert Dirven, Unni Cecilie Nygaard & Johanna Bodin. (2018) Decreased macrophage phagocytic function due to xenobiotic exposures in vitro, difference in sensitivity between various macrophage models. Food and Chemical Toxicology 112, pages 86-96.
Crossref
Crossref
James E. Klaunig & Zemin Wang. (2018) Oxidative stress in carcinogenesis. Current Opinion in Toxicology 7, pages 116-121.
Crossref
Crossref
S.M. Cohen. 2018. Comprehensive Toxicology. Comprehensive Toxicology
226
247
.
M.K. Manibusan & L.W. Touart. 2018. Comprehensive Toxicology. Comprehensive Toxicology
136
171
.
G.H. Perdew, I.A. Murray, A.D. Patterson & J.M. Peters. 2018. Comprehensive Toxicology. Comprehensive Toxicology
202
228
.
J.E. Klaunig & Z. Wang. 2018. Comprehensive Toxicology. Comprehensive Toxicology
233
254
.
J. Christopher Corton, Jeffrey M. Peters & James E. Klaunig. (2017) The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions. Archives of Toxicology 92:1, pages 83-119.
Crossref
Crossref
Gary L. Ginsberg & Giuliana Belleggia. (2017) Use of Monte Carlo analysis in a risk-based prioritization of toxic constituents in house dust. Environment International 109, pages 101-113.
Crossref
Crossref
Wolfgang Dekant, James Bridges & Anthony R. Scialli. (2017) A quantitative weight of evidence assessment of confidence in modes-of-action and their human relevance. Regulatory Toxicology and Pharmacology 90, pages 51-71.
Crossref
Crossref
Naoki Tanaka, Toshifumi Aoyama, Shioko Kimura & Frank J. Gonzalez. (2017) Targeting nuclear receptors for the treatment of fatty liver disease. Pharmacology & Therapeutics 179, pages 142-157.
Crossref
Crossref
Isabelle R. Miousse, Lynea A. Murphy, Haixia Lin, Melissa R. Schisler, Jinchun Sun, Marie-Cecile G. Chalbot, Radhakrishna Sura, Kamin Johnson, Matthew J. LeBaron, Ilias G. Kavouras, Laura K. Schnackenberg, Richard D. Beger, Reza J. Rasoulpour & Igor Koturbash. (2017) Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants. Food and Chemical Toxicology 109, pages 690-702.
Crossref
Crossref
Kan Li, Jie Sun, Jingping Yang, Stephen M. Roberts, Xuxiang Zhang, Xinyi Cui, Si Wei & Lena Q. Ma. (2017) Molecular Mechanisms of Perfluorooctanoate-Induced Hepatocyte Apoptosis in Mice Using Proteomic Techniques. Environmental Science & Technology 51:19, pages 11380-11389.
Crossref
Crossref
Małgorzata NepelskaJenny OdumSharon Munn. (2017) Adverse Outcome Pathway: Peroxisome Proliferator-Activated Receptor α Activation and Reproductive Toxicity—Development and Application in Assessment of Endocrine Disruptors/Reproductive Toxicants. Applied In Vitro Toxicology 3:3, pages 234-249.
Crossref
Crossref
Yu Okuda, Masahiko Kushida, Kayo Sumida, Hirohisa Nagahori, Yoshimasa Nakamura, Hashihiro Higuchi, Satoshi Kawamura, Brian G. Lake, Samuel M. Cohen & Tomoya Yamada. (2017) Editor’s Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes. Toxicological Sciences 158:2, pages 412-430.
Crossref
Crossref
Zemin Wang, Xilin Li, Qiangen Wu, James C. LambIVIV & James E. Klaunig. (2017) Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor. Journal of Applied Toxicology 37:8, pages 967-975.
Crossref
Crossref
Zhiying Ji & Matthew J. LeBaron. (2017)
Applying the erythrocyte
Pig-a
assay concept to rat epididymal sperm for germ cell mutagenicity evaluation
. Environmental and Molecular Mutagenesis 58:7, pages 485-493.
Crossref
Crossref
Mitchell B. Rosen, Kaberi P. Das, John Rooney, Barbara Abbott, Christopher Lau & J. Christopher Corton. (2017) PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling. Toxicology 387, pages 95-107.
Crossref
Crossref
Tomoya Yamada, Miwa Kondo, Kaori Miyata, Keiko Ogata, Masahiko Kushida, Kayo Sumida, Satoshi Kawamura, Thomas G. Osimitz, Brian G. Lake & Samuel M. Cohen. (2017) An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action. Toxicological Sciences 157:2, pages 465-486.
Crossref
Crossref
Zemin Wang, Xilin Li & James E. Klaunig. (2017) Investigation of the mechanism of triclosan induced mouse liver tumors. Regulatory Toxicology and Pharmacology 86, pages 137-147.
Crossref
Crossref
Richard A. Becker, Vicki Dellarco, Jennifer Seed, Joel M. Kronenberg, Bette Meek, Jennifer Foreman, Christine Palermo, Chris Kirman, Igor Linkov, Rita Schoeny, Michael Dourson, Lynn H. Pottenger & Mary K. Manibusan. (2017) Quantitative weight of evidence to assess confidence in potential modes of action. Regulatory Toxicology and Pharmacology 86, pages 205-220.
Crossref
Crossref
Timothy M. Coskran, Zhijie Jiang, James E. Klaunig, Dixie L. Mager, Leslie Obert, Andrew Robertson, Nicholas Tsinoremas, Zemin Wang & Mark Gosink. (2017) Induction of endogenous retroelements as a potential mechanism for mouse-specific drug-induced carcinogenicity. PLOS ONE 12:5, pages e0176768.
Crossref
Crossref
Sander Kersten & Rinke Stienstra. (2017) The role and regulation of the peroxisome proliferator activated receptor alpha in human liver. Biochimie 136, pages 75-84.
Crossref
Crossref
Rémi Terranova, Antonio Vitobello, Alberto Del Rio Espinola, C. Roland Wolf, Michael Schwarz, John Thomson, Richard Meehan & Jonathan Moggs. (2017) Progress in identifying epigenetic mechanisms of xenobiotic-induced non-genotoxic carcinogenesis. Current Opinion in Toxicology 3, pages 62-70.
Crossref
Crossref
Hozeifa M. Hassan, Hongli Guo, Bashir A. Yousef, Ding Ping-Ping, Luyong Zhang & Zhenzhou Jiang. (2017) Dexamethasone Pretreatment Alleviates Isoniazid/Lipopolysaccharide Hepatotoxicity: Inhibition of Inflammatory and Oxidative Stress. Frontiers in Pharmacology 8.
Crossref
Crossref
Kaberi P. Das, Carmen R. Wood, Mimi T. Lin, Anatoly A. Starkov, Christopher Lau, Kendall B. Wallace, J. Christopher Corton & Barbara D. Abbott. (2017) Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis. Toxicology 378, pages 37-52.
Crossref
Crossref
Shujie Liu, Taisuke Kawamoto, Osamu Morita, Kouichi Yoshinari & Hiroshi Honda. (2017) Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models. Toxicology and Applied Pharmacology 318, pages 79-87.
Crossref
Crossref
Kan Li, Peng Gao, Ping Xiang, Xuxiang Zhang, Xinyi Cui & Lena Q. Ma. (2017) Molecular mechanisms of PFOA-induced toxicity in animals and humans: Implications for health risks. Environment International 99, pages 43-54.
Crossref
Crossref
L. W. B. Olaniyan, N. Mkwetshana & A. I. Okoh. (2016) Triclosan in water, implications for human and environmental health. SpringerPlus 5:1.
Crossref
Crossref
Susan D. Hester, Virunya Bhat, Brian N. Chorley, Gleta Carswell, Wendell Jones, Leah C. Wehmas & Charles E. Wood. (2016) Editor’s Highlight: Dose–Response Analysis of RNA-Seq Profiles in Archival Formalin-Fixed Paraffin-Embedded Samples. Toxicological Sciences 154:2, pages 202-213.
Crossref
Crossref
G. Christopher Cutler & Cynthia D. Scott-Dupree. (2016) Bee Ecotoxicology and Data Veracity: Appreciating the GLP Process. BioScience 66:12, pages 1066-1069.
Crossref
Crossref
Yun Zhang, Hongli Guo, Hozeifa M. Hassan, Ping-ping Ding, Yijing Su, Yuming Song, Tao Wang, Lixin Sun, Luyong Zhang & Zhenzhou Jiang. (2016) Pyrazinamide induced hepatic injury in rats through inhibiting the PPARα pathway. Journal of Applied Toxicology 36:12, pages 1579-1590.
Crossref
Crossref
Bethany R. Hannas, Robert G. Ellis-Hutchings, Valerie A. Marshall, Claire Terry, Alene A. McCoy, Shakil A. Saghir, Keith Brooks, David Eisenbrandt, Edward W. Carney, Richard Billington & Reza J. Rasoulpour. (2016) Dietary Route of Exposure for Rabbit Developmental Toxicity Studies. Toxicological Sciences 154:1, pages 90-100.
Crossref
Crossref
Sheela Sathyanarayana, Emily Barrett, Ruby Nguyen, Bruce Redmon, Wren Haaland & Shanna Swan. (2016) First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study. International Journal of Environmental Research and Public Health 13:10, pages 945.
Crossref
Crossref
Matthew C. Cave, Heather B. Clair, Josiah E. Hardesty, K. Cameron Falkner, Wenke Feng, Barbara J. Clark, Jennifer Sidey, Hongxue Shi, Bashar A. Aqel, Craig J. McClain & Russell A. Prough. (2016) Nuclear receptors and nonalcoholic fatty liver disease. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:9, pages 1083-1099.
Crossref
Crossref
Kevin M. Beggs, Steven R. McGreal, Alex McCarthy, Sumedha Gunewardena, Jed N. Lampe, Christoper Lau & Udayan Apte. (2016) The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction. Toxicology and Applied Pharmacology 304, pages 18-29.
Crossref
Crossref
Christopher J. Borgert, Richard A. Becker, Betsy D. Carlton, Mark Hanson, Patricia L. Kwiatkowski, Mary Sue Marty, Lynn S. McCarty, Terry F. Quill, Keith Solomon, Glen Van Der Kraak, Raphael J. Witorsch & Kun Don Yi. (2016) Does GLP enhance the quality of toxicological evidence for regulatory decisions?: TABLE 1.. Toxicological Sciences 151:2, pages 206-213.
Crossref
Crossref
Kazunori Kuwata, Kaoru Inoue, Ryohei Ichimura, Miwa Takahashi, Yukio Kodama, Makoto Shibutani & Midori Yoshida. (2016) Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. Toxicological Sciences 151:2, pages 271-285.
Crossref
Crossref
Keiyu Oshida, David J. Waxman & J. Christopher Corton. (2016) Chemical and Hormonal Effects on STAT5b-Dependent Sexual Dimorphism of the Liver Transcriptome. PLOS ONE 11:3, pages e0150284.
Crossref
Crossref
April D. Lake, Charles E. Wood, Virunya S. Bhat, Brian N. Chorley, Gleta K. Carswell, Yusupha M. Sey, Elaina M. Kenyon, Beth Padnos, Tanya M. Moore, Alan H. Tennant, Judith E. Schmid, Barbara Jane George, David G. Ross, Michael F. Hughes, J. Christopher Corton, Jane Ellen Simmons, Charlene A. McQueen & Susan D. Hester. (2016) Dose and Effect Thresholds for Early Key Events in a PPARα-Mediated Mode of Action. Toxicological Sciences 149:2, pages 312-325.
Crossref
Crossref
Johanna Bodin, Else-Carin Groeng, Monica Andreassen, Hubert Dirven & Unni Cecilie Nygaard. (2016) Exposure to perfluoroundecanoic acid (PFUnDA) accelerates insulitis development in a mouse model of type 1 diabetes. Toxicology Reports 3, pages 664-672.
Crossref
Crossref
Rebecca A. Clewell, Patrick D. McMullen, Yeyejide Adeleye, Paul L. Carmichael & Melvin E. Andersen. 2016. Validation of Alternative Methods for Toxicity Testing. Validation of Alternative Methods for Toxicity Testing
205
230
.
Aafke W.F. Janssen, Bark Betzel, Geert Stoopen, Frits J. Berends, Ignace M. Janssen, Ad A. Peijnenburg & Sander Kersten. (2015) The impact of PPARα activation on whole genome gene expression in human precision cut liver slices. BMC Genomics 16:1.
Crossref
Crossref
Brian G. Lake & Roger J. Price. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics
309
332
.
Zemin Wang, Barbara H. Neal, James C. Lamb & James E. Klaunig. (2015) Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors. Toxicological Sciences 147:2, pages 549-561.
Crossref
Crossref
Hong Sik Yoo, Joseph A. Cichocki, Sungkyoon Kim, Abhishek Venkatratnam, Yasuhiro Iwata, Oksana Kosyk, Wanda Bodnar, Stephen Sweet, Anthony Knap, Terry Wade, Jerry Campbell, Harvey J. Clewell, Stepan B. Melnyk, Weihsueh A. Chiu & Ivan Rusyn. (2015) The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene. Toxicological Sciences 147:2, pages 339-349.
Crossref
Crossref
Sarah Niermann, Saniya Rattan, Emily Brehm & Jodi A. Flaws. (2015) Prenatal exposure to di-(2-ethylhexyl) phthalate (DEHP) affects reproductive outcomes in female mice. Reproductive Toxicology 53, pages 23-32.
Crossref
Crossref
Marie Pierre Krafft & Jean G. Riess. (2015) Per- and polyfluorinated substances (PFASs): Environmental challenges. Current Opinion in Colloid & Interface Science 20:3, pages 192-212.
Crossref
Crossref
Brian G Lake, Roger J Price & Thomas G Osimitz. (2014) Mode of action analysis for pesticide‐induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk. Pest Management Science 71:6, pages 829-834.
Crossref
Crossref
Alejandra V. Contreras, Claudia Rangel-Escareño, Nimbe Torres, Gabriela Alemán-Escondrillas, Victor Ortiz, Lilia G. Noriega, Ivan Torre-Villalvazo, Omar Granados, Laura A. Velázquez-Villegas, Sandra Tobon-Cornejo, Diana González-Hirschfeld, Félix Recillas-Targa, Elizabeth Tejero-Barrera, Frank J. Gonzalez & Armando R. Tovar. (2015) PPARα via HNF4α regulates the expression of genes encoding hepatic amino acid catabolizing enzymes to maintain metabolic homeostasis. Genes & Nutrition 10:2.
Crossref
Crossref
Keiyu Oshida, Naresh Vasani, Russell S. Thomas, Dawn Applegate, Mitch Rosen, Barbara Abbott, Christopher Lau, Grace Guo, Lauren M. Aleksunes, Curtis Klaassen & J. Christopher Corton. (2015) Identification of Modulators of the Nuclear Receptor Peroxisome Proliferator-Activated Receptor α (PPARα) in a Mouse Liver Gene Expression Compendium. PLOS ONE 10:2, pages e0112655.
Crossref
Crossref
Keiyu Oshida, Naresh Vasani, Carlton Jones, Tanya Moore, Susan Hester, Stephen Nesnow, Scott Auerbach, David R. Geter, Lauren M. Aleksunes, Russell S. Thomas, Dawn Applegate, Curtis D. Klaassen & J. Christopher Corton. (2015) Identification of Chemical Modulators of the Constitutive Activated Receptor (CAR) in a Gene Expression Compendium. Nuclear Receptor Signaling 13:1, pages nrs.13002.
Crossref
Crossref
Tomoya Yamada, Hiroko Kikumoto, Brian G. Lake & Satoshi Kawamura. (2015) Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes. Toxicology Research 4:4, pages 901-913.
Crossref
Crossref
Udayan Apte. 2015. Liver Regeneration. Liver Regeneration
2
11
.
Abigail Jacobs & Frank D. Sistare. 2015. Genotoxicity and Carcinogenicity Testing of Pharmaceuticals. Genotoxicity and Carcinogenicity Testing of Pharmaceuticals
109
124
.
Christopher Lau. 2015. Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances. Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances
1
21
.
Matthew J. LeBaron, Reza J. Rasoulpour, B. Bhaskar Gollapudi, Radhakrishna Sura, H. Lynn Kan, Melissa R. Schisler, Lynn H. Pottenger, Sabitha Papineni & David L. Eisenbrandt. (2014) Characterization of Nuclear Receptor-Mediated Murine Hepatocarcinogenesis of the Herbicide Pronamide and Its Human Relevance. Toxicological Sciences 142:1, pages 74-92.
Crossref
Crossref
Yuanfeng Wu, Qiangen Wu, Frederick A. Beland, Peter Ge, Mugimane G. Manjanatha & Jia-Long Fang. (2014) Differential effects of triclosan on the activation of mouse and human peroxisome proliferator-activated receptor alpha. Toxicology Letters 231:1, pages 17-28.
Crossref
Crossref
Jun Maeda, Aki Kijima, Kaoru Inoue, Yuji Ishii, Ryohei Ichimura, Shinji Takasu, Ken Kuroda, Kohei Matsushita, Yukio Kodama, Naoaki Saito, Takashi Umemura & Midori Yoshida. (2014) In Vivo Genotoxicity of Ginkgo Biloba Extract in gpt Delta Mice and Constitutive Androstane Receptor Knockout Mice. Toxicological Sciences 140:2, pages 298-306.
Crossref
Crossref
Charles E. Wood, Micheal P. Jokinen, Crystal L. Johnson, Greg R. Olson, Susan Hester, Michael George, Brian N. Chorley, Gleta Carswell, Julia H. Carter, Carmen R. Wood, Virunya S. Bhat, J. Christopher Corton & Anthony B. DeAngelo. (2014) Comparative Time Course Profiles of Phthalate Stereoisomers in Mice. Toxicological Sciences 139:1, pages 21-34.
Crossref
Crossref
M.E. Andersen, S. Bhattacharya & W. Hanneman. 2014. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.