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Original Article

Serum Proteins as Drug Carriers of Anticancer Agents: A Review

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Pages 281-299 | Received 02 May 1998, Accepted 19 Jun 1998, Published online: 02 Jul 2009

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Felix Kratz. (2002) Drug conjugates with albumin and transferrin. Expert Opinion on Therapeutic Patents 12:3, pages 433-439.
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Felix Kratz. (2008) Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles. Journal of Controlled Release 132:3, pages 171-183.
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Alberto Martínez, Virtudes Moreno, Laura Sanglas, Rafael de Llorens, Francesc X. Avilés & Julia Lorenzo. (2008) Study by HPLC-MS of the interaction of platinum antitumor complexes with potato carboxypeptidase inhibitor (PCI). Bioorganic & Medicinal Chemistry 16:14, pages 6832-6840.
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Felix Kratz, Ivonne A. Müller, Claudia Ryppa & André Warnecke. (2008) Prodrug Strategies in Anticancer Chemotherapy. ChemMedChem 3:1, pages 20-53.
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Paul D. Thornton, Robert J. Mart, Simon J. Webb & Rein V. Ulijn. (2008) Enzyme-responsive hydrogel particles for the controlled release of proteins: designing peptide actuators to match payload. Soft Matter 4:4, pages 821.
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Michael A. Jakupec, Mathea S. Galanski, Vladimir B. Arion, Christian G. Hartinger & Bernhard K. Keppler. (2008) Antitumour metal compounds: more than theme and variations. Dalton Transactions:2, pages 183-194.
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Clemens Unger, Brigitte Häring, Michael Medinger, Joachim Drevs, Simone Steinbild, Felix Kratz & Klaus Mross. (2007) Phase I and Pharmacokinetic Study of the (6-Maleimidocaproyl)Hydrazone Derivative of Doxorubicin. Clinical Cancer Research 13:16, pages 4858-4866.
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Angela R. Jones & Eric V. Shusta. (2007) Blood–Brain Barrier Transport of Therapeutics via Receptor-Mediation. Pharmaceutical Research 24:9, pages 1759-1771.
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Björn SchmidDa-Eun ChungAndré WarneckeIduna FichtnerFelix Kratz. (2007) Albumin-Binding Prodrugs of Camptothecin and Doxorubicin with an Ala-Leu-Ala-Leu-Linker That Are Cleaved by Cathepsin B:  Synthesis and Antitumor Efficacy. Bioconjugate Chemistry 18:3, pages 702-716.
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F Kratz, G Ehling, H-M Kauffmann & C Unger. (2016) Acute and repeat-dose toxicity studies of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin (DOXO-EMCH), an albumin-binding prodrug of the anticancer agent doxorubicin. Human & Experimental Toxicology 26:1, pages 19-35.
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Felix Kratz. 2008. Anthracycline Chemistry and Biology II. Anthracycline Chemistry and Biology II 73 97 .
Mariusz Skwarczynski, Yoshio Hayashi & Yoshiaki Kiso. (2006) Paclitaxel Prodrugs:  Toward Smarter Delivery of Anticancer Agents. Journal of Medicinal Chemistry 49:25, pages 7253-7269.
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Da-Eun Chung & Felix Kratz. (2006) Development of a novel albumin-binding prodrug that is cleaved by urokinase-type-plasminogen activator (uPA). Bioorganic & Medicinal Chemistry Letters 16:19, pages 5157-5163.
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Andrei R. Timerbaev, Christian G. Hartinger, Svetlana S. Aleksenko & Bernhard K. Keppler. (2006) Interactions of Antitumor Metallodrugs with Serum Proteins:  Advances in Characterization Using Modern Analytical Methodology. Chemical Reviews 106:6, pages 2224-2248.
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Michael A. Jakupec, Erwin Reisner, Anna Eichinger, Martina Pongratz, Vladimir B. Arion, Mathea Sophia Galanski, Christian G. Hartinger & Bernhard K. Keppler. (2005) Redox-Active Antineoplastic Ruthenium Complexes with Indazole:  Correlation of in Vitro Potency and Reduction Potential. Journal of Medicinal Chemistry 48:8, pages 2831-2837.
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Alexander V. Rudnev, Svetlana S. Aleksenko, Olga Semenova, Christian G. Hartinger, Andrei R. Timerbaev & Bernhard K. Keppler. (2005) Determination of binding constants and stoichiometries for platinum anticancer drugs and serum transport proteins by capillary electrophoresis using the Hummel-Dreyer method. Journal of Separation Science 28:2, pages 121-127.
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Zhenghong Xu, Wangwen Gu, Jun Huang, Hong Sui, Zhaohui Zhou, Yongxin Yang, Zhou Yan & Yaping Li. (2005) In vitro and in vivo evaluation of actively targetable nanoparticles for paclitaxel delivery. International Journal of Pharmaceutics 288:2, pages 361-368.
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André Warnecke, Iduna Fichtner, Dirk Garmann, Ulrich Jaehde & Felix Kratz. (2004) Synthesis and Biological Activity of Water-Soluble Maleimide Derivatives of the Anticancer Drug Carboplatin Designed as Albumin-Binding Prodrugs. Bioconjugate Chemistry 15:6, pages 1349-1359.
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Du Xiu-lian, Wang Kui, Ke Ya, Yuan Lan, Li Rong-chang, Chang Yan Zhong, Ho Kwok Ping & Qian Zhong Ming. (2004) Apotransferrin is internalized and distributed in the same way as holotransferrin in K562 cells. Journal of Cellular Physiology 201:1, pages 45-54.
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Lilianna Trynda-Lemiesz. (2004) Paclitaxel–HSA interaction. Binding sites on HSA molecule. Bioorganic & Medicinal Chemistry 12:12, pages 3269-3275.
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Felix Kratz, André Warnecke, Karin Scheuermann, Cornelia Stockmar, Jürgen Schwab, Peter Lazar, Peter Drückes, Norbert Esser, Joachim Drevs, Didier Rognan, Caterina Bissantz, Caterina Hinderling, Gerd Folkers, Iduna Fichtner & Clemens Unger. (2002) Probing the Cysteine-34 Position of Endogenous Serum Albumin with Thiol-Binding Doxorubicin Derivatives. Improved Efficacy of an Acid-Sensitive Doxorubicin Derivative with Specific Albumin-Binding Properties Compared to That of the Parent Compound. Journal of Medicinal Chemistry 45:25, pages 5523-5533.
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Stephen L. Hussey & Blake R. Peterson. (2002) Efficient Delivery of Streptavidin to Mammalian Cells:  Clathrin-Mediated Endocytosis Regulated by a Synthetic Ligand. Journal of the American Chemical Society 124:22, pages 6265-6273.
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Hongyan Li & Zhong Ming Qian. (2002) Transferrin/transferrin receptor‐mediated drug delivery. Medicinal Research Reviews 22:3, pages 225-250.
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Carlo Bertucci & Enrico Domenici. 2002. Wiley Encyclopedia of Molecular Medicine. Wiley Encyclopedia of Molecular Medicine.
Felix Kratz, Joachim Drevs, Gerlinde Bing, Cornelia Stockmar, Karin Scheuermann, Peter Lazar & Clemens Unger. (2001) Development and in vitro efficacy of novel MMP2 and MMP9 specific doxorubicin albumin conjugates. Bioorganic & Medicinal Chemistry Letters 11:15, pages 2001-2006.
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A. Muvaffak, I. Gurhan, U. Gunduz & N. Hasirci. (2001) Development of a drug targeting approach for cancer therapy: drug carrier-protein conjugate. Development of a drug targeting approach for cancer therapy: drug carrier-protein conjugate.
Felix Kratz, Ralph Müller-Driver, Inga Hofmann, Joachim Drevs & Clemens Unger. (2000) A Novel Macromolecular Prodrug Concept Exploiting Endogenous Serum Albumin as a Drug Carrier for Cancer Chemotherapy. Journal of Medicinal Chemistry 43:7, pages 1253-1256.
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