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Original Article

Increased Tumor Oxygenation and Radiation Sensitivity in two Rat Tumors by A Hemoglobin-Based, Oxygen-Carrying Preparation

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Pages 431-438 | Published online: 11 Jul 2009

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Xiao-Bing Liu, Qiao Cheng, Wei Geng, Chang-Chun Ling, Yan Liu, Kevin Tak-Pan Ng, Judy Wai-Ping Yam, Xin-Yuan Guan, Chung-Mau Lo & Kwan Man. (2014) Enhancement of cisplatin-based TACE by a hemoglobin-based oxygen carrier in an orthotopic rat HCC model. Artificial Cells, Nanomedicine, and Biotechnology 42:4, pages 229-236.
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Jianqun Han, Minhua Yu, Min Dai, Hongwei Li, Ruijuan Xiu & Qian Liu. (2012) Decreased expression of MDR1 in PEG-conjugated hemoglobin solution combined cisplatin treatment in a tumor xenograft model. Artificial Cells, Blood Substitutes, and Biotechnology 40:4, pages 239-244.
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Wei Wu, Qian Yang, Wei Wu, Qian Yang, Tao Li, Pu Zhang, Ronghua Zhou & Chengmin Yang. (2009) Hemoglobin-based Oxygen Carriers Combined with Anticancer Drugs May Enhance Sensitivity of Radiotherapy and Chemotherapy to Solid Tumors. Artificial Cells, Blood Substitutes, and Biotechnology 37:4, pages 163-165.
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Minghua Yu, Jianqun Han, Min Dai, Peilin Cui, Hongwei Li, Qian Liu & Ruijuan Xiu. (2008) Influence of PEG-conjugated Hemoglobin on Tumor Oxygenation and Response to Chemotherapy. Artificial Cells, Blood Substitutes, and Biotechnology 36:6, pages 551-561.
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Min Dai, Minghua Yu, Jianqun Han, Hongwei Li, Peilin Cui, Qian Liu & Ruijuan Xiu. (2008) PEG-conjugated Hemoglobin Combination with Cisplatin Enforced the Antiangiogeic Effect in a Cervical Tumor Xenograft Model. Artificial Cells, Blood Substitutes, and Biotechnology 36:6, pages 487-497.
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Articles from other publishers (23)

Martyna Krzykawska-Serda, Dariusz Szczygieł, Szymon Gaweł, Agnieszka Drzał, Małgorzata Szczygieł, Maciej M. Kmieć, Andrzej Mackiewicz, Claudine Kieda & Martyna Elas. (2023) Oxygen therapeutic window induced by myo-inositol trispyrophosphate (ITPP)–Local pO2 study in murine tumors. PLOS ONE 18:5, pages e0285318.
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Inês Godet, Steven Doctorman, Fan Wu & Daniele M. Gilkes. (2022) Detection of Hypoxia in Cancer Models: Significance, Challenges, and Advances. Cells 11:4, pages 686.
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Thomas Ming Swi Chang. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 99 115 .
Donald A. Belcher, Alfredo Lucas, Pedro Cabrales & Andre F. Palmer. (2020) Polymerized human hemoglobin facilitated modulation of tumor oxygenation is dependent on tumor oxygenation status and oxygen affinity of the hemoglobin-based oxygen carrier. Scientific Reports 10:1.
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Donald A. Belcher, Alfredo Lucas, Pedro Cabrales & Andre F. Palmer. (2020) Tumor vascular status controls oxygen delivery facilitated by infused polymerized hemoglobins with varying oxygen affinity. PLOS Computational Biology 16:8, pages e1008157.
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Andre Francis Palmer & Donald Andrew Belcher. 2020. Principles of Tissue Engineering. Principles of Tissue Engineering 785 801 .
Kazuaki Taguchi, Keishi Yamasaki, Hiromi Sakai, Toru Maruyama & Masaki Otagiri. (2017) The Use of Hemoglobin Vesicles for Delivering Medicinal Gas for the Treatment of Intractable Disorders. Journal of Pharmaceutical Sciences 106:9, pages 2392-2400.
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Nikki P. Lee, Kin Tak Chan, Mei Yuk Choi, Ho Yu Lam, Lai Nar Tung, Fei Chuen Tzang, Heron Han, Ian P. Y. Lam, Sui Yi Kwok, Sze Hang Lau, Cornelia Man, Daniel K. Tong, Bing L. Wong & Simon Law. (2015) Oxygen carrier YQ23 can enhance the chemotherapeutic drug responses of chemoresistant esophageal tumor xenografts. Cancer Chemotherapy and Pharmacology 76:6, pages 1199-1207.
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Thomas Ming Swi Chang. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 3 26 .
Robert W. Gotshall, Karyn L. Hamilton, Benjamin Foreman, Martha C. Tissot van Patot & David C. Irwin. (2009) Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition*. Critical Care Medicine 37:6, pages 1988-1993.
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Manabu Yamamoto, Yotaro Izumi, Hirohisa Horinouchi, Yuji Teramura, Hiromi Sakai, Mitsutomo Kohno, Masazumi Watanabe, Masafumi Kawamura, Takeshi Adachi, Eiji Ikeda, Shinji Takeoka, Eishun Tsuchida & Koichi Kobayashi. (2009) Systemic Administration of Hemoglobin Vesicle Elevates Tumor Tissue Oxygen Tension and Modifies Tumor Response to Irradiation. Journal of Surgical Research 151:1, pages 48-54.
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Sharon I. Gundersen & Andre F. Palmer. (2008) Hemoglobin‐based oxygen carrier enhanced tumor oxygenation: A novel strategy for cancer therapy. Biotechnology Progress 24:6, pages 1353-1364.
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Hirohisa Horinouchi, Hisashi Yamamoto, Teruyuki Komatsu, Yubin Huang, Eishun Tsuchida & Koichi Kobayashi. (2008) Enhanced radiation response of a solid tumor with the artificial oxygen carrier ‘albumin-heme’. Cancer Science 99:6, pages 1274-1278.
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Minghua Yu, Min Dai, Qian Liu & Ruijuan Xiu. (2007) Oxygen carriers and cancer chemo- and radiotherapy sensitization: Bench to bedside and back. Cancer Treatment Reviews 33:8, pages 757-761.
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Virginia T. Rentko, L. Bruce Pearce, Paula F. Moon-Massat & Maria S. Gawryl. 2006. Blood Substitutes. Blood Substitutes 424 436 .
H. Northoff & C. Weinstock. 2004. Transfusionsmedizin. Transfusionsmedizin 565 575 .
Peter Büchler, Howard A. Reber, Manuela Büchler, Shailesh Shrinkante, Markus W. Büchler, Helmut Friess, Gregg L. Semenza & Oscar J. Hines. (2003) Hypoxia-Inducible Factor 1 Regulates Vascular Endothelial Growth Factor Expression in Human Pancreatic Cancer. Pancreas 26:1, pages 56-64.
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Christopher P. Stowell. (2002) Hemoglobin-based oxygen carriers. Current Opinion in Hematology 9:6, pages 537-543.
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Ron Vin, Daniela Bedenice, Virginia T. Rentko & Mary Rose Paradis. (2002) The use of ultrapurified bovine hemoglobin solution in the treatment of two cases of presumed red maple toxicosis in a miniature horse and a pony. Journal of Veterinary Emergency and Critical Care 12:3, pages 169-175.
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Jean G. Riess. (2001) Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft . Chemical Reviews 101:9, pages 2797-2920.
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Christopher P. Stowell, Jack Levin, Bruce D. Spiess & Robert M. Winslow. (2002) Progress in the development of RBC substitutes. Transfusion 41:2, pages 287-299.
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Gus J. Vlahakes. 2001. Surgical Research. Surgical Research 1037 1046 .
Peter Vaupel, DebraK Kelleher & Oliver Thews. (1998) Modulation of tumor oxygenation. International Journal of Radiation Oncology*Biology*Physics 42:4, pages 843-848.
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