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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 6
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Research Article

Hydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease

Dayanne da Rocha de MenezesBIOINOVAR – Biotechnology Laboratories: Biocatalysis, Bioproducts and Bioenergy, Institute of Microbiology Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, ;Faculdade São Francisco de Barreiras (FASB), Barreiras, BA, Brazil,
,
Claudia Magalhães CalvetLaboratório de Ultra-estrutura Celular, Instituto Oswaldo Cruz – Fiocruz, Rio de Janeiro, RJ, Brazil,
,
Giseli Capaci RodriguesEscola de Ciência e Tecnologia e Programa de Pós-Graduação em Ensino das Ciências, Universidade do Grande Rio, Duque de Caxias, RJ, Brazil,
,
Mirian Claudia de Souza PereiraLaboratório de Ultra-estrutura Celular, Instituto Oswaldo Cruz – Fiocruz, Rio de Janeiro, RJ, Brazil, Correspondence[email protected]
,
Igor Rodrigues AlmeidaDepartamento de Produtos Naturais e Alimentos, Faculdade de Farmácia, UFRJ, Rio de Janeiro, RJ, Brazil,
,
Alcino Palermo de AguiarLaboratório de Síntese Orgânica, Departamento de Química, Instituto Militar de Engenharia, Rio de Janeiro, Brazil, and
,
Claudiu T. SupuranLaboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Polo Scientifico, Sesto Fiorentino (Florence), Italy
&
Alane Beatriz VermelhoBIOINOVAR – Biotechnology Laboratories: Biocatalysis, Bioproducts and Bioenergy, Institute of Microbiology Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Correspondence[email protected]
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Pages 964-973 | Received 03 Jul 2015, Accepted 25 Jul 2015, Published online: 31 Aug 2015

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Alane Beatriz Vermelho, Giseli Capaci Rodrigues, Alessio Nocentini, Felipe R. P. Mansoldo & Claudiu T. Supuran. (2022) Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?. Expert Opinion on Drug Discovery 17:10, pages 1147-1158.
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Alessio Nocentini, Sameh M. Osman, Igor A. Rodrigues, Veronica S. Cardoso, Fatmah Ali S. Alasmary, Zeid AlOthman, Alane B. Vermelho, Paola Gratteri & Claudiu T. Supuran. (2019) Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1164-1171.
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Verônica da Silva Cardoso, Alane Beatriz Vermelho, Eduardo Ricci Junior, Igor Almeida Rodrigues, Ana Maria Mazotto & Claudiu T. Supuran. (2018) Antileishmanial activity of sulphonamide nanoemulsions targeting the β-carbonic anhydrase from Leishmania species. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 850-857.
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Alessio Nocentini, Roberta Cadoni, Pascal Dumy, Claudiu T. Supuran & Jean-Yves Winum. (2018) Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 286-289.
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Alane Beatriz Vermelho, Verônica da Silva Cardoso, Eduardo Ricci Junior, Elisabete Pereira dos Santos & Claudiu T. Supuran. (2018) Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 139-146.
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Sonia Del Prete, Viviana De Luca, Giuseppina De Simone, Claudiu T. Supuran & Clemente Capasso. (2016) Cloning, expression and purification of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup4, pages 54-59.
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Articles from other publishers (17)

Aline A. Zuma & Wanderley de Souza. (2021) Chagas Disease Chemotherapy: What Do We Know So Far?. Current Pharmaceutical Design 27:38, pages 3963-3995.
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Julia M. Souza, Tatiana M. Vieira, Ana Carolina B.B. Candido, Daiane Y. Tezuka, G. Subba Rao, Sérgio de Albuquerque, Antônio E.M. Crotti, Jair L. Siqueira-Neto & Lizandra G. Magalhães. (2021) In vitro anti-Trypanosoma cruzi activity enhancement of curcumin by its monoketone tetramethoxy analog diveratralacetone. Current Research in Parasitology & Vector-Borne Diseases 1, pages 100031.
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Clemente Capasso & Claudiu T. Supuran. 2022. Antiprotozoal Drug Development and Delivery. Antiprotozoal Drug Development and Delivery 241 258 .
Chiagoziem A. Otuechere, Adewale Adewuyi & Oluwabukola Bankole. (2020) Green synthesized hydroxamic acid administered in high dose disrupts the antioxidant balance in the hepatic and splenic tissues of albino rats. Clinical Phytoscience 6:1.
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Rodrigo M. Fráguas, Viviane A. Costa, Willian C. Terra, Alcino P. Aguiar, Samuel J. Martins, Vicente P. Campos & Denilson F. Oliveira. (2020) Toxicities of 4,5-Dihydroisoxazoles Against Root-Knot Nematodes and in Silico Studies of Their Modes of Action. Journal of Agricultural and Food Chemistry 68:2, pages 523-529.
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Erofili Giannakopoulou, Vasiliki Pardali, Efseveia Frakolaki, Vasileios Siozos, Vassilios Myrianthopoulos, Emmanuel Mikros, Martin C. Taylor, John M. Kelly, Niki Vassilaki & Grigoris Zoidis. (2019) Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species . MedChemComm 10:6, pages 991-1006.
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Anacleto S. de Souza, Leonardo L. G. Ferreira, Aldo S. de Oliveira & Adriano D. Andricopulo. (2019) Quantitative Structure–Activity Relationships for Structurally Diverse Chemotypes Having Anti-Trypanosoma cruzi Activity. International Journal of Molecular Sciences 20:11, pages 2801.
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Alessandro Bonardi, Alane Beatriz Vermelho, Veronica da Silva Cardoso, Mirian Claudia de Souza Pereira, Leonardo da Silva Lara, Silvia Selleri, Paola Gratteri, Claudiu T. Supuran & Alessio Nocentini. (2018) N -Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis . ACS Medicinal Chemistry Letters 10:4, pages 413-418.
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Silvia Bua, Susanna Haapanen, Marianne Kuuslahti, Seppo Parkkila & Claudiu T. Supuran. (2019) Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica with Amino Acids and Amines. Metabolites 9:2, pages 26.
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Ashok Aspatwar, Harlan Barker, Martti Tolvanen, Reza Zolfaghari Emameh & Seppo Parkkila. 2019. Carbonic Anhydrases. Carbonic Anhydrases 449 475 .
Andrea Angeli, Sonia Del Prete, Fatmah A.S. Alasmary, Linah S. Alqahtani, Zeid AlOthman, William A. Donald, Clemente Capasso & Claudiu T. Supuran. (2018) The first activation studies of the η-carbonic anhydrase from the malaria parasite Plasmodium falciparum with amines and amino acids. Bioorganic Chemistry 80, pages 94-98.
Crossref
Andrea Angeli, Marianne Kuuslahti, Seppo Parkkila & Claudiu T. Supuran. (2018) Activation studies with amines and amino acids of the α-carbonic anhydrase from the pathogenic protozoan Trypanosoma cruzi. Bioorganic & Medicinal Chemistry 26:14, pages 4187-4190.
Crossref
Andrea Angeli, William A. Donald, Seppo Parkkila & Claudiu T. Supuran. (2018) Activation studies with amines and amino acids of the β-carbonic anhydrase from the pathogenic protozoan Leishmania donovani chagasi. Bioorganic Chemistry 78, pages 406-410.
Crossref
Morteza Abdoli, Murat Bozdag, Andrea Angeli & Claudiu Supuran. (2018) Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors. Metabolites 8:2, pages 37.
Crossref
Claudiu Supuran. (2018) Carbonic Anhydrases and Metabolism. Metabolites 8:2, pages 25.
Crossref
Suleyman Akocak, Nabih Lolak, Alessio Nocentini, Gulcin Karakoc, Anzel Tufan & Claudiu T. Supuran. (2017) Synthesis and biological evaluation of novel aromatic and heterocyclic bis-sulfonamide Schiff bases as carbonic anhydrase I, II, VII and IX inhibitors. Bioorganic & Medicinal Chemistry 25:12, pages 3093-3097.
Crossref
Alane B. Vermelho, Giseli R. Capaci, Igor A. Rodrigues, Verônica S. Cardoso, Ana Maria Mazotto & Claudiu T. Supuran. (2017) Carbonic anhydrases from Trypanosoma and Leishmania as anti-protozoan drug targets. Bioorganic & Medicinal Chemistry 25:5, pages 1543-1555.
Crossref

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