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ORIGINAL RESEARCH

Cardiovascular Safety of QVA149, a Combination of Indacaterol and NVA237, in COPD Patients

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Pages 418-427 | Published online: 20 Dec 2010

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Paola Rogliani, Josuel Ora, Maria Gabriella Matera, Mario Cazzola & Luigino Calzetta. (2018) The safety of dual bronchodilation on cardiovascular serious adverse events in COPD. Expert Opinion on Drug Safety 17:6, pages 589-596.
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Santosh Dhungana & Gerard J Criner. (2017) Spotlight on glycopyrronium/formoterol fumarate inhalation aerosol in the management of COPD: design, development, and place in therapy. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 2307-2312.
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David Price, Anders Østrem, Mike Thomas & Tobias Welte. (2017) Dual bronchodilation in COPD: lung function and patient-reported outcomes – a review. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 141-168.
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Peter Kardos, Sally Worsley, Dave Singh, Miguel Román-Rodríguez, David E Newby & Hana Müllerová. (2016) Randomized controlled trials and real-world observational studies in evaluating cardiovascular safety of inhaled bronchodilator therapy in COPD. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 2885-2895.
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Subhabrata Moitra, Arvind B Bhome & Bill B Brashier. (2015) Aclidinium bromide/formoterol fixed-dose combination therapy for COPD: the evidence to date. Drug Design, Development and Therapy 9, pages 1989-1999.
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Charlotte Suppli Ulrik. (2015) Once-daily glycopyrronium bromide (Seebri Breezhaler®) for the treatment of chronic obstructive pulmonary disease (COPD). Expert Opinion on Pharmacotherapy 16:17, pages 2653-2659.
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Reynold A Panettieri Jr. (2015) Bronchodilators, receptors and cross-talk: Together is better?. Postgraduate Medicine 127:7, pages 771-780.
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Morven Wilkie, Simon Finch & Stuart Schembri. (2015) Inhaled Corticosteroids for Chronic Obstructive Pulmonary Disease—The Shifting Treatment Paradigm. COPD: Journal of Chronic Obstructive Pulmonary Disease 12:5, pages 582-590.
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Nanshan Zhong, Changzheng Wang, Xiangdong Zhou, Nuofu Zhang, Michael Humphries, Linda Wang, Chau Thach, Francesco Patalano & Donald Banerji. (2015) LANTERN: a randomized study of QVA149 versus salmeterol/fluticasone combination in patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 1015-1026.
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Nobuyuki Horita & Takeshi Kaneko. (2015) Role of combined indacaterol and glycopyrronium bromide (QVA149) for the treatment of COPD in Japan. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 813-822.
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Maria Gabriella Matera, Paola Rogliani & Mario Cazzola. (2015) QVA149 (indacaterol/glycopyrronium) for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 16:7, pages 1079-1090.
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Ruben D Restrepo, Andrew Tate & Joshua Coquat. (2013) Evaluation of salmeterol xinafoate plus fluticasone propionate for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 14:14, pages 1993-2002.
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Ronald Dahl, Dalal Jadayel, Vijay KT Alagappan, Hungta Chen & Donald Banerji. (2013) Efficacy and safety of QVA149 compared to the concurrent administration of its monocomponents indacaterol and glycopyrronium: the BEACON study. International Journal of Chronic Obstructive Pulmonary Disease 8, pages 501-508.
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Andrea Rossi & Guido Polese. (2013) Indacaterol: a comprehensive review. International Journal of Chronic Obstructive Pulmonary Disease 8, pages 353-363.
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Anthony D'Urzo & Claus Vogelmeier. (2012) Future of chronic obstructive pulmonary disease management. Expert Review of Respiratory Medicine 6:3, pages 285-299.
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Roland Buhl & Donald Banerji. (2012) Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD. International Journal of Chronic Obstructive Pulmonary Disease 7, pages 729-741.
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Charlotte Suppli Ulrik. (2012) Once-daily glycopyrronium bromide, a long-acting muscarinic antagonist, for chronic obstructive pulmonary disease: a systematic review of clinical benefit. International Journal of Chronic Obstructive Pulmonary Disease 7, pages 673-678.
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Qinxia Zhang, Haifu Zhang, Jianjun Wang, Zhaoyang Ruan, Yifan Dai, Zehai Xia & Qun Lv. (2021) Indacaterol/glycopyrronium affects lung function and cardiovascular events in patients with chronic obstructive pulmonary diseases: A meta-analysis. Heart & Lung 50:4, pages 532-541.
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S. André, B. Conde, E. Fragoso, J.P. Boléo-Tomé, V. Areias & J. Cardoso. (2019) COPD and Cardiovascular Disease. Pulmonology 25:3, pages 168-176.
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Usman Maqsood, Terence N Ho, Karen Palmer, Fiona JR Eccles, Mohammed Munavvar, Ran Wang, Iain Crossingham & David JW Evans. (2019) Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2019:3.
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I. V. Leshchenko. (2018) Fixed dose long-acting bronchodilator combinations in chronic obstructive pulmonary disease: safety, effectiveness and cardiovascular system. Medical Council:15, pages 18-26.
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James F. Donohue, Paul W. Jones, Christian Bartels, Jessica Marvel, Peter D'Andrea, Donald Banerji, David G. Morris, Francesco Patalano & Robert Fogel. (2018) Correlations between FEV1 and patient-reported outcomes: A pooled analysis of 23 clinical trials in patients with chronic obstructive pulmonary disease. Pulmonary Pharmacology & Therapeutics 49, pages 11-19.
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Dave Singh, Giorgia Ciurlia, Annalisa Piccinno, Annamaria Muraro, Maria Bocchi & Mario Scuri. (2017) Acute cardiovascular safety of two formulations of beclometasone dipropionate/formoterol fumarate in COPD patients: A single-dose, randomised, placebo-controlled crossover study. Pulmonary Pharmacology & Therapeutics 42, pages 43-51.
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Kazuhisa Asai, Kazuto Hirata, Shu Hashimoto, Yoshinosuke Fukuchi, Tetsuji Kitawaki, Kimitoshi Ikeda, Robert Fogel & Donald Banerji. (2016) Efficacy and safety of indacaterol/glycopyrronium in Japanese patients with COPD: Pooled analysis of SHINE and ARISE. Respiratory Investigation 54:6, pages 428-435.
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Editorial Article. (2016) Therapeutic strategy to prevent acute exacerbations of chronic obstructive pulmonary disease: clinical guidelines of American College of Chest Physicians and Canadian Thoracic Society Guideline (Part 2). PULMONOLOGIYA 26:3, pages 267-291.
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Maria Gabriella Matera, Paola Rogliani, Luigino Calzetta & Mario Cazzola. (2016) Safety Considerations with Dual Bronchodilator Therapy in COPD: An Update. Drug Safety 39:6, pages 501-508.
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Donald A. Mahler, Edward Kerwin, Tim Ayers, Angel FowlerTaylor, Samopriyo Maitra, Chau Thach, Mark Lloyd, Francesco Patalano & Donald Banerji. (2015) FLIGHT1 and FLIGHT2: Efficacy and Safety of QVA149 (Indacaterol/Glycopyrrolate) versus Its Monocomponents and Placebo in Patients with Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine 192:9, pages 1068-1079.
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Gerard J. Criner, Jean Bourbeau, Rebecca L. Diekemper, Daniel R. Ouellette, Donna Goodridge, Paul Hernandez, Kristen Curren, Meyer S. Balter, Mohit Bhutani, Pat G. Camp, Bartolome R. Celli, Gail Dechman, Mark T. Dransfield, Stanley B. Fiel, Marilyn G. Foreman, Nicola A. Hanania, Belinda K. Ireland, Nathaniel Marchetti, Darcy D. Marciniuk, Richard A. Mularski, Joseph Ornelas, Jeremy D. Road & Michael K. Stickland. (2015) Prevention of Acute Exacerbations of COPD. Chest 147:4, pages 894-942.
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Erminia Ridolo, Marcello Montagni, Gian Galeazzo Riario-Sforza, Marco Baroni & Cristoforo Incorvaia. (2015) Combination therapy with indacaterol and glycopyrronium bromide in the management of COPD: an update on the evidence for efficacy and safety. Therapeutic Advances in Respiratory Disease 9:2, pages 49-55.
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James B Geake, Eli J Dabscheck, Richard Wood-Baker & Christopher J Cates. (2015) Indacaterol, a once-daily beta 2 -agonist, versus twice-daily beta 2 -agonists or placebo for chronic obstructive pulmonary disease . Cochrane Database of Systematic Reviews 2017:3.
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Stefano Nardini, Gianna Camiciottoli, Salvatore Locicero, Rosario Maselli, Franco Pasqua, Giovanni Passalacqua, Riccardo Pela, Alberto Pesci, Alfredo Sebastiani & Alessandro Vatrella. (2014) COPD: maximization of bronchodilation. Multidisciplinary Respiratory Medicine 9:1.
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James E. Frampton. (2014) QVA149 (Indacaterol/Glycopyrronium Fixed-Dose Combination): A Review of Its Use in Patients with Chronic Obstructive Pulmonary Disease. Drugs 74:4, pages 465-488.
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Alexander G. Mathioudakis, Victoria Chatzimavridou-Grigoriadou & Georgios A. Mathioudakis. 2014. A worldwide yearly survey of new data in adverse drug reactions. A worldwide yearly survey of new data in adverse drug reactions 241 256 .
Paul Matthias Diderichsen, Eugène Cox, Steven W. Martin, Adriaan Cleton & Jakob Ribbing. (2013) Predicted heart rate effect of inhaled PF-00610355, a long acting β-adrenoceptor agonist, in volunteers and patients with chronic obstructive pulmonary disease. British Journal of Clinical Pharmacology 76:5, pages 752-762.
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J.F. Donohue, M.R. Maleki-Yazdi, S. Kilbride, R. Mehta, C. Kalberg & A. Church. (2013) Efficacy and safety of once-daily umeclidinium/vilanterol 62.5/25 mcg in COPD. Respiratory Medicine 107:10, pages 1538-1546.
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Ronald Dahl, Kenneth R. Chapman, Michael Rudolf, Rajendra Mehta, Pearl Kho, Vijay K.T. Alagappan, Hungta Chen & Donald Banerji. (2013) Safety and efficacy of dual bronchodilation with QVA149 in COPD patients: The ENLIGHTEN study. Respiratory Medicine 107:10, pages 1558-1567.
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C. Compton, D. McBryan, E. Bucchioni & F. Patalano. (2013) The Novartis view on emerging drugs and novel targets for the treatment of chronic obstructive pulmonary disease. Pulmonary Pharmacology & Therapeutics 26:5, pages 562-573.
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Mario Cazzola, Clive Page & Maria Gabriella Matera. (2013) Long-acting muscarinic receptor antagonists for the treatment of respiratory disease. Pulmonary Pharmacology & Therapeutics 26:3, pages 307-317.
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Fa-Ming Jiang, Zong-An Liang, Qiao-Ling Zheng, Rong-Chun Wang, Jian Luo & Chun-Tao Li. (2013) Safety and Efficacy of 12-Week or Longer Indacaterol Treatment in Moderate-to-Severe COPD Patients: A Systematic Review. Lung 191:2, pages 135-146.
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Donald P Tashkin & Gary T Ferguson. (2013) Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease. Respiratory Research 14:1, pages 49.
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Mario Cazzola, Clive P. Page, Luigino Calzetta & M. Gabriella Matera. (2012) Pharmacology and Therapeutics of Bronchodilators. Pharmacological Reviews 64:3, pages 450-504.
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Anders Bjerg, Bo Lundbäck & Jan Lötvall. (2012) The future of combining inhaled drugs for COPD. Current Opinion in Pharmacology 12:3, pages 252-255.
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Thys van der Molen & Mario Cazzola. (2012) Beyond lung function in COPD management: effectiveness of LABA/LAMA combination therapy on patient-centred outcomes. Primary Care Respiratory Journal 21:1, pages 101-108.
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Claus Vogelmeier & Donald Banerji. (2011) NVA237, a long-acting muscarinic antagonist, as an emerging therapy for chronic obstructive pulmonary disease. Therapeutic Advances in Respiratory Disease 5:3, pages 163-173.
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