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Research Papers

Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma

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Pages 336-345 | Received 24 Apr 2014, Accepted 28 Sep 2014, Published online: 10 Mar 2015

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Rex Devasahayam Arokia Balaya, Jaikanth Chandrasekaran, Saptami Kanekar, Prashant Kumar Modi, Shobha Dagamajalu, Kirthika Gopinathan, Rajesh Raju & T. S. Keshava Prasad. (2023) Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) inhibitors: a novel approach in small molecule discovery. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-11.
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Crossref
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Crossref
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Crossref
Peter O. Oladimeji, Wenwei Lin, C. Trent Brewer & Taosheng Chen. (2017) Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase. Scientific Reports 7:1.
Crossref
Ayesha S. Khan & Daniel E. Frigo. (2017) A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer. Nature Reviews Urology 14:3, pages 164-180.
Crossref
Vishalakshi Nanjappa, Gajanan J. Sathe, Ankit P. Jain, Pavithra Rajagopalan, Remya Raja, Tejaswini Subbannayya, Arun H. Patil, Prashant Kumar, T. S. Keshava Prasad, Premendu Prakash Mathur, David Sidransky, Harsha Gowda & Aditi Chatterjee. (2017) Investigation of curcumin-mediated signalling pathways in head and neck squamous cell carcinoma. Translational Research in Oral Oncology 2, pages 2057178X1774314.
Crossref
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Crossref
Ji Cheng, Tao Zhang, Hongbin Ji, Kaixiong Tao, Jianping Guo & Wenyi Wei. (2016) Functional characterization of AMP-activated protein kinase signaling in tumorigenesis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1866:2, pages 232-251.
Crossref
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Cheng Ye, Duo Zhang, Lei Zhao, Yan Li, Xiaohan Yao, Hui Wang, Shengjie Zhang, Wei Liu, Hongchao Cao, Shuxian Yu, Yucheng Wang, Jingjing Jiang, Hui Wang, Xihua Li & Hao Ying. (2016) CaMKK2 Suppresses Muscle Regeneration through the Inhibition of Myoblast Proliferation and Differentiation. International Journal of Molecular Sciences 17:10, pages 1695.
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Crossref
Da-Ming Liu, Hong-Jun Wang, Bo Han, Xiang-Qi Meng, Ming-Hui Chen, Dong-Bo Yang, Ying Sun, Yong-Li Li & Chuan-Lu Jiang. (2016) CAMKK2, Regulated by Promoter Methylation, is a Prognostic Marker in Diffuse Gliomas. CNS Neuroscience & Therapeutics 22:6, pages 518-524.
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Biplab Dasgupta & Rishi Raj Chhipa. (2016) Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer. Trends in Pharmacological Sciences 37:3, pages 192-206.
Crossref
Yashwanth Subbannayya, Sartaj Ahmad Mir, Santosh Renuse, Srikanth S. Manda, Sneha M. Pinto, Vinuth N. Puttamallesh, Hitendra Singh Solanki, H.C. Manju, Nazia Syed, Rakesh Sharma, Rita Christopher, M. Vijayakumar, K.V. Veerendra Kumar, T.S. Keshava Prasad, Girija Ramaswamy, Rekha V. Kumar, Aditi Chatterjee, Akhilesh Pandey & Harsha Gowda. (2015) Identification of differentially expressed serum proteins in gastric adenocarcinoma. Journal of Proteomics 127, pages 80-88.
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