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Review

The bacterial ghost platform system

Production and applications

, , , , &
Pages 326-336 | Received 14 Dec 2009, Accepted 01 Jun 2010, Published online: 01 Sep 2010

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Sefli Sri Wahyu Effendi & I-Son Ng. (2023) Prospective and challenges of live bacterial therapeutics from a superhero Escherichia coli Nissle 1917. Critical Reviews in Microbiology 49:5, pages 611-627.
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Siamak Alizadeh, Abolghasem Esmaeili, Abolfazl Barzegari, Mohammad A. Rafi & Yadollah Omidi. (2020) Bioengineered smart bacterial carriers for combinational targeted therapy of solid tumours. Journal of Drug Targeting 28:7-8, pages 700-713.
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Ali M. Batah & Tarek A. Ahmad. (2020) The development of ghost vaccines trials. Expert Review of Vaccines 19:6, pages 549-562.
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Wenxing Zhu, Lujiang Hao, Xinli Liu, Orlando Borrás-Hidalgo & Yuyu Zhang. (2018) Enhanced anti-proliferative efficacy of epothilone B loaded with Escherichia coli Nissle 1917 bacterial ghosts on the HeLa cells by mitochondrial pathway of apoptosis. Drug Development and Industrial Pharmacy 44:8, pages 1328-1335.
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Diana Groza, Sebastian Gehrig, Pavol Kudela, Martin Holcmann, Christine Pirker, Carina Dinhof, Hemma H. Schueffl, Marek Sramko, Julia Hoebart, Fatih Alioglu, Michael Grusch, Manfred Ogris, Werner Lubitz, Bernhard K. Keppler, Irena Pashkunova-Martic, Christian R. Kowol, Maria Sibilia, Walter Berger & Petra Heffeter. (2018) Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis. OncoImmunology 7:5.
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Songwe Fanuel, Saeideh Tabesh, Huda Fatima Rajani, Sahel Heidari, Esmaeil Sadroddiny & Gholam Ali Kardar. (2017) Decorating and loading ghosts with allergens for allergen immunotherapy. Human Vaccines & Immunotherapeutics 13:10, pages 2428-2433.
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Johannes Kassmannhuber, Mascha Rauscher, Lea Schöner, Angela Witte & Werner Lubitz. (2017) Functional display of ice nucleation protein InaZ on the surface of bacterial ghosts. Bioengineered 8:5, pages 488-500.
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Jacqueline Montanaro, Aleksandra Inic-Kanada, Angela Ladurner, Elisabeth Stein, Sandra Belij, Nora Bintner, Simone Schlacher, Nadine Schuerer, Ulrike Beate Mayr, Werner Lubitz, Nikolaus Leisch & Talin Barisani-Asenbauer. (2015) Escherichia coli Nissle 1917 bacterial ghosts retain crucial surface properties and express chlamydial antigen: an imaging study of a delivery system for the ocular surface. Drug Design, Development and Therapy 9, pages 3741-3754.
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Abbas Muhammad, Jonathan Champeimont, Ulrike Beate Mayr, Werner Lubitz & Pavol Kudela. (2012) Bacterial ghosts as carriers of protein subunit and DNA-encoded antigens for vaccine applications. Expert Review of Vaccines 11:1, pages 97-116.
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Jan Aleksander Kraśko, Karolina Žilionytė, Adas Darinskas, Marius Strioga, Svetlana Rjabceva, Iosif Zalutsky, Marina Derevyanko, Vladimir Kulchitsky, Werner Lubitz, Pavol Kudela, Edita Miseikyte-Kaubriene, Olha Karaman, Hennadii Didenko, Hryhorii Potebnya, Vasyl Chekhun & Vita Pašukonienė. (2017) Bacterial ghosts as adjuvants in syngeneic tumour cell lysate-based anticancer vaccination in a murine lung carcinoma model. Oncology Reports 37:1, pages 171-178.
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Hyun Park, Sung Oh, Nagarajan Vinod, Seongmi Ji, Han Noh, Jung Koo, Su Lee, Sei Kim, Ki-Sung Lee & Chang Choi. (2016) Characterization of Chemically-Induced Bacterial Ghosts (BGs) Using Sodium Hydroxide-Induced Vibrio parahaemolyticus Ghosts (VPGs). International Journal of Molecular Sciences 17:11, pages 1904.
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Zeinab Hosseinidoust, Babak Mostaghaci, Oncay Yasa, Byung-Wook Park, Ajay Vikram Singh & Metin Sitti. (2016) Bioengineered and biohybrid bacteria-based systems for drug delivery. Advanced Drug Delivery Reviews 106, pages 27-44.
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Sharan Bobbala & Sarah Hook. (2016) Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?. Pharmaceutical Research 33:9, pages 2078-2097.
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Milad Lagzian, Mohammad Reza Bassami & Hesam Dehghani. (2016) In vitro responses of chicken macrophage-like monocytes following exposure to pathogenic and non-pathogenic E. coli ghosts loaded with a rational design of conserved genetic materials of influenza and Newcastle disease viruses. Veterinary Immunology and Immunopathology 176, pages 5-17.
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Daniela Ehgartner, Christoph Herwig & Lukas Neutsch. (2016) At-line determination of spore inoculum quality in Penicillium chrysogenum bioprocesses. Applied Microbiology and Biotechnology 100:12, pages 5363-5373.
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Rongxian Guo, Shizhong Geng, Hongmei Jiao, Zhiming Pan, Xiang Chen & Xinan Jiao. (2016) Evaluation of protective efficacy of a novel inactivated Salmonella Pullorum ghost vaccine against virulent challenge in chickens. Veterinary Immunology and Immunopathology 173, pages 27-33.
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Andrea Meitz, Patrick Sagmeister, Werner Lubitz, Christoph Herwig & Timo Langemann. (2016) Fed-Batch Production of Bacterial Ghosts Using Dielectric Spectroscopy for Dynamic Process Control. Microorganisms 4:2, pages 18.
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Ae Jeong KWON, Ja Young MOON, Won Kyong KIM, Suk KIM & Jin HUR. (2016) Protection efficacy of the <i>Brucella abortus</i> ghost vaccine candidate lysed by the N-terminal 24-amino acid fragment (GI24) of the 36-amino acid peptide PMAP-36 (porcine myeloid antimicrobial peptide 36) in murine models. Journal of Veterinary Medical Science 78:10, pages 1541-1548.
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Timo Langemann, Ulrike Beate Mayr, Andrea Meitz, Werner Lubitz & Christoph Herwig. (2015) Multi-parameter flow cytometry as a process analytical technology (PAT) approach for the assessment of bacterial ghost production. Applied Microbiology and Biotechnology 100:1, pages 409-418.
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I HUSSAIN, S RAJKHOWA, D HASIN & S IQBAL. (2015) Bacterial ghosts and their potential future applications-A mini review. The Indian Journal of Animal Sciences 85:12.
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Aleksandra Inic-Kanada, Marijana Stojanovic, Simone Schlacher, Elisabeth Stein, Sandra Belij-Rammerstorfer, Emilija Marinkovic, Ivana Lukic, Jacqueline Montanaro, Nadine Schuerer, Nora Bintner, Vesna Kovacevic-Jovanovic, Ognjen Krnjaja, Ulrike Beate Mayr, Werner Lubitz & Talin Barisani-Asenbauer. (2015) Delivery of a Chlamydial Adhesin N-PmpC Subunit Vaccine to the Ocular Mucosa Using Particulate Carriers. PLOS ONE 10:12, pages e0144380.
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Ilka Sührer, Timo Langemann, Werner Lubitz, Dirk Weuster-Botz & Kathrin Castiglione. (2015) A novel one-step expression and immobilization method for the production of biocatalytic preparations. Microbial Cell Factories 14:1.
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Pan Gil Kim, Yeon Jo Ha, Su Man Lee, Sam Woong Kim & Sang Wan Gal. (2015) Immune Responses of BALB/c Mice Administrated via Oral Route to a Combined Salmonella Typhimurium Ghost Vaccine. Journal of Life Science 25:11, pages 1197-1203.
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Adrienne W. Paton, Austen Y. Chen, Hui Wang, Lauren J. McAllister, Florian Höggerl, Ulrike Beate Mayr, Lucy K. Shewell, Michael P. Jennings, Renato Morona, Werner Lubitz & James C. Paton. (2015) Protection against Shiga-Toxigenic Escherichia coli by Non-Genetically Modified Organism Receptor Mimic Bacterial Ghosts. Infection and Immunity 83:9, pages 3526-3533.
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Anna Walduck, Leif P. Andersen & Sukanya Raghavan. (2015) Inflammation, Immunity, and Vaccines for H elicobacter pylori Infection . Helicobacter 20:S1, pages 17-25.
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Nagarajan Vinod, Sung Oh, Hyun Jung Park, Jung Mo Koo, Chang Won Choi & Sei Chang Kim. (2015) Generation of a Novel Staphylococcus aureus Ghost Vaccine and Examination of Its Immunogenicity against Virulent Challenge in Rats. Infection and Immunity 83:7, pages 2957-2965.
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Wenxing Zhu, Yuyu Zhang & Xinli Liu. (2015) Efficient production of safety-enhanced Escherichia coli ghosts by tandem expression of PhiX 174 mutant gene E and staphylococcal nuclease A gene. Microbiological Research 176, pages 7-13.
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Nele Van Dessel, Charles A Swofford & Neil S Forbes. (2015) Potent and tumor specific: arming bacteria with therapeutic proteins. Therapeutic Delivery 6:3, pages 385-399.
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Daniela Ehgartner, Patrick Sagmeister, Christoph Herwig & Patrick Wechselberger. (2014) A novel real‐time method to estimate volumetric mass biodensity based on the combination of dielectric spectroscopy and soft‐sensors. Journal of Chemical Technology & Biotechnology 90:2, pages 262-272.
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Alfredo G. Torres, Jai S. Rudra & Gregg N. Milligan. 2015. Vaccinology. Vaccinology 127 151 .
Anna Hjelm, Bill Söderström, David Vikström, Wouter S. P. Jong, Joen Luirink & Jan-Willem de Gier. (2015) Autotransporter-Based Antigen Display in Bacterial Ghosts. Applied and Environmental Microbiology 81:2, pages 726-735.
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Jiasheng Wang, Ke Ding, Yujie Chen, Lifeng Zhang, Zukai Liu, Angli Xue, Wenjia Gu, Xiaoyue Yang, Xihan Li, Jin Huang, Congcong Xing, Yunlong Cao & Ming Chen. (2014) Detection of Thrombin with an Aptamer-Based Macromolecule Biosensor Using Bacterial Ghost System. ACS Synthetic Biology 3:12, pages 963-965.
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Jiansen Chen, Neng Li & Feifei She. (2014) Helicobacter pylori outer inflammatory protein DNA vaccine-loaded bacterial ghost enhances immune protective efficacy in C57BL/6 mice. Vaccine 32:46, pages 6054-6060.
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Jihua Guo & Rong Jia. (2013) A novel inducible expression system for the functional study of toxic gene in bacteria. World Journal of Microbiology and Biotechnology 30:5, pages 1527-1531.
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Elke Bergmann-Leitner & Wolfgang Leitner. (2014) Adjuvants in the Driver’s Seat: How Magnitude, Type, Fine Specificity and Longevity of Immune Responses Are Driven by Distinct Classes of Immune Potentiators. Vaccines 2:2, pages 252-296.
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Sam Vasilevsky, Gilbert Greub, Denise Nardelli-Haefliger & David Baud. (2014) Genital Chlamydia trachomatis: Understanding the Roles of Innate and Adaptive Immunity in Vaccine Research. Clinical Microbiology Reviews 27:2, pages 346-370.
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Yeon Jo Ha, Seung Tae Kim, Ho Young Kang, Sang Wan Gal & Sam Woong Kim. (2014) The Complex Salmonella typhimurium Ghost Cells Play an Additional Role as an Immune Adjuvant. Journal of Life Science 24:2, pages 154-160.
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Yeon Jo Ha, Tae Wan Kim, Seung Tae Kim, Sang Wan Gal & Sam Woong Kim. (2014) Ghost Vaccine Prepared from Strong Virulent Salmonella typhimurium Does not Improve Immune Responses of BALB/c Mice. Journal of Life Science 24:1, pages 39-45.
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Samir Gautam & David A. Spiegel. 2014. Micro- and Nanoengineering of the Cell Surface. Micro- and Nanoengineering of the Cell Surface 63 97 .
Hai-Feng Liu, Wei Li, Ming-Bo Lu & Long-Jiang Yu. (2012) Pharmacokinetics and risk evaluation of DNA vaccine against Schistosoma japonicum. Parasitology Research 112:1, pages 59-67.
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Adrienne W. Paton, Renato Morona & James C. Paton. (2012) Bioengineered microbes in disease therapy. Trends in Molecular Medicine 18:7, pages 417-425.
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Carmen Gutiérrez Millán, Clara Isabel Colino Gandarillas, María Luisa Sayalero Marinero & José M Lanao. (2012) Cell-based drug-delivery platforms. Therapeutic Delivery 3:1, pages 25-41.
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Wenxing Zhu, Guiwen Yang, Yuyu Zhang, Jinduo Yuan & Liguo An. (2012) Generation of Biotechnology-Derived Flavobacterium columnare Ghosts by PhiX174 Gene E -Mediated Inactivation and the Potential as Vaccine Candidates against Infection in Grass Carp . Journal of Biomedicine and Biotechnology 2012, pages 1-8.
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Pavol Kudela, Verena Juliana Koller, Ulrike Beate Mayr, Johannes Nepp, Werner Lubitz & Talin Barisani-Asenbauer. (2011) Bacterial Ghosts as antigen and drug delivery system for ocular surface diseases: Effective internalization of Bacterial Ghosts by human conjunctival epithelial cells. Journal of Biotechnology 153:3-4, pages 167-175.
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