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Cancer Biology & Therapy Volume 7, 2008 - Issue 10
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Special Article

Prevention of cancer by inhibiting aging

Mikhail V Blagosklonny
Pages 1520-1524 | Published online: 01 Oct 2008

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Vladimir N Anisimov, Irina G Popovich, Mark A Zabezhinski, Peter A Egormin, Maria N Yurova, Anna V Semenchenko, Margarita L Tyndyk, Andrey V Panchenko, Alexandr P Trashkov, Andrey G Vasiliev & Nikolai V Khaitsev. (2015) Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin. Cell Cycle 14:1, pages 46-55.
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Irina G Popovich, Vladimir N Anisimov, Mark A Zabezhinski, Anna V Semenchenko, Margarita L Tyndyk, Maria N Yurova & Mikhail V Blagosklonny. (2014) Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin. Cancer Biology & Therapy 15:5, pages 586-592.
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Olga V. Leontieva & Mikhail V Blagosklonny. (2014) M(o)TOR of pseudo-hypoxic state in aging: Rapamycin to the rescue. Cell Cycle 13:4, pages 509-515.
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Mikhail V Blagosklonny. (2013) Immunosuppressants in cancer prevention and therapy. OncoImmunology 2:12.
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Mikhail V Blagosklonny. (2013) Selective anti-cancer agents as anti-aging drugs. Cancer Biology & Therapy 14:12, pages 1092-1097.
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Olga V Leontieva, Liliya R Novototskaya, Geraldine M Paszkiewicz, Elena A Komarova, Andrei V Gudkov & Mikhail V Blagosklonny. (2013) Dysregulation of the mTOR pathway in p53-deficient mice. Cancer Biology & Therapy 14:12, pages 1182-1188.
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Mikhail V. Blagosklonny. (2012) Rapalogs in cancer prevention. Cancer Biology & Therapy 13:14, pages 1349-1354.
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Alejandro Vazquez-Martin, Tamara Sauri-Nadal, Octavio J. Menendez, Cristina Oliveras-Ferraros, Sílvia Cufí, Bruna Corominas-Faja, Eugeni López-Bonet & Javier A. Menendez. (2012) Ser2481-autophosphorylated mTOR colocalizes with chromosomal passenger proteins during mammalian cell cytokinesis. Cell Cycle 11:22, pages 4211-4221.
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Claudia Capparelli, Barbara Chiavarina, Diana Whitaker-Menezes, Timothy G. Pestell, Richard G. Pestell, James Hulit, Sebastiano Andò, Anthony Howell, Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle 11:19, pages 3599-3610.
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Aninda Basu, Pallavi Banerjee & Soumitro Pal. (2012) Critical role of mTOR in calcineurin inhibitor-induced renal cancer progression. Cell Cycle 11:4, pages 633-634.
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Adam Ertel, Aristotelis Tsirigos, Diana Whitaker-Menezes, Ruth Birbe, Stephanos Pavlides, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Anthony Howell, Federica Sotgia & Michael P. Lisanti. (2012) Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism. Cell Cycle 11:2, pages 253-263.
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Articles from other publishers (76)

Mikhail V. Blagosklonny. (2023) Cancer prevention with rapamycin. Oncotarget 14:1, pages 342-350.
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Negar Moradian & Nima Rezaei. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 24 .
Bikash Chandra Jena, Lipsa Rout, Ankita Dey & Mahitosh Mandal. (2021) Active autophagy in cancer‐associated fibroblasts: Recent advances in understanding the novel mechanism of tumor progression and therapeutic response. Journal of Cellular Physiology 236:11, pages 7887-7902.
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Mikhail V. Blagosklonny. (2021) The goal of geroscience is life extension. Oncotarget 12:3, pages 131-144.
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Alex Zhavoronkov. (2020) Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections. Aging 12:8, pages 6492-6510.
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Mikhail V. Blagosklonny. (2019) Rapamycin for longevity: opinion article. Aging 11:19, pages 8048-8067.
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V. A. Kobliakov. (2019) The Mechanisms of Regulation of Aerobic Glycolysis (Warburg Effect) by Oncoproteins in Carcinogenesis. Biochemistry (Moscow) 84:10, pages 1117-1128.
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I-Ping Yang, Zhi-Feng Miao, Ching-Wen Huang, Hsiang-Lin Tsai, Yung-Sung Yeh, Wei-Chih Su, Tsung-Kun Chang, Se-fen Chang & Jaw-Yuan Wang. (2019) High blood sugar levels but not diabetes mellitus significantly enhance oxaliplatin chemoresistance in patients with stage III colorectal cancer receiving adjuvant FOLFOX6 chemotherapy. Therapeutic Advances in Medical Oncology 11, pages 175883591986696.
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Aleksey V. Belikov. (2019) Age-related diseases as vicious cycles. Ageing Research Reviews 49, pages 11-26.
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Bor-Sen Chen. 2019. Computational Epigenetics and Diseases. Computational Epigenetics and Diseases 265 288 .
Mikhail V. Blagosklonny. (2018) Paradoxes of senolytics. Aging 10:12, pages 4289-4293.
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Mikhail V. Blagosklonny. (2018) Disease or not, aging is easily treatable. Aging 10:11, pages 3067-3078.
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Olga V. Leontieva & Mikhail V. Blagosklonny. (2017) While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts. Oncotarget 8:65, pages 109848-109856.
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Su-Ying Wen, Jia-Yi Chen, Yueh-Shan Weng, Ritu Aneja, Chih-Jung Chen, Chih-Yang Huang & Wei-Wen Kuo. (2017) Galangin suppresses H 2 O 2 -induced aging in human dermal fibroblasts . Environmental Toxicology 32:12, pages 2419-2427.
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Alexander Aliper, Leslie Jellen, Franco Cortese, Artem Artemov, Darla Karpinsky-Semper, Alexey Moskalev, Andrew G. Swick & Alex Zhavoronkov. (2017) Towards natural mimetics of metformin and rapamycin. Aging 9:11, pages 2245-2268.
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Mikhail V. Blagosklonny. (2017) From rapalogs to anti-aging formula. Oncotarget 8:22, pages 35492-35507.
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Erika Cadoni, Fabio Marongiu, Maura Fanti, Monica Serra & Ezio Laconi. (2017) Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment. Oncotarget 8:22, pages 36020-36032.
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Hsiao‐Chen Tu, Yung‐Chun Hsiao, Wan‐Yu Yang, Shin‐Lin Tsai, Hua‐Kuo Lin, Chong‐Yi Liao, Jeng‐Wei Lu, Yu‐Ting Chou, Horng‐Dar Wang & Chiou‐Hwa Yuh. (2017) Up‐regulation of golgi α‐mannosidase IA and down‐regulation of golgi α‐mannosidase IC activates unfolded protein response during hepatocarcinogenesis. Hepatology Communications 1:3, pages 230-247.
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María Rico, María Baglioni, Maryna Bondarenko, Nahuel Cesatti Laluce, Viviana Rozados, Nicolas André, Manon Carré, O. Graciela Scharovsky & Mauricio Menacho Márquez. (2016) Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models. Oncotarget 8:2, pages 2874-2889.
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Bor-Sen Chen & Cheng-Wei Li. 2017. Big Mechanisms in Systems Biology. Big Mechanisms in Systems Biology 431 526 .
Hanan Assaf, Mohamed A. Adly & Mahmoud R. Hussein. 2017. Textbook of Aging Skin. Textbook of Aging Skin 783 794 .
Fabio Marongiu, Maria Paola Serra, Silvia Doratiotto, Marcella Sini, Maura Fanti, Erika Cadoni, Monica Serra & Ezio Laconi. (2016) Aging promotes neoplastic disease through effects on the tissue microenvironment. Aging 8:12, pages 3390-3399.
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Gang Wang, Rui Cao, Yongzhi Wang, Guofeng Qian, Han C. Dan, Wei Jiang, Lingao Ju, Min Wu, Yu Xiao & Xinghuan Wang. (2016) Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway. Scientific Reports 6:1.
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I-Ping Yang, Hsiang-Lin Tsai, Ching-Wen Huang, Chien-Yu Lu, Zhi-Feng Miao, Se-Fen Chang, Suh-Hang Hank Juo & Jaw-Yuan Wang. (2016) High blood sugar levels significantly impact the prognosis of colorectal cancer patients through down-regulation of microRNA-16 by targeting Myb and VEGFR2 . Oncotarget 7:14, pages 18837-18850.
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Fei Wu, Sentai Ding, Xin Li, Hui Wang, Shuai Liu, Haihu Wu, Dongbin Bi, Kejia Ding & Jiaju Lu. (2016) Elevated expression of HIF-lα in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia. Oncotarget 7:11, pages 12053-12062.
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Cheng-Wei Li & Bor-Sen Chen. (2016) Network Biomarkers of Bladder Cancer Based on a Genome-Wide Genetic and Epigenetic Network Derived from Next-Generation Sequencing Data. Disease Markers 2016, pages 1-18.
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Noriko N. Yokoyama, Andria P. Denmon, Edward M. Uchio, Mark Jordan, Dan Mercola & Xiaolin Zi. (2015) When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?. Current Pharmacology Reports 1:6, pages 420-433.
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Alexey Moskalev, Elizaveta Chernyagina, João Pedro de Magalhães, Diogo Barardo, Harikrishnan Thoppil, Mikhail Shaposhnikov, Arie Budovsky, Vadim E. Fraifeld, Andrew Garazha, Vasily Tsvetkov, Evgeny Bronovitsky, Vladislav Bogomolov, Alexei Scerbacov, Oleg Kuryan, Roman Gurinovich, Leslie C. Jellen, Brian Kennedy, Polina Mamoshina, Evgeniya Dobrovolskaya, Alex Aliper, Dmitry Kaminsky & Alex Zhavoronkov. (2015) Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging 7:9, pages 616-628.
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Benling Xu, Long Yuan, Quanli Gao, Peng Yuan, Peng Zhao, Huijuan Yuan, Huijie Fan, Tiepeng Li, Peng Qin, Lu Han, Weijia Fang & Zhenhe Suo. (2015) Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer. Oncotarget 6:24, pages 20592-20603.
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Mikhail V. Blagosklonny. (2015) Rejuvenating immunity: “anti-aging drug today” eight years later. Oncotarget 6:23, pages 19405-19412.
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Lina Ma, Wen Dong, Rong Wang, Yun Li, Baolei Xu, Jingshuang Zhang, Zhiwei Zhao & Yulan Wang. (2015) Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice. Brain Research Bulletin 116, pages 67-72.
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Ekaterina A. Lesovaya, Kirill I. Kirsanov, Elena E. Antoshina, Lubov S. Trukhanova, Tatiana G. Gorkova, Elena V. Shipaeva, Ramiz M. Salimov, Gennady A. Belitsky, Mikhail V. Blagosklonny, Marianna G. Yakubovskaya & Olga B. Chernova. (2015) Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats. Oncotarget 6:12, pages 9718-9727.
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Curtis J. Henry, Andrii I. Rozhok & James DeGregori. 2015. Stem Cell Aging: Mechanisms, Consequences, Rejuvenation. Stem Cell Aging: Mechanisms, Consequences, Rejuvenation 259 286 .
Hanan Assaf, Mohamed A. Adly & Mahmoud R. Hussein. 2016. Textbook of Aging Skin. Textbook of Aging Skin 1 12 .
Alexey A. Moskalev, Ekaterina N. Proshkina & Mikhail V. Shaposhnikov. 2015. Life Extension. Life Extension 39 65 .
Evgeny Makarev, Charles Cantor, Alex Zhavoronkov, Anton Buzdin, Alexander Aliper & Antonei Benjamin Csoka. (2014) Pathway activation profiling reveals new insights into Age-related Macular Degeneration and provides avenues for therapeutic interventions. Aging 6:12, pages 1064-1075.
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Eftychia Oikonomou, Evangelos Koustas, Maria Goulielmaki & Alexander Pintzas. (2014) BRAF vs RAS oncogenes: are mutations of the same pathway equal? differential signalling and therapeutic implications. Oncotarget 5:23, pages 11752-11777.
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M V Blagosklonny. (2014) Koschei the immortal and anti-aging drugs. Cell Death & Disease 5:12, pages e1552-e1552.
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Bruna Corominas-Faja, Elvira Santangelo, Elisabet Cuyàs, Vicente Micol, Jorge Joven, Xavier Ariza, Antonio Segura-Carretero, Jordi García & Javier A. Menendez. (2014) Computer-aided discovery of biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins. Aging 6:9, pages 731-741.
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Anna Zagryazhskaya & Boris Zhivotovsky. (2014) miRNAs in lung cancer: A link to aging. Ageing Research Reviews 17, pages 54-67.
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Mingyi Wang & Deepak A. Deshpande. 2014. Molecular Aspects of Aging. Molecular Aspects of Aging 117 129 .
Mary C. White, Dawn M. Holman, Jennifer E. Boehm, Lucy A. Peipins, Melissa Grossman & S. Jane Henley. (2014) Age and Cancer Risk. American Journal of Preventive Medicine 46:3, pages S7-S15.
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Javier A. Menendez & Jorge Joven. 2014. Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics. Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics 117 140 .
Mikhail V. Blagosklonny. (2013) Rapamycin extends life- and health span because it slows aging. Aging 5:8, pages 592-598.
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Hannelore Maes, Noemí Rubio, Abhishek D. Garg & Patrizia Agostinis. (2013) Autophagy: shaping the tumor microenvironment and therapeutic response. Trends in Molecular Medicine 19:7, pages 428-446.
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E. Yu. Kochetkova, T. V. Bykova, S. G. Zubova & T. V. Pospelova. (2013) Involvement of MAP-kinase cascades in regulation of sodium-butyrate-induced premature senescence. Cell and Tissue Biology 7:2, pages 126-135.
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Carolina B. Livi, Rulon L. Hardman, Barbara A. Christy, Sherry G. Dodds, Diane Jones, Charnae Williams, Randy Strong, Alex Bokov, Martin A. Javors, Yuji Ikeno, Gene Hubbard, Paul Hasty & Zelton Dave Sharp. (2013) Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors. Aging 5:2, pages 100-110.
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Mikhail V. Blagosklonny. (2012) Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions. Oncotarget 3:12, pages 1711-1724.
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Elena A. Komarova, Marina P. Antoch, Liliya R. Novototskaya, Olga B. Chernova, Geraldine Paszkiewicz, Olga V. Leontieva, Mikhail V. Blagosklonny & Andrei V. Gudkov. (2012) Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice. Aging 4:10, pages 709-714.
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Mikhail V. Blagosklonny. (2012) Prospective Treatment of Age-Related Diseases by Slowing Down Aging. The American Journal of Pathology 181:4, pages 1142-1146.
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Mikhail V. Blagosklonny. (2012) How to save Medicare: the anti-aging remedy. Aging 4:8, pages 547-552.
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Nataliya G. Kolosova, Natalia A. Muraleva, Anna A. Zhdankina, Natalia A. Stefanova, Anzhela Z. Fursova & Mikhail V. Blagosklonny. (2012) Prevention of Age-Related Macular Degeneration–Like Retinopathy by Rapamycin in Rats. The American Journal of Pathology 181:2, pages 472-477.
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Mikhail V. Blagosklonny. (2012) Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?. Aging 4:7, pages 450-455.
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Isabelle Mercier, Jeanette Camacho, Kanani Titchen, Donna M. Gonzales, Kevin Quann, Kelly G. Bryant, Alexander Molchansky, Janet N. Milliman, Diana Whitaker-Menezes, Federica Sotgia, Jean-François Jasmin, Roland Schwarting, Richard G. Pestell, Mikhail V. Blagosklonny & Michael P. Lisanti. (2012) Caveolin-1 and Accelerated Host Aging in the Breast Tumor Microenvironment. The American Journal of Pathology 181:1, pages 278-293.
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Mikhail V. Blagosklonny. (2012) Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells. Oncotarget 3:6, pages 601-607.
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Alexey A. Moskalev, Zeljka Smit-McBride, Mikhail V. Shaposhnikov, Ekaterina N. Plyusnina, Alex Zhavoronkov, Arie Budovsky, Robi Tacutu & Vadim E. Fraifeld. (2012) Gadd45 proteins: Relevance to aging, longevity and age-related pathologies. Ageing Research Reviews 11:1, pages 51-66.
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Xiaolin Zi & Christopher Blair. 2012. Nutraceuticals and Cancer. Nutraceuticals and Cancer 151 169 .
Mikhail V. Blagosklonny. (2011) NCI's provocative questions on cancer: some answers to ignite discussion. Oncotarget 2:12, pages 1352-1367.
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Mikhail V. Blagosklonny. (2011) Molecular damage in cancer: an argument for mTOR-driven aging. Aging 3:12, pages 1130-1141.
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Mikhail V. Blagosklonny. (2011) Hormesis does not make sense except in the light of TOR-driven aging. Aging 3:11, pages 1051-1062.
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Mikhail V. Blagosklonny. (2011) Progeria, rapamycin and normal aging: recent breakthrough. Aging 3:7, pages 685-691.
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Hsin-Yi Chen & Eileen White. (2011) Role of Autophagy in Cancer Prevention. Cancer Prevention Research 4:7, pages 973-983.
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Curtis J. Henry, Andriy Marusyk & James DeGregori. (2011) Aging-Associated Changes in Hematopoiesis and Leukemogenesis: What's the Connection?. Aging 3:6, pages 643-656.
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Javier A. MenendezSílvia CufíCristina Oliveras-FerrarosLuciano VellonJorge JovenAlejandro Vazquez-Martin. (2011) Gerosuppressant Metformin: less is more. Aging 3:4, pages 348-362.
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Arie Budovsky, Vadim E. Fraifeld & Stella Aronov. (2010) Linking cell polarity, aging and rejuvenation. Biogerontology 12:2, pages 167-175.
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Mikhail V. Blagosklonny. (2011) Cell cycle arrest is not senescence. Aging 3:2, pages 94-101.
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Vladimir N. Anisimov, Tatiana S. Piskunova, Irina G. Popovich, Mark A. Zabezhinski, Margarita L. Tyndyk, Peter A. Egormin, Maria N. Yurova, Svetlana V. Rosenfeld, Anna V. Semenchenko, Irina G. Kovalenko, Tatiana E. Poroshina & Lev M. Berstein. (2010) Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice. Aging 2:12, pages 945-958.
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Vladimir N. Anisimov. (2010) Metformin for aging and cancer prevention. Aging 2:11, pages 760-774.
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Lev M Berstein. (2010) Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond. Future Oncology 6:8, pages 1313-1323.
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M. V. Blagosklonny. (2010) Solving puzzles of aging: From disposable soma to signal-transduction pathways. Russian Journal of General Chemistry 80:7, pages 1407-1414.
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Vladimir N. Anisimov, Mark A. Zabezhinski, Irina G. Popovich, Tatiana S. Piskunova, Anna V. Semenchenko, Margarita L. Tyndyk, Maria N. Yurova, Marina P. Antoch & Mikhail V. Blagosklonny. (2010) Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice. The American Journal of Pathology 176:5, pages 2092-2097.
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Mikhail V. Blagosklonny. (2010) Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis. Aging 2:4, pages 177-182.
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Hanan Assaf, Mohamed A. Adly & Mahmoud R. Hussein. 2010. Textbook of Aging Skin. Textbook of Aging Skin 129 138 .
Zoya N. Demidenko & Mikhail V. Blagosklonny. (2009) Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging 1:12, pages 1008-1016.
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Mikhail V. Blagosklonny. (2009) Inhibition of S6K by resveratrol: In search of the purpose. Aging 1:6, pages 511-514.
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Mikhail V. Blagosklonny, Judith Campisi & David A. Sinclair. (2009) Aging: past, present and future. Aging 1:1, pages 1-5.
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