Advanced search
Publication Cover
Cancer Biology & Therapy Volume 7, 2008 - Issue 4
Submit an article Journal homepage
496
Views
33
CrossRef citations to date
0
Altmetric
Clinical Study

Heterophilic NeuGcGM3 ganglioside cancer vaccine in advanced melanoma patients: Results of a phase Ib/IIa study

Marta Osorio
,
Elías Gracia
,
Edmundo Rodríguez
,
Giselle Saurez
,
Maria del Carmen Arango
,
Elena Noris
,
Adriana Torriella
,
Alejandro Joan
,
Erasmo Gómez
,
Lorenzo Anasagasti
,
Jorge Luis González
,
María de los Angeles Melgares
,
Imilla Torres
,
Joel González
,
Dayamí Alonso
,
Enrique Rengifo
,
Adriana Carr
,
Rolando Pérez
,
Rolando Pérez
&
Luis Enrique Fernández
 show all
Pages 488-495 | Published online: 01 May 2008

Citations (33)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Myron Christodoulides, Maria Victoria Humbert & John E Heckels. (2021) The potential utility of liposomes for Neisseria vaccines. Expert Review of Vaccines 20:10, pages 1235-1256.
Read now
Mayrel Labrada, Isabel Pablos, Francesca Prete, Giselle Hevia, Marilyn Clavell, Federica Benvenuti & Luis E Fernández. (2014) Induction of leukocyte infiltration at metastatic site mediates the protective effect of NGcGM3-based vaccine. Human Vaccines & Immunotherapeutics 10:8, pages 2312-2320.
Read now
Kirenia Pérez, Marta Osorio, Julio Hernández, Adriana Carr & Luis Enrique Fernández. (2013) NGcGM3/VSSP vaccine as treatment for melanoma patients. Human Vaccines & Immunotherapeutics 9:6, pages 1237-1240.
Read now
Marta Osorio, Elias Gracia, Edmundo Reigosa, Julio Hernandez, Ana de la Torre, Giselle Saurez, Kirenia Perez, Carmen Viada, Meylán Cepeda, Adriana Carr, Yisel Ávila, Migdalia Rodríguez & Luis E Fernandez. (2012) Effect of vaccination with N-glycolyl GM3/VSSP vaccine by subcutaneous injection in patients with advanced cutaneous melanoma. Cancer Management and Research 4, pages 341-345.
Read now
Zhaojun Yin & Xuefei Huang. (2012) Recent Development in Carbohydrate Based Anticancer Vaccines. Journal of Carbohydrate Chemistry 31:3, pages 143-186.
Read now

Articles from other publishers (28)

Lucy K. Shewell, Christopher J. Day, Tiana Hippolite, Xavier De Bisscop, James C. Paton, Adrienne W. Paton & Michael P. Jennings. (2023) Serum Neu5Gc biomarkers are elevated in primary cutaneous melanoma. Biochemical and Biophysical Research Communications 642, pages 162-166.
Crossref
Elisabetta Cribioli, Greta Maria Paola Giordano Attianese, George Coukos & Melita Irving. (2022) CAR T cells targeting the ganglioside NGcGM3 control ovarian tumors in the absence of toxicity against healthy tissues. Frontiers in Immunology 13.
Crossref
Juntao Wang, Dan Lu, Ran Sun, Shuwen Lei, Shuhua Luo, Xin Dang, Yang Zhang, Chang Yuan, Yong Zhang, Jinhong Wu, Guangyu Yang, Lei Fu & Faqin Jiang. (2022) One-Pot Enzymatic Synthesis and Biological Evaluation of Ganglioside GM3 Derivatives as Potential Cancer Immunotherapeutics. Journal of Medicinal Chemistry 65:3, pages 1883-1897.
Crossref
Do-Hyeon Kim, Hong Minh Triet & Sung Ho Ryu. (2021) Regulation of EGFR activation and signaling by lipids on the plasma membrane. Progress in Lipid Research 83, pages 101115.
Crossref
Shyamasree Ghosh. 2020. Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease. Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease 211 245 .
Changping Zheng, Marco Terreni, Matthieu Sollogoub & Yongmin Zhang. (2019) Ganglioside GM3 and Its Role in Cancer. Current Medicinal Chemistry 26:16, pages 2933-2947.
Crossref
Addys González Palomo, Armando López Medinilla, Valeria Segatori, María del Carmen Barroso, Rances Blanco, Mariano R. Gabri, Adriana Carr Pérez & Kalet León Monzón. (2018) Synergistic potentiation of the anti-metastatic effect of anti EGFR mAb by its combination with immunotherapies targeting the ganglioside NGcGM3. Oncotarget 9:35, pages 24069-24080.
Crossref
Mayrel Labrada, Denise Dorvignit, Giselle Hevia, Nely Rodríguez-Zhurbenko, Ana M. Hernández, Ana M. Vázquez & Luis E. Fernández. (2018) GM3(Neu5Gc) ganglioside: an evolution fixed neoantigen for cancer immunotherapy. Seminars in Oncology 45:1-2, pages 41-51.
Crossref
Anet Valdes-Zayas, Zuyen Gonzalez, Vladimir Mulens, Aliz M. Vega, Kirenia Perez, Patricia Lorenzo-Luaces, Maria C. Rubio, Anabely Estevez, Idelmis Curbelo, Luis E. Fernandez, Tania Crombet & Zaima Mazorra. (2017) Immunologic Response Elicited in Breast Cancer Patients Receiving a NeuGcGM3-based Vaccine as Adjuvant Therapy. Journal of Immunotherapy 40:8, pages 289-301.
Crossref
Jacob Pitcovski, Ehud Shahar, Elina Aizenshtein & Raphael Gorodetsky. (2017) Melanoma antigens and related immunological markers. Critical Reviews in Oncology/Hematology 115, pages 36-49.
Crossref
Addys González Palomo, Rancés Blanco Santana, Xiomara Escobar Pérez, Damián Blanco Santana, Mariano Rolando Gabri, Kalet León Monzon & Adriana Carr Pérez. (2016) Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications. Clinical & Experimental Metastasis 33:7, pages 717-725.
Crossref
Danyang Feng, Abdul Sami Shaikh & Fengshan Wang. (2016) Recent Advance in Tumor-associated Carbohydrate Antigens (TACAs)-based Antitumor Vaccines. ACS Chemical Biology 11:4, pages 850-863.
Crossref
Hansje-Eva TeulingsJacqueline LimpensSophia N. JansenAeilko H. ZwindermanJohannes B. ReitsmaPhyllis I. SpulsRosalie M. Luiten. (2015) Vitiligo-Like Depigmentation in Patients With Stage III-IV Melanoma Receiving Immunotherapy and Its Association With Survival: A Systematic Review and Meta-Analysis. Journal of Clinical Oncology 33:7, pages 773-781.
Crossref
Cristina Tringali, Ilaria Silvestri, Francesca Testa, Paola Baldassari, Luigi Anastasia, Roberta Mortarini, Andrea Anichini, Alejandro López-Requena, Guido Tettamanti & Bruno Venerando. (2014) Molecular subtyping of metastatic melanoma based on cell ganglioside metabolism profiles. BMC Cancer 14:1.
Crossref
Osama E. Rahma, Emily Gammoh, Richard M. Simon & Samir N. Khleif. (2014) Is the “3+3” Dose-Escalation Phase I Clinical Trial Design Suitable for Therapeutic Cancer Vaccine Development? A Recommendation for Alternative Design. Clinical Cancer Research 20:18, pages 4758-4767.
Crossref
O. V. Kozyreva, E. M. Novikova, E. A. Khatuntseva, Yu. E. Tsvetkov, N. E. Nifantiev & R. N. Stepanenko. (2015) Antitumor effect of the conjugate of synthetic carbohydrate moiety of the tumor-associated ganglioside GM3 with hemocyanin in combination with the cytostatic cyclophosphamide. Russian Chemical Bulletin 63:6, pages 1431-1437.
Crossref
Rancés Blanco, Damián Blanco, Yisel Quintana, Xiomara Escobar, Charles E. Rengifo, Marta Osorio, Zailí Gutiérrez, Janet Lamadrid, Mercedes Cedeño, Milagros Frómeta, Adriana Carr & Enrique Rengifo. (2013) Immunoreactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Primary Lymphoid Tumors and Lymph Node Metastasis. Pathology Research International 2013, pages 1-12.
Crossref
Ana Victoria Casadesús, Yuniel Fernández-Marrero, Marilyn Clavell, José Alberto Gómez, Tays Hernández, Ernesto Moreno & Alejandro López-Requena. (2013) A shift from N-glycolyl- to N-acetyl-sialic acid in the GM3 ganglioside impairs tumor development in mouse lymphocytic leukemia cells. Glycoconjugate Journal 30:7, pages 687-699.
Crossref
Y Zhong, Y Wu, C Li, J Tang, X Wang, G Ren, A Carr, R Pérez & W Guo. (2012) N ‐Glycolyl GM3 ganglioside immunoexpression in oral mucosal melanomas of Chinese . Oral Diseases 18:8, pages 741-747.
Crossref
L G Durrant, P Noble & I Spendlove. (2012) Immunology in the clinic review series; focus on cancer: glycolipids as targets for tumour immunotherapy. Clinical and Experimental Immunology 167:2, pages 206-215.
Crossref
Rancés Blanco, Enrique Rengifo, Mercedes Cedeño, Charles E. Rengifo, Daniel F. Alonso & Adriana Carr. (2011) Immunoreactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Epithelial Malignant Tumors from Digestive System. ISRN Gastroenterology 2011, pages 1-8.
Crossref
Jamie Heimburg-Molinaro, Michelle Lum, Geraldine Vijay, Miten Jain, Adel Almogren & Kate Rittenhouse-Olson. (2011) Cancer vaccines and carbohydrate epitopes. Vaccine 29:48, pages 8802-8826.
Crossref
Rancés Blanco, Enrique Rengifo, Charles E. Rengifo, Mercedes Cedeño, Milagros Frómeta & Adriana Carr. (2011) Immunohistochemical Reactivity of the 14F7 Monoclonal Antibody Raised against N-Glycolyl GM3 Ganglioside in Some Benign and Malignant Skin Neoplasms. ISRN Dermatology 2011, pages 1-8.
Crossref
Pedro C Rodriguez, Elia Neninger, Beatriz García, Xitlally Popa, Carmen Viada, Patricia Luaces, Gisela González, Agustin Lage, Enrique Montero & Tania Crombet. (2011) Safety, immunogenicity and preliminary efficacy of multiple-site vaccination with an Epidermal Growth Factor (EGF) based cancer vaccine in advanced non small cell lung cancer (NSCLC) patients. Journal of Immune Based Therapies and Vaccines 9:1, pages 7.
Crossref
Christopher A. Klebanoff, Nicolas Acquavella, Zhiya Yu & Nicholas P. Restifo. (2011) Therapeutic cancer vaccines: are we there yet?. Immunological Reviews 239:1, pages 27-44.
Crossref
Luis E. Fernandez, Mariano R. Gabri, Marcelo D. Guthmann, Roberto E. Gomez, Silvia Gold, Leonardo Fainboim, Daniel E. Gomez & Daniel F. Alonso. (2010) NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines. Clinical and Developmental Immunology 2010, pages 1-8.
Crossref
Anastas Pashov, Bejatolah Monzavi-Karbassi, Gajendra P. S. Raghava & Thomas Kieber-Emmons. (2010) Bridging Innate and Adaptive Antitumor Immunity Targeting Glycans. Journal of Biomedicine and Biotechnology 2010, pages 1-19.
Crossref
J. Michael Pierce. 2010. Handbook of Glycomics. Handbook of Glycomics 397 429 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.