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Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis

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Pages 251-262 | Published online: 15 Jan 2012

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J. Jacob Wamsley, Natalia Issaeva, Hanbing An, Xinyuan Lu, Lawrence A. Donehower & Wendell G. Yarbrough. (2017) LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro. Cell Cycle 16:2, pages 213-223.
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Jan Brazina, Jan Svadlenka, Libor Macurek, Ladislav Andera, Zdenek Hodny, Jiri Bartek & Hana Hanzlikova. (2015) DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase. Cell Cycle 14:3, pages 375-387.
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Jan Benada, Kamila Burdová, Tomáš Lidak, Patrick von Morgen & Libor Macurek. (2015) Polo-like kinase 1 inhibits DNA damage response during mitosis. Cell Cycle 14:2, pages 219-231.
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Articles from other publishers (32)

Yingchu Dai, Yongduo Yu, Jing Nie, Ke Gu & Hailong Pei. (2023) X-ray-downregulated nucleophosmin induces abnormal polarization by anchoring to G-actin. Life Sciences in Space Research.
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Hartwig Visser & Adam D. Thomas. (2021) MicroRNAs and the DNA damage response: How is cell fate determined?. DNA Repair 108, pages 103245.
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Caroline Molinaro, Alain Martoriati & Katia Cailliau. (2021) Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies. Cancers 13:15, pages 3819.
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Cecilia Aquino Perez, Monika Burocziova, Gabriela Jenikova & Libor Macurek. (2021) CK1‐mediated phosphorylation of FAM110A promotes its interaction with mitotic spindle and controls chromosomal alignment. EMBO reports 22:7.
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Maria Chiara Fontana, Jacopo Nanni, Andrea Ghelli Luserna di Rorà, Elisabetta Petracci, Antonella Padella, Martina Ghetti, Anna Ferrari, Giovanni Marconi, Simona Soverini, Ilaria Iacobucci, Cristina Papayannidis, Antonio Curti, Ernesta Audisio, Maria Benedetta Giannini, Michela Rondoni, Francesco Lanza, Michele Cavo, Giovanni Martinelli & Giorgia Simonetti. (2021) Pharmacological Inhibition of WIP1 Sensitizes Acute Myeloid Leukemia Cells to the MDM2 Inhibitor Nutlin-3a. Biomedicines 9:4, pages 388.
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Xianghua Zhang, Ji Eun Park, Eun Ho Kim, Jihee Hong, Ki-Tae Hwang, Young A. Kim & Chang-Young Jang. (2020) Wip1 controls the translocation of the chromosomal passenger complex to the central spindle for faithful mitotic exit. Cellular and Molecular Life Sciences 78:6, pages 2821-2838.
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Simon Husby, Emma Hjermind Justesen & Kirsten Grønbæk. (2020) Protein phosphatase, Mg 2+ /Mn 2+ ‐dependent 1D (PPM1D) mutations in haematological cancer . British Journal of Haematology 192:4, pages 697-705.
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Rita Nahta & Robert Craig Castellino. (2021) Phosphatase magnesium-dependent 1 δ (PPM1D), serine/threonine protein phosphatase and novel pharmacological target in cancer. Biochemical Pharmacology 184, pages 114362.
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Gururaj Rao Kidiyoor, Qingsen Li, Giulia Bastianello, Christopher Bruhn, Irene Giovannetti, Adhil Mohamood, Galina V. Beznoussenko, Alexandre Mironov, Matthew Raab, Matthieu Piel, Umberto Restuccia, Vittoria Matafora, Angela Bachi, Sara Barozzi, Dario Parazzoli, Emanuela Frittoli, Andrea Palamidessi, Tito Panciera, Stefano Piccolo, Giorgio Scita, Paolo Maiuri, Kristina M. Havas, Zhong-Wei Zhou, Amit Kumar, Jiri Bartek, Zhao-Qi Wang & Marco Foiani. (2020) ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration. Nature Communications 11:1.
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Jin Osawa, Kazutoshi Akizuki, Akari Kashimura, Saki Ueta, Misato Nakatani, Yuiko Inui, Yasushi Shigeri, Atsuhiko Ishida, Isamu Kameshita & Noriyuki Sueyoshi. (2020) Dual phosphorylation of protein phosphatase PPM1H promotes dephosphorylation of Smad1 in cellulo. Biochemical and Biophysical Research Communications 530:3, pages 513-519.
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Kamila Burdova, Radka Storchova, Matous Palek & Libor Macurek. (2019) WIP1 Promotes Homologous Recombination and Modulates Sensitivity to PARP Inhibitors. Cells 8:10, pages 1258.
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Lenno Krenning, Jeroen van den Berg & René H. Medema. (2019) Life or Death after a Break: What Determines the Choice?. Molecular Cell 76:2, pages 346-358.
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Borahm Kim, Dongju Won, Seung-Tae Lee & Jong Rak Choi. (2019) Somatic mosaic truncating mutations of PPM1D in blood can result from expansion of a mutant clone under selective pressure of chemotherapy. PLOS ONE 14:6, pages e0217521.
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K. Schwarzerová, E. Bellinvia, J. Martinek, L. Sikorová, V. Dostál, L. Libusová, P. Bokvaj, L. Fischer, A. C. Schmit & P. Nick. (2019) Tubulin is actively exported from the nucleus through the Exportin1/CRM1 pathway. Scientific Reports 9:1.
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Jiyeon Leem, Jae-Sung Kim & Jeong Su Oh. (2018) WIP1 phosphatase suppresses the DNA damage response during G2/prophase arrest in mouse oocytes†. Biology of Reproduction 99:4, pages 798-805.
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Lei Xue, Zhijun Wu, Jinyuan Liu & Jinhua Luo. (2018) FPHPB inhibits gastric tumor cell proliferation by inducing G2-M cell cycle arrest. Biomedicine & Pharmacotherapy 98, pages 694-700.
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Anne Fernandez-Vidal, Julien Vignard & Gladys Mirey. (2017) Around and beyond 53BP1 Nuclear Bodies. International Journal of Molecular Sciences 18:12, pages 2611.
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Erik Müllers, Helena Silva Cascales, Kamila Burdova, Libor Macurek & Arne Lindqvist. (2017) Residual Cdk1/2 activity after DNA damage promotes senescence. Aging Cell 16:3, pages 575-584.
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Soňa Pecháčková, Kamila Burdová & Libor Macurek. (2017) WIP1 phosphatase as pharmacological target in cancer therapy. Journal of Molecular Medicine 95:6, pages 589-599.
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Katarzyna Jonak, Monika Kurpas, Katarzyna Szoltysek, Patryk Janus, Agata Abramowicz & Krzysztof Puszynski. (2016) A novel mathematical model of ATM/p53/NF- κB pathways points to the importance of the DDR switch-off mechanisms. BMC Systems Biology 10:1.
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Yuuki Kozakai, Rui Kamada, Junya Furuta, Yuhei Kiyota, Yoshiro Chuman & Kazuyasu Sakaguchi. (2016) PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin. Scientific Reports 6:1.
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Stefano Ferrari & Christian Gentili. (2016) Maintaining Genome Stability in Defiance of Mitotic DNA Damage. Frontiers in Genetics 7.
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Sona Pechackova, Kamila Burdova, Jan Benada, Petra Kleiblova, Gabriela Jenikova & Libor Macurek. (2016) Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3. Oncotarget 7:12, pages 14458-14475.
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Ahmed Y. Ali, Ji‐Young Kim, Jean‐François Pelletier, Barbara C. Vanderhyden, Dimcho R. Bachvarov & Benjamin K. Tsang. (2014) Akt confers cisplatin chemoresistance in human gynecological carcinoma cells by modulating PPM1D stability. Molecular Carcinogenesis 54:11, pages 1301-1314.
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Ho-Chang Jeong, Na-Yeon Gil, Ho-Soo Lee, Seung-Ju Cho, Kyungtae Kim, Kwang-Hoon Chun, Hyeseong Cho & Hyuk-Jin Cha. (2015) Timely Degradation of Wip1 Phosphatase by APC/C Activator Protein Cdh1 is Necessary for Normal Mitotic Progression. Journal of Cellular Biochemistry 116:8, pages 1602-1612.
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Xia Ma, Jingling Han, Qiyun Wu, Hanzhang Liu, Shangshi Shi, Cheng Wang, Yueran Wang, Jing Xiao, Jianya Zhao, Junkang Jiang & Chunhua Wan. (2015) Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis. Toxicology Letters 235:1, pages 17-27.
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C.S. Ruan, F.H. Zhou, Z.Y. He, S.F. Wang, C.R. Yang, Y.J. Shen, Y. Guo, H.B. Zhao, L. Chen, D. Liu, J. Liu, B.T. Baune, Z.C. Xiao & X.F. Zhou. (2015) Mice deficient for wild-type p53-induced phosphatase 1 display elevated anxiety- and depression-like behaviors. Neuroscience 293, pages 12-22.
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Ji-Seon Lee, Jeong-Rak Park, Ok-Seon Kwon, Hyongbum Kim, Albert J. FornaceJr.Jr. & Hyuk-Jin Cha. (2014) Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. Journal of Dermatological Science 73:2, pages 125-134.
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Mohammad R. Akbari, Pierre Lepage, Barry Rosen, John McLaughlin, Harvey Risch, Mark Minden & Steven A. Narod. (2014) PPM1D Mutations in Circulating White Blood Cells and the Risk for Ovarian Cancer. JNCI: Journal of the National Cancer Institute 106:1.
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Ryan Kelly & Scott K. Davey. (2013) Tousled-Like Kinase-Dependent Phosphorylation of Rad9 Plays a Role in Cell Cycle Progression and G2/M Checkpoint Exit. PLoS ONE 8:12, pages e85859.
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Klaus Heese. (2013) The protein p17 signaling pathways in cancer. Tumor Biology 34:6, pages 4081-4087.
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Nicole Hustedt, Susan Gasser & Kenji Shimada. (2013) Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase. Genes 4:3, pages 388-434.
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