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Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status

Pages 3831-3838 | Published online: 15 Sep 2010

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Lan Sun, Hong-Juan Yao, Jing-Cao Li, Bao-Quan Zhao, Yong-An Wang & Ying-Ge Zhang. (2023) Activated Carbon nanoparticles Loaded with Metformin for Effective Against Hepatocellular Cancer Stem Cells. International Journal of Nanomedicine 18, pages 2891-2910.
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A. Keshandehghan, S. Nikkhah, H. Tahermansouri, S. Heidari-Keshel & M. Gardaneh. (2020) Co-Treatment with Sulforaphane and Nano-Metformin Molecules Accelerates Apoptosis in HER2+ Breast Cancer Cells by Inhibiting Key Molecules. Nutrition and Cancer 72:5, pages 835-848.
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Julianna M. Santos & Fazle Hussain. (2020) Higher Glucose Enhances Breast Cancer Cell Aggressiveness. Nutrition and Cancer 72:5, pages 734-746.
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Anne-Sophie Hamy, Lisa Derosa, Constance Valdelièvre, Satoru Yonekura, Paule Opolon, Maël Priour, Julien Guerin, Jean-Yves Pierga, Bernard Asselain, Diane De Croze, Alice Pinheiro, Marick Lae, Laure-Sophie Talagrand, Enora Laas, Lauren Darrigues, Beatriz Grandal, Elisabetta Marangoni, Elodie Montaudon, Guido Kroemer, Laurence Zitvogel & Fabien Reyal. (2020) Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer. OncoImmunology 9:1.
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Elisabet Cuyàs, Begoña Martin-Castillo, Joaquim Bosch-Barrera & Javier A. Menendez. (2017) Metformin inhibits RANKL and sensitizes cancer stem cells to denosumab. Cell Cycle 16:11, pages 1022-1028.
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Corinna Seliger, Anne-Louise Meyer, Kathrin Renner, Verena Leidgens, Sylvia Moeckel, Birgit Jachnik, Katja Dettmer, Ulrike Tischler, Valeria Gerthofer, Lisa Rauer, Martin Uhl, Martin Proescholdt, Ulrich Bogdahn, Markus J. Riemenschneider, Peter J. Oefner, Marina Kreutz, Arabel Vollmann-Zwerenz & Peter Hau. (2016) Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2. Cell Cycle 15:13, pages 1755-1766.
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Reema Wahdan-Alaswad, Zeying Fan, Susan M Edgerton, Bolin Liu, Xin-Sheng Deng, Sigrid Salling Arnadottir, Jennifer K Richer, Steven M Anderson & Ann D Thor. (2013) Glucose promotes breast cancer aggression and reduces metformin efficacy. Cell Cycle 12:24, pages 3759-3769.
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JAVIER MENENDEZ, Jorge Joven, SÍLVIA CUFÍ, BRUNA COROMINAS-FAJA, Cristina Oliveras-Ferraros, ELISABET CUYÀS, Begoña Martin-Castillo, Eugeni López-Bonet, TOMÁS ALARCÓN & Alejandro Vazquez-Martin. (2013) The Warburg effect version 2.0: Metabolic reprogramming of cancer stem cells. Cell Cycle 12:8, pages 1166-1179.
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Begoña Martin-Castillo, Cristina Oliveras-Ferraros, Alejandro Vazquez-Martin, Silvia Cufí, José Manuel Moreno, Bruna Corominas-Faja, Ander Urruticoechea, Ángel G. Martín, Eugeni López-Bonet & Javier A. Menendez. (2013) Basal/HER2 breast carcinomas. Cell Cycle 12:2, pages 225-245.
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William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Michelle M. LaHair, Giuseppe Montalto, Melchiorre Cervello, Alberto M. Martelli, Ferdinando Nicoletti, Saverio Candido, Massimo Libra, Jerry Polesel, Renato Talamini, Michele Milella, Agostino Tafuri, Linda S. Steelman & James A. McCubrey. (2012) Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine. Cell Cycle 11:23, pages 4447-4461.
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Cristina Oliveras-Ferraros, Bruna Corominas-Faja, Sílvia Cufí, Alejandro Vazquez-Martin, Begoña Martin-Castillo, Juan Manuel Iglesias, Eugeni López-Bonet, Ángel G. Martin & Javier A. Menendez. (2012) Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin). Cell Cycle 11:21, pages 4020-4032.
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Ashwani Khurana & Viji Shridhar. (2012) Metformin is synthetically lethal with glucose withdrawal in cancer cells. Cell Cycle 11:15, pages 2779-2779.
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Javier A. Menendez, Cristina Oliveras-Ferraros, Sílvia Cufí, BRUNA COROMINAS-FAJA, Jorge Joven, Begoña Martin-Castillo & Alejandro Vazquez-Martin. (2012) Metformin is synthetically lethal with glucose withdrawal in cancer cells. Cell Cycle 11:15, pages 2782-2792.
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Francesca Ricci, Sergio Bernasconi, Patrizia Perego, Monica Ganzinelli, Giorgio Russo, Francesca Bono, Costantino Mangioni, Robert Fruscio, Mario Signorelli, Massimo Broggini & Giovanna Damia. (2012) Ovarian carcinoma tumor-initiating cells have a mesenchymal phenotype. Cell Cycle 11:10, pages 1966-1976.
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Alejandro Vazquez-Martin, Luciano Vellon, Pedro M. Quirós, Sílvia Cufí, Eunate Ruiz de Galarreta, Cristina Oliveras-Ferraros, Angel G. Martin, Begoña Martin-Castillo, Carlos López-Otín & Javier A. Menendez. (2012) Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells. Cell Cycle 11:5, pages 974-989.
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Diana Whitaker-Menezes, Ubaldo E. Martinez-Outschoorn, Neal Flomenberg, Ruth Birbe, Agnieszka K. Witkiewicz, Anthony Howell, Stephanos Pavlides, Aristotelis Tsirigos, Adam Ertel, Richard G. Pestell, Paolo Broda, Carlo Minetti, Michael P. Lisanti & Federica Sotgia. (2011) Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ. Cell Cycle 10:23, pages 4047-4064.
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Ubaldo E. Martinez-Outschoorn, Marco Prisco, Adam Ertel, Aristotelis Tsirigos, Zhao Lin, Stephanos Pavlides, Chengwang Wang, Neal Flomenberg, Erik S. Knudsen, Anthony Howell, Richard G. Pestell, Federica Sotgia & Michael P Lisanti. (2011) Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer. Cell Cycle 10:8, pages 1271-1286.
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