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Epigenetics Volume 2, 2007 - Issue 2
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Research Paper

Induction of DNA Hypomethylation by Tumor Hypoxia

Siranoush Shahrzad
,
Kelsey Bertrand
,
Kanwal Minhas
&
Brenda Coomber
Pages 119-125 | Published online: 25 Jun 2007

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Ahrim Youn & Shuang Wang. (2018) The MiAge Calculator: a DNA methylation-based mitotic age calculator of human tissue types. Epigenetics 13:2, pages 192-206.
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Gordon Greville, Amanda McCann, Pauline M. Rudd & Radka Saldova. (2016) Epigenetic regulation of glycosylation and the impact on chemo-resistance in breast and ovarian cancer. Epigenetics 11:12, pages 845-857.
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Mohammad Reza Alivand, Farzaneh Sabouni & Zahra-Soheila Soheili. (2016) Probable Chemical Hypoxia Effects on Progress of CNV Through Induction of Promoter CpG Demethylation and Overexpression of IL17RC in Human RPE Cells. Current Eye Research 41:9, pages 1245-1254.
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Peter Vrtačnik, Janja Marc & Barbara Ostanek. (2015) Hypoxia mimetic deferoxamine influences the expression of histone acetylation- and DNA methylation-associated genes in osteoblasts. Connective Tissue Research 56:3, pages 228-235.
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Yi Cui, Il-Hoon Cho, Basudev Chowdhury & Joseph Irudayaraj. (2013) Real-time dynamics of methyl-CpG-binding domain protein 3 and its role in DNA demethylation by fluorescence correlation spectroscopy. Epigenetics 8:10, pages 1089-1100.
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Ryan K.C. Yuen, Baosheng Chen, John D. Blair, Wendy P. Robinson & D. Michael Nelson. (2013) Hypoxia alters the epigenetic profile in cultured human placental trophoblasts. Epigenetics 8:2, pages 192-202.
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Claire M. Robinson, Chris J. Watson & John A. Baugh. (2012) Epigenetics within the matrix. Epigenetics 7:9, pages 987-993.
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Karolina Skowronski, Sonam Dubey, David I. Rodenhiser & Brenda Coomber. (2010) Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells. Epigenetics 5:6, pages 547-556.
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Mariam A. Fouad, Salem E. Salem, Marwa M. Hussein, Abdel Rahman N. Zekri, Hafez F. Hafez, Eman D. El Desouky & Samia A. Shouman. (2018) Impact of Global DNA Methylation in Treatment Outcome of Colorectal Cancer Patients. Frontiers in Pharmacology 9.
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Crossref
Pushpak Bhandari, Gloriia Novikova, Craig J. Goergen & Joseph Irudayaraj. (2018) Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Scientific Reports 8:1.
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Hani Choudhry & Adrian L. Harris. (2018) Advances in Hypoxia-Inducible Factor Biology. Cell Metabolism 27:2, pages 281-298.
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Crossref
Pushpak N. Bhandari, Yi Cui, Bennett D. Elzey, Craig J. Goergen, Christopher M. Long & Joseph Irudayaraj. (2017) Oxygen nanobubbles revert hypoxia by methylation programming. Scientific Reports 7:1.
Crossref
Jingping Zhu, Kai Wang, Ting Li, Jiayu Chen, Dandan Xie, Xinwen Chang, Julei Yao, Jinting Wu, Qian Zhou, Yuanhui Jia & Tao Duan. (2017) Hypoxia-induced TET1 facilitates trophoblast cell migration and invasion through HIF1α signaling pathway. Scientific Reports 7:1.
Crossref
Giuseppina Improta, Cathrin Ritter, Angela Pettinato, Valeria Vasta, David Schrama, Filippo Fraggetta & Jürgen C. Becker. (2017) MGMT promoter methylation status in Merkel cell carcinoma: in vitro versus invivo. Journal of Cancer Research and Clinical Oncology 143:8, pages 1489-1497.
Crossref
Pankaj Prasad, Shivani Arora Mittal, Jonita Chongtham, Sujata Mohanty & Tapasya Srivastava. (2017) Hypoxia-Mediated Epigenetic Regulation of Stemness in Brain Tumor Cells. Stem Cells 35:6, pages 1468-1478.
Crossref
Sergio Rey, Luana Schito, Marianne Koritzinsky & Bradly G. Wouters. (2017) Molecular targeting of hypoxia in radiotherapy. Advanced Drug Delivery Reviews 109, pages 45-62.
Crossref
Jie Cui, Biao Duan, Xuyang Zhao, Yan Chen, Shixun Sun, Wenjie Deng, Yujie Zhang, Jun Du, Yongchang Chen & Luo Gu. (2016) MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer. Tumor Biology 37:10, pages 13455-13467.
Crossref
Layale Yaghi, Isabelle Poras, Renata T. Simoes, Eduardo A. Donadi, Jörg Tost, Antoine Daunay, Bibiana Sgorla de Almeida, Edgardo D. Carosella & Philippe Moreau. (2016) Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2. Oncotarget 7:39, pages 63690-63707.
Crossref
Kenichi Nakamura, Yoshifumi Baba, Keisuke Kosumi, Kazuto Harada, Hironobu Shigaki, Keisuke Miyake, Yuki Kiyozumi, Mayuko Ohuchi, Junji Kurashige, Takatsugu Ishimoto, Masaaki Iwatsuki, Yasuo Sakamoto, Naoya Yoshida, Masayuki Watanabe, Mitsuyoshi Nakao & Hideo Baba. (2016) UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma. Oncotarget 7:36, pages 57821-57831.
Crossref
Elise Duval, Mouloud Bouyoucef, Sylvain Leclercq, Catherine Baugé & Karim Boumédiene. (2016) Hypoxia inducible factor 1 alpha down-regulates type i collagen through Sp3 transcription factor in human chondrocytes. IUBMB Life 68:9, pages 756-763.
Crossref
Yasuo Iwadate, Tomoo Matsutani, Seiichiro Hirono, Natsuki Shinozaki & Naokatsu Saeki. (2016) Transforming growth factor-? and stem cell markers are highly expressed around necrotic areas in glioblastoma. Journal of Neuro-Oncology 129:1, pages 101-107.
Crossref
Bryan Oronsky, Jan Scicinski, Michelle Kim, Pedro Cabrales, Michael Salacz, Corey Carter, Neil Oronsky, Harry Lybeck, Michelle Lybeck, Christopher Larson, Tony Reid & Arnold Oronsky. (2016) Turning on the Radio: Epigenetic Inhibitors as Potential Radiopriming Agents. Biomolecules 6:3, pages 32.
Crossref
Woo-Young Sun, Woo-Hee Jung & Ja Seung Koo. (2015) Expression of cancer-associated fibroblast-related proteins in thyroid papillary carcinoma. Tumor Biology 37:6, pages 8197-8207.
Crossref
Fiona McDonnell, Mustapha Irnaten, Abbot F. Clark, Colm J. O’Brien & Deborah M. Wallace. (2016) Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGFβ1 Expression in Human Trabecular Meshwork Cells. PLOS ONE 11:4, pages e0153354.
Crossref
Anoek Zomer & Jacco van Rheenen. (2016) Implications of Extracellular Vesicle Transfer on Cellular Heterogeneity in Cancer: What Are the Potential Clinical Ramifications?. Cancer Research 76:8, pages 2071-2075.
Crossref
Hsiao-Fan Chen & Kou-Juey Wu. (2016) Epigenetics, TET proteins, and hypoxia in epithelial-mesenchymal transition and tumorigenesis. BioMedicine 6:1.
Crossref
Shih-Han Kao, Kou-Juey Wu & Wen-Hwa Lee. (2016) Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes. Journal of Clinical Medicine 5:2, pages 24.
Crossref
M. A. Nezami, Steven Hager & Jessica Garner. (2016) Epigenetic Tumor Response to Hypoxia: An Epimutation Pattern and a Method of Multi Targeted Epigenetic Therapy (MTET). Journal of Cancer Therapy 07:04, pages 254-269.
Crossref
Stephen C Mack, Christopher G Hubert, Tyler E Miller, Michael D Taylor & Jeremy N Rich. (2015) An epigenetic gateway to brain tumor cell identity. Nature Neuroscience 19:1, pages 10-19.
Crossref
Qinglin Yang, Xiangmei Wu, Jing Sun, Jing Cui & Liang Li. (2014) Epigenetic Features Induced by Ischemia-Hypoxia in Cultured Rat Astrocytes. Molecular Neurobiology 53:1, pages 436-445.
Crossref
A. Cimini, A. Fidoamore, M. d’Angelo, A. Antonosante, L. Cristiano, E. Benedetti & Antonio Giordano. 2016. Radiobiology of Glioblastoma. Radiobiology of Glioblastoma 177 187 .
Julie Cannuyer, Aurélie Van Tongelen, Axelle Loriot & Charles De Smet. (2015) A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma. Clinical Epigenetics 7:1.
Crossref
Roisin Neary, Chris J. Watson & John A. Baugh. (2015) Epigenetics and the overhealing wound: the role of DNA methylation in fibrosis. Fibrogenesis & Tissue Repair 8:1.
Crossref
Joshua J. Glass, Phoebe A. Phillips, Peter W. Gunning & Justine R. Stehn. (2015) Hypoxia alters the recruitment of tropomyosins into the actin stress fibres of neuroblastoma cells. BMC Cancer 15:1.
Crossref
Maria José de los Santos, Pilar Gámiz, José María de los Santos, Josep Lluís Romero, Nicolás Prados, Cristina Alonso, José Remohí & Francisco Dominguez. (2015) The Metabolomic Profile of Spent Culture Media from Day-3 Human Embryos Cultured under Low Oxygen Tension. PLOS ONE 10:11, pages e0142724.
Crossref
Shaliny Ramachandran, Jonathan Ient, Eva-Leonne Göttgens, Adam Krieg & Ester Hammond. (2015) Epigenetic Therapy for Solid Tumors: Highlighting the Impact of Tumor Hypoxia. Genes 6:4, pages 935-956.
Crossref
Min-Zu Wu, Su-Feng Chen, Shin Nieh, Christopher Benner, Luo-Ping Ger, Chia-Ing Jan, Li Ma, Chien-Hung Chen, Tomoaki Hishida, Hong-Tai Chang, Yaoh-Shiang Lin, Nuria Montserrat, Pedro Gascon, Ignacio Sancho-Martinez & Juan Carlos Izpisua Belmonte. (2015) Hypoxia Drives Breast Tumor Malignancy through a TET–TNFα–p38–MAPK Signaling Axis. Cancer Research 75:18, pages 3912-3924.
Crossref
Rebecca L Hancock, Kate Dunne, Louise J Walport, Emily Flashman & Akane Kawamura. (2015) Epigenetic regulation by histone demethylases in hypoxia. Epigenomics 7:5, pages 791-811.
Crossref
X N Gao, F Yan, J Lin, L Gao, X L Lu, S C Wei, N Shen, J X Pang, Q Y Ning, Y Komeno, A L Deng, Y H Xu, J L Shi, Y H Li, D E Zhang, C Nervi, S J Liu & L Yu. (2015) AML1/ETO cooperates with HIF1α to promote leukemogenesis through DNMT3a transactivation. Leukemia 29:8, pages 1730-1740.
Crossref
Susan E. Scanlon & Peter M. Glazer. (2015) Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment. DNA Repair 32, pages 180-189.
Crossref
Kazuto Harada, Yoshifumi Baba, Takatsugu Ishimoto, Akira Chikamoto, Keisuke Kosumi, Hiromitsu Hayashi, Hidetoshi Nitta, Daisuke Hashimoto, Toru Beppu & Hideo Baba. (2014) LINE-1 Methylation Level and Patient Prognosis in a Database of 208 Hepatocellular Carcinomas. Annals of Surgical Oncology 22:4, pages 1280-1287.
Crossref
Gregory McCarty & David M. Loeb. (2015) Hypoxia-Sensitive Epigenetic Regulation of an Antisense-Oriented lncRNA Controls WT1 Expression in Myeloid Leukemia Cells. PLOS ONE 10:3, pages e0119837.
Crossref
Ken W.K. Lee, Rebecca Richmond, Pingzhao Hu, Leon French, Jean Shin, Celine Bourdon, Eva Reischl, Melanie Waldenberger, Sonja Zeilinger, Tom Gaunt, Wendy McArdle, Susan Ring, Geoff Woodward, Luigi Bouchard, Daniel Gaudet, George Davey Smith, Caroline Relton, Tomas Paus & Zdenka Pausova. (2015) Prenatal Exposure to Maternal Cigarette Smoking and DNA Methylation: Epigenome-Wide Association in a Discovery Sample of Adolescents and Replication in an Independent Cohort at Birth through 17 Years of Age. Environmental Health Perspectives 123:2, pages 193-199.
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Kurosh Ameri, Arman Jahangiri, Anthony M. Rajah, Kathryn V. Tormos, Ravi Nagarajan, Melike Pekmezci, Vien Nguyen, Matthew L. Wheeler, Michael P. Murphy, Timothy A. Sanders, Stefanie S. Jeffrey, Yerem Yeghiazarians, Paolo F. Rinaudo, Joseph F. Costello, Manish K. Aghi & Emin Maltepe. (2015) HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Reports 10:6, pages 891-899.
Crossref
Katie L. PenningtonMargaret M. Deangelis. (2016) Epigenetic Mechanisms of the Aging Human Retina. Journal of Experimental Neuroscience 9s2, pages JEN.S25513.
Crossref
J. G. Ortega Avila, I. Echeverri, C. A. de Plata & A. Castillo. (2014) Impact of oxidative stress during pregnancy on fetal epigenetic patterns and early origin of vascular diseases. Nutrition Reviews 73:1, pages 12-21.
Crossref
Tomáš Paus & Zdenka Pausova. 2015. Neuroimaging and Psychosocial Addiction Treatment. Neuroimaging and Psychosocial Addiction Treatment 212 230 .
Qingyi Ma & Lubo Zhang. (2015) Epigenetic programming of hypoxic–ischemic encephalopathy in response to fetal hypoxia. Progress in Neurobiology 124, pages 28-48.
Crossref
Hui Liu & Weidong Le. (2014) Epigenetic modifications of chronic hypoxia-mediated neurodegeneration in Alzheimer’s disease. Translational Neurodegeneration 3:1.
Crossref
Shu ZhangYanbo ZhangShuyuan JiangYou LiuLihua HuangTao ZhangGuowei LuKerui GongXunming JiGuo Shao. (2014) The Effect of Hypoxia Preconditioning on DNA Methyltransferase and PP1γ in Hippocampus of Hypoxia Preconditioned Mice. High Altitude Medicine & Biology 15:4, pages 483-490.
Crossref
Qingyi Ma, Fuxia Xiong & Lubo Zhang. (2014) Gestational hypoxia and epigenetic programming of brain development disorders. Drug Discovery Today 19:12, pages 1883-1896.
Crossref
Xiangmei Wu, Jing Sun, Xiaowen Zhang, Xiaona Li, Zichen Liu, Qinglin Yang & Liang Li. (2014) Epigenetic Signature of Chronic Cerebral Hypoperfusion and Beneficial Effects of S-adenosylmethionine in Rats. Molecular Neurobiology 50:3, pages 839-851.
Crossref
Claire M. Robinson & Michael Ohh. (2014) The multifaceted von Hippel-Lindau tumour suppressor protein. FEBS Letters 588:16, pages 2704-2711.
Crossref
Karolina Skowronki, Joseph Andrews, David I. Rodenhiser & Brenda L. Coomber. (2014) Genome-Wide Analysis in Human Colorectal Cancer Cells Reveals Ischemia-Mediated Expression of Motility Genes via DNA Hypomethylation. PLoS ONE 9:7, pages e103243.
Crossref
Leonie Roos, Timothy D Spector & Christopher G Bell. (2014) Using epigenomic studies in monozygotic twins to improve our understanding of cancer. Epigenomics 6:3, pages 299-309.
Crossref
Daniela Valletta, Barbara Czech, Thilo Spruss, Kristian Ikenberg, Peter Wild, Arndt Hartmann, Thomas S. Weiss, Peter J. Oefner, Martina Müller, Anja-Katrin Bosserhoff & Claus Hellerbrand. (2014) Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma. Carcinogenesis 35:6, pages 1407-1415.
Crossref
Christopher J. Mariani, Aparna Vasanthakumar, Jozef Madzo, Ali Yesilkanal, Tushar Bhagat, Yiting Yu, Sanchari Bhattacharyya, Roland H. Wenger, Susan L. Cohn, Jayasri Nanduri, Amit Verma, Nanduri R. Prabhakar & Lucy A. Godley. (2014) TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma. Cell Reports 7:5, pages 1343-1352.
Crossref
Alyssa A. Chamberlain, Mingyan Lin, Rolanda L. Lister, Alex A. Maslov, Yidong Wang, Masako Suzuki, Bingruo Wu, John M. Greally, Deyou Zheng & Bin Zhou. (2014) DNA Methylation is Developmentally Regulated for Genes Essential for Cardiogenesis. Journal of the American Heart Association 3:3.
Crossref
Kim M. Smits, Veerle Melotte, Hanneke E.C. Niessen, Ludwig Dubois, Cary Oberije, Esther G.C. Troost, Maud H.W. Starmans, Paul C. Boutros, Marc Vooijs, Manon van Engeland & Philippe Lambin. (2014) Epigenetics in radiotherapy: Where are we heading?. Radiotherapy and Oncology 111:2, pages 168-177.
Crossref
Kartik Gupta, Esha Madan, Muzzammil Sayyid, Hugo Arias-Pulido, Eduardo Moreno, Periannan Kuppusamy & Rajan Gogna. (2013) Oxygen regulates molecular mechanisms of cancer progression and metastasis. Cancer and Metastasis Reviews 33:1, pages 183-215.
Crossref
Agnieszka Stembalska, Przemysław Leszczyński, Justyna Gil, David Ramsey, Grzegorz Pitala, Adam Maciejczyk & Marcin Frączek. (2014) Global DNA methylation status in laryngeal cancer. Head & Neck 36:3, pages 419-424.
Crossref
Alejandra Ward & John W. Hudson. (2014) p53-Dependent and Cell Specific Epigenetic Regulation of the Polo-like kinases under Oxidative Stress. PLoS ONE 9:1, pages e87918.
Crossref
Ya-Ping Tsai & Kou-Juey Wu. (2014) Epigenetic regulation of hypoxia-responsive gene expression: Focusing on chromatin and DNA modifications. International Journal of Cancer 134:2, pages 249-256.
Crossref
Fiona McDonnell, Colm O’Brien & Deborah Wallace. (2014) The Role of Epigenetics in the Fibrotic Processes Associated with Glaucoma. Journal of Ophthalmology 2014, pages 1-13.
Crossref
Agnieszka A Rawluszko, Katarzyna E Bujnicka, Karolina Horbacka, Piotr Krokowicz & Paweł P Jagodziński. (2013) Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer. BMC Cancer 13:1.
Crossref
Zehua Wang. (2013) Cancer-associated fibroblasts enhance the migration ability of ovarian cancer cells by increasing EZH2 expression. International Journal of Molecular Medicine.
Crossref
Iain Hartley, Fuad F. Elkhoury, Joo Heon Shin, Bin Xie, Xiangqun Gu, Yuan Gao, Dan Zhou & Gabriel G. Haddad. (2013) Long-Lasting Changes in DNA Methylation Following Short-Term Hypoxic Exposure in Primary Hippocampal Neuronal Cultures. PLoS ONE 8:10, pages e77859.
Crossref
J. D. Blair, R. K. C. Yuen, B. K. Lim, D. E. McFadden, P. von Dadelszen & W. P. Robinson. (2013) Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia. Molecular Human Reproduction 19:10, pages 697-708.
Crossref
F.I. Milagro, M.L. Mansego, C. De Miguel & J.A. Martínez. (2013) Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives. Molecular Aspects of Medicine 34:4, pages 782-812.
Crossref
Shiro Iwagami, Yoshifumi Baba, Masayuki Watanabe, Hironobu Shigaki, Keisuke Miyake, Takatsugu Ishimoto, Masaaki Iwatsuki, Kentaro Sakamaki, Yasuo Ohashi & Hideo Baba. (2013) LINE-1 Hypomethylation Is Associated With a Poor Prognosis Among Patients With Curatively Resected Esophageal Squamous Cell Carcinoma. Annals of Surgery 257:3, pages 449-455.
Crossref
Rodrigo Herrera-Molina, Alejandra Valdivia, Milene Kong, Alvaro Alvarez, Areli Cárdenas, Andrew F.G. Quest & Lisette Leyton. 2013. 163 216 .
Lorena E. Mora-Blanco, James B. Lorens & Mark A. LaBarge. 2013. Trends in Stem Cell Proliferation and Cancer Research. Trends in Stem Cell Proliferation and Cancer Research 463 478 .
Vincent L. Wilson. 2013. Environmental Toxicology. Environmental Toxicology 203 238 .
Claire M Robinson, Roisin Neary, Ashleigh Levendale, Chris J Watson & John A Baugh. (2012) Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype. Respiratory Research 13:1.
Crossref
Lei Xiong, Fei Wang, Xin Huang, Zhao‐hui Liu, Tong Zhao, Li‐ying Wu, Kuiwu Wu, Xuefeng Ding, Shuhong Liu, Yan Wu, Yongqi Zhao, Ling‐ling Zhu & Ming Fan. (2012) DNA demethylation regulates the expression of miR‐210 in neural progenitor cells subjected to hypoxia . The FEBS Journal 279:23, pages 4318-4326.
Crossref
R Schmidt-Kastner, J van Os, G Esquivel, H W M Steinbusch & B P F Rutten. (2012) An environmental analysis of genes associated with schizophrenia: hypoxia and vascular factors as interacting elements in the neurodevelopmental model. Molecular Psychiatry 17:12, pages 1194-1205.
Crossref
Akiko Horiuchi, Takuma Hayashi, Norihiko Kikuchi, Akiko Hayashi, Chiho Fuseya, Tanri Shiozawa & Ikuo Konishi. (2012) Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1α to a hypoxia-induced, methylation-free hypoxia response element of S100A4 gene. International Journal of Cancer 131:8, pages 1755-1767.
Crossref
Wenni Tong & Lubo Zhang. (2012) Fetal hypoxia and programming of matrix metalloproteinases. Drug Discovery Today 17:3-4, pages 124-134.
Crossref
Felipe de Almeida Sassi, Algemir Lunardi Brunetto, Gilberto Schwartsmann, Rafael Roesler & Ana Lucia Abujamra. (2012) Glioma Revisited: From Neurogenesis and Cancer Stem Cells to the Epigenetic Regulation of the Niche. Journal of Oncology 2012, pages 1-20.
Crossref
Andrew Melvin & Sonia Rocha. (2012) Chromatin as an oxygen sensor and active player in the hypoxia response. Cellular Signalling 24:1, pages 35-43.
Crossref
Vincent L. Wilson. 2012. Encyclopedia of Sustainability Science and Technology. Encyclopedia of Sustainability Science and Technology 3595 3620 .
C Thirlwell, LKE Schulz, HK Dibra & S Beck. (2011) Suffocating cancer: hypoxia-associated epimutations as targets for cancer therapy. Clinical Epigenetics 3:1.
Crossref
Yoko Aoi, Ken-ichi Nakahama, Ikuo Morita & Olga Safronova. (2011) The involvement of DNA and histone methylation in the repression of IL-1β-induced MCP-1 production by hypoxia. Biochemical and Biophysical Research Communications 414:1, pages 252-258.
Crossref
Paul Cordero, Javier Campion, Fermin I. Milagro, Estibaliz Goyenechea, Thais Steemburgo, Biola M. Javierre & J. Alfredo Martinez. (2011) Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet. Journal of Physiology and Biochemistry 67:3, pages 463-470.
Crossref
Quanyan Liu, Li Liu, Yuhong Zhao, Jin Zhang, Dongfeng Wang, Jiwei Chen, Yueming He, Jianguo Wu, Zhonglin Zhang & Zhisu Liu. (2011) Hypoxia Induces Genomic DNA Demethylation through the Activation of HIF-1α and Transcriptional Upregulation of MAT2A in Hepatoma Cells. Molecular Cancer Therapeutics 10:6, pages 1113-1123.
Crossref
Shichun Zheng, E. Andres Houseman, Zachary Morrison, Margaret R. Wrensch, Joseph S. Patoka, Christian Ramos, Daphne A. Haas-Kogan, Sean McBride, Carmen J. Marsit, Brock C. Christensen, Heather H. Nelson, David Stokoe, Joseph L. Wiemels, Susan M. Chang, Michael D. Prados, Tarik Tihan, Scott R. Vandenberg, Karl T. Kelsey, Mitchel S. Berger & John K. Wiencke. (2011) DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression. Neuro-Oncology 13:3, pages 280-289.
Crossref
Yoshifumi Baba, Curtis Huttenhower, Katsuhiko Nosho, Noriko Tanaka, Kaori Shima, Aditi Hazra, Eva S Schernhammer, David J Hunter, Edward L Giovannucci, Charles S Fuchs & Shuji Ogino. (2010) Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. Molecular Cancer 9:1.
Crossref
Christopher A Hamm, Jeff W Stevens, Hehuang Xie, Elio F Vanin, Jose A Morcuende, Hakeem Abdulkawy, Elisabeth A Seftor, Simone T Sredni, Jared M Bischof, Deli Wang, Sergey Malchenko, Maria de Fatima Bonaldo, Thomas L Casavant, Mary JC Hendrix & Marcelo B Soares. (2010) Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors. BMC Cancer 10:1.
Crossref
C. G. Bell & S. Beck. (2010) The epigenomic interface between genome and environment in common complex diseases. Briefings in Functional Genomics 9:5-6, pages 477-485.
Crossref
Arnab Pal, Tapasya Srivastava, Manish K Sharma, Mohit Mehndiratta, Prerna Das, Subrata Sinha & Parthaprasad Chattopadhyay. (2010) Aberrant methylation and associated transcriptional mobilization of Alu elements contributes to genomic instability in hypoxia. Journal of Cellular and Molecular Medicine 14:11, pages 2646-2654.
Crossref
Ryan KC Yuen, Maria S Peñaherrera, Peter von Dadelszen, Deborah E McFadden & Wendy P Robinson. (2010) DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia. European Journal of Human Genetics 18:9, pages 1006-1012.
Crossref
O. Safronova & I. Morita. (2010) Transcriptome Remodeling in Hypoxic Inflammation. Journal of Dental Research 89:5, pages 430-444.
Crossref
Tamas A. Gonda, Andrea Varro, Timothy C. Wang & Benjamin Tycko. (2010) Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy?. Seminars in Cell & Developmental Biology 21:1, pages 2-10.
Crossref
Adam Yagui-Beltrán, Qizhi Tang & David M. Jablons. 2010. The Tumor Microenvironment. The Tumor Microenvironment 409 430 .
J. A. Watson, C. J. Watson, A.-M. McCrohan, K. Woodfine, M. Tosetto, J. McDaid, E. Gallagher, D. Betts, J. Baugh, J. O'Sullivan, A. Murrell, R. W. G. Watson & A. McCann. (2009) Generation of an epigenetic signature by chronic hypoxia in prostate cells. Human Molecular Genetics 18:19, pages 3594-3604.
Crossref
Rolf Bjerkvig, Mikael Johansson, Hrvoje Miletic & Simone P. Niclou. (2009) Cancer stem cells and angiogenesis. Seminars in Cancer Biology 19:5, pages 279-284.
Crossref
Unai Silván, Alejandro Díez-Torre, Jon Arluzea, Ricardo Andrade, Margarita Silió & Juan Aréchaga. (2009) Hypoxia and pluripotency in embryonic and embryonal carcinoma stem cell biology. Differentiation 78:2-3, pages 159-168.
Crossref
Huey-Jen L. Lin, Tao Zuo, Jennifer R. Chao, Zhengang Peng, Lisa K. Asamoto, Sonya S. Yamashita & Tim H.-M. Huang. (2009) Seed in soil, with an epigenetic view. Biochimica et Biophysica Acta (BBA) - General Subjects 1790:9, pages 920-924.
Crossref
Masayo Naito, Richard A. Zager & Karol Bomsztyk. (2009) BRG1 Increases Transcription of Proinflammatory Genes in Renal Ischemia. Journal of the American Society of Nephrology 20:8, pages 1787-1796.
Crossref
J. Campión, F. I. Milagro & J. A. Martínez. (2009) Individuality and epigenetics in obesity. Obesity Reviews 10:4, pages 383-392.
Crossref
F. I. Milagro, J. Campión, D. F. García-Díaz, E. Goyenechea, L. Paternain & J. A. Martínez. (2009) High fat diet-induced obesity modifies the methylation pattern of leptin promoter in ratsLa obesidad inducida por dieta alta en grasas modifica el patrón de metilación del promotor de la leptina en la rata. Journal of Physiology and Biochemistry 65:1, pages 1-9.
Crossref
Yasufumi Shutoh, Makio Takeda, Ryoichi Ohtsuka, Atsuko Haishima, Satoru Yamaguchi, Hideaki Fujie, Yutaka Komatsu, Keizo Maita & Takanori Harada. (2009) Low dose effects of dichlorodiphenyltrichloroethane (DDT) on gene transcription and DNA methylation in the hypothalamus of young male rats: implication of hormesis-like effects. The Journal of Toxicological Sciences 34:5, pages 469-482.
Crossref
Shuji Ogino, Katsuhiko Nosho, Gregory J. Kirkner, Takako Kawasaki, Andrew T. Chan, Eva S. Schernhammer, Edward L. Giovannucci & Charles S. Fuchs. (2008) A Cohort Study of Tumoral LINE-1 Hypomethylation and Prognosis in Colon Cancer. JNCI: Journal of the National Cancer Institute 100:23, pages 1734-1738.
Crossref
George WM Millington. (2008) Epigenetics and dermatological disease. Pharmacogenomics 9:12, pages 1835-1850.
Crossref
Marc Reismann, Daniel Lehmann, Matthias Quandte, Benno M. Ure & Sylvia Glüer. (2008) Carbon dioxide does not affect the methylation status of prognostic important oncogenes Rassf1A and DCR2 in neuroblastoma cells. Pediatric Surgery International 24:12, pages 1327-1330.
Crossref
Nicholas R ForsythAlasdair KayKaren HampsonAlison Downing, Richard Talbot & Jim McWhir. (2008) Transcriptome alterations due to physiological normoxic (2% O 2 ) culture of human embryonic stem cells . Regenerative Medicine 3:6, pages 817-833.
Crossref
PAUL GOSS, ALISON L. ALLAN, DAVID I. RODENHISER, PAULA J. FOSTER & ANN F. CHAMBERS. (2008) New clinical and experimental approaches for studying tumor dormancy: does tumor dormancy offer a therapeutic target? . APMIS 116:7-8, pages 552-568.
Crossref

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