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Review

STAT3 activation

A key factor in tumor immunoescape

, , &
Article: e23010 | Published online: 01 Jan 2013

Keep up to date with the latest research on this topic with citation updates for this article.

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Maya Vladova Gulubova, Dimitur Chavdarov Chonov, Koni Vancho Ivanova, Mariyna Kostova Hristova, Maria Magdalena Krasimirova-Ignatova & Tatyana Ivanova Vlaykova. (2022) Intratumoural expression of IL-6/STAT3, IL-17 and FOXP3 immune cells in the immunosuppressive tumour microenvironment of colorectal cancer Immune cells-positive for IL-6, STAT3, IL-17 and FOXP3 and colorectal cancer development . Biotechnology & Biotechnological Equipment 36:1, pages 327-338.
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Yi Zhang, Xiaoya Wang, Rongchao Zhang, Xi Wang, Haiying Fu & Wei Yang. (2022) MDSCs interactions with other immune cells and their role in maternal-fetal tolerance. International Reviews of Immunology 41:5, pages 534-551.
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Jamile Ramos da Silva, Ana Carolina Ramos Moreno, Natiely Silva Sales, Mariângela de Oliveira Silva, Luana R. M. M. Aps, Bruna F.M.M. Porchia, Karine Bitencourt Rodrigues, Natália Cestari Moreno, Aléxia Adrianne Venceslau-Carvalho, Carlos Frederico M. Menck, Mariana de Oliveira Diniz & Luís Carlos de Souza Ferreira. (2021) A therapeutic DNA vaccine and gemcitabine act synergistically to eradicate HPV-associated tumors in a preclinical model. OncoImmunology 10:1.
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Misagh Rajabinejad, Farhad Salari, Ali Gorgin Karaji & Alireza Rezaiemanesh. (2019) The role of myeloid-derived suppressor cells in the pathogenesis of rheumatoid arthritis; anti- or pro-inflammatory cells?. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 4149-4158.
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Shachi Pranjal Vyas, Arman Kunwar Hansda & Ritobrata Goswami. (2019) Rheumatoid arthritis: ‘melting pot’ of T helper subsets. International Reviews of Immunology 38:5, pages 212-231.
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Matthias Schröder, Simone Loos, Svenja Kerstin Naumann, Christopher Bachran, Marit Krötschel, Viktor Umansky, Laura Helming & Lee Kim Swee. (2017) Identification of inhibitors of myeloid-derived suppressor cells activity through phenotypic chemical screening. OncoImmunology 6:1.
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Katrien De Wolf, Karim Vermaelen, Gert De Meerleer, Bart N Lambrecht & Piet Ost. (2015) The potential of radiotherapy to enhance the efficacy of renal cell carcinoma therapy. OncoImmunology 4:10.
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Paulina Pathria, Dagmar Gotthardt, Michaela Prchal-Murphy, Eva-Maria Putz, Martin Holcmann, Michaela Schlederer, Beatrice Grabner, Ilija Crncec, Jasmin Svinka, Monica Musteanu, Thomas Hoffmann, Martin Filipits, Walter Berger, Valeria Poli, Lukas Kenner, Martin Bilban, Emilio Casanova, Mathias Müller, Birgit Strobl, Editha Bayer, Thomas Mohr, Veronika Sexl & Robert Eferl. (2015) Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice. OncoImmunology 4:4.
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Rebecka Hellsten, Lisa Lilljebjörn, Martin Johansson, Karin Leandersson & Anders Bjartell. (2019) The STAT3 inhibitor galiellalactone inhibits the generation of MDSC‐like monocytes by prostate cancer cells and decreases immunosuppressive and tumorigenic factors. The Prostate 79:14, pages 1611-1621.
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Ryo Yokomizo, Nozomu Yanaihara, Noriko Yamaguchi, Misato Saito, Ayako Kawabata, Kazuaki Takahashi, Masataka Takenaka, Kyosuke Yamada, Jason Solomon Shapiro & Aikou Okamoto. (2019) MicroRNA-34a /IL-6R pathway as a potential therapeutic target for ovarian high-grade serous carcinoma . Oncotarget 10:47, pages 4880-4893.
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Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly & Nigel J. Stevenson. (2019) The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)‐ α via signal transducer and activator of transcription (STAT)3 and extracellular signal‐regulated kinase (ERK)–mediated induction of suppressor of cytokine signaling (SOCS)3 . The FASEB Journal 33:8, pages 8732-8744.
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Tobias Heigl, Anurag Singh, Berta Saez-Gimenez, Janne Kaes, Anke Van Herck, Annelore Sacreas, Hanne Beeckmans, Arno Vanstapel, Stijn E. Verleden, Dirk E. Van Raemdonck, Geert Verleden, Bart M. Vanaudenaerde, Dominik Hartl & Robin Vos. (2019) Myeloid-Derived Suppressor Cells in Lung Transplantation. Frontiers in Immunology 10.
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Rahul K. Nelli, Jenne De Koster, Jennifer N. Roberts, Jonas de Souza, Adam L. Lock, William Raphael, Dalen Agnew & G. Andres Contreras. (2019) Impact of uterine macrophage phenotype on placental retention in dairy cows. Theriogenology 127, pages 145-152.
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Zhenzhou Liu, Yanru Han, Fucheng Zhao, Zhenxia Zhao, Junlei Tian & Kui Jia. (2018) Nobiletin suppresses high‐glucose–induced inflammation and ECM accumulation in human mesangial cells through STAT3/NF‐κB pathway. Journal of Cellular Biochemistry 120:3, pages 3467-3473.
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Rebekah L. Robinson, Ashok Sharma, Shan Bai, Saleh Heneidi, Tae Jin Lee, Sai Karthik Kodeboyina, Nikhil Patel & Shruti Sharma. (2019) Comparative STAT3-Regulated Gene Expression Profile in Renal Cell Carcinoma Subtypes. Frontiers in Oncology 9.
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Chao Zhou, Jie Ma, Mengyuan Su, Dan Shao, Jianan Zhao, Tongjian Zhao, Zhuoyao Song, Yan Meng & Ping Jiao. (2018) Down-regulation of STAT3 induces the apoptosis and G1 cell cycle arrest in esophageal carcinoma ECA109 cells. Cancer Cell International 18:1.
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Swati Uniyal, Anupam Dhasmana, Amit Tyagi & Jai Prakash Muyal. (2018) ATRA reduces inflammation and improves alveolar epithelium regeneration in emphysematous rat lung. Biomedicine & Pharmacotherapy 108, pages 1435-1450.
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Moses Kasembeli, Uddalak Bharadwaj, Prema Robinson & David Tweardy. (2018) Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment. International Journal of Molecular Sciences 19:8, pages 2299.
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Francesco MaininiDavid S. LarsenGill A. WebsterSarah L. YoungMichael R. Eccles. (2018) MIS416 as a siRNA Delivery System with the Ability to Target Antigen-Presenting Cells. Nucleic Acid Therapeutics 28:4, pages 225-232.
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Gang Chen, Yixin Wang, Pengkai Wu, Yiwen Zhou, Fei Yu, Chenfei Zhu, Zhaoting Li, Yu Hang, Kaikai Wang, Jing Li, Minjie Sun & David Oupicky. (2018) Reversibly Stabilized Polycation Nanoparticles for Combination Treatment of Early- and Late-Stage Metastatic Breast Cancer. ACS Nano 12:7, pages 6620-6636.
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Catrin Youssif, Monica Cubillos‐Rojas, Mònica Comalada, Elisabeth Llonch, Cristian Perna, Nabil Djouder & Angel R Nebreda. (2018) Myeloid p38α signaling promotes intestinal IGF ‐1 production and inflammation‐associated tumorigenesis . EMBO Molecular Medicine 10:7.
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Yijing Chu, Yan Wang, Wei Peng, Lin Xu, Meixin Liu, Jing Li, Xiaoyu Hu, Yan Li, Jianxin Zuo & Yuanhua Ye. (2018) STAT3 activation by IL-6 from adipose-derived stem cells promotes endometrial carcinoma proliferation and metastasis. Biochemical and Biophysical Research Communications 500:3, pages 626-631.
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Hemn Mohammadpour, Rachel O’Neil, Jingxin Qiu, Philip L. McCarthy, Elizabeth A. Repasky & Xuefang Cao. (2018) Blockade of Host β2-Adrenergic Receptor Enhances Graft-versus-Tumor Effect through Modulating APCs. The Journal of Immunology 200:7, pages 2479-2488.
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Kun Fan, Chao Yang, Zhiyao Fan, Qiuyi Huang, Yiyin Zhang, He Cheng, Kaizhou Jin, Yu Lu, Zhengshi Wang, Guopei Luo, Xianjun Yu & Chen Liu. (2018) MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated Treg enrichment in pancreatic cancer. Cancer Letters 418, pages 167-175.
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Mingyue Li, Grace Gar-Lee Yue, Li-Hua Song, Mao-Bo Huang, Julia Kin-Ming Lee, Stephen Kwok-Wing Tsui, Kwok-Pui Fung, Ning-Hua Tan & Clara Bik-San Lau. (2018) Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway. Biochemical Pharmacology 150, pages 191-201.
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Filippo Veglia, Michela Perego & Dmitry Gabrilovich. (2018) Myeloid-derived suppressor cells coming of age. Nature Immunology 19:2, pages 108-119.
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Yu Wang, Yicheng Shen, Sinan Wang, Qiang Shen & Xuan Zhou. (2018) The role of STAT3 in leading the crosstalk between human cancers and the immune system. Cancer Letters 415, pages 117-128.
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Mitsuhiko Abe, Takafumi Yoshida, Jun Akiba, Yu Ikezono, Fumitaka Wada, Atsutaka Masuda, Takahiko Sakaue, Toshimitsu Tanaka, Hideki Iwamoto, Toru Nakamura, Michio Sata, Hironori Koga, Akihiko Yoshimura & Takuji Torimura. (2017) STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury. World Journal of Gastroenterology 23:37, pages 6833-6844.
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Dhan V Kalvakolanu. (2017) Twenty five years of Cytokine: on a forward path to exciting discoveries of pathological mechanisms and therapeutics. Cytokine 98, pages 1-3.
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Gabor J. Szebeni, Csaba Vizler, Klara Kitajka & Laszlo G. Puskas. (2017) Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. Mediators of Inflammation 2017, pages 1-13.
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Meirong Huo, Yan Zhao, Andrew Benson Satterlee, Yuhua Wang, Ying Xu & Leaf Huang. (2017) Tumor-targeted delivery of sunitinib base enhances vaccine therapy for advanced melanoma by remodeling the tumor microenvironment. Journal of Controlled Release 245, pages 81-94.
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Athalia Rachel Pyzer, Leandra Cole, Jacalyn Rosenblatt & David E Avigan. (2016) Myeloid-derived suppressor cells as effectors of immune suppression in cancer. International Journal of Cancer 139:9, pages 1915-1926.
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Joella Xu, Guannan Huang & Tai Guo. (2016) Developmental Bisphenol A Exposure Modulates Immune-Related Diseases. Toxics 4:4, pages 23.
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Zilma Escobar, Anders Bjartell, Giacomo Canesin, Susan Evans-Axelsson, Olov Sterner, Rebecka Hellsten & Martin H Johansson. (2016) Preclinical Characterization of 3β-( N -Acetyl l -cysteine methyl ester)-2aβ,3-dihydrogaliellalactone (GPA512), a Prodrug of a Direct STAT3 Inhibitor for the Treatment of Prostate Cancer . Journal of Medicinal Chemistry 59:10, pages 4551-4562.
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Heiko M?hl. (2016) STAT3, a Key Parameter of Cytokine-Driven Tissue Protection during Sterile Inflammation ? the Case of Experimental Acetaminophen (Paracetamol)-Induced Liver Damage. Frontiers in Immunology 7.
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