Citations (54)
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Michael J. Knight, Léontine Floret, Nisha Patel, John O’Hara & Elizabeth Rodriguez. (2022) The impact of forced degradation conditions on mAb dimer formation and subsequent influence on aggregation propensity. mAbs 14:1.
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Yue Sun, Alberto Estevez, Tilman Schlothauer & Aaron T. Wecksler. (2020) Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity. mAbs 12:1.
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G. Rouby, N. T. Tran, Y. Leblanc, M. Taverna & N. Bihoreau. (2020) Investigation of monoclonal antibody dimers in a final formulated drug by separation techniques coupled to native mass spectrometry. mAbs 12:1.
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Patanachai Limpikirati, John E. Hale, Mark Hazelbaker, Yongbo Huang, Zhiguang Jia, Mahdieh Yazdani, Eric M. Graban, Robert C. Vaughan & Richard W. Vachet. (2019) Covalent labeling and mass spectrometry reveal subtle higher order structural changes for antibody therapeutics. mAbs 11:3, pages 463-476.
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Dan Boyd, Arpa Ebrahimi, Sarah Ronan, Brian Mickus, Matthew Schenauer, Jenny Wang, Darren Brown & Alexandre Ambrogelly. (2018) Isolation and characterization of a monoclonal antibody containing an extra heavy-light chain Fab arm. mAbs 10:3, pages 346-353.
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Lucy Yan Pan, Oscar Salas-Solano & John F. Valliere-Douglass. (2017) Localized conformational interrogation of antibody and antibody-drug conjugates by site-specific carboxyl group footprinting. mAbs 9:2, pages 307-318.
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Friederike Plath, Philippe Ringler, Alexandra Graff-Meyer, Henning Stahlberg, Matthias E. Lauer, Arne C. Rufer, Melissa A. Graewert, Dmitri Svergun, Gerald Gellermann, Christof Finkler, Jan O. Stracke, Atanas Koulov & Volker Schnaible. (2016) Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs. mAbs 8:5, pages 928-940.
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Sayan Gupta, Rich Celestre, Jun Feng & Corie Ralston. (2016) Advancements and Application of Microsecond Synchrotron X-ray Footprinting at the Advanced Light Source. Synchrotron Radiation News 29:1, pages 39-44.
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Jayant Arora, John M Hickey, Ranajoy Majumdar, Reza Esfandiary, Steven M Bishop, Hardeep S Samra, C Russell Middaugh, David D Weis & David B Volkin. (2015) Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody. mAbs 7:3, pages 525-539.
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Parminder Kaur, Sara E Tomechko, Janna Kiselar, Wuxian Shi, Galahad Deperalta, Aaron T Wecksler, Giridharan Gokulrangan, Victor Ling & Mark R Chance. (2015) Characterizing monoclonal antibody structure by carboxyl group footprinting. mAbs 7:3, pages 540-552.
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Parminder Kaur, Sara Tomechko, Janna Kiselar, Wuxian Shi, Galahad Deperalta, Aaron T Wecksler, Giridharan Gokulrangan, Victor Ling & Mark R Chance. (2014) Characterizing monoclonal antibody structure by carbodiimide/GEE footprinting. mAbs 6:6, pages 1486-1499.
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R. Jeremy Woods, Michael Hongwei Xie, Thomas Spreter Von Kreudenstein, Gordon Y. Ng & Surjit B. Dixit. (2013) LC-MS characterization and purity assessment of a prototype bispecific antibody. mAbs 5:5, pages 711-722.
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Articles from other publishers (42)
Corie Y. Ralston & Joshua S. Sharp. (2022) Structural Investigation of Therapeutic Antibodies Using Hydroxyl Radical Protein Footprinting Methods. Antibodies 11:4, pages 71.
Crossref
Crossref
Catherine Y. Tremblay, Zachary J. Kirsch & Richard W. Vachet. (2022) Complementary Structural Information for Antibody–Antigen Complexes from Hydrogen–Deuterium Exchange and Covalent Labeling Mass Spectrometry. Journal of the American Society for Mass Spectrometry 33:7, pages 1303-1314.
Crossref
Crossref
Xiao Pan & Richard W. Vachet. (2020) MEMBRANE PROTEIN STRUCTURES AND INTERACTIONS FROM COVALENT LABELING COUPLED WITH MASS SPECTROMETRY. Mass Spectrometry Reviews 41:1, pages 51-69.
Crossref
Crossref
M. Degterev, M. Smolov & R. Shukurov. (2021) Improvement of the Degradation Profiling of Eculizumab and Omalizumab Monoclonal Antibodies by Liquid Chromatography–Mass Spectrometry. Journal of Analytical Chemistry 76:14, pages 1596-1609.
Crossref
Crossref
Yuetian Yan, Tao Xing, Anita P. Liu, Zhengqi Zhang, Shunhai Wang & Ning Li. (2021) Post-Column Denaturation-Assisted Native Size-Exclusion Chromatography–Mass Spectrometry for Rapid and In-Depth Characterization of High Molecular Weight Variants in Therapeutic Monoclonal Antibodies. Journal of the American Society for Mass Spectrometry 32:12, pages 2885-2894.
Crossref
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Rohit Jain, Donald Abel, Maksim Rakitin, Michael Sullivan, David T. Lodowski, Mark R. Chance & Erik R. Farquhar. (2021) New high-throughput endstation to accelerate the experimental optimization pipeline for synchrotron X-ray footprinting. Journal of Synchrotron Radiation 28:5, pages 1321-1332.
Crossref
Crossref
Blaise G. Arden, Xiao Pan, Zachary J. Kirsch & Richard W. Vachet. 2021. Encyclopedia of Biological Chemistry III. Encyclopedia of Biological Chemistry III
742
756
.
Natalie K. Garcia, Alavattam Sreedhara, Galahad Deperalta & Aaron T. Wecksler. (2020) Optimizing Hydroxyl Radical Footprinting Analysis of Biotherapeutics Using Internal Standard Dosimetry. Journal of the American Society for Mass Spectrometry 31:7, pages 1563-1571.
Crossref
Crossref
Patanachai K. Limpikirati, Bo Zhao, Xiao Pan, Stephen J. Eyles & Richard W. Vachet. (2020) Covalent Labeling/Mass Spectrometry of Monoclonal Antibodies with Diethylpyrocarbonate: Reaction Kinetics for Ensuring Protein Structural Integrity. Journal of the American Society for Mass Spectrometry 31:6, pages 1223-1232.
Crossref
Crossref
Xiao Pan, Patanachai Limpikirati, Huan Chen, Tianying Liu & Richard W. Vachet. (2020) Higher-Order Structure Influences the Kinetics of Diethylpyrocarbonate Covalent Labeling of Proteins. Journal of the American Society for Mass Spectrometry 31:3, pages 658-665.
Crossref
Crossref
Sayan Gupta, Yan Chen, Christopher J. Petzold, Daniel P. DePonte & Corie Y. Ralston. (2019) Development of Container Free Sample Exposure for Synchrotron X-ray Footprinting. Analytical Chemistry 92:1, pages 1565-1573.
Crossref
Crossref
Mengyuan XuJanna KiselarTawna L. WhitedWilnelly Hernandez-SanchezDerek J. Taylor. (2019) POT1-TPP1 differentially regulates telomerase via POT1 His266 and as a function of single-stranded telomere DNA length. Proceedings of the National Academy of Sciences 116:47, pages 23527-23533.
Crossref
Crossref
Hannah R. Doss, Mathura Raman, Ryan Knihtila, Naresh Chennamsetty, David Wang, Alan Shupe & Nesredin Mussa. (2019) Streamlining the polishing step development process via physicochemical characterization of monoclonal antibody aggregates. Journal of Chromatography A 1598, pages 101-112.
Crossref
Crossref
Patanachai Limpikirati, Xiao Pan & Richard W. Vachet. (2019) Covalent Labeling with Diethylpyrocarbonate: Sensitive to the Residue Microenvironment, Providing Improved Analysis of Protein Higher Order Structure by Mass Spectrometry. Analytical Chemistry 91:13, pages 8516-8523.
Crossref
Crossref
Natalie K. Garcia, Galahad Deperalta & Aaron T. Wecksler. (2019) Current Trends in Biotherapeutic Higher Order Structure Characterization by Irreversible Covalent Footprinting Mass Spectrometry. Protein & Peptide Letters 26:1, pages 35-43.
Crossref
Crossref
Simon A. Morton, Sayan Gupta, Christopher J. Petzold & Corie Y. Ralston. (2019) Recent Advances in X-Ray Hydroxyl Radical Footprinting at the Advanced Light Source Synchrotron. Protein & Peptide Letters 26:1, pages 70-75.
Crossref
Crossref
Jen Bohon. (2019) Development of Synchrotron Footprinting at NSLS and NSLS-II. Protein & Peptide Letters 26:1, pages 55-60.
Crossref
Crossref
Jun Zhang, Christopher Woods, Feng He, Mei Han, Michael J. Treuheit & David B. Volkin. (2018) Structural Changes and Aggregation Mechanisms of Two Different Dimers of an IgG2 Monoclonal Antibody. Biochemistry 57:37, pages 5466-5479.
Crossref
Crossref
Devrishi Goswami, Jun Zhang, Pavel V. Bondarenko & Zhongqi Zhang. (2018) MS-based conformation analysis of recombinant proteins in design, optimization and development of biopharmaceuticals. Methods 144, pages 134-151.
Crossref
Crossref
Patanachai Limpikirati, Tianying Liu & Richard W. Vachet. (2018) Covalent labeling-mass spectrometry with non-specific reagents for studying protein structure and interactions. Methods 144, pages 79-93.
Crossref
Crossref
Rupesh Bommana, Qing Chai, Christian Schöneich, William F. WeissIVIV & Ranajoy Majumdar. (2018) Understanding the Increased Aggregation Propensity of a Light-Exposed IgG1 Monoclonal Antibody Using Hydrogen Exchange Mass Spectrometry, Biophysical Characterization, and Structural Analysis. Journal of Pharmaceutical Sciences 107:6, pages 1498-1511.
Crossref
Crossref
Janna KiselarMark R. Chance. (2018) High-Resolution Hydroxyl Radical Protein Footprinting: Biophysics Tool for Drug Discovery. Annual Review of Biophysics 47:1, pages 315-333.
Crossref
Crossref
A. Baud, L. Aymé, F. Gonnet, I. Salard, Y. Gohon, P. Jolivet, K. Brodolin, P. Da Silva, A. Giuliani, B. Sclavi, T. Chardot, P. Mercère, P. Roblin & R. Daniel. (2017) SOLEIL shining on the solution-state structure of biomacromolecules by synchrotron X-ray footprinting at the Metrology beamline. Journal of Synchrotron Radiation 24:3, pages 576-585.
Crossref
Crossref
Liwen Wang & Mark R. Chance. (2017) Protein Footprinting Comes of Age: Mass Spectrometry for Biophysical Structure Assessment. Molecular & Cellular Proteomics 16:5, pages 706-716.
Crossref
Crossref
Sin-Yi Jhan, Li-Juan Huang, Tzu-Fan Wang, Ho-Hsuan Chou & Shu-Hui Chen. (2017) Dimethyl Labeling Coupled with Mass Spectrometry for Topographical Characterization of Primary Amines on Monoclonal Antibodies. Analytical Chemistry 89:7, pages 4255-4263.
Crossref
Crossref
Deqiang Yu, Yuanli Song, Richard Y.-C. Huang, Ryan K. Swanson, Zhijun Tan, Elizabeth Schutsky, Angela Lewandowski, Guodong Chen & Zheng Jian Li. (2016) Molecular perspective of antibody aggregates and their adsorption on Protein A resin. Journal of Chromatography A 1457, pages 66-75.
Crossref
Crossref
Ying Zhang, Weidong Cui, Aaron T. Wecksler, Hao Zhang, Patricia Molina, Galahad Deperalta & Michael L. Gross. (2016) Native MS and ECD Characterization of a Fab–Antigen Complex May Facilitate Crystallization for X-ray Diffraction. Journal of the American Society for Mass Spectrometry 27:7, pages 1139-1142.
Crossref
Crossref
Olivier Mozziconacci, Jayant Arora, Ronald T. TothIVIV, Sangeeta B. Joshi, Shuxia Zhou, David B. Volkin & Christian Schöneich. (2016) Site-Specific Hydrolysis Reaction C-Terminal of Methionine in Met-His during Metal-Catalyzed Oxidation of IgG-1. Molecular Pharmaceutics 13:4, pages 1317-1328.
Crossref
Crossref
Laura R. Stingaciu, Oxana Ivanova, Michael Ohl, Ralf Biehl & Dieter Richter. (2016) Fast antibody fragment motion: flexible linkers act as entropic spring. Scientific Reports 6:1.
Crossref
Crossref
James A. Madsen, Yan Yin, Jing Qiao, Vanessa Gill, Kutralanathan Renganathan, Wing-Yee Fu, Stephen Smith & James Anderson. (2016) Covalent Labeling Denaturation Mass Spectrometry for Sensitive Localized Higher Order Structure Comparisons. Analytical Chemistry 88:4, pages 2478-2488.
Crossref
Crossref
Szabolcs Fekete, Davy Guillarme, Pat Sandra & Koen Sandra. (2015) Chromatographic, Electrophoretic, and Mass Spectrometric Methods for the Analytical Characterization of Protein Biopharmaceuticals. Analytical Chemistry 88:1, pages 480-507.
Crossref
Crossref
Jonathan Sjögren, Fredrik Olsson & Alain Beck. (2016) Rapid and improved characterization of therapeutic antibodies and antibody related products using IdeS digestion and subunit analysis. The Analyst 141:11, pages 3114-3125.
Crossref
Crossref
Aaron T. Wecksler, Matt S. Kalo & Galahad Deperalta. (2015) Mapping of Fab-1:VEGF Interface Using Carboxyl Group Footprinting Mass Spectrometry. Journal of the American Society for Mass Spectrometry 26:12, pages 2077-2080.
Crossref
Crossref
Nicholas B. Borotto, Yuping Zhou, Stephen R. Hollingsworth, John E. Hale, Eric M. Graban, Robert C. Vaughan & Richard W. Vachet. (2015) Investigating Therapeutic Protein Structure with Diethylpyrocarbonate Labeling and Mass Spectrometry. Analytical Chemistry 87:20, pages 10627-10634.
Crossref
Crossref
Violette Gautier, Anja J. Boumeester, Philip Lössl & Albert J. R. Heck. (2015) Lysine conjugation properties in human IgGs studied by integrating high‐resolution native mass spectrometry and bottom‐up proteomics. PROTEOMICS 15:16, pages 2756-2765.
Crossref
Crossref
Parminder Kaur, Janna Kiselar, Wuxian Shi, Sichun Yang & Mark R. Chance. 2015. State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 3. Defining the Next Generation of Analytical and Biophysical Techniques. State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 3. Defining the Next Generation of Analytical and Biophysical Techniques
45
73
.
David A. Michels, Anna Y. Ip, Thomas M. Dillon, Kurt Brorson, Scott Lute, Brittany Chavez, Ken M. Prentice, Lowell J. Brady & Karen J. Miller. 2015. State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 2. Biopharmaceutical Characterization: The NISTmAb Case Study. State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 2. Biopharmaceutical Characterization: The NISTmAb Case Study
237
284
.
Mauro Lapelosa, Thomas W. Patapoff & Isidro E. Zarraga. (2014) Molecular Simulations of the Pairwise Interaction of Monoclonal Antibodies. The Journal of Physical Chemistry B 118:46, pages 13132-13141.
Crossref
Crossref
Sayan Gupta, Richard Celestre, Christopher J. Petzold, Mark R. Chance & Corie Ralston. (2014) Development of a microsecond X-ray protein footprinting facility at the Advanced Light Source. Journal of Synchrotron Radiation 21:4, pages 690-699.
Crossref
Crossref
Chris A Singleton. (2014) MS in the analysis of biosimilars. Bioanalysis 6:12, pages 1627-1637.
Crossref
Crossref
Max T. Bourdillon, Benjamin A. Ford, Ashley T. Knulty, Colleen N. Gray, Miao Zhang, David A. Ford & Ryan D. McCulla. (2014) Oxidation of Plasmalogen, Low-Density Lipoprotein and RAW 264.7 Cells by Photoactivatable Atomic Oxygen Precursors. Photochemistry and Photobiology 90:2, pages 386-393.
Crossref
Crossref
Hao Zhang, Weidong Cui & Michael L. Gross. (2014) Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies. FEBS Letters 588:2, pages 308-317.
Crossref
Crossref