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Original Research

CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses

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Article: e26859 | Received 27 Jul 2013, Accepted 17 Oct 2013, Published online: 11 Nov 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Kang Yi Lee, Hiu Yi Wong, Qun Zeng, Jia Le Lin, Man Si Cheng, Chik Hong Kuick, Kenneth Tou En Chang, Amos Hong Pheng Loh & Herbert Schwarz. (2021) Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting. OncoImmunology 10:1.
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Bhushan Dharmadhikari, Meihui Wu, Nur Sharalyn Abdullah, Sakthi Rajendran, Nur Diana Ishak, Emily Nickles, Zulkarnain Harfuddin & Herbert Schwarz. (2016) CD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses. OncoImmunology 5:4.
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Qianqiao Tang, Dongsheng Jiang, Zulkarnain Harfuddin, Kin Cheng, Mei Chung Moh & Herbert Schwarz. (2014) Regulation of Myelopoiesis by CD137L Signaling. International Reviews of Immunology 33:6, pages 454-469.
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An Coosemans, Sandra Tuyaerts, Anke Vanderstraeten, Ignace Vergote, Frédéric Amant & Stefaan W Van Gool. (2014) Dendritic cell immunotherapy in uterine cancer. Human Vaccines & Immunotherapeutics 10:7, pages 1822-1827.
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Articles from other publishers (20)

Shahram Salek-Ardakani, Dirk M. Zajonc & Michael Croft. (2023) Agonism of 4-1BB for immune therapy: a perspective on possibilities and complications. Frontiers in Immunology 14.
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Emily Nickles, Runze Xia, Rui Sun & Herbert Schwarz. 2023.
Jiao Wu & Yunpeng Wang. (2022) Role of TNFSF9 bidirectional signal transduction in antitumor immunotherapy. European Journal of Pharmacology 928, pages 175097.
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Emily Nickles, Bhushan Dharmadhikari, Li Yating, Robert J. Walsh, Liang Piu Koh, Michelle Poon, Lip Kun Tan, Ling-Zhi Wang, Yvonne Ang, Yugarajah Asokumaran, Wan Qin Chong, Yiqing Huang, Kwok Seng Loh, Joshua Tay, Ross Soo, Mickey Koh, Liam Pock Ho, Marieta Chan, Madelaine Niam, Melissa Soh, Yen Hoon Luah, Chwee Ming Lim, Nivashini Kaliaperumal, Veonice B. Au, Najwa Binte Said Nasir Talib, Reina Sng, John E. Connolly, Boon Cher Goh & Herbert Schwarz. (2021) Dendritic cell therapy with CD137L-DC-EBV-VAX in locally recurrent or metastatic nasopharyngeal carcinoma is safe and confers clinical benefit. Cancer Immunology, Immunotherapy 71:6, pages 1531-1543.
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Jiage Ding, Nan Jiang, Yanyan Zheng, Jiawei Wang, Lin Fang, Huizhong Li, Jie Yang, Ankang Hu, Pengli Xiao, Qing Zhang, Dafei Chai, Junnian Zheng & Gang Wang. (2022) Adenovirus vaccine therapy with CD137L promotes CD8+ DCs-mediated multifunctional CD8+ T cell immunity and elicits potent anti-tumor activity. Pharmacological Research 175, pages 106034.
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Patrick Innamarato, Sarah Asby, Jennifer Morse, Amy Mackay, MacLean Hall, Scott Kidd, Luz Nagle, Amod A. Sarnaik & Shari Pilon-Thomas. (2020) Intratumoral Activation of 41BB Costimulatory Signals Enhances CD8 T Cell Expansion and Modulates Tumor-Infiltrating Myeloid Cells. The Journal of Immunology 205:10, pages 2893-2904.
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Qun Zeng, Ye Mon Soe, Yanting Lim, Radoslaw M. Sobota & Herbert Schwarz. (2020) CD137 ligand interacts with CD32a to trigger reverse CD137 ligand signaling. Cellular & Molecular Immunology 17:11, pages 1188-1189.
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Meihui Wu, Hiu Yi Wong, Jia Le Lin, Annalena Moliner & Herbert Schwarz. (2019) Induction of CD137 expression by viral genes reduces T cell costimulation. Journal of Cellular Physiology 234:11, pages 21076-21088.
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Qun Zeng, Yubin Zhou & Herbert Schwarz. (2019) CD137L-DCs, Potent Immune-Stimulators—History, Characteristics, and Perspectives. Frontiers in Immunology 10.
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Anselm Mak & Herbert Schwarz. (2019) The Progress of Investigating the CD137-CD137L Axis as a Potential Target for Systemic Lupus Erythematosus. Cells 8:9, pages 1044.
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Mohammed F. Alosaimi, Manfred Hoenig, Faris Jaber, Craig D. Platt, Jennifer Jones, Jacqueline Wallace, Klaus-Michael Debatin, Ansgar Schulz, Eva Jacobsen, Peter Möller, Hanan E. Shamseldin, Ferdous Abdulwahab, Niema Ibrahim, Hosam Alardati, Faisal Almuhizi, Ibraheem F. Abosoudah, Talal A. Basha, Janet Chou, Fowzan S. Alkuraya & Raif S. Geha. (2019) Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency. Journal of Allergy and Clinical Immunology 144:2, pages 574-583.e5.
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Qun Zeng, Karthik Mallilankaraman & Herbert Schwarz. (2019) Increased Akt-Driven Glycolysis Is the Basis for the Higher Potency of CD137L-DCs. Frontiers in Immunology 10.
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Bhushan Dharmadhikari, Emily Nickles, Zulkarnain Harfuddin, Nur Diana Binte Ishak, Qun Zeng, Antonio Bertoletti & Herbert Schwarz. (2018) CD137L dendritic cells induce potent response against cancer-associated viruses and polarize human CD8+ T cells to Tc1 phenotype. Cancer Immunology, Immunotherapy 67:6, pages 893-905.
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Xiaobo Wang, Ligong Chen, Wanzhe Yuan, Yanqin Li, Limin Li, Tanqing Li, Huanrong Li & Qinye Song. (2017) Effect of porcine circovirus type 2 (PCV2) on the function of splenic CD11c+ dendritic cells in mice. Archives of Virology 162:5, pages 1289-1298.
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Jeremy D. Waight, Randi B. Gombos & Nicholas S. Wilson. (2017) Harnessing co-stimulatory TNF receptors for cancer immunotherapy: Current approaches and future opportunities. Human Antibodies 25:3-4, pages 87-109.
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Zulkarnain Harfuddin, Bhushan Dharmadhikari, Siew Cheng Wong, Kaibo Duan, Michael Poidinger, Shaqireen Kwajah & Herbert Schwarz. (2016) Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype. Scientific Reports 6:1.
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Zhe Shao, Zulkarnain Harfuddin, Wan Lu Pang, Emily Nickles, Liang Kai Koh & Herbert Schwarz. (2015) Trogocytic CD137 transfer causes an internalization of CD137 ligand on murine APCs leading to reduced T cell costimulation. Journal of Leukocyte Biology 97:5, pages 909-919.
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T. W. H. Flinsenberg, L. Spel, M. Jansen, D. Koning, C. de Haar, M. Plantinga, R. Scholman, M. M. van Loenen, S. Nierkens, L. Boon, D. van Baarle, M. H. M. Heemskerk, J. J. Boelens & M. Boes. (2015) Cognate CD4 T-Cell Licensing of Dendritic Cells Heralds Anti-Cytomegalovirus CD8 T-Cell Immunity after Human Allogeneic Umbilical Cord Blood Transplantation. Journal of Virology 89:2, pages 1058-1069.
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Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo, Lisa Coussens, Madhav V. Dhodapkar, Alexander M. Eggermont, Douglas T. Fearon, Wolf H. Fridman, Jitka Fučíková, Dmitry I. Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M. Kirkwood, Eva Klein, Alexander Knuth, Claire E. Lewis, Roland Liblau, Michael T. Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J. Melief, Elizabeth A. Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E. Peter, Kenneth J. Pienta, Angel Porgador, George C. Prendergast, Gabriel A. Rabinovich, Nicholas P. Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J. Smyth, Daniel E. Speiser, Radek Spisek, Pramod K. Srivastava, James E. Talmadge, Eric Tartour, Sjoerd H. Van Der Burg, Benoît J. Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S. Weber, Theresa L. Whiteside, Jedd D. Wolchok, Laurence Zitvogel, Weiping Zou & Guido Kroemer. (2014) Classification of current anticancer immunotherapies. Oncotarget 5:24, pages 12472-12508.
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Qianwen Shang, Zhaojing Dong, Chunmei Liu, Yang Bai, Chun Guo, Lining Zhang & Qun Wang. (2014) Differential effects of agonistic 4-1BB (CD137) monoclonal antibody on the maturation and functions of hypoxic dendritic cells. International Immunopharmacology 23:2, pages 609-616.
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