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Review

α-Cleavage of cellular prion protein

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Pages 453-460 | Published online: 10 Oct 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Niall Mungo Pollock, Patricia Leighton, Gavin Neil & W. Ted Allison. (2021) Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein. Prion 15:1, pages 70-81.
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Santra Brenna, Hermann C. Altmeppen, Behnam Mohammadi, Björn Rissiek, Florence Schlink, Peter Ludewig, Christoph Krisp, Hartmut Schlüter, Antonio Virgilio Failla, Carola Schneider, Markus Glatzel, Berta Puig & Tim Magnus. (2020) Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake. Journal of Extracellular Vesicles 9:1.
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Katrin Thüne, Matthias Schmitz, Anna Villar-Piqué, Hermann Clemens Altmeppen, Markus Schlomm, Saima Zafar, Markus Glatzel, Franc Llorens & Inga Zerr. (2019) The cellular prion protein and its derived fragments in human prion diseases and their role as potential biomarkers. Expert Review of Molecular Diagnostics 19:11, pages 1007-1018.
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Atsushi Okamoto, Nao Hosoda & Shin-ichi Hoshino. (2018) Proteolysis: a double-edged sword for the development of amyloidoses. Prion 12:5-6, pages 273-279.
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Tae-Young Suh, In Soon Roh, Hyo-Jin Kim, Peter C. Griffiths, Kyung Je Park, Hoo Chang Park, James Hope, Hae Eun Kang, Dae-Yong Kim & Hyun Joo Sohn. (2017) Biological and biochemical characterization of M2B cells: Classical BSE prion is conserved in transgenic mice overexpressing bovine prion protein gene. Prion 11:6, pages 405-414.
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Nathalie Daude, Hristina Gapeshina, Bin Dong, Ian Winship & David Westaway. (2015) Neuroprotective properties of the PrP-like Shadoo glycoprotein assessed in the middle cerebral artery occlusion model of ischemia. Prion 9:5, pages 376-393.
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Markus Glatzel, Luise Linsenmeier, Frank Dohler, Susanne Krasemann, Berta Puig & Hermann C Altmeppen. (2015) Shedding light on prion disease. Prion 9:4, pages 244-256.
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Federico Benetti & Giuseppe Legname. (2015) New insights into structural determinants of prion protein folding and stability. Prion 9:2, pages 119-124.
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Berta Puig, Hermann Altmeppen & Markus Glatzel. (2014) The GPI-anchoring of PrP. Prion 8:1, pages 11-18.
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Articles from other publishers (41)

Maciej Gielnik, Aneta Szymańska, Xiaolin Dong, Jüri Jarvet, Željko M. Svedružić, Astrid Gräslund, Maciej Kozak & Sebastian K. T. S. Wärmländer. (2023) Prion Protein Octarepeat Domain Forms Transient β-Sheet Structures upon Residue-Specific Binding to Cu(II) and Zn(II) Ions. Biochemistry 62:11, pages 1689-1705.
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Behnam Mohammadi, Feizhi Song, Andreu Matamoros-Angles, Mohsin Shafiq, Markus Damme, Berta Puig, Markus Glatzel & Hermann Clemens Altmeppen. (2022) Anchorless risk or released benefit? An updated view on the ADAM10-mediated shedding of the prion protein. Cell and Tissue Research 392:1, pages 215-234.
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Ilaria Vanni, Floriana Iacobone, Claudia D’Agostino, Matteo Giovannelli, Laura Pirisinu, Hermann Clemens Altmeppen, Joaquin Castilla, Juan Maria Torres, Umberto Agrimi & Romolo Nonno. (2023) An optimized Western blot assay provides a comprehensive assessment of the physiological endoproteolytic processing of the prion protein. Journal of Biological Chemistry 299:2, pages 102823.
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Yanahi Posadas, Víctor E. López-Guerrero, Trinidad Arcos-López, Richard I. Sayler, Carolina Sánchez-López, José Segovia, Claudia Perez-Cruz & Liliana Quintanar. 2023. Comprehensive Inorganic Chemistry III. Comprehensive Inorganic Chemistry III 575 628 .
Manuel Camacho & Qingzhong Kong. 2023. Prions and Diseases. Prions and Diseases 745 755 .
Yejin Shin, Kang-Sug Jo, Minseok Shin, Duri Lee, Hyejin Yeo, Youngsup Song & Sang-Wook Kang. (2022) Role of redox-sensitive catalytic interaction with ADAM10 in mutant-selective extracellular shedding of prion protein. Redox Biology 56, pages 102456.
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Nathalie Daude, Agnes Lau, Ilaria Vanni, Sang-Gyun Kang, Andrew R. Castle, Serene Wohlgemuth, Lyudmyla Dorosh, Holger Wille, Maria Stepanova & David Westaway. (2022) Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high–molecular weight complexes. Journal of Biological Chemistry 298:4, pages 101770.
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Carolina Sánchez-López & Liliana Quintanar. (2022) β-cleavage of the human prion protein impacts Cu(II) coordination at its non-octarepeat region. Journal of Inorganic Biochemistry 228, pages 111686.
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Doris Loh & Russel J. Reiter. (2022) Melatonin: Regulation of Prion Protein Phase Separation in Cancer Multidrug Resistance. Molecules 27:3, pages 705.
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Jiunn-Jye Sheu, Han-Tan Chai, John Y. Chiang, Pei-Hsun Sung, Yi-Ling Chen & Hon-Kan Yip. (2022) Cellular Prion Protein Is Essential for Myocardial Regeneration but Not the Recovery of Left Ventricular Function from Apical Ballooning. Biomedicines 10:1, pages 167.
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Aishwarya Agarwal & Samrat Mukhopadhyay. (2022) Prion Protein Biology Through the Lens of Liquid-Liquid Phase Separation. Journal of Molecular Biology 434:1, pages 167368.
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Jessica D. Panes, Paulina Saavedra, Benjamin Pineda, Kathleen Escobar, Magdalena E. Cuevas, Gustavo Moraga-Cid, Jorge Fuentealba, Coralia I. Rivas, Human Rezaei & Carola Muñoz-Montesino. (2021) PrPC as a Transducer of Physiological and Pathological Signals. Frontiers in Molecular Neuroscience 14.
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Suman Chaudhary, Ajay Ashok, Aaron S. Wise, Neil A. Rana, Alexander E. Kritikos, Ewald Lindner & Neena Singh. (2021) β-Cleavage of the prion protein in the human eye: Implications for the spread of infectious prions and human ocular disorders. Experimental Eye Research 212, pages 108787.
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Hamza Arshad, Zeel Patel, Mohadeseh Mehrabian, Matthew E.C. Bourkas, Zaid A.M. Al-Azzawi, Gerold Schmitt-Ulms & Joel C. Watts. (2021) The aminoglycoside G418 hinders de novo prion infection in cultured cells. Journal of Biological Chemistry 297:3, pages 101073.
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Ramona Gerhards, Lena Kristina Pfeffer, Jessica Lorenz, Laura Starost, Luise Nowack, Franziska S. Thaler, Miriam Schlüter, Heike Rübsamen, Caterina Macrini, Stephan Winklmeier, Simone Mader, Mattias Bronge, Hans Grönlund, Regina Feederle, Hung-En Hsia, Stefan F. Lichtenthaler, Juliane Merl-Pham, Stefanie M. Hauck, Tanja Kuhlmann, Isabel J. Bauer, Eduardo Beltran, Lisa Ann Gerdes, Aleksandra Mezydlo, Amit Bar-Or, Brenda Banwell, Mohsen Khademi, Tomas Olsson, Reinhard Hohlfeld, Hans Lassmann, Tania Kümpfel, Naoto Kawakami & Edgar Meinl. (2020) Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS. Acta Neuropathologica Communications 8:1.
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Berta Puig, Denise Yang, Santra Brenna, Hermann Clemens Altmeppen & Tim Magnus. (2020) Show Me Your Friends and I Tell You Who You Are: The Many Facets of Prion Protein in Stroke. Cells 9:7, pages 1609.
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Graham P. Roseman, Bei Wu, Mark A. Wadolkowski, David A. Harris & Glenn L. Millhauser. (2020) Intrinsic toxicity of the cellular prion protein is regulated by its conserved central region. The FASEB Journal 34:6, pages 8734-8748.
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Behnam Mohammadi, Luise Linsenmeier, Mohsin Shafiq, Berta Puig, Giovanna Galliciotti, Camilla Giudici, Michael Willem, Thomas Eden, Friedrich Koch-Nolte, Yu-Hsuan Lin, Jörg Tatzelt, Markus Glatzel & Hermann C. Altmeppen. (2020) Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation. Molecular Neurobiology 57:6, pages 2812-2829.
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Yutaka Nakagawa & Shizuo Yamada. (2020) Metal homeostasis disturbances in neurodegenerative disorders, with special emphasis on Creutzfeldt-Jakob disease – Potential pathogenetic mechanism and therapeutic implications. Pharmacology & Therapeutics 207, pages 107455.
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Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S. Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, Jörg Tatzelt, Paul Saftig, Markus Glatzel & Hermann C. Altmeppen. (2018) Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein. Molecular Neurodegeneration 13:1.
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Carolina Sánchez-López, Lina Rivillas-Acevedo, Octavio Cruz-Vásquez & Liliana Quintanar. (2018) Methionine 109 plays a key role in Cu(II) binding to His111 in the 92–115 fragment of the human prion protein. Inorganica Chimica Acta 481, pages 87-97.
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Jun Hee Lee, Chul Won Yun & Sang Hun Lee. (2018) Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway. Biomolecules & Therapeutics 26:3, pages 313-321.
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Xiao-meng Shi, Hua Zhang, Zhang-jiuzhi Zhou, Ying-ying Ruan, Jie Pang, Lu Zhang, Wei Zhai & Yan-li Hu. (2018) Effects of safflower yellow on beta-amyloid deposition and activation of astrocytes in the brain of APP/PS1 transgenic mice. Biomedicine & Pharmacotherapy 98, pages 553-565.
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Carolina Sánchez-López, Claudio O. Fernández & Liliana Quintanar. (2018) Neuroprotective alpha-cleavage of the human prion protein significantly impacts Cu( ii ) coordination at its His111 site . Dalton Transactions 47:28, pages 9274-9282.
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Wilfred Goldmann. 2018. Human Prion Diseases. Human Prion Diseases 111 120 .
Luise Linsenmeier, Hermann C. Altmeppen, Sebastian Wetzel, Behnam Mohammadi, Paul Saftig & Markus Glatzel. (2017) Diverse functions of the prion protein – Does proteolytic processing hold the key?. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:11, pages 2128-2137.
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Keiji Uchiyama, Mitsuru Tomita, Masashi Yano, Junji Chida, Hideyuki Hara, Nandita Rani Das, Anders Nykjaer & Suehiro Sakaguchi. (2017) Prions amplify through degradation of the VPS10P sorting receptor sortilin. PLOS Pathogens 13:6, pages e1006470.
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Ádám Annus, Anett Csáti & László Vécsei. (2016) Prion diseases: New considerations. Clinical Neurology and Neurosurgery 150, pages 125-132.
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Alexander Arkhipenko, Sylvie Syan, Guiliana Soraya Victoria, Stéphanie Lebreton & Chiara Zurzolo. (2016) PrPC Undergoes Basal to Apical Transcytosis in Polarized Epithelial MDCK Cells. PLOS ONE 11:7, pages e0157991.
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Pawel Stocki, Maxime Sawicki, Charles E. Mays, Seo Jung Hong, Daniel C. Chapman, David Westaway & David B. Williams. (2016) Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein. Molecular Biology of the Cell 27:5, pages 757-767.
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Yanuar Alan Sulistio & Klaus Heese. (2015) The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer’s Disease. Molecular Neurobiology 53:2, pages 905-931.
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Baiya Li. (2016) The pathogenesis of soluble PrP fragments containing Aβ binding sites. Virus Research 211, pages 194-198.
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Elizaveta Katorcha, Nina Klimova, Natallia Makarava, Regina Savtchenko, Xuefang Pan, Ida Annunziata, Kohta Takahashi, Taeko Miyagi, Alexey V. Pshezhetsky, Alessandra d’Azzo & Ilia V. Baskakov. (2015) Loss of Cellular Sialidases Does Not Affect the Sialylation Status of the Prion Protein but Increases the Amounts of Its Proteolytic Fragment C1. PLOS ONE 10:11, pages e0143218.
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Jiapu ZhangJiapu Zhang. 2015. Molecular Structures and Structural Dynamics of Prion Proteins and Prions. Molecular Structures and Structural Dynamics of Prion Proteins and Prions 143 166 .
Federico Benetti, Xevi Biarnés, Francesco Attanasio, Gabriele Giachin, Enrico Rizzarelli & Giuseppe Legname. (2014) Structural Determinants in Prion Protein Folding and Stability. Journal of Molecular Biology 426:22, pages 3796-3810.
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Francois-Xavier Theillet, Andres Binolfi, Tamara Frembgen-Kesner, Karan Hingorani, Mohona Sarkar, Ciara Kyne, Conggang Li, Peter B. Crowley, Lila Gierasch, Gary J. Pielak, Adrian H. Elcock, Anne Gershenson & Philipp Selenko. (2014) Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs). Chemical Reviews 114:13, pages 6661-6714.
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Maxime Béland, Mikaël Bédard, Guillaume Tremblay, Pierre Lavigne & Xavier Roucou. (2014) Aβ induces its own prion protein N-terminal fragment (PrPN1)–mediated neutralization in amorphous aggregates. Neurobiology of Aging 35:7, pages 1537-1548.
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Charles E. Mays, Janaky Coomaraswamy, Joel C. Watts, Jing Yang, Kerry W.S. Ko, Bob Strome, Robert C.C. Mercer, Serene L. Wohlgemuth, Gerold Schmitt-Ulms & David Westaway. (2014) Endoproteolytic processing of the mammalian prion glycoprotein family. FEBS Journal 281:3, pages 862-876.
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Gaetano Malgieri & Giuseppe Grasso. (2014) The clearance of misfolded proteins in neurodegenerative diseases by zinc metalloproteases: An inorganic perspective. Coordination Chemistry Reviews 260, pages 139-155.
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Ann LiebertBrian BicknellRoger Adams. (2014) Prion Protein Signaling in the Nervous System—A Review and Perspective. Signal Transduction Insights 3, pages STI.S12319.
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Hermann C. Altmeppen, Johannes Prox, Berta Puig, Frank Dohler, Clemens Falker, Susanne Krasemann & Markus Glatzel. (2013) Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration. FEBS Journal 280:18, pages 4338-4347.
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