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Volume 33, Issue 8

Expert Opinion on Investigational Drugs

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Expert Opinion on Investigational Drugs, Volume 33, Issue 8 (2024)

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Expert Opinion on Investigational Drugs, Volume 33, Issue 8 (2024)

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Volume 33, 2024 Vol 32, 2023 Vol 31, 2022 Vol 30, 2021 Vol 29, 2020 Vol 28, 2019 Vol 27, 2018 Vol 26, 2017 Vol 25, 2016 Vol 24, 2015 Vol 23, 2014 Vol 22, 2013 Vol 21, 2012 Vol 20, 2011 Vol 19, 2010 Vol 18, 2009 Vol 17, 2008 Vol 16, 2007 Vol 15, 2006 Vol 14, 2005 Vol 13, 2004 Vol 12, 2003 Vol 11, 2002 Vol 10, 2001 Vol 9, 2000 Vol 8, 1999 Vol 7, 1998 Vol 6, 1997 Vol 5, 1996 Vol 4, 1995 Vol 3, 1994

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Editorial

VERVE-101, a CRISPR base-editing therapy designed to permanently inactivate hepatic PCSK9 and reduce LDL-cholesterol

Amanda J. Hooper, Xuan L. Tang & John R. Burnett

Pages: 753-756

Published online: 21 Jun 2024

First Page PreviewforVERVE-101, a CRISPR base-editing therapy designed to permanently inactivate hepatic PCSK9 and reduce LDL-cholesterol | Full Text | References | PDF (167.7 KB) | EPUB

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Review

Review Article

Investigational and emerging gastric inhibitory polypeptide (GIP) receptor-based therapies for the treatment of obesity

Robert H. Gaffey, Afua K. Takyi & Alpana Shukla

Pages: 757-773

Published online: 17 Jul 2024

AbstractforInvestigational and emerging gastric inhibitory polypeptide (GIP) receptor-based therapies for the treatment of obesity | Full Text | References | PDF (459.6 KB) | EPUB

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Review Article

Secondary hyperparathyroidism in chronic kidney disease: pathophysiology, current treatments and investigational drugs

Lorenza Magagnoli, Paola Ciceri & Mario Cozzolino

Pages: 775-789

Published online: 19 Jun 2024

AbstractforSecondary hyperparathyroidism in chronic kidney disease: pathophysiology, current treatments and investigational drugs | Full Text | References | PDF (1.6 MB) | EPUB

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Review Article

New investigational drugs for steroid-refractory acute graft-versus-host disease: a review of the literature

Na Hyun Kim, Mehdi Hamadani & Sameem Abedin

Pages: 791-799

Published online: 09 Jul 2024

AbstractforNew investigational drugs for steroid-refractory acute graft-versus-host disease: a review of the literature | Full Text | References | PDF (1 MB) | EPUB

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Review Article

Monoclonal antibodies targeting interleukins for systemic lupus erythematosus: updates in early clinical drug development

Claudio Cruciani, Mariele Gatto, Luca Iaccarino, Andrea Doria & Margherita Zen

Pages: 801-814

Published online: 09 Jul 2024

AbstractforMonoclonal antibodies targeting interleukins for systemic lupus erythematosus: updates in early clinical drug development | Full Text | References | PDF (1,019.2 KB) | EPUB

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Review Article

Rheumatoid arthritis extra-articular lung disease: new insights on pathogenesis and experimental drugs

Marco Sebastiani, Andreina Manfredi, Stefania Croci, Paola Faverio, Giulia Cassone, Caterina Vacchi, Carlo Salvarani & Fabrizio Luppi

Pages: 815-827

Published online: 05 Jul 2024

AbstractforRheumatoid arthritis extra-articular lung disease: new insights on pathogenesis and experimental drugs | Full Text | References | PDF (404.1 KB) | EPUB

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Review Article

An overview of the safety and efficacy of LX-9211 in treating neuropathic pain conditions

William C. Upshaw, John M. Richey, Gurjot Ravi, Adrian Chen, Shahab Ahmadzadeh, Sahar Shekoohi, Omar Viswanath & Alan D. Kaye

Pages: 829-837

Published online: 08 Jul 2024

AbstractforAn overview of the safety and efficacy of LX-9211 in treating neuropathic pain conditions | Full Text | References | PDF (554.1 KB) | EPUB

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Review Article

Developing targeted therapeutics for hepatocellular carcinoma: a critical assessment of promising phase II agents

Elisabeth Amadeo, Silvia Foti, Silvia Camera, Federico Rossari, Mara Persano, Federica Lo Prinzi, Francesco Vitiello, Andrea Casadei-Gardini & Margherita Rimini

Pages: 839-849

Published online: 22 Jul 2024

AbstractforDeveloping targeted therapeutics for hepatocellular carcinoma: a critical assessment of promising phase II agents | Full Text | References | PDF (2.1 MB) | EPUB

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Review Article

Trastuzumab-deruxtecan in solid tumors with HER2 alterations: from early phase development to the first agnostic approval of an antibody–drug conjugate

Crimini Edoardo & Curigliano Giuseppe

Pages: 851-865

Published online: 09 Jul 2024

AbstractforTrastuzumab-deruxtecan in solid tumors with HER2 alterations: from early phase development to the first agnostic approval of an antibody–drug conjugate | Full Text | References | PDF (2.6 MB) | EPUB

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Open Access

Original Research

Article

Safety, tolerability and pharmacokinetics of ASC10, a novel oral double prodrug of a broad-spectrum antiviral agent, β-d-N4-hydroxycytidine: results from a randomized, double-blind, placebo-controlled phase 1 study in Chinese healthy subjects

Jian Liu, Qingwei Zhao, You Zhai, Xia Wu, Jiejing Kai, Jie Ruan, Minglan Wu, Meijia Wu, Zhuojun Zhou, Yuemei Yan, Jinzi J. Wu & Yunqing Qiu

Pages: 867-876

Published online: 12 Jul 2024

AbstractforSafety, tolerability and pharmacokinetics of ASC10, a novel oral double prodrug of a broad-spectrum antiviral agent, β-d-N4-hydroxycytidine: results from a randomized, double-blind, placebo-controlled phase 1 study in Chinese healthy subjects | Full Text | References | PDF (1.4 MB) | EPUB

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Expert Opinion on Investigational Drugs (Vol.33, Iss.8, 2024)

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