Expert Review of Clinical Pharmacology, Volume 14, Issue 2 (2021)

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Expert Review of Clinical Pharmacology, Volume 14, Issue 2 (2021)

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Editorial

Editorial
Tumor mutational burden as a tissue-agnostic biomarker for cancer immunotherapy
Winnie W. Y. Sung, James C. H. Chow & William C. S. Cho
Pages: 141-143
Published online: 23 Dec 2020
First Page PreviewforTumor mutational burden as a tissue-agnostic biomarker for cancer immunotherapy | Full Text | References | PDF (147.8 KB) | EPUB
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Editorial
An update on the complex relationship between clozapine and pneumonia
Georgios Schoretsanitis, Can-Jun Ruan, Christopher Rohde, Hélène Verdoux, Carlos De Las Cuevas, Edoardo Spina & Jose de Leon
Pages: 145-149
Published online: 24 Jan 2021
First Page PreviewforAn update on the complex relationship between clozapine and pneumonia | Full Text | References | PDF (477.8 KB) | EPUB
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Drug Profile

Article
Afamelanotide for prevention of phototoxicity in erythropoietic protoporphyria
Debby Wensink, Margreet A.E.M. Wagenmakers & Janneke G. Langendonk
Pages: 151-160
Published online: 18 Mar 2021
AbstractforAfamelanotide for prevention of phototoxicity in erythropoietic protoporphyria | Full Text | References | PDF (395 KB) | EPUB
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Open Access
Article
Cenobamate tablets as a treatment for focal-onset seizures in adults
Bernhard J. Steinhoff
Pages: 161-172
Published online: 26 Jan 2021
AbstractforCenobamate tablets as a treatment for focal-onset seizures in adults | Full Text | References | PDF (456.2 KB) | EPUB
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Perspective

Reliance: a smarter way of regulating medical products - The IPRP survey
Petra Doerr, Marie Valentin, Nobumasa Nakashima, Nick Orphanos, Gustavo Santos, Georgios Balkamos & Agnes Saint-Raymond
Pages: 173-177
Published online: 23 Dec 2020
AbstractforReliance: a smarter way of regulating medical products - The IPRP survey | Full Text | References | PDF (219.5 KB) | EPUB
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Open Access

Review

Biologic and advanced immunomodulating therapeutic options for sarcoidosis: a clinical update
Ogugua Ndili Obi, Elyse E. Lower & Robert P. Baughman
Pages: 179-210
Published online: 31 Jan 2021
AbstractforBiologic and advanced immunomodulating therapeutic options for sarcoidosis: a clinical update | Full Text | References | PDF (3.3 MB) | EPUB
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The paradigm of norgestimate: a third-generation testosterone-derivative progestin with a peripheral anti-androgenic activity and the lowest risk of venous thromboembolism
Giovanni Grandi, Maria Chiara Del Savio & Fabio Facchinetti
Pages: 211-224
Published online: 26 Jan 2021
AbstractforThe paradigm of norgestimate: a third-generation testosterone-derivative progestin with a peripheral anti-androgenic activity and the lowest risk of venous thromboembolism | Full Text | References | PDF (2.5 MB) | EPUB
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Open Access
SARS-CoV-2 protein drug targets landscape: a potential pharmacological insight view for the new drug development
Chiranjib Chakraborty, Manojit Bhattacharya, Bidyut Mallick, Ashish Ranjan Sharma, Sang-Soo Lee & Govindasamy Agoramoorthy
Pages: 225-237
Published online: 27 Jan 2021
AbstractforSARS-CoV-2 protein drug targets landscape: a potential pharmacological insight view for the new drug development | Full Text | References | PDF (6.1 MB) | EPUB
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The protective effect of tanshinone IIa on endothelial cells: a generalist among clinical therapeutics
Jun Feng, Lina Liu, Fangfang Yao, Daixing Zhou, Yang He & Junshuai Wang
Pages: 239-248
Published online: 31 Jan 2021
AbstractforThe protective effect of tanshinone IIa on endothelial cells: a generalist among clinical therapeutics | Full Text | References | PDF (507.8 KB) | EPUB
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Original Research

Article
Clinical course of severe patients with COVID-19 treated with tocilizumab: report from a cohort study in Spain
Esther Chamorro-de-Vega, Carmen-Guadalupe Rodriguez-Gonzalez, Silvia Manrique-Rodríguez, Elena Lobato-Matilla, Felix García-Moreno, Maria Olmedo, Rafael Correa-Rocha, Maricela Valerio, Teresa Aldámiz-Echevarria, Marina Machado, Milagros Sancho-Gonzalez, Juan Carlos Lopez-Bernaldo-de-Quirós, Paula Ruiz-Briones, Rosa Romero-Jiménez, Camino Sarobe-González, Alvaro Gimenez-Manzorro, Roberto Collado-Borrell, Cecilia M Fernandez-Llamazares, Jose Luis Revuelta-Herrero, Beatriz Somoza-Fernandez, Sebastian Garcia-Sanchez, Irene Taladriz-Sender, Emilio Bouza, Ana Herranz, Patricia Muñoz & Maria Sanjurjo
Pages: 249-260
Published online: 26 Jan 2021
AbstractforClinical course of severe patients with COVID-19 treated with tocilizumab: report from a cohort study in Spain | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Radical metastasectomy followed by sorafenib versus observation in patients withclear cell renal cell carcinoma: extended follow -up of efficacy results from the randomized phase II RESORT trial
A. Mennitto, E. Verzoni, F. Cognetti, R. Miceli, M. Milella, A. Mosca, V. E. Chiuri, A. Bearz, F. Morelli, C. Ortega, F. Atzori, M. Donini, M. Claps, V. Guadalupi, P. Sepe, V. Cappelletti, F. G. de Braud & G. Procopio
Pages: 261-268
Published online: 31 Jan 2021
AbstractforRadical metastasectomy followed by sorafenib versus observation in patients withclear cell renal cell carcinoma: extended follow -up of efficacy results from the randomized phase II RESORT trial | Full Text | References | PDF (2 MB) | EPUB
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Article
Real-world effectiveness of olanzapine and risperidone in the treatment of schizophrenia in Brazil over a 16-year follow-up period; findings and implications
Wallace Breno Barbosa, Rosângela Maria Gomes, Brian Godman, Francisco de Assis Acurcio & Augusto Afonso Guerra Júnior
Pages: 269-279
Published online: 31 Dec 2020
AbstractforReal-world effectiveness of olanzapine and risperidone in the treatment of schizophrenia in Brazil over a 16-year follow-up period; findings and implications | Full Text | References | PDF (1.9 MB) | EPUB
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Letter to the editor

Article
Letter to the editor re: ‘serious adverse events and deaths in PCSK9 inhibitor trials reported on ClinicalTrials.gov: a systematic review’
Marc S. Sabatine, Robert P. Giugliano & Gregory G. Schwartz
Pages: 281-282
Published online: 12 Jan 2021
CitationforLetter to the editor re: ‘serious adverse events and deaths in PCSK9 inhibitor trials reported on ClinicalTrials.gov: a systematic review’ | Full Text | References | PDF (136 KB) | EPUB
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Article
Response to letter to the editor re: ‘serious adverse events and deaths in PCSK9 inhibitor trials reported on ClinicalTrials.gov: a systematic review’
F. H van Bruggen, G. B. J. Nijhuis, S. U. Zuidema & H. J. Luijendijk
Pages: 283-284
Published online: 19 Jan 2021
CitationforResponse to letter to the editor re: ‘serious adverse events and deaths in PCSK9 inhibitor trials reported on ClinicalTrials.gov: a systematic review’ | Full Text | References | PDF (135.5 KB) | EPUB
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