Xenobiotica, Volume 46, Issue 10 (2016)

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Xenobiotica, Volume 46, Issue 10 (2016)

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General Xenobiochemistry

Article
Investigation of selective inhibitory effects of glycyrol on human CYP 1A1 and 2C9
Sun Joo Kim, Su Jin Kim, Miri Hong, Hyun Gyu Choi, Jeong Ah Kim & Sangkyu Lee
Pages: 857-861
Published online: 10 Jan 2016
AbstractforInvestigation of selective inhibitory effects of glycyrol on human CYP 1A1 and 2C9 | Full Text | References | PDF (372.2 KB)
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Article
Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors
Ken-Ichi Umehara, Markus Zollinger, Elizabeth Kigondu, Marc Witschi, Claire Juif, Felix Huth, Hilmar Schiller, Kelly Chibale & Gian Camenisch
Pages: 862-867
Published online: 18 Feb 2016
AbstractforEsterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors | Full Text | References | PDF (198.5 KB)
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Article
Dydrogesterone metabolism in human liver by aldo-keto reductases and cytochrome P450 enzymes
Matthias Olbrich, Kevin Weigl, Elke Kahler & Katsuhiro Mihara
Pages: 868-874
Published online: 21 Jan 2016
AbstractforDydrogesterone metabolism in human liver by aldo-keto reductases and cytochrome P450 enzymes | Full Text | References | PDF (325.2 KB)
  • 319 Views
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Article
Decreased exposure of atorvastatin in diabetic rats partly due to induction of hepatic Cyp3a and Oatp2
Nan Shu, Mengyue Hu, Can Liu, Mian Zhang, Zhaoli Ling, Ji Zhang, Ping Xu, Zeyu Zhong, Yang Chen, Li Liu & Xiaodong Liu
Pages: 875-881
Published online: 10 Feb 2016
AbstractforDecreased exposure of atorvastatin in diabetic rats partly due to induction of hepatic Cyp3a and Oatp2 | Full Text | References | PDF (396.9 KB)
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Clinical Pharmacokinetics and Metabolism

Article
In vitro and in vivo characterisation of the metabolism and disposition of suvorexant in humans
Donghui Cui, Tamara Cabalu, Ka Lai Yee, James Small, Xiaodong Li, Bo Liu, Cheri Maciolek, Sheri Smith, Wen Liu, Jacqueline B. McCrea & Thomayant Prueksaritanont
Pages: 882-895
Published online: 10 Feb 2016
AbstractforIn vitro and in vivo characterisation of the metabolism and disposition of suvorexant in humans | Full Text | References | PDF (1.1 MB)
  • 986 Views
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Article
Effects of quercetin on pharmacokinetics of cefprozil in Chinese-Han male volunteers
Fei-Fei Jia, Zhi-Rong Tan, Howard L. McLeod, Yao Chen, Dong-Sheng Ou-Yang & Hong-Hao Zhou
Pages: 896-900
Published online: 29 Feb 2016
AbstractforEffects of quercetin on pharmacokinetics of cefprozil in Chinese-Han male volunteers | Full Text | References | PDF (206.5 KB)
  • 206 Views
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Article
Metabolic profile of Fructus Gardeniae in human plasma and urine using ultra high-performance liquid chromatography coupled with high-resolution LTQ-orbitrap mass spectrometry
Gao-Wa Wang, Burenbatu Bao, Zhi-Qiang Han, Qing-Yu Han & Xiu-Lan Yang
Pages: 901-912
Published online: 10 Jan 2016
AbstractforMetabolic profile of Fructus Gardeniae in human plasma and urine using ultra high-performance liquid chromatography coupled with high-resolution LTQ-orbitrap mass spectrometry | Full Text | References | PDF (722.6 KB) | Supplemental
  • 264 Views
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Animal Pharmacokinetics and Metabolism

Article
Factors limiting the extent of absolute bioavailability of pradefovir in rat
Qingqing Xiao, Wanqiu Yang, Dan Wang, Lin Chen, Linwen Yuan, Yitao Ding & Jin Yang
Pages: 913-921
Published online: 05 Feb 2016
AbstractforFactors limiting the extent of absolute bioavailability of pradefovir in rat | Full Text | References | PDF (666.4 KB)
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Article
In vivo drug metabolite identification in preclinical ADME studies by means of UPLC/TWIMS/high resolution-QTOF MSE and control comparison: cost and benefit of vehicle-dosed control samples
Lukas Fiebig, Ralf Laux, Rudolf Binder & Thomas Ebner
Pages: 922-930
Published online: 19 Feb 2016
AbstractforIn vivo drug metabolite identification in preclinical ADME studies by means of UPLC/TWIMS/high resolution-QTOF MSE and control comparison: cost and benefit of vehicle-dosed control samples | Full Text | References | PDF (1.2 MB) | Supplemental
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Molecular Toxicology

Article
3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2
Huiting Xue, Wenyan Xie, Zhihui Jiang, Meng Wang, Jian Wang, Hongqiong Zhao & Xiaoying Zhang
Pages: 931-939
Published online: 01 Mar 2016
Abstractfor3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2 | Full Text | References | PDF (1.9 MB)
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Xenobiotic Transporters

Article
Proteomic analysis for the impact of hypercholesterolemia on expressions of hepatic drug transporters and metabolizing enzymes
Yan Liu, Qiang-Hong Pu, Ming-Jun Wu & Chao Yu
Pages: 940-947
Published online: 18 Feb 2016
AbstractforProteomic analysis for the impact of hypercholesterolemia on expressions of hepatic drug transporters and metabolizing enzymes | Full Text | References | PDF (611 KB) | Supplemental
  • 333 Views
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Pharmacogenetics

Article
Impacts of ABCB1 (G1199A) polymorphism on resistance, uptake, and efflux to steroid drugs
Rui Peng, Hong Zhang, Ying Zhang & Dan-Yun Wei
Pages: 948-952
Published online: 28 Jan 2016
AbstractforImpacts of ABCB1 (G1199A) polymorphism on resistance, uptake, and efflux to steroid drugs | Full Text | References | PDF (143.9 KB)
  • 214 Views
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