Xenobiotica, Volume 46, Issue 4 (2016)

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Xenobiotica, Volume 46, Issue 4 (2016)

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General Xenobiochemistry

Article
Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9
Naoki Kishi, Akane Takasuka, Yuki Kokawa, Takashi Isobe, Maho Taguchi, Masato Shigeyama, Mikio Murata, Manabu Suno & Nobumitsu Hanioka
Pages: 289-295
Published online: 06 Aug 2015
AbstractforRaloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9 | Full Text | References | PDF (634.6 KB)
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Article
Structural elucidation of in vitro metabolites of bavachinin in rat liver microsomes by LC-ESI-MSn and chemical synthesis
Fan Xie, Guoxin Du, Shunan Ma, Yiming Li, Rui Wang & Fujiang Guo
Pages: 296-306
Published online: 10 Aug 2015
AbstractforStructural elucidation of in vitro metabolites of bavachinin in rat liver microsomes by LC-ESI-MSn and chemical synthesis | Full Text | References | PDF (2 MB)
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Article
The impact of the concentration of drug binding plasma proteins on drug distribution according to Øie-Tozer’s model
Andreas Mats Svennebring
Pages: 307-314
Published online: 10 Aug 2015
AbstractforThe impact of the concentration of drug binding plasma proteins on drug distribution according to Øie-Tozer’s model | Full Text | References | PDF (581.7 KB)
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Article
Enantiospecific effects of chiral drugs on cytochrome P450 inhibition in vitro
Kristyna Krasulova, Michal Siller, Ondrej Holas, Zdenek Dvorak & Pavel Anzenbacher
Pages: 315-324
Published online: 24 Aug 2015
AbstractforEnantiospecific effects of chiral drugs on cytochrome P450 inhibition in vitro | Full Text | References | PDF (871.1 KB)
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Article
In vitro identification of human cytochrome P450 isoforms involved in the metabolism of Geissoschizine methyl ether, an active component of the traditional Japanese medicine Yokukansan
Takashi Matsumoto, Hirotaka Kushida, Takeshi Maruyama, Hiroaki Nishimura, Junko Watanabe, Kazuya Maemura & Yoshio Kase
Pages: 325-334
Published online: 17 Aug 2015
AbstractforIn vitro identification of human cytochrome P450 isoforms involved in the metabolism of Geissoschizine methyl ether, an active component of the traditional Japanese medicine Yokukansan | Full Text | References | PDF (1.1 MB)
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Article
Mechanism-based inactivation of cytochrome P450 2B6 by isopsoralen
Dan Lu, Lin Ji, Liwei Zheng, Jiaojiao Cao, Ying Peng & Jiang Zheng
Pages: 335-341
Published online: 17 Aug 2015
AbstractforMechanism-based inactivation of cytochrome P450 2B6 by isopsoralen | Full Text | References | PDF (605.6 KB)
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Article
Population pharmacokinetic modeling of cefadroxil renal transport in wild-type and Pept2 knockout mice
Yehua Xie, Hong Shen, Yongjun Hu, Meihua Rose Feng & David E. Smith
Pages: 342-349
Published online: 15 Sep 2015
AbstractforPopulation pharmacokinetic modeling of cefadroxil renal transport in wild-type and Pept2 knockout mice | Full Text | References | PDF (1.2 MB)
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Article
In vitro characterization of 4′-(p-toluenesulfonylamide)-4-hydroxychalcone using human liver microsomes and recombinant cytochrome P450s
Boram Lee, Zhexue Wu, Taeho Lee, Xue Fei Tan, Ki Hun Park & Kwang-Hyeon Liu
Pages: 350-356
Published online: 02 Sep 2015
AbstractforIn vitro characterization of 4′-(p-toluenesulfonylamide)-4-hydroxychalcone using human liver microsomes and recombinant cytochrome P450s | Full Text | References | PDF (494.6 KB) | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
Comprehensive characterization of the in vitro and in vivo metabolites of geniposide in rats using ultra-high-performance liquid chromatography coupled with linear ion trap–Orbitrap mass spectrometer
Yun Li, Wei Cai, Qian Cai, Yanyun Che, Baosheng Zhao & Jiayu Zhang
Pages: 357-368
Published online: 02 Sep 2015
AbstractforComprehensive characterization of the in vitro and in vivo metabolites of geniposide in rats using ultra-high-performance liquid chromatography coupled with linear ion trap–Orbitrap mass spectrometer | Full Text | References | PDF (1 MB) | Supplemental
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Molecular Toxicology

Article
Involvement of oxidative stress and mitochondrial/lysosomal cross-talk in olanzapine cytotoxicity in freshly isolated rat hepatocytes
Aziz Eftekhari, Yadollah Azarmi, Alireza Parvizpur & Mohammad Ali Eghbal
Pages: 369-378
Published online: 12 Sep 2015
AbstractforInvolvement of oxidative stress and mitochondrial/lysosomal cross-talk in olanzapine cytotoxicity in freshly isolated rat hepatocytes | Full Text | References | PDF (336.4 KB)
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Pharmacogenetics

Article
Phenylalanine monooxygenase and the sulfur oxygenation of S-carboxymethyl-l-cysteine in mice
Evita Vandenbossche, Christopher Lucas, Lata Mistry, Emma Garfield, Stephen C. Mitchell & Glyn B. Steventon
Pages: 379-384
Published online: 17 Aug 2015
AbstractforPhenylalanine monooxygenase and the sulfur oxygenation of S-carboxymethyl-l-cysteine in mice | Full Text | References | PDF (214 KB)
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