Xenobiotica, Volume 49, Issue 7 (2019)

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Xenobiotica, Volume 49, Issue 7 (2019)

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General Xenobiochemistry

Article
The impact of azole antifungal drugs on imatinib metabolism in human liver microsomes
Xingxian Luo, Taifeng Li, Ze Yu, Xuecai Xue, Haiyang Zhao, Na li, Liping Ma, Changqing Yang, Lin Huang & Wanyu Feng
Pages: 753-761
Published online: 25 Mar 2019
AbstractforThe impact of azole antifungal drugs on imatinib metabolism in human liver microsomes | Full Text | References | PDF (1 MB) | EPUB
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Article
Deciphering the absorption profile and interaction of multi-components of Zhi-Zi-Da-Huang decoction based on in vitro–in silico–in vivo integrated strategy
Qing Hu, Xixi Li, Qingshui Shi, Gongjun Yang & Fang Feng
Pages: 762-777
Published online: 12 Sep 2018
AbstractforDeciphering the absorption profile and interaction of multi-components of Zhi-Zi-Da-Huang decoction based on in vitro–in silico–in vivo integrated strategy | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
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Article
LC-MS/MS based detection and characterization of covalent glutathione modifications formed by reactive drug of abuse metabolites
R. Allen Gilliland, Carolina Möller & Anthony P. DeCaprio
Pages: 778-790
Published online: 28 Sep 2018
AbstractforLC-MS/MS based detection and characterization of covalent glutathione modifications formed by reactive drug of abuse metabolites | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes
Haruna Nagayoshi, Norie Murayama, Kensaku Kakimoto, Shigeo Takenaka, Jun Katahira, Young-Ran Lim, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, Masayuki Komori, F. Peter Guengerich & Tsutomu Shimada
Pages: 791-802
Published online: 28 Sep 2018
AbstractforSite-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
Computational and experimental studies on the interaction between butyrylcholinesterase and fluoxetine: implications in health and disease
Ozlem Dalmizrak, Kerem Teralı, Osman Yetkin, I. Hamdi Ogus & Nazmi Ozer
Pages: 803-810
Published online: 29 Nov 2018
AbstractforComputational and experimental studies on the interaction between butyrylcholinesterase and fluoxetine: implications in health and disease | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans
Vishal Shah, Chun Yang, Zancong Shen, Bradley M. Kerr, Kathy Tieu, David M. Wilson, Jesse Hall, Michael Gillen & Caroline A. Lee
Pages: 811-822
Published online: 12 Sep 2018
AbstractforMetabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
Model-based pharmacokinetic and pharmacodynamic analysis for acute effects of a small molecule inhibitor of diacylglycerol acyltransferase-1 in the TallyHo/JngJ polygenic mouse
Yoon-Jee Chae, Jin Sook Song, Jin Hee Ahn, Myung Ae Bae & Kyeong-Ryoon Lee
Pages: 823-832
Published online: 05 Sep 2018
AbstractforModel-based pharmacokinetic and pharmacodynamic analysis for acute effects of a small molecule inhibitor of diacylglycerol acyltransferase-1 in the TallyHo/JngJ polygenic mouse | Full Text | References | PDF (1.2 MB) | EPUB
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Animal pharmacokinetics and metabolism

Article
Investigation of disposition for TAK-448, a synthetic peptide of kisspeptin analog, in rats and dogs using the radiolabeled TAK-448 suitable for pharmacokinetic study
Yuu Moriya, Akifumi Kogame, Yoshihiko Tagawa, Akio Morohashi, Takahiro Kondo & Satoru Asahi
Pages: 833-839
Published online: 12 Sep 2018
AbstractforInvestigation of disposition for TAK-448, a synthetic peptide of kisspeptin analog, in rats and dogs using the radiolabeled TAK-448 suitable for pharmacokinetic study | Full Text | References | PDF (704.7 KB) | EPUB
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Xenobiotic transporters

Article
Inhibitor selectivity of CNTs and ENTs
Balázs Vaskó, Viktória Juhász, Beáta Tóth, Anita Kurunczi, Zsolt Fekete, Joseph Krisjanis Zolnerciks, Emese Kis, Rémi Magnan, Axel Bidon-Chanal Badia, Marçal Pastor-Anglada, Eszter Hazai, Zsolt Bikadi, Ferenc Fülöp & Peter Krajcsi
Pages: 840-851
Published online: 12 Sep 2018
AbstractforInhibitor selectivity of CNTs and ENTs | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans
Mingxiang Liao, Qing Zhu, Andy Zhu, Christopher Gemski, Bingli Ma, Emily Guan, Albert P. Li, Guangqing Xiao & Cindy Q. Xia
Pages: 852-862
Published online: 21 Sep 2018
AbstractforComparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans | Full Text | References | PDF (995.4 KB) | EPUB
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Topics in Xenobiochemistry

Review
The current understanding of the interactions between nanoparticles and cytochrome P450 enzymes – a literature-based review
Yan Pan, Chin Eng Ong, Yuh Fen Pung & Jin Yu Chieng
Pages: 863-876
Published online: 12 Sep 2018
AbstractforThe current understanding of the interactions between nanoparticles and cytochrome P450 enzymes – a literature-based review | Full Text | References | PDF (1.2 MB) | EPUB
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