Xenobiotica, Volume 51, Issue 1 (2021)

Browse this journal
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Xenobiotica, Volume 51, Issue 1 (2021)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Vol 52, 2022 Volume 51, 2021 Vol 50, 2020 Vol 49, 2019 Vol 48, 2018 Vol 47, 2017 Vol 46, 2016 Vol 45, 2015 Vol 44, 2014 Vol 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

General Xenobiochemistry

Meeting report: 2nd workshop of the peptide ADME discussion group
Anders Sonesson, Inga Bjørnsdottir & Jesper Kammersgaard Christensen
Pages: 1-4
Published online: 29 Jun 2020
AbstractforMeeting report: 2nd workshop of the peptide ADME discussion group | Full Text | References | PDF (374.4 KB) | EPUB
  • 390 Views
  • 3 CrossRef citations
  • 0Altmetric
Article
Understanding metabolism related differences in ocular efficacy of MGV354
Jennifer L. Dumouchel, Upendra A. Argikar, Christopher M. Adams, Ganesh Prasanna, Takeru Ehara, Sean Kim, Chris Breen & Muneto Mogi
Pages: 5-14
Published online: 21 Jul 2020
AbstractforUnderstanding metabolism related differences in ocular efficacy of MGV354 | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 139 Views
  • 2 CrossRef citations
  • 0Altmetric
Article
Comparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes
Wei Wang, Mulder Teresa, Jingwei Cai, Chenghong Zhang, Susan Wong, Zhengyin Yan, S. Cyrus Khojasteh & Donglu Zhang
Pages: 15-23
Published online: 27 Jul 2020
AbstractforComparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 594 Views
  • 6 CrossRef citations
  • 0Altmetric
Article
An in vitro approach to simulate the process of 5-fluorouracil degradation with dihydropyrimidine dehydrogenase: the process in accordance to the first-order kinetic reaction
Wei Qin, Xiaoxue Wang, Wenqian Chen, Wenwen Du, Dan Zhang, Xianglin Zhang & Pengmei Li
Pages: 24-30
Published online: 27 Jul 2020
AbstractforAn in vitro approach to simulate the process of 5-fluorouracil degradation with dihydropyrimidine dehydrogenase: the process in accordance to the first-order kinetic reaction | Full Text | References | PDF (1,014.1 KB) | EPUB
  • 114 Views
  • 1 CrossRef citations
  • 0Altmetric
Article
Evaluation of the changes in exposure to thiol compounds in chronic kidney disease patients using the PBPK model
Hiroaki Takubo, Toshio Taniguchi, Kazunori Iwanaga & Yukihiro Nomura
Pages: 31-39
Published online: 12 Aug 2020
AbstractforEvaluation of the changes in exposure to thiol compounds in chronic kidney disease patients using the PBPK model | Full Text | References | PDF (1.9 MB) | EPUB
  • 338 Views
  • 2 CrossRef citations
  • 0Altmetric
Article
Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol
Roger J. Price, Mary P. Scott, Carina Cantrill, Larry G. Higgins, Marjory Moreau, Miyoung Yoon, Harvey J. Clewell, Moire R. Creek, Thomas G. Osimitz, J. Brian Houston & Brian G. Lake
Pages: 40-50
Published online: 26 Aug 2020
AbstractforKinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol | Full Text | References | PDF (1 MB) | EPUB
  • 232 Views
  • 0 CrossRef citations
  • 0Altmetric
Article
Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse
Maki Miyamoto, Yohei Kosugi, Shinji Iwasaki, Ikumi Chisaki, Sayaka Nakagawa, Nobuyuki Amano & Hideki Hirabayashi
Pages: 51-60
Published online: 25 Aug 2020
AbstractforCharacterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 533 Views
  • 4 CrossRef citations
  • 0Altmetric
Article
Main contribution of UGT1A1 and CYP2C9 in the metabolism of UR-1102, a novel agent for the treatment of gout
Mizuki Yamane, Fumihiko Igarashi, Tsuyoshi Yamauchi & Toshito Nakagawa
Pages: 61-71
Published online: 30 Aug 2020
AbstractforMain contribution of UGT1A1 and CYP2C9 in the metabolism of UR-1102, a novel agent for the treatment of gout | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 312 Views
  • 2 CrossRef citations
  • 0Altmetric

Animal Pharmacokinetics and Metabolism

Article
Plasma protein binding, metabolism, reaction phenotyping and toxicokinetic studies of fenarimol after oral and intravenous administration in rats
Kajal Karsauliya, Ashish Kumar Sonker, Manisha Bhateria, Isha Taneja, Anshuman Srivastava, Manu Sharma & Sheelendra Pratap Singh
Pages: 72-81
Published online: 27 Jul 2020
AbstractforPlasma protein binding, metabolism, reaction phenotyping and toxicokinetic studies of fenarimol after oral and intravenous administration in rats | Full Text | References | PDF (1.4 MB) | EPUB
  • 132 Views
  • 4 CrossRef citations
  • 0Altmetric
Article
The influence of multiple oral administration on the pharmacokinetics and distribution profile of dalcetrapib in rats
Hiroaki Takubo, Tomohiro Ishikawa, Toshio Taniguchi, Kazunori Iwanaga & Yukihiro Nomura
Pages: 82-87
Published online: 20 Aug 2020
AbstractforThe influence of multiple oral administration on the pharmacokinetics and distribution profile of dalcetrapib in rats | Full Text | References | PDF (630.7 KB) | EPUB
  • 122 Views
  • 0 CrossRef citations
  • 0Altmetric

Molecular Toxicology

Article
Evaluation of covalent binding of flutamide and its risk assessment using 19F-NMR
Nobuyuki Kakutani, Takahiro Iwai, Yasushi Ohno, Satoru Kobayashi & Yukihiro Nomura
Pages: 88-94
Published online: 22 Sep 2020
AbstractforEvaluation of covalent binding of flutamide and its risk assessment using 19F-NMR | Full Text | References | PDF (858.3 KB) | EPUB
  • 376 Views
  • 5 CrossRef citations
  • 0Altmetric

Xenobiotic Transporters

Article
Inhibitory effect of sixteen pharmaceutical excipients on six major organic cation and anion uptake transporters
Ruicong Ma, Gentao Li, Xue Wang, Yajuan Bi & Youcai Zhang
Pages: 95-104
Published online: 12 Oct 2020
AbstractforInhibitory effect of sixteen pharmaceutical excipients on six major organic cation and anion uptake transporters | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 302 Views
  • 3 CrossRef citations
  • 0Altmetric
Article
MRP4 is responsible for the efflux transport of mycophenolic acid β-d glucuronide (MPAG) from hepatocytes to blood
Joseph Berthier, Mehdi Benmameri, François-Ludovic Sauvage, Gabin Fabre, Benjamin Chantemargue, Hélène Arnion, Pierre Marquet, Patrick Trouillas, Nicolas Picard & Franck Saint-Marcoux
Pages: 105-114
Published online: 06 Sep 2020
AbstractforMRP4 is responsible for the efflux transport of mycophenolic acid β-d glucuronide (MPAG) from hepatocytes to blood | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 319 Views
  • 5 CrossRef citations
  • 0Altmetric

Pharmacogenetics

Article
Genetic variants of UDP-glucuronosyltransferases 1A1, 1A6, and 1A9 in cynomolgus and rhesus macaques
Yasuhiro Uno, Takahiro Mikami, Yasuko Tsukazaki, Yasuharu Nakanishi, Norie Murayama, Shinichi Ikushiro, Hideshi Tsusaki & Hiroshi Yamazaki
Pages: 115-121
Published online: 19 Aug 2020
AbstractforGenetic variants of UDP-glucuronosyltransferases 1A1, 1A6, and 1A9 in cynomolgus and rhesus macaques | Full Text | References | PDF (965.3 KB) | EPUB
  • 115 Views
  • 1 CrossRef citations
  • 0Altmetric

Review

Meeting report: 1st workshop of the peptide ADME discussion group
Anders Sonesson, Kevin Brady, Inga Bjørnsdottir & Jesper Kammersgaard Christensen
Pages: 122-125
Published online: 19 Feb 2020
AbstractforMeeting report: 1st workshop of the peptide ADME discussion group | Full Text | References | PDF (364.9 KB) | EPUB
  • 483 Views
  • 4 CrossRef citations
  • 0Altmetric

Explore articles