Xenobiotica, Volume 53, Issue 5 (2023)

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Xenobiotica, Volume 53, Issue 5 (2023)

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General Xenobiochemistry

Article
Physiologically based pharmacokinetic modeling (PBPK) to predict drug-drug interactions for encorafenib. Part II. Prospective predictions in hepatic and renal impaired populations with clinical inhibitors and inducers
Sivacharan Kollipara, Tausif Ahmed & Sivadasu Praveen
Pages: 339-356
Published online: 29 Aug 2023
AbstractforPhysiologically based pharmacokinetic modeling (PBPK) to predict drug-drug interactions for encorafenib. Part II. Prospective predictions in hepatic and renal impaired populations with clinical inhibitors and inducers | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Article
The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro
Michiaki Kojima, Kanami Machida, Sumie Cho, Daichi Watanabe, Hiroyuki Seki, Miyuki Shimoji, Ayuko Imaoka, Hiroshi Yamazaki, F. Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto, Takeshi Akiyoshi & Hisakazu Ohtani
Pages: 357-365
Published online: 23 Aug 2023
AbstractforThe influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Article
Physiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and transporter inhibitors
Sivacharan Kollipara, Tausif Ahmed & Sivadasu Praveen
Pages: 366-381
Published online: 04 Sep 2023
AbstractforPhysiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and transporter inhibitors | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Article
A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate
Richard Reiss, Anne Loccisano, Andrew Deines, Myoungwoo Kim, Gopinath Nallani, Appavu Chandrasekaran & Paul Whatling
Pages: 382-395
Published online: 14 Sep 2023
AbstractforA physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
Absorption, distribution, metabolism and excretion of 14C-vatiquinone in rats, dogs, and human subjects
Jiyuan Ma, Lucy Lee, Bert Yao, Peter Giannousis, Martin Thoolen, Qing Ye, Lee Golden, Matthew Klein & Ronald Kong
Pages: 396-411
Published online: 18 Aug 2023
AbstractforAbsorption, distribution, metabolism and excretion of 14C-vatiquinone in rats, dogs, and human subjects | Full Text | References | PDF (2.5 MB) | EPUB
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Open Access

Animal Pharmacokinetics and Metabolism

Article
Toxicokinetic and mass balance of morpholine in rats
Aleksandra Piotrowski, Saïd Kinani, Fabrice Nesslany, Nicolas Aubert, Sylvaine Ronga, Magali Boize, Salma Achawi & Pierre-André Cabanes
Pages: 412-420
Published online: 17 Aug 2023
AbstractforToxicokinetic and mass balance of morpholine in rats | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Article
Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats
Shuhei Fukuno, Katsuhito Nagai, Akemi Kurotobi, Yuki Sahori, Ryo Nakagawa, Rena Nomura, Takuya Ito & Hiroki Konishi
Pages: 421-428
Published online: 05 Sep 2023
AbstractforDanazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats | Full Text | References | PDF (863.8 KB) | EPUB
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Article
Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats
Min Zhang, Bin Wang, Xu-ting Li, Qin Yin, Ge Liang & Si-cong Li
Pages: 429-437
Published online: 05 Oct 2023
AbstractforImpact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Pharmacokinetics of the novel 5-HT4 receptor agonist, DA-6886, in dogs
Dae Young Lee & Hee Eun Kang
Pages: 438-444
Published online: 05 Oct 2023
AbstractforPharmacokinetics of the novel 5-HT4 receptor agonist, DA-6886, in dogs | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Molecular Toxicology

Article
Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death
Mohammad A. Alfhili & Jawaher Alsughayyir
Pages: 445-453
Published online: 21 Aug 2023
AbstractforMetabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death | Full Text | References | PDF (1.6 MB) | EPUB
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Xenobiotic transporters

Article
Two curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: in vitro and in vivo studies
Chung-Ping Yu, Yi-Ru Wang, Yu-Chi Hou, Min-Tsang Hsieh, Pei-Ying Li, Sheng-Chu Kuo & Shiuan-Pey Lin
Pages: 454-464
Published online: 05 Oct 2023
AbstractforTwo curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: in vitro and in vivo studies | Full Text | References | PDF (1.3 MB) | EPUB
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