Autophagy, Volume 17, Issue 8 (2021)

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Autophagy, Volume 17, Issue 8 (2021)

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Editor’s Corner

Editorial
Multiple structural rearrangements mediated by high-plasticity regions in Atg3 are key for efficient conjugation of Atg8 to PE during autophagy
Hana Popelka & Daniel J. Klionsky
Pages: 1805-1808
Published online: 31 Jul 2021
AbstractforMultiple structural rearrangements mediated by high-plasticity regions in Atg3 are key for efficient conjugation of Atg8 to PE during autophagy | Full Text | References | PDF (649.4 KB) | EPUB
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Review

Review
Autophagy in farm animals: current knowledge and future challenges
Sophie Tesseraud, Pascale Avril, Muriel Bonnet, Anne Bonnieu, Isabelle Cassar-Malek, Béatrice Chabi, Frédéric Dessauge, Jean-Charles Gabillard, Marie-Hélène Perruchot & Iban Seiliez
Pages: 1809-1827
Published online: 30 Jul 2020
AbstractforAutophagy in farm animals: current knowledge and future challenges | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Research Paper

Article
Differential activation of eMI by distinct forms of cellular stress
Ana Mesquita, James Glenn & Andreas Jenny
Pages: 1828-1840
Published online: 09 Jul 2020
AbstractforDifferential activation of eMI by distinct forms of cellular stress | Full Text | References | PDF (13.6 MB) | EPUB | Supplemental
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Article
The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB
Zeyuan Zhang, Qingwen Qian, Mark Li, Fan Shao, Wen-Xing Ding, Vitor A. Lira, Sophia X. Chen, Sara C. Sebag, Gökhan S. Hotamisligil, Huojun Cao & Ling Yang
Pages: 1841-1855
Published online: 15 Jul 2020
AbstractforThe unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 9110 Views
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Article
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers
Tetsushi Kataura, Etsu Tashiro, Shota Nishikawa, Kensuke Shibahara, Yoshihito Muraoka, Masahiro Miura, Shun Sakai, Naohiro Katoh, Misato Totsuka, Masafumi Onodera, Kazuo Shin-Ya, Kengo Miyamoto, Yukiko Sasazawa, Nobutaka Hattori, Shinji Saiki & Masaya Imoto
Pages: 1856-1872
Published online: 07 Aug 2020
AbstractforA chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
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Open Access
Article
Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation
Mingyu Pan, Yue Yin, Xinxia Wang, Quanyi Wang, Lele Zhang, Haiyang Hu & Chen Wang
Pages: 1873-1888
Published online: 02 Aug 2020
AbstractforMice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation | Full Text | References | PDF (8.6 MB) | EPUB | Supplemental
  • 3402 Views
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Article
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation
Patricia Richard, Shuang Feng, Yueh-Lin Tsai, Wencheng Li, Paola Rinchetti, Ubayed Muhith, Juan Irizarry-Cole, Katharine Stolz, Lionel A. Sanz, Stella Hartono, Mainul Hoque, Saba Tadesse, Hervé Seitz, Francesco Lotti, Michio Hirano, Frédéric Chédin, Bin Tian & James L. Manley
Pages: 1889-1906
Published online: 07 Aug 2020
AbstractforSETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation | Full Text | References | PDF (7.7 MB) | EPUB | Supplemental
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Article
PtdIns4P restriction by hydrolase SAC1 decides specific fusion of autophagosomes with lysosomes
Hongjun Zhang, Jiao Zhou, Peng Xiao, Yong Lin, Xin Gong, Shiyan Liu, Qingjia Xu, Minjin Wang, Haiyan Ren, Mengji Lu, Yuan Wang, Jing Zhu, Zhiping Xie, Huihui Li & Kefeng Lu
Pages: 1907-1917
Published online: 30 Jul 2020
AbstractforPtdIns4P restriction by hydrolase SAC1 decides specific fusion of autophagosomes with lysosomes | Full Text | References | PDF (8.5 MB) | EPUB | Supplemental
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Article
Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection
Mengling Tang, Zhiqiang Hu, Chenglong Rao, Jiangao Chen, Siqi Yuan, Jiangang Zhang, Chan Mao, Jingmin Yan, Yupei Xia, Meijuan Zhang, Juanjuan Yue, Yang Xiang, Jianping Xie, Xuhu Mao & Qian Li
Pages: 1918-1933
Published online: 11 Aug 2020
AbstractforBurkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection | Full Text | References | PDF (14.5 MB) | EPUB | Supplemental
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Article
BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains
Xiaoli Wu, Yanrong Zheng, Mengru Liu, Yue Li, Shijia Ma, Weidong Tang, Wenping Yan, Ming Cao, Wanqing Zheng, Lei Jiang, Jiaying Wu, Feng Han, Zhenghong Qin, Liang Fang, Weiwei Hu, Zhong Chen & Xiangnan Zhang
Pages: 1934-1946
Published online: 12 Aug 2020
AbstractforBNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains | Full Text | References | PDF (7.3 MB) | EPUB | Supplemental
  • 9840 Views
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Article
1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation
Mario A. Lauterbach, Victor Saavedra, Matthew S. J. Mangan, Anke Penno, Christoph Thiele, Eicke Latz & Lars Kuerschner
Pages: 1947-1961
Published online: 24 Aug 2020
Abstractfor1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation | Full Text | References | PDF (8.8 MB) | EPUB | Supplemental
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Article
HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation
Juan Liu, Xiaopeng Wu, Hailong Wang, Jiayu Wei, Qian Wu, Xingbo Wang, Yan Yan, Jun Cui, Junxia Min, Fudi Wang & Jiyong Zhou
Pages: 1962-1977
Published online: 18 Aug 2020
AbstractforHFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation | Full Text | References | PDF (13.1 MB) | EPUB | Supplemental
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Article
LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells
Suyeon Kim, Hanbyoul Cho, Soon-Oh Hong, Se Jin Oh, Hyo-Jung Lee, Eunho Cho, Seon Rang Woo, Joon Seon Song, Joon-Yong Chung, Sung Wook Son, Sang Min Yoon, Yu-Min Jeon, Seunghyun Jeon, Cassian Yee, Kyung-Mi Lee, Stephen M. Hewitt, Jae-Hoon Kim, Kwon-Ho Song & Tae Woo Kim
Pages: 1978-1997
Published online: 14 Aug 2020
AbstractforLC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells | Full Text | References | PDF (9.4 MB) | EPUB | Supplemental
  • 4121 Views
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Article
ATM loss disrupts the autophagy-lysosomal pathway
Aifang Cheng, Kai-Hei Tse, Hei-Man Chow, Yunqiao Gan, Xuan Song, Fulin Ma, Yi Xuan Yvonne Qian, Weiyi She & Karl Herrup
Pages: 1998-2010
Published online: 14 Aug 2020
AbstractforATM loss disrupts the autophagy-lysosomal pathway | Full Text | References | PDF (7.3 MB) | EPUB | Supplemental
  • 5935 Views
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Article
Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy
Waka Kojima, Koji Yamano, Hidetaka Kosako, Kenichiro Imai, Reika Kikuchi, Keiji Tanaka & Noriyuki Matsuda
Pages: 2011-2036
Published online: 26 Jan 2021
AbstractforMammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy | Full Text | References | PDF (13.4 MB) | EPUB | Supplemental
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Autophagic Punctum

Article Commentary
Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging
Sebastian J. Hofer, YongTian Liang, Andreas Zimmermann, Sabrina Schroeder, Jörn Dengjel, Guido Kroemer, Tobias Eisenberg, Stephan J. Sigrist & Frank Madeo
Pages: 2037-2039
Published online: 09 Jun 2021
AbstractforSpermidine-induced hypusination preserves mitochondrial and cognitive function during aging | Full Text | References | PDF (490.1 KB) | EPUB
  • 9038 Views
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Article Commentary
Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis
Mathieu Bourdenx, Evripidis Gavathiotis & Ana Maria Cuervo
Pages: 2040-2042
Published online: 10 Jun 2021
AbstractforChaperone-mediated autophagy: a gatekeeper of neuronal proteostasis | Full Text | References | PDF (368.9 KB) | EPUB
  • 3342 Views
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Article
Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes
C. Alexander Boecker & Erika L.F. Holzbaur
Pages: 2043-2045
Published online: 10 Jun 2021
AbstractforHyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes | Full Text | References | PDF (279.6 KB) | EPUB
  • 1653 Views
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Article Commentary
Autophagy induction by IGF1R inhibition with picropodophyllin and linsitinib
Qi Wu, Ai-Ling Tian, Guido Kroemer & Oliver Kepp
Pages: 2046-2047
Published online: 10 Jun 2021
AbstractforAutophagy induction by IGF1R inhibition with picropodophyllin and linsitinib | Full Text | References | PDF (390.1 KB) | EPUB
  • 2114 Views
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Article Commentary
TMEM41B and VMP1 are phospholipid scramblases
Tizhong Zhang, Yang E. Li, Yiqiong Yuan, Ximing Du, Yichang Wang, Xiuju Dong, Hongyuan Yang & Shiqian Qi
Pages: 2048-2050
Published online: 12 Jun 2021
AbstractforTMEM41B and VMP1 are phospholipid scramblases | Full Text | References | PDF (394.5 KB) | EPUB
  • 2783 Views
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Article
The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor
Thaddaeus Mutugi Nthiga, Birendra Kumar Shrestha, Trond Lamark & Terje Johansen
Pages: 2051-2052
Published online: 24 Jun 2021
AbstractforThe soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor | Full Text | References | PDF (333 KB) | EPUB
  • 1882 Views
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