Cancer Biology & Therapy, Volume 8, Issue 12 (2009)

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Cancer Biology & Therapy, Volume 8, Issue 12 (2009)

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Editor's Corner

Editorial
Cover Image
Page: i
Published online: 15 Jun 2009
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News

News
Penn researchers discover genetic risk factor for testicular cancer: Gene is associated with a three-fold increase in risk for testicular cancer
Pages: 1083-1082
Published online: 15 Jun 2009
AbstractforPenn researchers discover genetic risk factor for testicular cancer: Gene is associated with a three-fold increase in risk for testicular cancer | PDF (102.7 KB)
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News
U-M researchers link pathway to breast cancer stem cells
Pages: 1083-1082
Published online: 15 Jun 2009
AbstractforU-M researchers link pathway to breast cancer stem cells | PDF (102.7 KB)
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News
Lawrence receives radiation oncology award
Pages: 1083-1082
Published online: 15 Jun 2009
AbstractforLawrence receives radiation oncology award | PDF (102.7 KB)
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News
Researchers find breast cancer gene that’s blocked by blood pressure drug
Pages: 1083-1082
Published online: 15 Jun 2009
AbstractforResearchers find breast cancer gene that’s blocked by blood pressure drug | PDF (102.7 KB)
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Review

Review Article
The evolving role of mass spectrometry in cancer biomarker discovery
Pei Wang, Jeffrey R. Whiteaker & Amanda G. Paulovich
Pages: 1083-1094
Published online: 15 Jun 2009
Abstractfor The evolving role of mass spectrometry in cancer biomarker discovery | PDF (5.4 MB)
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Clinical Study

Article
Utility of the systemic inflammatory response syndrome (SIRS) criteria in predicting the onset of septic shock in hospitalized patients with hematologic malignancies
Anthony Mato, Barry D. Fuchs, Daniel F. Heitjan, Rosemarie Mick, Scott D. Halpern, Payal D. Shah, Samantha Jacobs, Erin M. Olson, Stephen J. Schuster, Chaitra Ujjani, Elise A. Chong, Alison W. Loren, Andrea N. Miltiades & Selina Luger
Pages: 1095-1100
Published online: 15 Jun 2009
Abstractfor Utility of the systemic inflammatory response syndrome (SIRS) criteria in predicting the onset of septic shock in hospitalized patients with hematologic malignancies | PDF (304.8 KB)
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Commentary

SIRS criteria in prediction of septic shock in hospitalized patients with hematologic malignancies
Sulfi Ibrahim & David F. Claxton
Page: 1101
Published online: 15 Jun 2009
AbstractforSIRS criteria in prediction of septic shock in hospitalized patients with hematologic malignancies | PDF (68.9 KB)
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Clinical Study

Article
Osteosarcoma: Limb salvaging treatment by ultrasonographically guided high-intensity focused ultrasound
Chuanxing Li, Peihong Wu, Zhang Liang, Weijun Fan, Jinhua Huang & Fujun Zhang
Pages: 1102-1108
Published online: 15 Jun 2009
AbstractforOsteosarcoma: Limb salvaging treatment by ultrasonographically guided high-intensity focused ultrasound | PDF (826.9 KB)
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Research Paper

Article
Death receptor 5 agonist TRA8 in combination with the bisphosphonate zoledronic acid attenuated the growth of breast cancer metastasis
April Adams Szafran, Karri Folks, Jason Warram, Diptiman Chanda, Deli Wang & Kurt R. Zinn
Pages: 1109-1116
Published online: 15 Jun 2009
AbstractforDeath receptor 5 agonist TRA8 in combination with the bisphosphonate zoledronic acid attenuated the growth of breast cancer metastasis | PDF (4.2 MB)
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Article
Co-suppression of MDR1 (multidrug resistance 1) and GCS（glucosylceramide synthase）restores sensitivity to multidrug resistance breast cancer cells by RNA interference (RNAi)
Xiaofang Zhang, Juan Li, Zhengang Qiu, Peng Gao, Xiaojuan Wu & Genyin Zhou
Pages: 1117-1121
Published online: 15 Jun 2009
AbstractforCo-suppression of MDR1 (multidrug resistance 1) and GCS（glucosylceramide synthase）restores sensitivity to multidrug resistance breast cancer cells by RNA interference (RNAi) | PDF (385.1 KB)
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Commentary

The relationship between multidrug resistance and glucosylceramide levels: An opportunity for combined therapies
Margaret A. Park
Pages: 1122-1124
Published online: 15 Jun 2009
AbstractforThe relationship between multidrug resistance and glucosylceramide levels: An opportunity for combined therapies | PDF (270.4 KB)
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Research Paper

Article
Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells
Qin Lu, De-Hong Yu, Chao Fang, Fang Liu, Xun Ye, Yi Zhao, Jie Qin, Xiao-Kui Guo, Min Liang, Fang Hu & Hong-Zhuan Chen
Pages: 1125-1132
Published online: 15 Jun 2009
AbstractforInfluence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells | PDF (1 MB)
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Commentary

Adenovirus E3 proteins help tumors to evade innate and adaptive immune responses
Sherven Sharma & Åsa Andersson
Pages: 1133-1135
Published online: 15 Jun 2009
AbstractforAdenovirus E3 proteins help tumors to evade innate and adaptive immune responses | PDF (429.4 KB)
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Research Paper

Article
Therapeutic doses of Hydroxyurea cause telomere dysfunction and reduce TRF2 binding to telomeres
Andrew R Snyder, Jing Zhou, Zhong Deng & Paul M. Lieberman
Pages: 1136-1145
Published online: 15 Jun 2009
AbstractforTherapeutic doses of Hydroxyurea cause telomere dysfunction and reduce TRF2 binding to telomeres | PDF (2.3 MB)
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Article
Villin1, a novel diagnostic marker for cervical adenocarcinoma
Etsuko Nakamura, Mayumi Iwakawa, Reiko Furuta, Tatsuya Ohno, Toyomi Satoh, Miyako Nakawatari, Ken-ichi Ishikawa, Kaori Imadome, Yuichi Michikawa, Tomoaki Tamaki, Shingo Katoh, Tomoyuki Kitagawa & Takashi Imai
Pages: 1146-1153
Published online: 15 Jun 2009
AbstractforVillin1, a novel diagnostic marker for cervical adenocarcinoma | PDF (670 KB)
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Commentary

A novel biomarker for cervical cancer
Takashi Tokino
Pages: 1154-1155
Published online: 15 Jun 2009
AbstractforA novel biomarker for cervical cancer | PDF (70.4 KB)
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Research Paper

Article
Modulation of the activity of methyl binding domain protein 4 (MBD4/MED1) while processing iododeoxyuridine generated DNA mispairs
Mohammad Azhar Aziz, Jane E. Schupp & Timothy J. Kinsella
Pages: 1156-1163
Published online: 15 Jun 2009
AbstractforModulation of the activity of methyl binding domain protein 4 (MBD4/MED1) while processing iododeoxyuridine generated DNA mispairs | PDF (591.3 KB)
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Commentary

Article Commentary
The mismatch repair and base excision repair pathways: An opportunity for individualized (personalized) sensitization of cancer therapy
Sean P. Collins & Anatoly Dritschilo
Pages: 1164-1166
Published online: 15 Jun 2009
First Page PreviewforThe mismatch repair and base excision repair pathways: An opportunity for individualized (personalized) sensitization of cancer therapy | PDF (258.1 KB)
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Research Paper

Article
Alteration of tumor spectrum by ISGylation in p53-deficient mice
Xiaoyan Yin, Xiuli Cong, Ming Yan & Dong-Er Zhang
Pages: 1167-1172
Published online: 15 Jun 2009
AbstractforAlteration of tumor spectrum by ISGylation in p53-deficient mice | PDF (591.5 KB)
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Article
ERK activation increases nitroprusside induced apoptosis in  human melanoma  cells  irrespective of p53 status: Role of  superoxide dismutases
Luis Alberto Gomez–Sarosi, Mary Strasberg–Rieber & Manuel Rieber
Pages: 1173-1182
Published online: 15 Jun 2009
AbstractforERK activation increases nitroprusside induced apoptosis in  human melanoma  cells  irrespective of p53 status: Role of  superoxide dismutases | PDF (1.8 MB)
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Article
Leptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast cancer cells
Silvio Naviglio, Davide Di Gesto, Annunziata Sorrentino, Fausto Illiano, Luca Sorvillo, Alberto Abbruzzese, Monica Marra, Michele Caraglia, Emilio Chiosi, Annamaria Spina & Gennaro Illiano
Pages: 1183-1190
Published online: 15 Jun 2009
AbstractforLeptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast cancer cells | PDF (1.6 MB)
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Commentary

A new therapeutic strategy against cancer: cAMP elevating drugs and leptin
Giovanni Vitale, Alessandra Dicitore, Daniela Mari & Francesco Cavagnini
Pages: 1191-1193
Published online: 15 Jun 2009
AbstractforA new therapeutic strategy against cancer: cAMP elevating drugs and leptin | PDF (458.4 KB)
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