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The Journal of Maternal-Fetal & Neonatal Medicine Volume 22, 2009 - Issue 10
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Original Article

Fragment Bb in amniotic fluid: evidence for complement activation by the alternative pathway in women with intra-amniotic infection/inflammation

Edi Vaisbuch Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA; Wayne State University School of Medicine, Department of Obstetrics and Gynecology, Detroit, Michigan, USACorrespondence[email protected]
, MD,
Roberto Romero Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA; Wayne State University School of Medicine, Department of Obstetrics and Gynecology, Detroit, Michigan, USA; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USACorrespondence[email protected]
, MD,
Offer Erez Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA; Wayne State University School of Medicine, Department of Obstetrics and Gynecology, Detroit, Michigan, USA
,
Shali Mazaki-Tovi Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA; Wayne State University School of Medicine, Department of Obstetrics and Gynecology, Detroit, Michigan, USA
,
Kusanovic Juan Pedro Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA; Wayne State University School of Medicine, Department of Obstetrics and Gynecology, Detroit, Michigan, USA
,
Eleazar Soto Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA
,
Francesca Gotsch Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA
,
Zhong Dong Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA
,
Tinnakorn Chaiworapongsa Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA; Wayne State University School of Medicine, Department of Obstetrics and Gynecology, Detroit, Michigan, USA
,
Sun Kwon Kim Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA
,
Pooja Mittal Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA; Wayne State University School of Medicine, Department of Obstetrics and Gynecology, Detroit, Michigan, USA
,
Percy Pacora Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA
,
Lami Yeo Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA; Wayne State University School of Medicine, Department of Obstetrics and Gynecology, Detroit, Michigan, USA
&
Sonia S. Hassan Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA; Wayne State University School of Medicine, Department of Obstetrics and Gynecology, Detroit, Michigan, USA
 show all
Pages 905-916 | Received 31 Dec 2008, Accepted 20 Feb 2009, Published online: 15 Sep 2009

Citations (30)

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Piya Chaemsaithong, Roberto Romero, Steven J. Korzeniewski, Alicia Martinez-Varea, Zhong Dong, Bo Hyun Yoon, Sonia S. Hassan, Tinnakorn Chaiworapongsa & Lami Yeo. (2016) A rapid interleukin-6 bedside test for the identification of intra-amniotic inflammation in preterm labor with intact membranes. The Journal of Maternal-Fetal & Neonatal Medicine 29:3, pages 349-359.
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Piya Chaemsaithong, Roberto Romero, Steven J. Korzeniewski, Zhong Dong, Lami Yeo, Sonia S. Hassan, Yeon Mee Kim, Bo Hyun Yoon & Tinnakorn Chaiworapongsa. (2015) A point of care test for the determination of amniotic fluid interleukin-6 and the chemokine CXCL-10/IP-10. The Journal of Maternal-Fetal & Neonatal Medicine 28:13, pages 1510-1519.
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Sun Min Kim, Roberto Romero, Jeong Woo Park, Kyung Joon Oh, Jong Kwan Jun & Bo Hyun Yoon. (2015) The relationship between the intensity of intra-amniotic inflammation and the presence and severity of acute histologic chorioamnionitis in preterm gestation. The Journal of Maternal-Fetal & Neonatal Medicine 28:13, pages 1500-1509.
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Roberto Romero, Jezid Miranda, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Juan P. Kusanovic, Zhong Dong, Ahmed I. Ahmed, Majid Shaman, Kia Lannaman, Bo Hyun Yoon, Sonia S. Hassan, Chong Jai Kim, Steven Jai Korzeniewski, Lami Yeo & Yeon Mee Kim. (2015) Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes. The Journal of Maternal-Fetal & Neonatal Medicine 28:12, pages 1394-1409.
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Roberto Romero, Bo Hyun Yoon, Piya Chaemsaithong, Josef Cortez, Chan-Wook Park, Rogelio Gonzalez, Ernesto Behnke, Sonia S. Hassan, Tinnakorn Chaiworapongsa & Lami Yeo. (2014) Bacteria and endotoxin in meconium-stained amniotic fluid at term: could intra-amniotic infection cause meconium passage?. The Journal of Maternal-Fetal & Neonatal Medicine 27:8, pages 775-788.
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Roberto Romero, Eleazar Soto, Stanley M. Berry, Sonia S. Hassan, Juan Pedro Kusanovic, Bo Hyun Yoon, Samuel Edwin, Moshe Mazor & Tinnakorn Chaiworapongsa. (2012) Blood pH and gases in fetuses in preterm labor with and without systemic inflammatory response syndrome. The Journal of Maternal-Fetal & Neonatal Medicine 25:7, pages 1160-1170.
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Roberto Romero, Shali Mazaki-Tovi, Edi Vaisbuch, Juan Pedro Kusanovic, Tinnakorn Chaiworapongsa, Ricardo Gomez, Jyh Kae Nien, Bo Hyun Yoon, Moshe Mazor, Jingqin Luo, David Banks, John Ryals & Chris Beecher. (2010) Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery. The Journal of Maternal-Fetal & Neonatal Medicine 23:12, pages 1344-1359.
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Eleazar Soto, Roberto Romero, Edi Vaisbuch, Offer Erez, Shali Mazaki-Tovi, Juan Pedro Kusanovic, Zhong Dong, Tinnakorn Chaiworapongsa, Lami Yeo, Pooja Mittal & Sonia S. Hassan. (2010) Fragment Bb: evidence for activation of the alternative pathway of the complement system in pregnant women with acute pyelonephritis. The Journal of Maternal-Fetal & Neonatal Medicine 23:10, pages 1085-1090.
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Articles from other publishers (22)

Veronica Feijoli Santiago, Jamille Gregorio Dombrowski, Rebeca Kawahara, Livia Rosa-Fernandes, Simon Ngao Mule, Oscar Murillo, Thais Viggiani Santana, Joao Victor Paccini Coutinho, Janaina Macedo-da-Silva, Lucas Cardoso Lazari, Erika Paula Machado Peixoto, Marcel Ivan Ramirez, Martin R. Larsen, Cláudio Romero Farias Marinho & Giuseppe Palmisano. (2023) Complement System Activation Is a Plasma Biomarker Signature during Malaria in Pregnancy. Genes 14:8, pages 1624.
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Kate Smith‐Jackson & Richard Alexander Harrison. (2022) Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events. Immunological Reviews 313:1, pages 298-319.
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Tina Šket, Taja Železnik Ramuta, Marjanca Starčič Erjavec & Mateja Erdani Kreft. (2021) The Role of Innate Immune System in the Human Amniotic Membrane and Human Amniotic Fluid in Protection Against Intra-Amniotic Infections and Inflammation. Frontiers in Immunology 12.
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Jiao Yu, Ting Peng, Jiong Lu, Xiao-Tian Li & Rong Hu. (2021) Analysis of the Microbiome Based on 16S rRNA Gene Signature in Women with Preterm versus Term Birth. Reproductive and Developmental Medicine 5:2, pages 81-89.
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Kenichiro Motomura, Roberto Romero, Adi L. Tarca, Jose Galaz, Gaurav Bhatti, Bogdan Done, Marcia Arenas-Hernandez, Dustyn Levenson, Rebecca Slutsky, Chaur-Dong Hsu & Nardhy Gomez-Lopez. (2020) Pregnancy-specific transcriptional changes upon endotoxin exposure in mice. Journal of Perinatal Medicine 48:7, pages 700-722.
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Marcia Arenas-Hernandez, Nardhy Gomez-Lopez, Valeria Garcia-Flores, Claudia Rangel-Escareño, Luis M. Alvarez-Salas, Natalia Martinez-Acuña, Joel A. Vazquez-Perez & Rodrigo Vega-Sanchez. (2018) Choriodecidual leukocytes display a unique gene expression signature in spontaneous labor at term. Genes & Immunity 20:1, pages 56-68.
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Ivana Musilova, Ctirad Andrys, Jan Krejsek, Marcela Drahosova, Barbora Zednikova, Lenka Pliskova, Helena Zemlickova, Bo Jacobsson & Marian Kacerovsky. (2017) Amniotic fluid pentraxins: Potential early markers for identifying intra‐amniotic inflammatory complications in preterm pre‐labor rupture of membranes. American Journal of Reproductive Immunology 79:5.
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Louise C. Kenny & Douglas B. Kell. (2018) Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father†. Frontiers in Medicine 4.
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Yu Mi Kim, Kyo Hoon Park, Hyunsoo Park, Ha-Na Yoo, Song Yi Kook & Se Jeong Jeon. (2018) Complement C3a, But Not C5a, Levels in Amniotic Fluid Are Associated with Intra-amniotic Infection and/or Inflammation and Preterm Delivery in Women with Cervical Insufficiency or an Asymptomatic Short Cervix (≤ 25 mm). Journal of Korean Medical Science 33:35.
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Alexis B. Dunn, Anne L. Dunlop, Carol J. Hogue, Andrew Miller & Elizabeth J. Corwin. (2017) The Microbiome and Complement Activation: A Mechanistic Model for Preterm Birth. Biological Research For Nursing 19:3, pages 295-307.
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Roberto Romero, Piya Chaemsaithong, Lami Yeo, Nikolina Docheva & Noppadol Chaiyasit. 2017. Fetal and Neonatal Physiology. Fetal and Neonatal Physiology 144 159.e12 .
Areej Al Rabea, Mathieu Nadeau-Vallée & Xin Hou. (2015) Implication of the complement system, specifically the active form and the anaphylatoxins, in human parturition. Journal of Reproductive Immunology 112, pages 81.
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Manu Banadakoppa, Alex C. Vidaeff, Uma Yallampalli, Susan M. Ramin, Michael A. Belfort & Chandra Yallampalli. (2015) Complement Split Products in Amniotic Fluid in Pregnancies Subsequently Developing Early-Onset Preeclampsia. Disease Markers 2015, pages 1-7.
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Juan M. Gonzalez, Roberto Romero & Guillermina Girardi. (2013) Comparison of the mechanisms responsible for cervical remodeling in preterm and term labor. Journal of Reproductive Immunology 97:1, pages 112-119.
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Roberto Romero, Zeynep Alpay Savasan, Tinnakorn Chaiworapongsa, Stanley M. Berry, Juan Pedro Kusanovic, Sonia S. Hassan, Bo Hyun Yoon, Samuel Edwin & Moshe Mazor. (2012) Hematologic profile of the fetus with systemic inflammatory response syndrome. Journal of Perinatal Medicine 40:1.
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Juan M. Gonzalez, Zhong Dong, Roberto Romero & Guillermina Girardi. (2011) Cervical Remodeling/Ripening at Term and Preterm Delivery: The Same Mechanism Initiated by Different Mediators and Different Effector Cells. PLoS ONE 6:11, pages e26877.
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Juan M. Gonzalez, Claus-Werner Franzke, Fengyuan Yang, Roberto Romero & Guillermina Girardi. (2011) Complement Activation Triggers Metalloproteinases Release Inducing Cervical Remodeling and Preterm Birth in Mice. The American Journal of Pathology 179:2, pages 838-849.
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Andrea L. Conroy, Chloe R. McDonald, Karlee L. Silver, W. Conrad Liles & Kevin C. Kain. (2011) Complement activation: a critical mediator of adverse fetal outcomes in placental malaria?. Trends in Parasitology 27:7, pages 294-299.
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Pooja Mittal, Roberto Romero, Adi L. Tarca, Sorin Draghici, Chia-Ling Nhan-Chang, Tinnakorn Chaiworapongsa, John Hotra, Ricardo Gomez, Juan Pedro Kusanovic, Deug-Chan Lee, Chong Jai Kim & Sonia S. Hassan. (2011) A molecular signature of an arrest of descent in human parturition. American Journal of Obstetrics and Gynecology 204:2, pages 177.e15-177.e33.
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Byoung Jae Kim, Roberto Romero, Seung Mi Lee, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun & Bo Hyun Yoon. (2011) Clinical significance of oligohydramnios in patients with preterm labor and intact membranes*,**. Journal of Perinatal Medicine 39:2.
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Edi Vaisbuch, Roberto Romero, Offer Erez, Shali Mazaki‐Tovi, Juan Pedro Kusanovic, Eleazar Soto, Zhong Dong, Tinnakorn Chaiworapongsa, Sun Kwon Kim, Giovanna Ogge, Percy Pacora, Lami Yeo & Sonia S. Hassan. (2010) ORIGINAL ARTICLE: Activation of the Alternative Pathway of Complement is a Feature of Pre‐Term Parturition but not of Spontaneous Labor at Term. American Journal of Reproductive Immunology 63:4, pages 318-330.
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Pooja Mittal, Roberto Romero, Adi L. Tarca, Juan Gonzalez, Sorin Draghici, Yi Xu, Zhong Dong, Chia-Ling Nhan-Chang, Tinnakorn Chaiworapongsa, Stephen Lye, Juan Pedro Kusanovic, Leonard Lipovich, Shali Mazaki-Tovi, Sonia S. Hassan, Sam Mesiano & Chong Jai Kim. (2010) Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term. Journal of Perinatal Medicine 38:6.
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