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Original Article

Exenatide versus insulin glargine in patients with type 2 diabetes in the UK: a model of long-term clinical and cost outcomes

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Pages 609-622 | Accepted 23 Jan 2007, Published online: 16 Feb 2007

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Read on this site (10)

Pernilla Huetson, James L. Palmer, Andrée Levorsen, Marie Fournier, Maeva Germe & Euan McLeod. (2015) Cost-effectiveness of once daily GLP-1 receptor agonist lixisenatide compared to bolus insulin both in combination with basal insulin for the treatment of patients with type 2 diabetes in Norway. Journal of Medical Economics 18:8, pages 573-585.
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Victoria K. Brennan, Ann D. Colosia, Catherine Copley-Merriman, Josephine Mauskopf, Bastian Hass & Roberto Palencia. (2014) Incremental costs associated with myocardial infarction and stroke in patients with type 2 diabetes mellitus: an overview for economic modeling. Journal of Medical Economics 17:7, pages 469-480.
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Urpo Kiiskinen, Stephan Matthaei, Matthew Reaney, Chantal Mathieu, Claes-Göran Östenson, Thure Krarup, Michael Theodorakis, Jacek Kiljański, Carole Salaun-Martin, Hélène Sapin & Bruno Guerci. (2013) Resource use and costs of exenatide bid or insulin in clinical practice: the European CHOICE study. ClinicoEconomics and Outcomes Research 5, pages 355-367.
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R. F. Pollock, J. Chilcott, G. Muduma & W. J. Valentine. (2013) Laparoscopic adjustable gastric banding vs standard medical management in obese patients with type 2 diabetes: a budget impact analysis in the UK. Journal of Medical Economics 16:2, pages 249-259.
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Amélie Beaudet, James L. Palmer, Louise Timlin, Bernard Wilson, David Bruhn, Kristina S. Boye & Adam Lloyd. (2011) Cost-utility of exenatide once weekly compared with insulin glargine in patients with type 2 diabetes in the UK. Journal of Medical Economics 14:3, pages 357-366.
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Manjiri Pawaskar, Anthony Zagar, Tomoko Sugihara & Lizheng Shi. (2011) Healthcare resource utilization and costs assessment of type 2 diabetes patients initiating exenatide BID or glargine: a retrospective database analysis. Journal of Medical Economics 14:1, pages 16-27.
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Y. Yi, Z. Philips, G. Bergman & K. Burslem. (2010) Economic models in type 2 diabetes. Current Medical Research and Opinion 26:9, pages 2105-2118.
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Joan Khoo, Christopher K Rayner, Karen L Jones & Michael Horowitz. (2009) Incretin-based therapies: new treatments for type 2 diabetes in the new millennium. Therapeutics and Clinical Risk Management 5, pages 683-698.
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Stanislav Goykhman, Andjela Drincic, Jean Claude Desmangles & Marc Rendell. (2009) Insulin Glargine: a review 8 years after its introduction. Expert Opinion on Pharmacotherapy 10:4, pages 705-718.
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Articles from other publishers (35)

Chun-Ting Yang, Wen-Yu Yao, Huang-Tz Ou & Shihchen Kuo. (2023) Value of GLP-1 receptor agonists versus long-acting insulins for type 2 diabetes patients with and without established cardiovascular or chronic kidney diseases: A model-based cost-effectiveness analysis using real-world data. Diabetes Research and Clinical Practice 198, pages 110625.
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Chen-Yi Yang, Ying-Ren Chen, Huang-Tz Ou & Shihchen Kuo. (2021) Cost-effectiveness of GLP-1 receptor agonists versus insulin for the treatment of type 2 diabetes: a real-world study and systematic review. Cardiovascular Diabetology 20:1.
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Bhavani Shankara Bagepally, Usa Chaikledkaew, Yogesh Krishnarao Gurav, Thunyarat Anothaisintawee, Sitaporn Youngkong, Nathorn Chaiyakunapruk, Mark McEvoy, John Attia & Ammarin Thakkinstian. (2020) Glucagon-like peptide 1 agonists for treatment of patients with type 2 diabetes who fail metformin monotherapy: systematic review and meta-analysis of economic evaluation studies. BMJ Open Diabetes Research & Care 8:1, pages e001020.
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Dongzhe Hong, Lei Si, Minghuan Jiang, Hui Shao, Wai-kit Ming, Yingnan Zhao, Yan Li & Lizheng Shi. (2019) Cost Effectiveness of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors, Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists, and Dipeptidyl Peptidase-4 (DPP-4) Inhibitors: A Systematic Review. PharmacoEconomics.
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Louis S. Matza, Kristina S. Boye, Katie D. Stewart, Evan W. Davies & Rosirene Paczkowski. (2017) Health state utilities associated with attributes of weekly injection devices for treatment of type 2 diabetes. BMC Health Services Research 17:1.
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Shuyan Gu, Xiaoyong Wang, Qing Qiao, Weiguo Gao, Jian Wang & Hengjin Dong. (2017) Cost‐effectiveness of exenatide twice daily vs insulin glargine as add‐on therapy to oral antidiabetic agents in patients with type 2 diabetes in China. Diabetes, Obesity and Metabolism 19:12, pages 1688-1697.
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Sarah E. Holden, Christopher Ll. Morgan, Qing Qiao, Sara Jenkins-Jones, Ellen R. Berni & Craig J. Currie. (2017) Healthcare resource utilization and related financial costs associated with glucose lowering with either exenatide or basal insulin: A retrospective cohort study. Diabetes, Obesity and Metabolism 19:8, pages 1097-1105.
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Kurt Fortwaengler, Christopher G. Parkin, Kurt Neeser, Monika Neumann & Oliver Mast. (2016) Description of a New Predictive Modeling Approach That Correlates the Risk and Associated Cost of Well-Defined Diabetes-Related Complications With Changes in Glycated Hemoglobin (HbA1c). Journal of Diabetes Science and Technology 11:2, pages 315-323.
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Xinyang Hua, Thomas Wai-Chun Lung, Andrew Palmer, Lei Si, William H. Herman & Philip Clarke. (2016) How Consistent is the Relationship between Improved Glucose Control and Modelled Health Outcomes for People with Type 2 Diabetes Mellitus? a Systematic Review. PharmacoEconomics 35:3, pages 319-329.
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Asrul Akmal Shafie, Chin Hui Ng, Yui Ping Tan & Nathorn Chaiyakunapruk. (2016) Systematic Review of the Cost Effectiveness of Insulin Analogues in Type 1 and Type 2 Diabetes Mellitus. PharmacoEconomics 35:2, pages 141-162.
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Barnaby Hunt, Qing Ye, William J. Valentine & Donna Ashley. (2017) Evaluating the Long-Term Cost-Effectiveness of Daily Administered GLP-1 Receptor Agonists for the Treatment of Type 2 Diabetes in the United Kingdom. Diabetes Therapy 8:1, pages 129-147.
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Paul L. McCormack. (2014) Exenatide Twice Daily: A Review of Its Use in the Management of Patients with Type 2 Diabetes Mellitus. Drugs 74:3, pages 325-351.
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Carl V. Asche, Stephen E. Hippler & Dean T. Eurich. (2013) Review of Models Used in Economic Analyses of New Oral Treatments for Type 2 Diabetes Mellitus. PharmacoEconomics 32:1, pages 15-27.
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P Karagianni, SA Polyzos, N Kartali, I Zografou & C Sambanis. (2013) Comparative efficacy of exenatide versus insulin glargine on glycemic control in type 2 diabetes mellitus patients inadequately treated with metformin monotherapy. Advances in Medical Sciences 58:1, pages 38-43.
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R. F. Pollock, G. Muduma & W. J. Valentine. (2012) Evaluating the cost‐effectiveness of laparoscopic adjustable gastric banding versus standard medical management in obese patients with type 2 diabetes in the UK . Diabetes, Obesity and Metabolism 15:2, pages 121-129.
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Richard F. Pollock, Bradley H. Curtis, Jayne Smith-Palmer & William J. Valentine. (2012) A UK Analysis of the Cost-Effectiveness of Humalog Mix75/25 and Mix50/50 Versus Long-Acting Basal Insulin. Advances in Therapy 29:12, pages 1051-1066.
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Dhanwantee Mundil, Alison Cameron-Vendrig & Mansoor Husain. (2012) GLP-1 receptor agonists: A clinical perspective on cardiovascular effects. Diabetes and Vascular Disease Research 9:2, pages 95-108.
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Roger S. Mazze, Ellie S. Strock, Richard M. Bergenstal, Amy Criego, Robert Cuddihy, Oded Langer, Gregg D. Simonson & Margaret A. Powers. 2011. Staged Diabetes Management. Staged Diabetes Management 77 137 .
William J. Valentine, Andrew J. Palmer, Morten Lammert, Jakob Langer & Michael Brändle. (2011) Evaluating the Long-Term Cost-Effectiveness of Liraglutide Versus Exenatide BID in Patients With Type 2 Diabetes Who Fail to Improve With Oral Antidiabetic Agents. Clinical Therapeutics 33:11, pages 1698-1712.
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Gordon Goodall, María Costi, Louise Timlin, Jesús Reviriego, José Antonio Sacristán, Jayne Smith-Palmer & Tatiana Dilla. (2011) Coste-efectividad de exenatida en comparación con insulina glargina en pacientes con obesidad y diabetes mellitus tipo 2 en España. Endocrinología y Nutrición 58:7, pages 331-340.
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Gordon Goodall, María Costi, Louise Timlin, Jesús Reviriego, José Antonio Sacristán, Jayne Smith-Palmer & Tatiana Dilla. (2011) Cost-effectiveness of exenatide versus insulin glargine in Spanish patients with obesity and type 2 diabetes mellitus. Endocrinología y Nutrición (English Edition) 58:7, pages 331-340.
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Daniel M.D. Tucker & Andrew J. Palmer. (2011) The cost-effectiveness of interventions in diabetes: A review of published economic evaluations in the UK setting, with an eye on the future. Primary Care Diabetes 5:1, pages 9-17.
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Won Chan Lee, Christopher Conner & Mette Hammer. (2010) Results of a model analysis of the cost-effectiveness of liraglutide versus exenatide added to metformin, glimepiride, or both for the treatment of type 2 diabetes in the United States. Clinical Therapeutics 32:10, pages 1756-1767.
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Wei-Xin Li, Jian-Feng Gou, Jin-Hui Tian, Xiang Yan & Lin Yang. (2010) Glucagon-like peptide-1 receptor agonists versus insulin glargine for type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Current Therapeutic Research 71:4, pages 211-238.
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Davida F. Kruger, Bruce Bode & Geralyn R. Spollett. (2010) Understanding GLP-1 Analogs and Enhancing Patient Success. The Diabetes Educator 36:3_suppl, pages 44S-72S.
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Anushua SinhaMangala RajanThomas HoergerLen Pogach. (2010) Costs and Consequences Associated With Newer Medications for Glycemic Control in Type 2 Diabetes. Diabetes Care 33:4, pages 695-700.
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Derek Misurski, Maureen J. Lage, Rosalind Fabunmi & Kristina S. Boye. (2012) A comparison of costs among patients with type 2 diabetes mellitus who initiated therapy with exenatide or insulin glargine. Applied Health Economics and Health Policy 7:4, pages 245-254.
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T. Mittendorf, J. Smith-Palmer, L. Timlin, M. Happich & G. Goodall. (2009) Evaluation of exenatide vs. insulin glargine in type 2 diabetes: cost-effectiveness analysis in the German setting. Diabetes, Obesity and Metabolism 11:11, pages 1068-1079.
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Irene A. Weiss, Guy Valiquette & Monica D. Schwarcz. (2009) Impact of Glycemic Treatment Choices on Cardiovascular Complications in Type 2 Diabetes. Cardiology in Review 17:4, pages 165-175.
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Julia M. Bottomley & Frank D. Raymond. (2009) Pharmaco-economic issues for diabetes therapy. Insulin 4:1, pages 32-60.
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P. Levin. (2008) The cost-effectiveness of insulin glargine vs. neutral protamine Hagedorn insulin in type 2 diabetes: a focus on health economics. Diabetes, Obesity and Metabolism 10:s2, pages 66-75.
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R. Ravasio. (2013) Analisi di costo-efficacia di exenatide versus insulina glargine nel trattamento dei pazienti diabetici di tipo 2 in fallimento secondario al doppio ipoglicemizzante orale. Giornale Italiano di Health Technology Assessment 1:1, pages 21-30.
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Julia M. Bottomley & Frank D. Raymond. (2007) Pharmaco-economic issues for diabetes therapy. Best Practice & Research Clinical Endocrinology & Metabolism 21:4, pages 657-685.
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. (2013) Exenatide looks attractive in the UK setting. PharmacoEconomics & Outcomes News 529:1, pages 5-5.
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Risto S Cvetkovi??Greg L Plosker. (2007) Exenatide. Drugs 67:6, pages 935-954.
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