Advanced search
Publication Cover
Expert Opinion on Drug Discovery Volume 5, 2010 - Issue 3
Submit an article Journal homepage
6,773
Views
612
CrossRef citations to date
0
Altmetric
Reviews

Lipophilicity in drug discovery

Michael J Waring AstraZeneca, CVGI Medicinal Chemsitry, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK +44 1625 230942; +44 1625 516667; [email protected]
Pages 235-248 | Published online: 26 Feb 2010

Citations (612)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (24)

Rahul D. Jawarkar, Magdi E. A. Zaki, Sami A. Al-Hussain, Abdullah Yahya Abdullah Alzahrani, Long Chiau Ming, Abdul Samad, Summya Rashid, Suraj Mali & Gehan M. Elossaily. (2023) Mechanistic QSAR analysis to predict the binding affinity of diverse heterocycles as selective cannabinoid 2 receptor inhibitor. Journal of Taibah University for Science 17:1.
Read now
Robert J. Young. (2023) Today’s drug discovery and the shadow of the rule of 5. Expert Opinion on Drug Discovery 18:9, pages 965-972.
Read now
Kehinde F. Paul-Odeniran, Paul O. Odeniran, Isaiah O. Ademola & Hezekiel Kumalo. (2023) “Mango in all her majesty”—the potential of mangiferin and its analogues in the inhibition of Eimeria tenella hexokinase—a computational approach. Journal of Biomolecular Structure and Dynamics 41:11, pages 5291-5304.
Read now
Muhammad Yasin, Wardah Shahid, Muhammad Ashraf, Muhammad Saleem, Saima Muzaffar, Aziz-ur-Rehman  , Syeda Abida Ejaz, Hafiz Mohammad Kashif Mahmood, Keshab Bhattarai & Naheed Riaz. (2023) Targeting new N-furfurylated 4-chlorophenyl-1,2,4-triazolepropionamide hybrids as potential 15-lipoxygenase inhibitors supported with in vitro and in silico studies. Journal of Biomolecular Structure and Dynamics 41:11, pages 5166-5182.
Read now
Elvis Awuni & Radiatu Abdallah Musah. (2023) Proposing lead compounds for the development of SARS-CoV-2 receptor-binding inhibitors. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-16.
Read now
Bibi Hanifa, Naila Bibi, Muhammad Sirajuddin, Edward R. T. Tiekink, Maciej Kubicki, Ishaq Khan, Ahmed Bari, Abdul Wadood & Sulaiman Shams. (2023) Synthesis, spectral characterisation, biocidal investigation, in-silico and molecular docking studies of 4-[(2-chloro-4-methylphenyl)carbamoyl]butanoic acid derived triorganotin(IV) compounds. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-20.
Read now
Bushra Bashir, Naheed Riaz, Syeda Abida Ejaz, Muhammad Saleem, Ambar Iqbal, Muhammad Ashraf, Samina Ejaz, Aziz-ur -Rehman, Mubashir Aziz & Keshab Bhattarai. (2023) Investigations of p-tolyloxy-1,3,4-oxadiazole propionamides as soybean 15-lipoxygenase inhibitors in comforting with in vitro and in silico studies. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-20.
Read now
Patricia A. Lucero, Cynthia Magallanes-Noguera, Fernando A. Giannini, Mirtha Nassetta, Alejandro A. Orden & Marcela Kurina-Sanz. (2023) Remediation of endosulfan-contaminated water by hairy roots: removal and phytometabolization assessment. International Journal of Phytoremediation 25:1, pages 106-114.
Read now
Mousumi Sinha, Rahul Jagadeesan, Neeraj Kumar, Satabdi Saha, Gugan Kothandan & Diwakar Kumar. (2022) In-silico studies on Myo inositol-1-phosphate synthase of Leishmania donovani in search of anti-leishmaniasis. Journal of Biomolecular Structure and Dynamics 40:8, pages 3371-3384.
Read now
Hanumanth Srikanth Cheruvu, Xin Liu, Jeffrey E. Grice & Michael S. Roberts. (2020) Modeling percutaneous absorption for successful drug discovery and development. Expert Opinion on Drug Discovery 15:10, pages 1181-1198.
Read now
Jovana Krmar, Ana Protić, Nevena Đajić, Mira Zečević & Biljana Otašević. (2020) Chromatographic and computational lipophilicity assessment of novel antibiofilm agents. Journal of Liquid Chromatography & Related Technologies 43:15-16, pages 615-623.
Read now
Sonia Lobo. (2020) Is there enough focus on lipophilicity in drug discovery?. Expert Opinion on Drug Discovery 15:3, pages 261-263.
Read now
Kuldeep K. Roy & Mushtaq Ahmad Wani. (2020) Emerging opportunities of exploiting mycobacterial electron transport chain pathway for drug-resistant tuberculosis drug discovery. Expert Opinion on Drug Discovery 15:2, pages 231-241.
Read now
Chunyong He & Hong Wan. (2018) Drug metabolism and metabolite safety assessment in drug discovery and development. Expert Opinion on Drug Metabolism & Toxicology 14:10, pages 1071-1085.
Read now
Rafael Claveria-Gimeno, Sonia Vega, Olga Abian & Adrian Velazquez-Campoy. (2017) A look at ligand binding thermodynamics in drug discovery. Expert Opinion on Drug Discovery 12:4, pages 363-377.
Read now
Agnieszka Zagórska, Adam Bucki, Marcin Kołaczkowski, Agata Siwek, Monika Głuch-Lutwin, Gabriela Starowicz, Grzegorz Kazek, Anna Partyka, Anna Wesołowska, Karolina Słoczyńska, Elżbieta Pękala & Maciej Pawłowski. (2016) Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 10-24.
Read now
Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Małgorzata Jeleń & Dariusz Kuśmierz. (2016) Synthesis and anticancer and lipophilic properties of 10-dialkylaminobutynyl derivatives of 1,8- and 2,7-diazaphenothiazines. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1132-1138.
Read now
Zheng Li, Qianqian Qiu, Xinqian Geng, Jianyong Yang, Wenlong Huang & Hai Qian. (2016) Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development. Expert Opinion on Investigational Drugs 25:8, pages 871-890.
Read now
Ibrahim Ali M. Radini, Bakr F. Abdel-Wahab & Rizk E. Khidre. (2016) Synthetic routes to imidazothiazines. Phosphorus, Sulfur, and Silicon and the Related Elements 191:6, pages 844-856.
Read now
Jian Guo, Eric W. Miele, April Chen, Ricardo A. Luzietti, Mark Zambrowski, Robert L. Walsky & Ed T. Buurman. (2015) Pharmacokinetics of the natural antibiotic negamycin. Xenobiotica 45:7, pages 625-633.
Read now
Herbert A Kirst. (2013) Developing new antibacterials through natural product research. Expert Opinion on Drug Discovery 8:5, pages 479-493.
Read now
Paul Bamborough. (2012) System-based drug discovery within the human kinome. Expert Opinion on Drug Discovery 7:11, pages 1053-1070.
Read now
John A Arnott & Sonia Lobo Planey. (2012) The influence of lipophilicity in drug discovery and design. Expert Opinion on Drug Discovery 7:10, pages 863-875.
Read now
Peter Ballard, Patrick Brassil, Khanh H. Bui, Hugues Dolgos, Carl Petersson, Anders Tunek & Peter J. H. Webborn. (2012) The right compound in the right assay at the right time: an integrated discovery DMPK strategy. Drug Metabolism Reviews 44:3, pages 224-252.
Read now

Articles from other publishers (588)

Radek Jerga, Veronika Brablecová, Veronika Talášková, Hana Tomková, Jitka Součková, Petr Barták & Jana Skopalová. (2024) A novel device for the determination of liposome/water partition coefficients. Talanta 269, pages 125434.
Crossref
Angelica V. Sharapova, Svetlana V. Blokhina & Marina V. Ol'khovich. (2023) Thermodynamic analysis of nifedipine sublimation, dissolution and solvation. The Journal of Chemical Thermodynamics 187, pages 107139.
Crossref
Satyajit Pal, Subhankar Sarkar, Anindita Mukherjee, Anupam Kundu, Animesh Sen, Jnanendra Rath, Sougata Santra, Grigory V. Zyryanov & Adinath Majee. (2023) Metal-free, tert -butyl nitrite promoted C(sp 2 )–S coupling reaction: the synthesis of aryl dithiocarbamates and analysis of antimicrobial activity by ‘ in silico ’ and ‘ in vitro ’ methods for drug modification . Green Chemistry 25:23, pages 9847-9856.
Crossref
Andrey S. Kuzovlev, Mikhail D. Zybalov, Andrey V. Golovin, Maxim A. Gureev, Mariia A. Kasatkina, Mikhail V. Biryukov, Albina R. Belik, Sergey A. Silonov, Maxim A. Yunin, Nailya A. Zigangirova, Vasiliy V. Reshetnikov, Yulia E. Isakova, Yuri B. Porozov & Roman A. Ivanov. (2023) Naphthyl-Substituted Indole and Pyrrole Carboxylic Acids as Effective Antibiotic Potentiators—Inhibitors of Bacterial Cystathionine γ-Lyase. International Journal of Molecular Sciences 24:22, pages 16331.
Crossref
J.N. Cheerlin Mishma, V. Bena Jothy, Ahmad Irfan, B. Narayana & S. Muthu. (2023) Role of solvents in molecular level interaction, reactivity and spectral characterisation of 2-Amino-3-(((E)-4-(dimethylamino)benzylidene)amino) maleonitrile: Anti depressant agent. Journal of Molecular Liquids 389, pages 122937.
Crossref
Brooke Langevin, Jogarao V.S. Gobburu & Mathangi Gopalakrishnan. (2023) Is There a Need for a Dedicated Pharmacokinetic Trial for a Drug in Obese Populations? A Drug Prioritization Decision Tree Framework. The Journal of Clinical Pharmacology 63:S2.
Crossref
Austen Bernardi, W. F. Drew Bennett, Stewart He, Derek Jones, Dan Kirshner, Brian J. Bennion & Timothy S. Carpenter. (2023) Advances in Computational Approaches for Estimating Passive Permeability in Drug Discovery. Membranes 13:11, pages 851.
Crossref
Esteban Bertsch, Sebastián Suñer, Silvana Pinheiro & William J. Zamora. (2023) Critical Assessment of pH‐Dependent Lipophilicity Profiles of Small Molecules: Which One Should We Use and In Which Cases?. ChemPhysChem.
Crossref
Viola, Niaz Muhammad, Awal Noor, Muhammad Sirajuddin, Maciej Kubicki, Shahnaz Rahim, Abdus Samad, Shaukat Shujah, Abdul Wadood & Saqib Ali. (2023) Designing and Exploration of the Biological Potentials of Novel Centrosymmetric Heteroleptic Copper(II) Carboxylates. Pharmaceuticals 16:10, pages 1462.
Crossref
Anjaneyulu Mamindla, Manikandan Varadhan, Radhakrishnan Kartikeyan, Anbalagan Amuthamozhi, Mohammad Abdulkader Akbarsha & Venugopal Rajendiran. (2023) Comparative DNA-/BSA-binding, DNA cleavage, and cytotoxic properties of copper(II) amino/salicyl-phenolate Schiff bases (phen) complexes that induce generation of phenoxyl radicals. Polyhedron 243, pages 116534.
Crossref
J.N. Cheerlin Mishma, V. Bena Jothy, B. Narayana, Suresh N Kodlady, Naiyf S. Alharbi, Ghulam Abbas & S. Muthu. (2023) Synthesis, DFT, solvent effect and biological attributes of NLO active 4-bromo-2-((2-(2,4-Dinitrophenyl) hydrazono)methyl) phenol -Potent drug anti-brain cancer. Journal of Molecular Structure 1289, pages 135839.
Crossref
Małgorzata Strzelecka, Benita Wiatrak, Paulina Jawień, Żaneta Czyżnikowska & Piotr Świątek. (2023) New Schiff bases derived from dimethylpyridine-1,2,4-triazole hybrid as cytotoxic agents targeting gastrointestinal cancers: Design, synthesis, biological evaluation and molecular docking studies. Bioorganic Chemistry 139, pages 106758.
Crossref
Casey J. Patterson-Gardner, Gretchen M. Pavelich, April T. Cannon, Alexander J. Menke & Eric E. Simanek. (2023) Adaptation of Empirical Methods to Predict the LogD of Triazine Macrocycles. ACS Medicinal Chemistry Letters.
Crossref
Yitian Wang, Jiacheng Xiong, Fu Xiao, Wei Zhang, Kaiyang Cheng, Jingxin Rao, Buying Niu, Xiaochu Tong, Ning Qu, Runze Zhang, Dingyan Wang, Kaixian Chen, Xutong Li & Mingyue Zheng. (2023) LogD7.4 prediction enhanced by transferring knowledge from chromatographic retention time, microscopic pKa and logP. Journal of Cheminformatics 15:1.
Crossref
Md Shamim, Jason Dinh, Chengeng Yang, Shinsuke Nomura, Satoshi Kashiwagi, Homan Kang, Hak Soo Choi & Maged Henary. (2023) Synthesis, Optical Properties, and In Vivo Biodistribution Performance of Polymethine Cyanine Fluorophores. ACS Pharmacology & Translational Science 6:8, pages 1192-1206.
Crossref
Mohammad Saiful Islam & Somenath Mitra. (2023) Effect of nano graphene oxide (nGO) incorporation on the lipophilicity of hydrophobic drugs. Hybrid Advances 3, pages 100074.
Crossref
Siyu He, Linjie Li, Rui Jin & Xiaojie Lu. (2023) Biological Function of Pin1 in Vivo and Its Inhibitors for Preclinical Study: Early Development, Current Strategies, and Future Directions. Journal of Medicinal Chemistry 66:14, pages 9251-9277.
Crossref
Anna Seetsi, David D. N'da, Nthatisi Molefe‐Nyembe, Keisuke Suganuma, Tsepo Ramatla & Oriel Thekisoe. (2023) In vitro anti‐trypanosomal activity of synthetic nitrofurantoin‐triazole hybrids against Trypanosoma species causing human African trypanosomosis . Fundamental & Clinical Pharmacology.
Crossref
Yi Jin, Yanjie Tan, Jian Wu & Zhuqing Ren. (2023) Lipid droplets: a cellular organelle vital in cancer cells. Cell Death Discovery 9:1.
Crossref
Manasa Punaha Ravindra, Martin Lee, Silviya Dimova, Craig F. Steven, Marie T. J. Bluntzer, Valerie G. Brunton & Alison N. Hulme. (2023) Stretching the Bisalkyne Raman Spectral Palette Reveals a New Electrophilic Covalent Motif. Chemistry – A European Journal 29:38.
Crossref
Radhakrishnan Kartikeyan, Dhanashree Murugan, Tamilarasan Ajaykamal, Manikandan Varadhan, Loganathan Rangasamy, Marappan Velusamy, Mallayan Palaniandavar & Venugopal Rajendiran. (2023) Mixed ligand copper( ii )-diimine complexes of 2-formylpyridine- N 4 -phenylthiosemicarbazone: diimine co-ligands tune the in vitro nanomolar cytotoxicity . Dalton Transactions 52:26, pages 9148-9169.
Crossref
Anton Lindberg, Melissa Chassé, Cassis Varlow, Anna Pees & Neil Vasdev. (2023) Strategies for designing novel positron emission tomography (PET) radiotracers to cross the blood–brain barrier. Journal of Labelled Compounds and Radiopharmaceuticals 66:9, pages 205-221.
Crossref
Samira Bendjedid & Djamila Benouchenne. (2023) In silico studies for assessing physicochemical, pharmacokinetic and cytotoxic properties of bioactive molecules identified by LC-MS in Aloe vera leaf extracts. South African Journal of Botany 157, pages 75-81.
Crossref
Xiangwei Zhu, Valery R. Polyakov, Krishna Bajjuri, Huiyong Hu, Andreas Maderna, Clare A. ToveeSuzanna C. Ward. (2023) Building Machine Learning Small Molecule Melting Points and Solubility Models Using CCDC Melting Points Dataset. Journal of Chemical Information and Modeling 63:10, pages 2948-2959.
Crossref
Zhong Wang, Hannah R. Felstead, Robert I. Troup, Bruno Linclau & Philip T. F. Williamson. (2023) Lipophilicity Modulations by Fluorination Correlate with Membrane Partitioning. Angewandte Chemie International Edition 62:21.
Crossref
Preantha Poonan, Xylia Q. Peters, Mahmoud E.S. Soliman, Mohamed I. Alahmdi & Nader E. Abo-Dya. (2023) Pharmacophore-based Identification of Potential Mutant Isocitrate Dehydrogenases I/2 Inhibitors: An Explorative Avenue in Cancer Drug Design. Anti-Cancer Agents in Medicinal Chemistry 23:8, pages 953-966.
Crossref
Ahmed H.E. Hassan, Trong-Nhat Phan, Suyeon Moon, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Selwan M. El-Sayed, Yeonwoo Choi, Joo Hwan No & Yong Sup Lee. (2023) Design, synthesis, and repurposing of O-aminoalkyl-sulfuretin analogs towards discovery of potential lead compounds as antileishmanial agents. European Journal of Medicinal Chemistry 251, pages 115256.
Crossref
Yan-Jing Duan, Li Fu, Xiao-Chen Zhang, Teng-Zhi Long, Yuan-Hang He, Zhao-Qian Liu, Ai-Ping Lu, Ya-Feng Deng, Chang-Yu Hsieh, Ting-Jun Hou & Dong-Sheng Cao. (2023) Improved GNNs for Log  D 7.4 Prediction by Transferring Knowledge from Low-Fidelity Data . Journal of Chemical Information and Modeling 63:8, pages 2345-2359.
Crossref
Manokaran Malini, Ramasamy Thilagavathi, Sanjeev Kumar Singh, Arun Pravin & Chelliah Selvam. (2023) Structure‐Based Drug Design: Identification of Glucokinase Activators from Natural Compounds for the Treatment of Type 2 Diabetes. ChemistrySelect 8:15.
Crossref
Md. Kamrul Islam, Ah-Rum Baek, Byeong-Woo Yang, Soyeon Kim, Dong Wook Hwang, Sung-Wook Nam, Gang-Ho Lee & Yongmin Chang. (2023) Manganese (II) Complex of 1,4,7-Triazacyclononane-1,4,7-Triacetic Acid (NOTA) as a Hepatobiliary MRI Contrast Agent. Pharmaceuticals 16:4, pages 602.
Crossref
Zhong Wang, Hannah R. Felstead, Robert I. Troup, Bruno Linclau & Philip T. F. Williamson. (2023) Lipophilicity Modulations by Fluorination Correlate with Membrane Partitioning. Angewandte Chemie.
Crossref
Luca Blicker, Rafael González-Cano, Erik Laurini, Francisco R. Nieto, Judith Schmidt, Dirk Schepmann, Sabrina Pricl & Bernhard Wünsch. (2023) Conformationally Restricted σ 1 Receptor Antagonists from (−)-Isopulegol . Journal of Medicinal Chemistry 66:7, pages 4999-5020.
Crossref
Zaw-Myo Win, Allen M. Y. Cheong & W. Scott Hopkins. (2023) Using Machine Learning To Predict Partition Coefficient (Log P ) and Distribution Coefficient (Log D ) with Molecular Descriptors and Liquid Chromatography Retention Time . Journal of Chemical Information and Modeling 63:7, pages 1906-1913.
Crossref
Jadwiga Maniewska, Justyna Gąsiorowska, Żaneta Czyżnikowska, Krystyna Michalak & Berenika M. Szczęśniak-Sięga. (2023) New Meloxicam Derivatives—Synthesis and Interaction with Phospholipid Bilayers Measured by Differential Scanning Calorimetry and Fluorescence Spectroscopy. Membranes 13:4, pages 416.
Crossref
J.N.Cheerlin Mishma, V.Bena Jothy, Ahmad Irfan, B. Narayana, Suresh N Kodlady & S. Muthu. (2023) Solvent potential effects (topological aspects, electron excitation), spectral characterization and biological attributes of NLO active 1-(2,4-dinitrophenyl)-2-((E)-3-phenylallylidene) hydrazine: Multiple anti tuberculosis agent. Journal of Molecular Liquids 376, pages 121439.
Crossref
Binimol Mary Mathew, S. Suma, M.R. Sudarsanakumar, I. Hubert Joe, L. Anitha, Suganya Suresh & S. Anusree. (2023) Experimental and theoretical analyses and investigation of intermolecular interactions and antibacterial activity of a novel proton transfer compound:8-hydroxyquinolinium oxalate monohydrate. Heliyon 9:4, pages e14703.
Crossref
Keiichi Suzuki, Hiroko Koyama, Narumasa Nakamura, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Hideki Ishii, Ming-Rong Zhang, Kazunori Kawamura, Takafumi Minamimoto, Yuji Nagai, Hiroshi Katsuki, Tetsuya Kimura, Nobuyuki Kimura, Masanori Ichise, Takashi Kato, Kengo Ito & Masaaki Suzuki. (2023) 11C-Labeling of acyclic retinoid peretinoin by rapid C-[11C]methylation to disclose novel brain permeability and central nervous system activities hidden in antitumor agent. Bioorganic & Medicinal Chemistry Letters 85, pages 129212.
Crossref
Naheed Riaz, Muhammad Yasin, Muhammad Ashraf, Muhammad Saleem, Bushra Bashir, Ambar Iqbal, Aziz-ur-Rehman, Syeda Abida Ejaz, Samina Ejaz, Hafiz Mohammad Kashif Mahmood & Keshab Bhattarai. (2023) Vetting of new N-furfurylated p-chlorophenyl-1,2,4-triazole acetamides as lipoxygenase inhibitors assisted with in vitro and in silico studies. Journal of the Iranian Chemical Society 20:4, pages 977-994.
Crossref
Marius R. Bittermann, Tatiana I. Morozova, Santiago F. Velandia, Elham Mirzahossein, Antoine Deblais, Sander Woutersen & Daniel Bonn. (2023) Surface-Mediated Molecular Transport of a Lipophilic Fluorescent Probe in Polydisperse Oil-in-Water Emulsions. Langmuir 39:12, pages 4207-4215.
Crossref
Lei Xu, Shourun Pan, Leiming Xia & Zhen Li. (2023) Molecular Property Prediction by Combining LSTM and GAT. Biomolecules 13:3, pages 503.
Crossref
Sajad Ahmad Bhat, Syed Kazim Hasan, Zahoor Ahmad Parray, Zaheenul Islam Siddiqui, Shabnam Ansari, Ayesha Anwer, Saniya Khan, Fatima Amir, Mahboubeh Mehmankhah, Asimul Islam, Zarrin Minuchehr & Syed Naqui Kazim. (2023) Potential antiviral activities of chrysin against hepatitis B virus. Gut Pathogens 15:1.
Crossref
Darren V. S. Green & Colin M. Edge. 2023. The Handbook of Medicinal Chemistry. The Handbook of Medicinal Chemistry 94 136 .
Andrew M. Davis & Paul D. Leeson. 2023. The Handbook of Medicinal Chemistry. The Handbook of Medicinal Chemistry 1 39 .
Danni Ramdhani, Nita Listiani, Maula Eka Sriyani, Eva Maria W, Hiroshi Watabe, Resmi Mustarichie, Sri Agung Fitri Kusuma & Regaputra S. Janitra. (2023) Estrogen receptor targeting with genistein radiolabeled Technetium-99m as radiotracer of breast cancer: Its optimization, characterization, and predicting stability constants by DFT calculation. Heliyon 9:2, pages e13169.
Crossref
Arka Das, Gurubasavaraja Swamy Purawarga Matada, Prasad Sanjay Dhiwar, Nulgumnalli Manjunathaiah Raghavendra, Nahid Abbas, Ekta Singh, Abhishek Ghara & Ganesh Prasad Shenoy. (2023) Molecular recognition of some novel mTOR kinase inhibitors to develop anticancer leads by drug-likeness, molecular docking and molecular dynamics based virtual screening strategy. Computational Toxicology 25, pages 100257.
Crossref
Dorottya Bai, Zsuzsanna Schelz, Dóra Erdős, Anna K. Kis, Viktória Nagy, István Zupkó, György T. Balogh & Zsolt Szakonyi. (2023) Stereoselective Synthesis and Antiproliferative Activities of Tetrafunctional Diterpene Steviol Derivatives. International Journal of Molecular Sciences 24:2, pages 1121.
Crossref
M. Akiful Haque, Akash Marathakam, Ritesh Rana, Samar J Almehmadi, Vishal B. Tambe, Manoj S. Charde, Fahadul Islam, Falak A. Siddiqui, Giulia Culletta, Anna Maria Almerico, Marco Tutone & Sharuk L. Khan. (2023) Fighting Antibiotic Resistance: New Pyrimidine-Clubbed Benzimidazole Derivatives as Potential DHFR Inhibitors. Molecules 28:2, pages 501.
Crossref
Tobias Winge, Dirk Schepmann, Judith Schmidt, Constantin Daniliuc, Ernst-Ulrich Würthwein & Bernhard Wünsch. (2023) Diastereoselective synthesis and structure–affinity relationships of σ 1 receptor ligands with spirocyclic scaffold . Organic & Biomolecular Chemistry.
Crossref
Celso de Oliveira Rezende Júnior, Pablo David Grigol Martinez, Rafael Augusto Alves Ferreira, Paul John Koovits, Bruna Miranda Soares, Leonardo L.G. Ferreira, Simone Michelan-Duarte, Rafael Consolin Chelucci, Adriano D. Andricopulo, An Matheeussen, Natascha Van Pelt, Guy Caljon, Louis Maes, Simon Campbell, Jadel M. Kratz, Charles E. Mowbray & Luiz Carlos Dias. (2023) Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease. European Journal of Medicinal Chemistry 246, pages 114925.
Crossref
Bin Wang, Zongyu Cai, Huixin Yao, Shixuan Jiao, Siliang Chen, Zhongcheng Yang, Wanqiu Huang, Qiang Ren, Zhijun Cao, Ya Chen, Luyong Zhang & Zheng Li. (2023) Discovery of a structurally novel, potent, and once-weekly free fatty acid receptor 1 agonist for the treatment of diabetes. European Journal of Medicinal Chemistry 245, pages 114883.
Crossref
Xinyan Peng, Qiushi Chen, Bo Han, Hao Zhang, Jianqi Li & Qingwei Zhang. 2023. Privileged Scaffolds in Drug Discovery. Privileged Scaffolds in Drug Discovery 273 299 .
Ezaldeen Esawi, Hamdi Nsairat, Ismail Sami Mahmoud, Zainab Lafi, Abdulfattah Al-Kadash, Bayan Abu Al-Ragheb, Said I. Ismail & Walhan Alhaer. 2023. Aptamers Engineered Nanocarriers for Cancer Therapy. Aptamers Engineered Nanocarriers for Cancer Therapy 481 520 .
Timothy J. Carlson. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 175 187 .
Cheng Zhou, Geraldine W. N. Chia & Ken-Tye Yong. (2022) Membrane-intercalating conjugated oligoelectrolytes. Chemical Society Reviews 51:24, pages 9917-9932.
Crossref
Prashant Agarwal, James Huckle, Jake Newman & Darren L. Reid. (2022) Trends in small molecule drug properties: A developability molecule assessment perspective. Drug Discovery Today 27:12, pages 103366.
Crossref
Bushra Bashir, Naheed Riaz, Syeda Abida Ejaz, Muhammad Saleem, Muhammad Ashraf, Ambar Iqbal, Saima Muzaffar, Samina Ejaz, Aziz-ur-Rehman, Hafiz Mohammad Kashif Mahmood & Keshab Bhattarai. (2022) Assessing p-tolyloxy-1,3,4-oxadiazole acetamides as lipoxygenase inhibitors assisted by in vitro and in silico studies. Bioorganic Chemistry 129, pages 106144.
Crossref
Asma Sardar, Obaid-ur-Rahman Abid, Saima Daud, Basit Ali Shah, Wardah Shahid, Muhammad Ashraf, Mahvish Fatima, Safa Ezzine, Abdul Wadood, Azam Shareef, Hanan A. Al-Ghulikah & Siham A. Alissa. (2022) Identification of novel diclofenac acid and naproxen bearing hydrazones as 15-LOX inhibitors: Design, synthesis, in vitro evaluation, cytotoxicity, and in silico studies. Arabian Journal of Chemistry 15:12, pages 104300.
Crossref
Hasnain Mehmood, Mustapha Musa, Simon Woodward, Md Shahadat Hossan, Tracey D. Bradshaw, Muhammad Haroon, Andrew Nortcliffe & Tashfeen Akhtar. (2022) Design, and synthesis of selectively anticancer 4-cyanophenyl substituted thiazol-2-ylhydrazones. RSC Advances 12:52, pages 34126-34141.
Crossref
Lu Hu, Yang Sun, Shun Liu, Hannah Erb, Alka Singh, Junhao Mao, Xuelian Luo & Xu Wu. (2022) Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. eLife 11.
Crossref
Lauren E. Brown, Scott Seitz, Ashley V. Kondas, Paul T. Marcyk, Claire Marie Filone, Mohammad M. Hossain, Scott E. Schaus, Victoria A. Olson & John H. Connor. (2022) Identification of Small Molecules with Improved Potency against Orthopoxviruses from Vaccinia to Smallpox. Antimicrobial Agents and Chemotherapy 66:11.
Crossref
Patrícia S. M. Amado, Christopher Woodley, Maria L. S. Cristiano & Paul M. O’Neill. (2022) Recent Advances of DprE1 Inhibitors against Mycobacterium tuberculosis : Computational Analysis of Physicochemical and ADMET Properties . ACS Omega 7:45, pages 40659-40681.
Crossref
Madoka Kawamura, Yohei Kobashi, Hiroaki Tanaka, Ayako Bohno-Mikami, Makoto Hamada, Yuji Ito, Takashi Hirata, Hiroki Ohara, Naoki Kojima, Hiroko Koretsune, Emi Gunji, Takuya Fukunaga, Shoko Inatani, Yoshitaka Hasegawa, Akinori Suzuki, Teisuke Takahashi & Hiroyuki Kakinuma. (2022) Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. Journal of Medicinal Chemistry 65:21, pages 14599-14613.
Crossref
Rui-qi Wang, Tong Zhou, Aimin Li, Jian Qu, Xin Zhang, Xiang-feng Zhu & Su Jing. (2022) The design of fluorescein–ferrocene derivatives as HOCl-triggered turn-on fluorescent probes and anticancer prodrugs. Dalton Transactions 51:40, pages 15330-15338.
Crossref
Makito Yamada, Yu Hirose, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Sirimangkalakitti Natchanun, Naoyuki Takahashi, Yuuta Ohki, Makoto Sako, Kenichi Murai, Kazuo Harada, Masayoshi Arai, Sayo Suzuki, Tomonori Nakamura, Junichi Haruta & Mitsuhiro Arisawa. (2022) Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N -Arylated Heliamine Analogues . ACS Medicinal Chemistry Letters 13:10, pages 1582-1590.
Crossref
Angelica Sharapova, Marina Ol’khovich, Svetlana Blokhina & German L. Perlovich. (2022) Experimental Examination of Solubility and Lipophilicity as Pharmaceutically Relevant Points of Novel Bioactive Hybrid Compounds. Molecules 27:19, pages 6504.
Crossref
Abirami Arunachalam, Ramesh Rengan, Devan Umapathy & Antony Joseph Velanganni Arockiam. (2022) Impact of Biphenyl Benzhydrazone-Incorporated Arene Ru(II) Complexes on Cytotoxicity and the Cancer Cell Death Mechanism. Organometallics 41:17, pages 2474-2486.
Crossref
Sharoen Y. M. Lim, Jason Siau Ee Loo, Mustafa Alshagga, Mohammed A. Alshawsh, Chin E. Ong & Yan Pan. (2022) Protein-Ligand Identification and In Vitro Inhibitory Effects of Cathine on 11 Major Human Drug Metabolizing Cytochrome P450s . International Journal of Toxicology 41:5, pages 355-366.
Crossref
Bruno L. Travi. (2022) Current status of antihistamine drugs repurposing for infectious diseases. Medicine in Drug Discovery 15, pages 100140.
Crossref
Jadwiga Maniewska, Żaneta Czyżnikowska, Berenika M. Szczęśniak-Sięga & Krystyna Michalak. (2022) Interaction of Oxicam Derivatives with the Artificial Models of Biological Membranes—Calorimetric and Fluorescence Spectroscopic Study. Membranes 12:8, pages 791.
Crossref
Anna Sophia Kamenik, Stephanie Maria Linker & Sereina Riniker. 2022. Approaching the Next Inflection in Peptide Therapeutics: Attaining Cell Permeability and Oral Bioavailability. Approaching the Next Inflection in Peptide Therapeutics: Attaining Cell Permeability and Oral Bioavailability 137 154 .
Matthew W.D. Perry, Ulf Börjesson, Antonios Nikitidis & Christian Tyrchan. (2022) Surprising lipophilicity observations identify unexpected conformational effects. Bioorganic & Medicinal Chemistry Letters 69, pages 128786.
Crossref
Cauê Benito Scarim & Chung Man Chin. (2022) Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds. Anti-Cancer Agents in Medicinal Chemistry 22:12, pages 2204-2240.
Crossref
Qiu-ju Huang, Guo-chao Liao, Xue-rong Zhuang, Meng-lan Yang, Jing-jing Yao, Jian-hua Deng, Yan-min Zhang, Ying Wang, Xiao-xiao Qi, Dong-feng Pan, Yang Guan, Zhi-ying Huang, Feng-xue Zhang, Zhong-qiu Liu & Lin-lin Lu. (2021) Ras inhibitor farnesylthiosalicylic acid conjugated with IR783 dye exhibits improved tumor-targeting and altered anti-breast cancer mechanisms in mice. Acta Pharmacologica Sinica 43:7, pages 1843-1856.
Crossref
Daniel Katz, Kate Fike, Justin Longenberger, Steve Placko, Laurence Philippe-Venec & Andrew Chervenak. (2022) AlphaLogD determination: An optimized Reversed-Phase Liquid Chromatography method to measure lipophilicity on neutral and basic small and Beyond-Rule-of-Five compounds. Journal of Chromatography A 1674, pages 463146.
Crossref
Lihua Chen, Pan Zhao, Jing Yang, Xiali Liao, Bo Yang & Chuanzhu Gao. (2022) Synthesis, characterization, and antitumor biological evaluation of novel fluorine‐containing platinum (IV) complexes. Applied Organometallic Chemistry 36:7.
Crossref
Ishay Columbus, Lee Ghindes-Azaria, Ravit Chen, Lea Yehezkel, Orit Redy-Keisar, Gil Fridkin, Dafna Amir, Daniele Marciano, Eyal Drug, Eytan Gershonov, Ziv Klausner, Sigal Saphier, Shlomi Elias, Alexander Pevzner, Yoav Eichen, Galit Parvari, Boris Smolkin & Yossi Zafrani. (2022) Studying Lipophilicity Trends of Phosphorus Compounds by 31 P-NMR Spectroscopy: A Powerful Tool for the Design of P-Containing Drugs . Journal of Medicinal Chemistry 65:12, pages 8511-8524.
Crossref
Matthew W. Boudreau & Paul J. Hergenrother. (2022) Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity. RSC Medicinal Chemistry 13:6, pages 711-725.
Crossref
Monika Pastewska, Beata Żołnowska, Strahinja Kovačević, Hanna Kapica, Maciej Gromelski, Filip Stoliński, Jarosław Sławiński, Wiesław Sawicki & Krzesimir Ciura. (2022) Modeling of Anticancer Sulfonamide Derivatives Lipophilicity by Chemometric and Quantitative Structure-Retention Relationships Approaches. Molecules 27:13, pages 3965.
Crossref
Muhammad Yasin, Wardah Shahid, Muhammad Ashraf, Muhammad Saleem, Saima Muzaffar, Aziz-ur-Rehman, Syed Abid Ejaz, Amna Saeed, Thomas Majer, Keshab Bhattarai & Naheed Riaz. (2022) 4-Chlorophenyl- N -furfuryl-1,2,4-triazole Methylacetamides as Significant 15-Lipoxygenase Inhibitors: an Efficient Approach for Finding Lead Anti-inflammatory Compounds . ACS Omega 7:23, pages 19721-19734.
Crossref
Zhengyuan Zhou, Michael R. Zalutsky & Satish K. Chitneni. (2022) Stapled peptides as scaffolds for developing radiotracers for intracellular targets: Preliminary evaluation of a radioiodinated MDM2-binding stapled peptide in the SJSA-1 osteosarcoma model. Bioorganic & Medicinal Chemistry Letters 66, pages 128725.
Crossref
Cauê Benito Scarim & Fernando Rogério Pavan. (2022) Recent advancement in drug development of nitro( NO 2 )‐heterocyclic compounds as lead scaffolds for the treatment of Mycobacterium tuberculosis . Drug Development Research 83:4, pages 842-858.
Crossref
Jun Zhang, Qin Wang, Yang Su, Saimeng Jin, Jingzheng Ren, Mario Eden & Weifeng Shen. (2022) An accurate and interpretable deep learning model for environmental properties prediction using hybrid molecular representations. AIChE Journal 68:6.
Crossref
Nonkululeko H. Zuma, Janine Aucamp, Maryna Viljoen & David D. N'Da. (2022) Synthesis, in vitro Antileishmanial Efficacy and Hit/Lead Identification of Nitrofurantoin‐Triazole Hybrids . ChemMedChem 17:10.
Crossref
Jarvis Hill & David Crich. (2022) The N,N,O -Trisubstituted Hydroxylamine Isostere and Its Influence on Lipophilicity and Related Parameters . ACS Medicinal Chemistry Letters 13:5, pages 799-806.
Crossref
Amrita Chakrabarti, Chintam Narayana, Nishant Joshi, Swati Garg, Lalit C. Garg, Anand Ranganathan, Ram Sagar, Soumya Pati & Shailja Singh. (2022) Metalloprotease Gp63-Targeting Novel Glycoside Exhibits Potential Antileishmanial Activity. Frontiers in Cellular and Infection Microbiology 12.
Crossref
Asma Sardar, Obaid-ur-Rahman Abid, Saima Daud, M. Fakhar-e-Alam, Muhammad Hussnain Siddique, Muhammad Ashraf, Wardah Shahid, Syeda Abida Ejaz, M. Atif, Shafiq Ahmad, Sulman Shafeeq & Muhammad Afzal. (2022) Design, synthesis, in vitro and in silico studies of naproxen derivatives as dual lipoxygenase and α-glucosidase inhibitors. Journal of Saudi Chemical Society 26:3, pages 101468.
Crossref
Kayo Alves Figueiredo, Rayla Kelly Magalhães Costa, Jefferson Almeida Rocha, Stanley Juan Chavez Gutierrez, Ricardo Martins Ramos, Michel Muálem de Moraes Alves, Fernando Aécio de Amorim Carvalho, André Luis Menezes Carvalho & Francisco das Chagas Alves Lima. (2022) Antileishmanial activity of Riparin structural analogs of Aniba riparia: Biological evaluation, in silico Adme-Tox, and molecular docking. Experimental Parasitology 236-237, pages 108257.
Crossref
Sawsan H. Alelaiwi, Jason E. Heindl, Vignesh Sivaganesh, Bela Peethambaran & James R. McKee. (2022) Structure–activity relationship of 2-aminodibenzothiophene pharmacophore and the discovery of aminobenzothiophenes as potent inhibitors of Mycobacterium smegmatis. Bioorganic & Medicinal Chemistry Letters 63, pages 128650.
Crossref
Olalla Novo Fernández, Diego Oliveros, Ramon Canela Garayoa, Mercè Balcells Fluvià, Jonh J. Méndez Arteaga & Jordi Eras Joli. (2022) Introducing Lipophilicity to (Polyhydroxyalkyl)thiazolidine Carboxylic Acids Via Acylation. ACS Omega 7:13, pages 11075-11081.
Crossref
Marina T. Varela, Maiara Amaral, Maiara M. Romanelli, Erica V. de Castro Levatti, Andre G. Tempone & João Paulo S. Fernandes. (2022) Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi. European Journal of Pharmaceutical Sciences 171, pages 106114.
Crossref
Mariko Orioka, Masatoshi Eguchi, Yuki Mizui, Yuma Ikeda, Akihiro Sakama, Qiaojing Li, Hideaki Yoshimura, Takeaki Ozawa, Daniel Citterio & Yuki Hiruta. (2022) A Series of Furimazine Derivatives for Sustained Live-Cell Bioluminescence Imaging and Application to the Monitoring of Myogenesis at the Single-Cell Level. Bioconjugate Chemistry 33:3, pages 496-504.
Crossref
Matthew W. Boudreau, Michael P. Mulligan, David J. Shapiro, Timothy M. Fan & Paul J. Hergenrother. (2022) Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. Journal of Medicinal Chemistry 65:5, pages 3894-3912.
Crossref
Tamires L Valverde, Eloísa G Sampiron, Débora C Montaholi, Vanessa P Baldin, Diego DR Insaurralde, Vanessa G Alves-Olher, Vera LD Siqueira, Katiany R Caleffi-Ferracioli, Rosilene F Cardoso, Fábio Vandresen & Regiane BL Scodro. (2022) 3,5-dinitrobenzoylhydrazone derivatives as a scaffold for antituberculosis drug development. Future Microbiology 17:4, pages 267-280.
Crossref
Chrisna Matthee, Gisella Terre’Blanche, Helena D. Janse van Rensburg, Janine Aucamp & Lesetja J. Legoabe. (2021) Chalcone‐inspired r A 1 /A 2A adenosine receptor ligands: Ring closure as an alternative to a reactive substructure . Chemical Biology & Drug Design 99:3, pages 416-437.
Crossref
Ignacio Aliagas, Alberto Gobbi, Man-Ling Lee & Benjamin D. Sellers. (2022) Comparison of logP and logD correction models trained with public and proprietary data sets. Journal of Computer-Aided Molecular Design 36:3, pages 253-262.
Crossref
Maja D. Nešić, Tanja Dučić, Manuel Algarra, Iva Popović, Milutin Stepić, Mara Gonçalves & Marijana Petković. (2022) Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study. Cancers 14:5, pages 1182.
Crossref
Bruno Linclau, Zhong Wang, Benjamin Jeffries, Jérôme Graton, Rodrigo J. Carbajo, Davy Sinnaeve, Jean‐Yves Le Questel, James S. Scott & Elisabetta Chiarparin. (2021) Relating Conformational Equilibria to Conformer‐Specific Lipophilicities: New Opportunities in Drug Discovery. Angewandte Chemie International Edition 61:7.
Crossref
Bruno Linclau, Zhong Wang, Benjamin Jeffries, Jérôme Graton, Rodrigo J. Carbajo, Davy Sinnaeve, Jean‐Yves Le Questel, James S. Scott & Elisabetta Chiarparin. (2021) Relating Conformational Equilibria to Conformer‐Specific Lipophilicities: New Opportunities in Drug Discovery. Angewandte Chemie 134:7.
Crossref
Lei Chen, Mei Su, Xian-Zhi Wu, De-Zhong Wang, Yang-yang Kang, Chun-Gu Wang, Israa Assani, Mu-Xuan Wang, Shi-Feng Zhao, Shen-Min Lv, Jia-Wei Wang, Bo Sun, Yan Li, Qiu Jin, Ri-Zhen Huang & Zhi-Xin Liao. (2022) Discovery of 2H-chromone-4-one based sulfonamide derivatives as potent retinoic acid receptor-related orphan receptor γt inverse agonists. European Journal of Medicinal Chemistry 229, pages 114065.
Crossref
Urszula K. Komarnicka, Alessandro Niorettini, Sandra Kozieł, Barbara Pucelik, Agata Barzowska, Daria Wojtala, Aleksandra Ziółkowska, Monika Lesiów, Agnieszka Kyzioł, Stefano Caramori, Marina Porchia & Alina Bieńko. (2022) Two out of Three Musketeers Fight against Cancer: Synthesis, Physicochemical, and Biological Properties of Phosphino CuI, RuII, IrIII Complexes. Pharmaceuticals 15:2, pages 169.
Crossref
Joanna Matalińska, Katarzyna Kosińska, Paweł K. Halik, Przemysław Koźmiński, Piotr F. J. Lipiński, Ewa Gniazdowska & Aleksandra Misicka. (2022) Novel NK1R-Targeted 68Ga-/177Lu-Radioconjugates with Potential Application against Glioblastoma Multiforme: Preliminary Exploration of Structure–Activity Relationships. International Journal of Molecular Sciences 23:3, pages 1214.
Crossref
Ivani Pauli, Celso de O. Rezende Jr.Brian W. Slafer, Marco A. Dessoy, Mariana L. de Souza, Leonardo L. G. Ferreira, Abraham L. M. Adjanohun, Rafaela S. Ferreira, Luma G. Magalhães, Renata Krogh, Simone Michelan-Duarte, Ricardo Vaz Del Pintor, Fernando B. R. da Silva, Fabio C. Cruz, Luiz C. Dias & Adriano D. Andricopulo. (2022) Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics. Frontiers in Pharmacology 12.
Crossref
Katarzyna Masłowska, Ewa Witkowska, Dagmara Tymecka, Paweł Krzysztof Halik, Aleksandra Misicka & Ewa Gniazdowska. (2022) Synthesis, Physicochemical and Biological Study of Gallium-68- and Lutetium-177-Labeled VEGF-A165/NRP-1 Complex Inhibitors Based on Peptide A7R and Branched Peptidomimetic. Pharmaceutics 14:1, pages 100.
Crossref
Nils-Jørgen Knudsen Dal, Martin Speth, Kerstin Johann, Matthias Barz, Claire Beauvineau, Jens Wohlmann, Federico Fenaroli, Brigitte Gicquel, Gareth Griffiths & Noelia Alonso-Rodriguez. (2022) The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds . Disease Models & Mechanisms 15:1.
Crossref
Sharoen Yu Ming Lim, Jason Siau Ee Loo, Mustafa Alshagga, Mohammed Abdullah Alshawsh, Chin Eng Ong & Yan Pan. (2022) In vitro and In silico studies of interactions of cathinone with human recombinant cytochrome P450 CYP(1A2), CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2E1, CYP2J2, and CYP3A5. Toxicology Reports 9, pages 759-768.
Crossref
Sangsoo Lim, Sangseon Lee, Yinhua Piao, MinGyu Choi, Dongmin Bang, Jeonghyeon Gu & Sun Kim. (2022) On modeling and utilizing chemical compound information with deep learning technologies: A task-oriented approach. Computational and Structural Biotechnology Journal 20, pages 4288-4304.
Crossref
Shivani Verma & Rajesh Kumar Pathak. 2022. Bioinformatics. Bioinformatics 253 267 .
Muhammad Moazzam Naseer. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 492 526 .
Victoria G. Klein, Adam G. Bond, Conner CraigonR. Scott Lokey & Alessio Ciulli. (2021) Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity. Journal of Medicinal Chemistry 64:24, pages 18082-18101.
Crossref
Xinxin Zheng, Hushuai Fan, Ze Song, Peixuan Cheng, Hongmei Jiang, Wenhua Shi, Chaoni Xiao, Jing Wang, Qian Li, Guowei Yin & Xinfeng Zhao. (2021) Immobilized beta2-adrenergic receptor: A powerful chromatographic platform for drug discovery and evaluation of drug-like property for natural products. Journal of Chromatography A 1659, pages 462635.
Crossref
Anthony C. Varca, Dominick Casalena, Wai Cheung Chan, Bin Hu, Robert S. Magin, Rebekka M. Roberts, Xiaoxi Liu, He Zhu, Hyuk-Soo Seo, Sirano Dhe-Paganon, Jarrod A. Marto, Douglas Auld & Sara J. Buhrlage. (2021) Identification and validation of selective deubiquitinase inhibitors. Cell Chemical Biology 28:12, pages 1758-1771.e13.
Crossref
Arpita Arora, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Sridevi Chigurupati, Rajwinder Kaur, Saurabh Bhatia, Ahmed Al-Harrasi, Celia Vargas-De-La-Cruz & Simona Bungau. (2021) Free fatty acid receptor 1: a ray of hope in the therapy of type 2 diabetes mellitus. Inflammopharmacology 29:6, pages 1625-1639.
Crossref
Yu-zhe Zhang, Meng-meng Wang, Si-yu Wang, Xiao-fang Wang, Wen-jiao Yang, Ya-nan Zhao, Feng-tong Han, Yao Zhang, Ning Gu & Chang-lin Wang. (2021) Novel Cyclic Endomorphin Analogues with Multiple Modifications and Oligoarginine Vector Exhibit Potent Antinociception with Reduced Opioid-like Side Effects. Journal of Medicinal Chemistry 64:22, pages 16801-16819.
Crossref
Abhichart Krissanaprasit, Carson M. Key, Sahil Pontula & Thomas H. LaBean. (2021) Self-Assembling Nucleic Acid Nanostructures Functionalized with Aptamers. Chemical Reviews 121:22, pages 13797-13868.
Crossref
Monika Richert, Renata Mikstacka, Mariusz Walczyk, Marcin Janusz Cieślak, Julia Kaźmierczak-Barańska, Karolina Królewska-Golińska, Tadeusz Mikołaj Muzioł & Stanisław Biniak. (2021) Gold(I) Complexes with P-Donor Ligands and Their Biological Evaluation. Processes 9:12, pages 2100.
Crossref
Yan-Kai Chen, Steven Shave & Manfred Auer. (2021) MRlogP: Transfer Learning Enables Accurate logP Prediction Using Small Experimental Training Datasets. Processes 9:11, pages 2029.
Crossref
Ariadna Fernández, José Luis Díaz, Mónica García, Sergi Rodríguez-Escrich, Adriana Lorente, Raquel Enrech, Albert Dordal, Enrique Portillo-Salido, Mónica Porras, Begoña Fernández, Raquel F. Reinoso, José Miguel Vela & Carmen Almansa. (2021) Piperazinyl Bicyclic Derivatives as Selective Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels. ACS Medicinal Chemistry Letters 12:11, pages 1802-1809.
Crossref
Lei Chen, Mei Su, Qiu Jin, Wei Wang, Chun-Gu Wang, Israa Assani, Mu-Xuan Wang, Shi-Feng Zhao, Shen-Min Lv, Jia-Wei Wang, Bo Sun, Yan Li & Zhi-Xin Liao. (2021) Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist. Journal of Medicinal Chemistry 64:21, pages 16106-16131.
Crossref
H Padmi, A N M Ansori, R T Probojati, A A A Murtadlo, A L Sunarwidhi, A Hernawan, H Sunarpi, S Widyastuti, A Nikmatullah & E S Prasedya. (2021) Anti-inflammatory potential of λ-carrageenan by inhibition of IL-6 receptor: in silico study. IOP Conference Series: Earth and Environmental Science 913:1, pages 012106.
Crossref
Yamini Thakur & Rama Pande. (2021) Exploration of In-silico screening of therapeutic agents against SARS-CoV-2. Chemical Physics 551, pages 111354.
Crossref
Francesco Fiorentino, Dante Rotili, Antonello Mai, Jani R. Bolla & Carol V. Robinson. (2021) Mass spectrometry enables the discovery of inhibitors of an LPS transport assembly via disruption of protein–protein interactions . Chemical Communications 57:82, pages 10747-10750.
Crossref
Angelica Sharapova, Marina Ol'khovich, Svetlana Blokhina, Ekaterina Zhirova & German Perlovich. (2021) Solubility and partition behavior of moxifloxacin: Experimental results and thermodynamics properties. Journal of Molecular Liquids 339, pages 116814.
Crossref
Mara Ibeth Campos-Almazán, Miguel Flores-Ramos, Alicia Hernández-Campos, Rafael Castillo, Erick Sierra-Campos, Kristiane Torgeson, Wolfgang Peti, Mónica Valdez-Solana, Jesús Oria-Hernández, Sara T. Méndez, Adriana Castillo-Villanueva, Hugo Jiménez-de Jesús, Claudia Avitia-Domínguez & Alfredo Téllez-Valencia. (2021) Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors. Bioorganic & Medicinal Chemistry 48, pages 116418.
Crossref
Mijanur Rahman, Asma Talukder & Rekha Akter. (2021) Computational Designing and Prediction of ADMET Properties of Four Novel Imidazole‐based Drug Candidates Inhibiting Heme Oxygenase‐1 Causing Cancers. Molecular Informatics 40:10.
Crossref
Chris Hoffmann, Sibel Evcüman, Felix Neumaier, Boris D. Zlatopolskiy, Swen Humpert, Dirk Bier, Marcus Holschbach, Annette Schulze, Heike Endepols & Bernd Neumaier. (2021) [ 18 F]ALX5406: A Brain-Penetrating Prodrug for GlyT1-Specific PET Imaging . ACS Chemical Neuroscience 12:18, pages 3335-3346.
Crossref
Li Fu, Zi-Yi Yang, Zhi-Jiang Yang, Ming-Zhu Yin, Ai-Ping Lu, Xiang Chen, Shao Liu, Ting-Jun Hou & Dong-Sheng Cao. (2021) QSAR-assisted-MMPA to expand chemical transformation space for lead optimization. Briefings in Bioinformatics 22:5.
Crossref
Monika Pastewska, Barbara Bednarczyk-Cwynar, Strahinja Kovačević, Natalia Buławska, Szymon Ulenberg, Paweł Georgiev, Hanna Kapica, Piotr Kawczak, Tomasz Bączek, Wiesław Sawicki & Krzesimir Ciura. (2021) Multivariate assessment of anticancer oleanane triterpenoids lipophilicity. Journal of Chromatography A, pages 462552.
Crossref
Vikas Jha, Darpan Kaur Matharoo, Sankalp Kasbe, Kunal Gharat, Meet Rathod, Neetu Sonawane & Tanvi Kanade. (2021) Computational screening of phytochemicals to discover potent inhibitors against chinkungunya virus. Vegetos 34:3, pages 515-527.
Crossref
Jean-François Fournier. 2021. The Medicinal Chemist's Guide to Solving ADMET Challenges. The Medicinal Chemist's Guide to Solving ADMET Challenges 364 381 .
Andy Pike & R. Ian Storer. 2021. The Medicinal Chemist's Guide to Solving ADMET Challenges. The Medicinal Chemist's Guide to Solving ADMET Challenges 36 61 .
Patrick Schnider. 2021. The Medicinal Chemist's Guide to Solving ADMET Challenges. The Medicinal Chemist's Guide to Solving ADMET Challenges 1 15 .
Abhaya Kumar Mishra, Romain Tessier, Durga Prasad Hari & Jerome Waser. (2021) Amphiphilic Iodine(III) Reagents for the Lipophilization of Peptides in Water. Angewandte Chemie International Edition 60:33, pages 17963-17968.
Crossref
Abhaya Kumar Mishra, Romain Tessier, Durga Prasad Hari & Jerome Waser. (2021) Amphiphilic Iodine(III) Reagents for the Lipophilization of Peptides in Water. Angewandte Chemie 133:33, pages 18107-18112.
Crossref
Alexander Serdyukov, Irina Kosenko, Anna Druzina, Mikhail Grin, Andrey F. Mironov, Vladimir I. Bregadze & Julia Laskova. (2021) Anionic polyhedral boron clusters conjugates with 7-diethylamino-4-hydroxycoumarin. Synthesis and lipophilicity determination. Journal of Organometallic Chemistry 946-947, pages 121905.
Crossref
Serah Kimani, Suparna Chakraborty, Ikponmwosa Irene, Jo de la Mare, Adrienne Edkins, André du Toit, Ben Loos, Angelique Blanckenberg, Annick Van Niekerk, Leticia V. Costa-Lotufo, KN. ArulJothi, Selwyn Mapolie & Sharon Prince. (2021) The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity. Biochemical Pharmacology 190, pages 114598.
Crossref
Kenneth Lopez, Silvana Pinheiro & William J. Zamora. (2021) Multiple linear regression models for predicting the n‑octanol/water partition coefficients in the SAMPL7 blind challenge. Journal of Computer-Aided Molecular Design 35:8, pages 923-931.
Crossref
Richard J. GlynGraham Pattison. (2021) Effects of Replacing Oxygenated Functionality with Fluorine on Lipophilicity. Journal of Medicinal Chemistry 64:14, pages 10246-10259.
Crossref
Katsunori Tsuboi, Hidenori Kimura, Yoshie Nakatsuji, Momoe Kassai, Yoko Deai & Yoshiaki Isobe. (2021) Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor. Bioorganic & Medicinal Chemistry Letters 44, pages 128115.
Crossref
Samson O. Oselusi, Samuel A. Egieyeh & Alan Christoffels. (2021) Cheminformatic Profiling and Hit Prioritization of Natural Products with Activities against Methicillin-Resistant Staphylococcus aureus (MRSA). Molecules 26:12, pages 3674.
Crossref
Paul D. Leeson, A. Patricia Bento, Anna Gaulton, Anne Hersey, Emma J. Manners, Chris J. Radoux & Andrew R. Leach. (2021) Target-Based Evaluation of “Drug-Like” Properties and Ligand Efficiencies. Journal of Medicinal Chemistry 64:11, pages 7210-7230.
Crossref
Binggang Guan & Chang Jiang. (2021) Design and development of 1,3,5-triazine derivatives as protective agent against spinal cord injury in rat via inhibition of NF-ĸB. Bioorganic & Medicinal Chemistry Letters 41, pages 127964.
Crossref
Vijaykumar D. Nimbarte, Julia Wirmer‐Bartoschek, Santosh L. Gande, Islam Alshamleh, Marcel Seibert, Hamid Reza Nasiri, Frank Schnütgen, Hubert Serve & Harald Schwalbe. (2021) Synthesis and in Vitro Evaluation of Novel 5‐Nitroindole Derivatives as c‐Myc G‐Quadruplex Binders with Anticancer Activity . ChemMedChem 16:10, pages 1667-1679.
Crossref
Joshua Northcote‐Smith, Pooja Kaur & Kogularamanan Suntharalingam. (2021) A Cancer Stem Cell Potent Copper(II) Complex with a S , N , S ‐Schiff base Ligand and Bathophenanthroline . European Journal of Inorganic Chemistry 2021:18, pages 1770-1775.
Crossref
Stefano Sainas, Marta Giorgis, Paola Circosta, Valentina Gaidano, Davide Bonanni, Agnese C. Pippione, Renzo Bagnati, Alice Passoni, Yaqi Qiu, Carina Florina Cojocaru, Barbara Canepa, Alessandro Bona, Barbara Rolando, Mariia Mishina, Cristina Ramondetti, Barbara Buccinnà, Marco Piccinini, Mohammad Houshmand, Alessandro Cignetti, Enrico Giraudo, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio & Marco L. Lolli. (2021) Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold: SAR of the Biphenyl Moiety . Journal of Medicinal Chemistry 64:9, pages 5404-5428.
Crossref
Daisy K. Mangwegape, Nonkululeko H. Zuma, Janine Aucamp & David D. N'Da. (2021) Synthesis and in vitro antileishmanial efficacy of novel benzothiadiazine‐1,1‐dioxide derivatives. Archiv der Pharmazie 354:5.
Crossref
Daria Kupczyk, Renata Studzińska, Szymon Baumgart, Rafał Bilski, Tomasz Kosmalski, Renata Kołodziejska & Alina Woźniak. (2021) A Novel N-Tert-Butyl Derivatives of Pseudothiohydantoin as Potential Target in Anti-Cancer Therapy. Molecules 26:9, pages 2612.
Crossref
Kirandeep Samby, Paul A. Willis, Jeremy N. Burrows, Benoît Laleu & Peter J. H. Webborn. (2021) Actives from MMV Open Access Boxes? A suggested way forward. PLOS Pathogens 17:4, pages e1009384.
Crossref
Valentina Albanese, Chiara Ruzza, Erika Marzola, Tatiana Bernardi, Martina Fabbri, Anna Fantinati, Claudio Trapella, Rainer K. Reinscheid, Federica Ferrari, Chiara Sturaro, Girolamo Calò, Giorgio Amendola, Sandro Cosconati, Salvatore Pacifico, Remo Guerrini & Delia Preti. (2021) Structure–Activity Relationship Studies on Oxazolo[3,4- a ]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent In Vivo Activity . Journal of Medicinal Chemistry 64:7, pages 4089-4108.
Crossref
Jasleen K. Sodhi & Leslie Z. Benet. (2021) Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization. Journal of Medicinal Chemistry 64:7, pages 3546-3559.
Crossref
Helena Laronha, Inês Carpinteiro, Jaime Portugal, Ana Azul, Mário Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona & Jorge Caldeira. (2021) Polymerizable Matrix Metalloproteinases’ Inhibitors with Potential Application for Dental Restorations. Biomedicines 9:4, pages 366.
Crossref
Shahla S. Smail, Mowafaq M. Ghareeb, Huner K. Omer, Ali A. Al-Kinani & Raid G. Alany. (2021) Studies on Surfactants, Cosurfactants, and Oils for Prospective Use in Formulation of Ketorolac Tromethamine Ophthalmic Nanoemulsions. Pharmaceutics 13:4, pages 467.
Crossref
Rafael Santana Nunes, Diogo Vila-Viçosa & Paulo J. Costa. (2021) Halogen Bonding: An Underestimated Player in Membrane–Ligand Interactions. Journal of the American Chemical Society 143:11, pages 4253-4267.
Crossref
Shifan Ma, Mark McGann & Istvan J. Enyedy. (2021) The influence of calculated physicochemical properties of compounds on their ADMET profiles. Bioorganic & Medicinal Chemistry Letters 36, pages 127825.
Crossref
Masahiro Kamaura, Osamu Kubo, Hiromichi Sugimoto, Naoyoshi Noguchi, Hirohisa Miyashita, Shinichi Abe, Kae Matsuda, Yoshiyuki Tsujihata, Tomoyuki Odani, Shinji Iwasaki, Toshiki Murata & Kenjiro Sato. (2021) Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach. Bioorganic & Medicinal Chemistry 34, pages 116034.
Crossref
Richard M. Beteck, Audrey Jordaan, Ronnett Seldon, Dustin Laming, Heinrich C. Hoppe, Digby F. Warner & Setshaba D. Khanye. (2021) Easy-To-Access Quinolone Derivatives Exhibiting Antibacterial and Anti-Parasitic Activities. Molecules 26:4, pages 1141.
Crossref
Malgorzata Tyszka-Czochara, Anna Adach, Tomasz Grabowski, Paweł Konieczny, Paweł Pasko, Joanna Ortyl, Tomasz Świergosz & Marcin Majka. (2021) Selective Cytotoxicity of Complexes with N,N,N-Donor Dipodal Ligand in Tumor Cells. International Journal of Molecular Sciences 22:4, pages 1802.
Crossref
Sabina Alexandra Cojocariu, Alexandra Maștaleru, Radu Andy Sascău, Cristian Stătescu, Florin Mitu & Maria Magdalena Leon-Constantin. (2021) Neuropsychiatric Consequences of Lipophilic Beta-Blockers. Medicina 57:2, pages 155.
Crossref
Shinji Kobuchi, Yusuke Kita, Yukiko Hiramatsu, Kenji Sasaki, Tomoya Uno, Yukako Ito & Toshiyuki Sakaeda. (2021) Comparison of In Vivo Transportability of Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents Into Intracellular and Extracellular Tissue Spaces in Rats. Journal of Pharmaceutical Sciences 110:2, pages 898-904.
Crossref
Robert I. TroupBenjamin JeffriesRaphael El-Bekri SaudainEleni GeorgiouJohanna FishJames S. Scott, Elisabetta Chiarparin, Charlene FallanBruno Linclau. (2021) Skipped Fluorination Motifs: Synthesis of Building Blocks and Comparison of Lipophilicity Trends with Vicinal and Isolated Fluorination Motifs. The Journal of Organic Chemistry 86:2, pages 1882-1900.
Crossref
Michael Schmiech, Judith Ulrich, Sophia Johanna Lang, Berthold Büchele, Christian Paetz, Alexis St-Gelais, Tatiana Syrovets & Thomas Simmet. (2021) 11-Keto-α-Boswellic Acid, a Novel Triterpenoid from Boswellia spp. with Chemotaxonomic Potential and Antitumor Activity against Triple-Negative Breast Cancer Cells. Molecules 26:2, pages 366.
Crossref
Andrew J. Hall, Amy G. Robertson, Leila R. Hill & Louis M. Rendina. (2021) Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes. Scientific Reports 11:1.
Crossref
Joshua Northcote-Smith, Alice Johnson, Kuldip Singh, Fabrizio Ortu & Kogularamanan Suntharalingam. (2021) Breast Cancer Stem Cell Active Copper(II) Complexes with Naphthol Schiff Base and Polypyridyl Ligands. Inorganics 9:1, pages 5.
Crossref
Sahar S. Anwar, Hanady S.A. Al-Shmgani, Amer T. Tawfeeq, Ghassan M. Sulaiman & Yasmin H. Al-Mousawi. (2021) In silico analysis of quercetin as potential anti-cancer agents. Materials Today: Proceedings 42, pages 2521-2526.
Crossref
Andrew G. Leach. 2021. The Design of Covalent-Based Inhibitors. The Design of Covalent-Based Inhibitors 135 201 .
Sylvia Richard-Bildstein, Hamed Aissaoui, Julien Pothier, Gabriel Schäfer, Carmela Gnerre, Eleanor Lindenberg, François Lehembre, Laetitia Pouzol & Philippe Guerry. (2020) Discovery of the Potent, Selective, Orally Available CXCR7 Antagonist ACT-1004-1239. Journal of Medicinal Chemistry 63:24, pages 15864-15882.
Crossref
Daria Różycka, Małgorzata Korycka-Machała, Anna Żaczek, Jarosław Dziadek, Dorota Gurda, Marta Orlicka-Płocka, Eliza Wyszko, Katarzyna Biniek-Antosiak, Wojciech Rypniewski & Agnieszka B. Olejniczak. (2020) Novel Isoniazid-Carborane Hybrids Active In Vitro against Mycobacterium tuberculosis. Pharmaceuticals 13:12, pages 465.
Crossref
Marta Bystrzanowska & Marek Tobiszewski. (2020) Chemometrics for Selection, Prediction, and Classification of Sustainable Solutions for Green Chemistry—A Review. Symmetry 12:12, pages 2055.
Crossref
Susan A. Charman, Alice Andreu, Helena Barker, Scott Blundell, Anna Campbell, Michael Campbell, Gong Chen, Francis C. K. Chiu, Elly Crighton, Kasiram Katneni, Julia Morizzi, Rahul Patil, Thao Pham, Eileen Ryan, Jessica Saunders, David M. Shackleford, Karen L. White, Lisa Almond, Maurice Dickins, Dennis A. Smith, Joerg J. Moehrle, Jeremy N. Burrows & Nada Abla. (2020) An in vitro toolbox to accelerate anti-malarial drug discovery and development. Malaria Journal 19:1.
Crossref
Chilaluck C. Konkankit, Brett A. Vaughn, Zhouyang Huang, Eszter Boros & Justin J. Wilson. (2020) Systematically altering the lipophilicity of rhenium( i ) tricarbonyl anticancer agents to tune the rate at which they induce cell death . Dalton Transactions 49:45, pages 16062-16066.
Crossref
Pedro F. Dalberto, Eduardo V. de Souza, Bruno L. Abbadi, Christiano E. Neves, Raoní S. Rambo, Alessandro S. Ramos, Fernanda S. Macchi, Pablo Machado, Cristiano V. Bizarro & Luiz A. Basso. (2020) Handling the Hurdles on the Way to Anti-tuberculosis Drug Development. Frontiers in Chemistry 8.
Crossref
Randy R. Miller, Maria Madeira, Harold B. Wood, Wayne M. Geissler, Conrad E. Raab & Iain J. Martin. (2020) Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization. Journal of Medicinal Chemistry 63:21, pages 12156-12170.
Crossref
David J. Hirst, Martin Brandt, Gordon Bruton, Erica Christodoulou, Leanne Cutler, Nigel Deeks, Jonathan D. Goodacre, Torquil Jack, Matthew Lindon, Afjal Miah, Kevin Page, Nigel Parr, Lena Shukla, Martin Sims, Pamela Thomas, James Thorpe & Duncan S. Holmes. (2020) Structure-based optimisation of orally active & reversible MetAP-2 inhibitors maintaining a tight ‘molecular budget’. Bioorganic & Medicinal Chemistry Letters 30:21, pages 127533.
Crossref
Fiona Bellany, Yugo Tsuchiya, Trang M. Tran, A.W. Edith Chan, Helen Allan, Ivan Gout & Alethea B. Tabor. (2020) Design and synthesis of Coenzyme A analogues as Aurora kinase A inhibitors: An exploration of the roles of the pyrophosphate and pantetheine moieties. Bioorganic & Medicinal Chemistry 28:22, pages 115740.
Crossref
Alejandro Cabrera-Andrade, Andrés López-Cortés, Cristian R. Munteanu, Alejandro Pazos, Yunierkis Pérez-Castillo, Eduardo Tejera, Sonia Arrasate & Humbert González-Díaz. (2020) Perturbation-Theory Machine Learning (PTML) Multilabel Model of the ChEMBL Dataset of Preclinical Assays for Antisarcoma Compounds. ACS Omega 5:42, pages 27211-27220.
Crossref
Xiting Wang, Meng Liu, Lan Zhang, Yun Wang, Yu Li & Tao Lu. (2020) Optimizing Pharmacokinetic Property Prediction Based on Integrated Datasets and a Deep Learning Approach. Journal of Chemical Information and Modeling 60:10, pages 4603-4613.
Crossref
Ding Xue, Wenmin Chen & Nouri Neamati. (2020) Discovery, structure-activity relationship study and biological evaluation of 2-thioureidothiophene-3-carboxylates as a novel class of C-X-C chemokine receptor 2 (CXCR2) antagonists. European Journal of Medicinal Chemistry 204, pages 112387.
Crossref

Displaying 200 of 612 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.