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Original Article

Tumour oxygenation is increased by hyperthermia at mild temperatures

, , &
Pages 367-373 | Received 11 Sep 1995, Accepted 01 Dec 1995, Published online: 09 Jul 2009

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Read on this site (31)

H. P. Kok, G. C. van Rhoon, T. D. Herrera, J. Overgaard & J. Crezee. (2022) Biological modeling in thermoradiotherapy: present status and ongoing developments toward routine clinical use. International Journal of Hyperthermia 39:1, pages 1126-1140.
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Alexander Rühle, Andreas Thomsen, Rainer Saffrich, Maren Voglstätter, Birgit Bieber, Tanja Sprave, Patrick Wuchter, Peter Vaupel, Peter E. Huber, Anca-Ligia Grosu & Nils H. Nicolay. (2020) Multipotent mesenchymal stromal cells are sensitive to thermic stress – potential implications for therapeutic hyperthermia. International Journal of Hyperthermia 37:1, pages 430-441.
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Meng He, Jinghua Sun, Danyi Zhao, Hongmei He, Bing Wang, Lingling Xu, Yu Shang, Shanling Ren, Yang Zhang & Tao Wu. (2019) Modified-FOLFIRINOX combined with deep regional hyperthermia in pancreatic cancer: a retrospective study in Chinese patients. International Journal of Hyperthermia 36:1, pages 393-401.
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Sun-Young Lee, Jong-Hun Kim, Yeon-Hee Han & Dong-Hyu Cho. (2018) The effect of modulated electro-hyperthermia on temperature and blood flow in human cervical carcinoma. International Journal of Hyperthermia 34:7, pages 953-960.
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A. L. Oei, L. E. M. Vriend, P. M. Krawczyk, M. R. Horsman, N. A. P. Franken & J. Crezee. (2017) Targeting therapy-resistant cancer stem cells by hyperthermia. International Journal of Hyperthermia 33:4, pages 419-427.
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Takayuki Ohguri, Naoki Kunugita, Katsuya Yahara, Hajime Imada, Hidehiko Uemura, Nadayoshi Shinya, Gotou Youjirou, Chijiwa Takashi, Ryuji Okazaki, Akira Ootsuyama & Yukunori Korogi. (2015) Efficacy of hyperbaric oxygen therapy combined with mild hyperthermia for improving the anti-tumour effects of carboplatin. International Journal of Hyperthermia 31:6, pages 643-648.
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Changlin Zhao, Jia Chen, Bin Yu & Xiaoyin Chen. (2014) Improvement in quality of life in patients with nasopharyngeal carcinoma treated with non-invasive extracorporeal radiofrequency in combination with chemoradiotherapy. International Journal of Radiation Biology 90:10, pages 853-858.
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Ana Portela, Mário Vasconcelos, Maria Helena Fernandes, Mónica Garcia, António Silva, Joaquim Gabriel, Fátima Gartner, Irina Amorim & José Cavalheiro. (2013) Highly focalised thermotherapy using a ferrimagnetic cement in the treatment of a melanoma mouse model by low temperature hyperthermia. International Journal of Hyperthermia 29:2, pages 121-132.
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Sumeeta Varma, Robert Myerson, Eduardo Moros, Marie Taylor, William Straube & Imran Zoberi. (2012) Simultaneous radiotherapy and superficial hyperthermia for high-risk breast carcinoma: A randomised comparison of treatment sequelae in heated versus non-heated sectors of the chest wall hyperthermia. International Journal of Hyperthermia 28:7, pages 583-590.
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Donald E. Thrall, Paolo Maccarini, Paul Stauffer, James Macfall, Marlene Hauck, Stacey Snyder, Beth Case, Keith Linder, Lan Lan, Linda Mccall & Mark W. Dewhirst. (2012) Thermal dose fractionation affects tumour physiological response. International Journal of Hyperthermia 28:5, pages 431-440.
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Zeljko Vujaskovic, Dong W. Kim, Ellen Jones, Lan Lan, Linda Mccall, Mark W. Dewhirst, Oana Craciunescu, Paul Stauffer, Vlayka Liotcheva, Allison Betof & Kimberly Blackwell. (2010) A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer. International Journal of Hyperthermia 26:5, pages 514-521.
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Chen-Ting Lee, Thomas Mace & Elizabeth A. Repasky. (2010) Hypoxia-driven immunosuppression: A new reason to use thermal therapy in the treatment of cancer?. International Journal of Hyperthermia 26:3, pages 232-246.
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Steffen L. Hokland, Thomas Nielsen, Morten Busk & Michael R. Horsman. (2010) Imaging tumour physiology and vasculature to predict and assess response to heat. International Journal of Hyperthermia 26:3, pages 264-272.
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L Lüdemann, G Sreenivasa, H Amthauer, R Michel, J Gellermann & P Wust. (2009) Use of H2 15O-PET for investigating perfusion changes in pelvic tumors due to regional hyperthermia. International Journal of Hyperthermia 25:4, pages 299-308.
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J. W. J. Bergs, N. A. P. Franken, J. Haveman, E. D. Geijsen, J. Crezee & C. van Bree. (2007) Hyperthermia, cisplatin and radiation trimodality treatment: A promising cancer treatment? A review from preclinical studies to clinical application. International Journal of Hyperthermia 23:4, pages 329-341.
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D. E. Thrall, S. M. LaRue, A. F. Pruitt, B. Case & M. W. Dewhirst. (2006) Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas. International Journal of Hyperthermia 22:5, pages 365-373.
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Gloria C. Li, Fuqiu He & C. Clifton Ling. (2006) Hyperthermia and gene therapy: Potential use of MicroPET imaging. International Journal of Hyperthermia 22:3, pages 215-221.
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. (2006) Letter to the editor. International Journal of Hyperthermia 22:5, pages 433-447.
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Robert J. Myerson, Anurag K. Singh, Heather M. Bigott, Bibiana Cha, John A. Engelbach, Joonyoung Kim, Wayne T. Lamoreaux, Eduardo Moros, Petr Novak, Terry L. Sharp, William Straube, Michael J. Welch & Mai Xu. (2006) Monitoring the effect of mild hyperthermia on tumour hypoxia by Cu-ATSM PET scanning. International Journal of Hyperthermia 22:2, pages 93-115.
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C. W. Song, H. J. Park, C. K. Lee & R. Griffin. (2005) Implications of increased tumor blood flow and oxygenation caused by mild temperature hyperthermia in tumor treatment. International Journal of Hyperthermia 21:8, pages 761-767.
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Hideyuki Sakurai, Yoshizumi Kitamoto, Jun-Ichi Saitoh, Tetsuo Nonaka, Hitoshi Ishikawa, Hiroki Kiyohara, Mariko Shioya, Masahide Fukushima, Tetsuo Akimoto, Masatoshi Hasegawa & Takashi Nakano. (2005) Attenuation of chronic thermotolerance by KNK437, a benzylidene lactam compound, enhances thermal radiosensitization in mild temperature hyperthermia combined with low dose-rate irradiation. International Journal of Radiation Biology 81:9, pages 711-718.
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S. Kinuya, K. Yokoyama, T. Michigishi & N. Tonami. (2004) Optimization of radioimmunotherapy interactions with hyperthermia. International Journal of Hyperthermia 20:2, pages 190-200.
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M. URANO. (1999) Invited Review: For the clinical application of thermochemotherapy given at mild temperatures. International Journal of Hyperthermia 15:2, pages 79-107.
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F. M. Waterman, L. Komarnicky & D. B. Leeper. (1998) The response of human tumour blood flow to a fractionated course of thermoradiotherapy. International Journal of Hyperthermia 14:5, pages 421-434.
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Harm H. Kampinga, Gerard C.van Rhoon & Jacoba van der Zee. (1997) Mild hyperthermia disturbs normal brains cells rather than that it helps killing tumours!. International Journal of Hyperthermia 13:1, pages 133-136.
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S. Masunaga, K. Ono, M. Suzuki, Y. Kinashi, M. Takagaki & M. Akaboshi. (1997) Alteration in the hypoxic fraction of quiescent cell populations by hyperthermia at mild temperatures. International Journal of Hyperthermia 13:4, pages 401-411.
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M. R. Horsman & J. Overgaard. (1997) Hot Topic: Can mild hyperthermia improve tumour oxygenation?. International Journal of Hyperthermia 13:2, pages 141-147.
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P. M. Corry. (1996) Editorial comment. International Journal of Hyperthermia 12:5, pages 661-662.
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