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Review Article

Design of oral insulin delivery systems

Pages 79-92 | Received 30 Aug 2009, Accepted 01 Sep 2009, Published online: 05 Oct 2009

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Read on this site (8)

Yazid Zaiki, Lee Yong Lim & Tin Wui Wong. (2023) Critical material designs for mucus- and mucosa-penetrating oral insulin nanoparticle development. International Materials Reviews 68:2, pages 121-139.
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Shangyong Li, Hui Zhang, Kaiwei Chen, Mengfei Jin, Son Hai Vu, Samil Jung, Ningning He, Zhou Zheng & Myeong-Sok Lee. (2022) Application of chitosan/alginate nanoparticle in oral drug delivery systems: prospects and challenges. Drug Delivery 29:1, pages 1142-1149.
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Mostafa Safari, Younes Kamari, Mehran Ghiaci, Hojjat Sadeghi-aliabadi & Mina Mirian. (2017) Synthesis and characterization of insulin/zirconium phosphate@TiO2 hybrid composites for enhanced oral insulin delivery applications. Drug Development and Industrial Pharmacy 43:5, pages 862-870.
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Yue Yuan Luo, Xiang Yuan Xiong, Yuan Tian, Zi Ling Li, Yan Chun Gong & Yu Ping Li. (2016) A review of biodegradable polymeric systems for oral insulin delivery. Drug Delivery 23:6, pages 1882-1891.
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Kai Dong, Yalin Dong, Cuiyu You, Wei Xu, Xiaoyan Huang, Yan Yan, Lu Zhang, Ke Wang & Jianfeng Xing. (2016) Assessment of the drug loading, in vitro and in vivo release behavior of novel pH-sensitive hydrogel. Drug Delivery 23:1, pages 174-184.
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Tin Wui Wong, Meenakshi Dhanawat & Michael John Rathbone. (2014) Vaginal drug delivery: strategies and concerns in polymeric nanoparticle development. Expert Opinion on Drug Delivery 11:9, pages 1419-1434.
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Ghislain Garrait, Eric Beyssac & Muriel Subirade. (2014) Development of a novel drug delivery system: chitosan nanoparticles entrapped in alginate microparticles. Journal of Microencapsulation 31:4, pages 363-372.
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Tin Wui Wong, Nurjaya Sumiran, Mohammad Tarmizi Mohd Mokhtar & Aminah Kadir. (2012) Blood glucose lowering property of water in oral insulin-fed diabetic rats. Pharmaceutical Biology 50:11, pages 1463-1466.
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Articles from other publishers (50)

Gayatri Iyer, Sathish Dyawanapelly, Ratnesh Jain & Prajakta Dandekar. (2022) An overview of oral insulin delivery strategies (OIDS). International Journal of Biological Macromolecules 208, pages 565-585.
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Susan Sarhadi, Seyedeh Alia Moosavian, Mohammad Mashreghi, Niloufar Rahiman, Shiva Golmohamadzadeh, Mohsen Tafaghodi, Kayvan Sadri, Jamshidkhan Chamani & Mahmoud Reza Jaafari. (2022) B12-functionalized PEGylated liposomes for the oral delivery of insulin: In vitro and in vivo studies. Journal of Drug Delivery Science and Technology 69, pages 103141.
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Shuai Zhou, Qin Zhong, Yang Wang, Po Hu, Wei Zhong, Chao-Bo Huang, Zhi-Qiang Yu, Chen-Di Ding, Hongxing Liu & Jiajun Fu. (2022) Chemically engineered mesoporous silica nanoparticles-based intelligent delivery systems for theranostic applications in multiple cancerous/non-cancerous diseases. Coordination Chemistry Reviews 452, pages 214309.
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Zhenyu Xu, Long Chen, Xiaoya Duan, Xueming Li & Hao Ren. (2021) Microparticles based on alginate/chitosan/casein three‐dimensional system for oral insulin delivery. Polymers for Advanced Technologies 32:11, pages 4352-4361.
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Oksana Zaitseva, Andrey Khudyakov, Marta Sergushkina, Olga Solomina & Tatyana Polezhaeva. (2020) Pectins as a universal medicine. Fitoterapia 146, pages 104676.
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Yumiao Hu, Juan Wang & Liyan Qiu. (2020) Polymeric nano-vesicles via intermolecular action to load and orally deliver insulin with enhanced hypoglycemic effect . RSC Advances 10:13, pages 7887-7897.
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G. Kaur, M. Arora & M.N.V. Ravi Kumar. (2019) Oral Drug Delivery Technologies—A Decade of Developments. Journal of Pharmacology and Experimental Therapeutics 370:3, pages 529-543.
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Piyasi Mukhopadhyay & P.P. Kundu. 2019. Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications. Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications 525 546 .
Santanu Patra, Rashmi Madhuri & Prashant K. Sharma. 2019. Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications. Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications 491 524 .
Qiaobin Hu & Yangchao Luo. (2018) Recent advances of polysaccharide-based nanoparticles for oral insulin delivery. International Journal of Biological Macromolecules 120, pages 775-782.
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Norul Nazilah Ab’lah, Nagarjun Konduru Venkata & Tin Wui Wong. (2018) Development of resistant corn starch for use as an oral colon-specific nanoparticulate drug carrier. Pure and Applied Chemistry 90:6, pages 1073-1084.
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Hui-Peng Lim, Chien-Wei Ooi, Beng-Ti Tey & Eng-Seng Chan. (2017) Controlled delivery of oral insulin aspart using pH-responsive alginate/κ-carrageenan composite hydrogel beads. Reactive and Functional Polymers 120, pages 20-29.
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Mokhamad Nur & Todor Vasiljevic. (2017) Can natural polymers assist in delivering insulin orally?. International Journal of Biological Macromolecules 103, pages 889-901.
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Ruifeng Mao, Dongli Wu, Shimeng Hu, Kangping Zhou, Man Wang & Yefu Wang. (2017) Secretory expression and surface display of a new and biologically active single-chain insulin (SCI-59) analog by lactic acid bacteria. Applied Microbiology and Biotechnology 101:8, pages 3259-3271.
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Jicheng Yu, Yuqi Zhang, Hunter Bomba & Zhen Gu. (2016) Stimuli‐responsive delivery of therapeutics for diabetes treatment. Bioengineering & Translational Medicine 1:3, pages 323-337.
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Zhuo Li, Haiyan Li, Caifen Wang, Jianghui Xu, Vikramjeet Singh, Dawei Chen & Jiwen Zhang. (2016) Sodium dodecyl sulfate/ β -cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release. Acta Pharmaceutica Sinica B 6:4, pages 344-351.
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Marlene Lopes, Neha Shrestha, Alexandra Correia, Mohammad-Ali Shahbazi, Bruno Sarmento, Jouni Hirvonen, Francisco Veiga, Raquel Seiça, António Ribeiro & Hélder A. Santos. (2016) Dual chitosan/albumin-coated alginate/dextran sulfate nanoparticles for enhanced oral delivery of insulin. Journal of Controlled Release 232, pages 29-41.
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Tatiana V. Burova, Natalia V. Grinberg, Alexander S. Dubovik, Elena D. Shibanova & Valerij Y. Grinberg. (2016) Conformational energetics of insulin in interpolyelectrolyte complexes insulin-poly(methylaminophosphazene) under near-physiological conditions. Polymer 85, pages 28-36.
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Andrés Esteban Ibañez, Lorena Mirta Coria, Marianela Verónica Carabajal, María Victoria Delpino, Gabriela Sofía Risso, Paula Gonzalez Cobiello, Jimena Rinaldi, Paula Barrionuevo, Laura Bruno, Fernanda Frank, Sebastián Klinke, Fernando Alberto Goldbaum, Gabriel Briones, Guillermo Hernán Giambartolomei, Karina Alejandra Pasquevich & Juliana Cassataro. (2015) A bacterial protease inhibitor protects antigens delivered in oral vaccines from digestion while triggering specific mucosal immune responses. Journal of Controlled Release 220, pages 18-28.
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Milind Sadashiv Alai, Wen Jen Lin & Shailaja Suresh Pingale. (2015) Application of polymeric nanoparticles and micelles in insulin oral delivery. Journal of Food and Drug Analysis 23:3, pages 351-358.
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Marlene Lopes, Susana Simões, Francisco Veiga, Raquel Seiça & António Ribeiro. (2015) Why most oral insulin formulations do not reach clinical trials. Therapeutic Delivery 6:8, pages 973-987.
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Nan Jiang, Leonie H. E. Leithold, Julia Post, Tamar Ziehm, Jörg Mauler, Lothar Gremer, Markus Cremer, Elena Schartmann, N. Jon Shah, Janine Kutzsche, Karl-Josef Langen, Jörg Breitkreutz, Dieter Willbold & Antje Willuweit. (2015) Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease. PLOS ONE 10:6, pages e0128553.
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C. Ibie, R. Knott & C.J. Thompson. (2015) In-vitro evaluation of the effect of polymer structure on uptake of novel polymer-insulin polyelectrolyte complexes by human epithelial cells. International Journal of Pharmaceutics 479:1, pages 103-117.
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Alejandro Sosnik, José das Neves & Bruno Sarmento. (2014) Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review. Progress in Polymer Science 39:12, pages 2030-2075.
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Syed Othman Syed Mohamad Al-Azi, Yvonne Tze Fung Tan & Tin Wui Wong. (2014) Transforming large molecular weight pectin and chitosan into oral protein drug nanoparticulate carrier. Reactive and Functional Polymers 84, pages 45-52.
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Hui-Peng Lim, Beng-Ti Tey & Eng-Seng Chan. (2014) Particle designs for the stabilization and controlled-delivery of protein drugs by biopolymers: A case study on insulin. Journal of Controlled Release 186, pages 11-21.
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Tin W Wong & Nurjaya Sumiran. (2014) Oral calcium pectinate-insulin nanoparticles: influences of alginate, sodium chloride and Tween 80 on their blood glucose lowering performance. Journal of Pharmacy and Pharmacology 66:5, pages 646-657.
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Xiaoye Gao, Yue Cao, Xiangfu Song, Zhe Zhang, Xiuli Zhuang, Chaoliang He & Xuesi Chen. (2014) Biodegradable, pH-Responsive Carboxymethyl Cellulose/Poly(Acrylic Acid) Hydrogels for Oral Insulin Delivery. Macromolecular Bioscience 14:4, pages 565-575.
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Aminah Kadir, Mohammad Tarmizi Mohd Mokhtar & Tin Wui Wong. (2013) Nanoparticulate Assembly of Mannuronic Acid-and Guluronic Acid-Rich Alginate: Oral Insulin Carrier and Glucose Binder. Journal of Pharmaceutical Sciences 102:12, pages 4353-4363.
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Yu Ping Li, Li Zhen Sun, Xiang Yuan Xiong, Zi Ling Li, Ting Kang Xing & Li Hua Yao. (2013) Controlled Release Characteristics of PLA-Pluronic-PLA Nano-Sized Vesicles<i> In Vitro</i>. Advanced Materials Research 785-786, pages 493-497.
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Xiuhua Zhao, Chang Shan, Yuangang Zu, Ying Zhang, Weiguo Wang, Kunlun Wang, Xiaoyu Sui & Ruiqiang Li. (2013) Preparation, characterization, and evaluation in vivo of Ins-SiO2-HP55 (insulin-loaded silica coating HP55) for oral delivery of insulin. International Journal of Pharmaceutics 454:1, pages 278-284.
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Pedro Fonte, Francisca Araújo, Salette Reis & Bruno Sarmento. (2013) Oral Insulin Delivery: How Far are We?. Journal of Diabetes Science and Technology 7:2, pages 520-531.
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Xiaoye Gao, Chaoliang He, Chunsheng Xiao, Xiuli Zhuang & Xuesi Chen. (2013) Biodegradable pH-responsive polyacrylic acid derivative hydrogels with tunable swelling behavior for oral delivery of insulin. Polymer 54:7, pages 1786-1793.
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Emmanuelle Déat-Lainé, Valérie Hoffart, Ghislain Garrait, Jean-François Jarrige, Jean-Michel Cardot, Muriel Subirade & Eric Beyssac. (2012) Efficacy of Mucoadhesive Hydrogel Microparticles of Whey Protein and Alginate for Oral Insulin Delivery. Pharmaceutical Research 30:3, pages 721-734.
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Robert S. Svingos, Erica M. Fernandez, Don N. Reeder & John J. Parker. (2013) Life‐Threatening Hypoglycemia Associated with Intentional Insulin Ingestion. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 33:3.
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Tatiana V. Burova, Natalia V. Grinberg, Dzidra R. Tur, Vladimir S. Papkov, Alexander S. Dubovik, Elena D. Shibanova, Dmitry I. Bairamashvili, Valerij Y. Grinberg & Alexei R. Khokhlov. (2013) Ternary Interpolyelectrolyte Complexes Insulin-Poly(methylaminophosphazene)-Dextran Sulfate for Oral Delivery of Insulin. Langmuir 29:7, pages 2273-2281.
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Xiaoye Gao, Yue Cao, Xiangfu Song, Zhe Zhang, Chunsheng Xiao, Chaoliang He & Xuesi Chen. (2013) pH- and thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid derivative) copolymers and hydrogels with LCST dependent on pH and alkyl side groups. Journal of Materials Chemistry B 1:41, pages 5578.
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Antonio J. Ribeiro, Raquel Seiça & Francisco Veiga. 2013. Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment. Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment 109 125 .
Neesha Ramchandani & Rubina A Heptulla. (2012) New technologies for diabetes: a review of the present and the future. International Journal of Pediatric Endocrinology 2012:1.
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Dimitris Tsiourvas, Zili Sideratou, Nikoletta Sterioti, Athanasios Papadopoulos, George Nounesis & Constantinos M. Paleos. (2012) Insulin complexes with PEGylated basic oligopeptides. Journal of Colloid and Interface Science 384:1, pages 61-72.
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Edgar P Herrero, Maria Jose Alonso & Noemi Csaba. (2012) Polymer-based oral peptide nanomedicines. Therapeutic Delivery 3:5, pages 657-668.
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Alessandra Maroni, Lucia Zema, Maria Dorly Del Curto, Anastasia Foppoli & Andrea Gazzaniga. (2012) Oral colon delivery of insulin with the aid of functional adjuvants. Advanced Drug Delivery Reviews 64:6, pages 540-556.
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Zhi Min Wu, Liying Zhou, Xin Dong Guo, Wei Jiang, Li Ling, Yu Qian, Kathy Qian Luo & Li Juan Zhang. (2012) HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin. International Journal of Pharmaceutics 425:1-2, pages 1-8.
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Valeria Grazú, María Moros & Christian Sánchez-Espinel. 2012. Nanobiotechnology - Inorganic Nanoparticles vs Organic Nanoparticles. Nanobiotechnology - Inorganic Nanoparticles vs Organic Nanoparticles 337 440 .
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