Drug Development and Industrial Pharmacy, Volume 45, Issue 4 (2019)

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Drug Development and Industrial Pharmacy, Volume 45, Issue 4 (2019)

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Review Article

Review Article
Particle engineering at the drug substance, drug product interface: a comprehensive platform approach to enabling continuous drug substance to drug product processing with differentiated material properties
Luke Schenck, Athanas Koynov & Aaron Cote
Pages: 521-531
Published online: 15 Jan 2019
AbstractforParticle engineering at the drug substance, drug product interface: a comprehensive platform approach to enabling continuous drug substance to drug product processing with differentiated material properties | Full Text | References | PDF (1.6 MB) | EPUB
  • 855 Views
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Research Article

Article
Facile development, characterization, and evaluation of novel bicalutamide loaded pH-sensitive mesoporous silica nanoparticles for enhanced prostate cancer therapy
Seema Saroj & Sadhana J. Rajput
Pages: 532-547
Published online: 30 Jan 2019
AbstractforFacile development, characterization, and evaluation of novel bicalutamide loaded pH-sensitive mesoporous silica nanoparticles for enhanced prostate cancer therapy | Full Text | References | PDF (7.8 MB) | EPUB
  • 211 Views
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Article
Self-emulsifying drug delivery system for enhanced solubility of asenapine maleate: design, characterization, in vitro, ex vivo and in vivo appraisal
Harani Avasarala, Sathis Kumar Dinakaran, Ravishankar Kakaraparthy & Vijaya Ratna Jayanti
Pages: 548-559
Published online: 03 Feb 2019
AbstractforSelf-emulsifying drug delivery system for enhanced solubility of asenapine maleate: design, characterization, in vitro, ex vivo and in vivo appraisal | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 171 Views
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Article
Amphotericin B loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carrier (NLCs): physicochemical and solid-solution state characterizations
Phatsawee Jansook, Zoltán Fülöp & Garnpimol C. Ritthidej
Pages: 560-567
Published online: 25 Jan 2019
AbstractforAmphotericin B loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carrier (NLCs): physicochemical and solid-solution state characterizations | Full Text | References | PDF (1.2 MB) | EPUB
  • 573 Views
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Article
Dual cross-linked chitosan microspheres formulated with spray-drying technique for the sustained release of levofloxacin
Jing Zhou, Yuanyuan Chen, Mengmeng Luo, Fen Deng, Sen Lin, Wencan Wu, Guqiang Li & Kaihui Nan
Pages: 568-576
Published online: 31 Jan 2019
AbstractforDual cross-linked chitosan microspheres formulated with spray-drying technique for the sustained release of levofloxacin | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 216 Views
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Article
Solid lipid nanoparticles of Annona muricata fruit extract: formulation, optimization and in vitro cytotoxicity studies
Mohanalakshmi Sabapati, Narahari N. Palei, Ashok Kumar C.K.Ravindra Babu Molakpogu
Pages: 577-586
Published online: 28 Jan 2019
AbstractforSolid lipid nanoparticles of Annona muricata fruit extract: formulation, optimization and in vitro cytotoxicity studies | Full Text | References | PDF (1.8 MB) | EPUB
  • 195 Views
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Article
Investigation of in vitro permeability and in vivo pharmacokinetic behavior of bare and functionalized MCM-41 and MCM-48 mesoporous silica nanoparticles: a burst and controlled drug release system for raloxifene
Priya Shah & Sadhana J. Rajput
Pages: 587-602
Published online: 04 Feb 2019
AbstractforInvestigation of in vitro permeability and in vivo pharmacokinetic behavior of bare and functionalized MCM-41 and MCM-48 mesoporous silica nanoparticles: a burst and controlled drug release system for raloxifene | Full Text | References | PDF (3.4 MB) | EPUB
  • 272 Views
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Article
Smart aptamer-modified calcium carbonate nanoparticles for controlled release and targeted delivery of epirubicin and melittin into cancer cells in vitro and in vivo
Rezvan Yazdian-Robati, Atefeh Arab, Mohammad Ramezani, Houshang Rafatpanah, Amirhossein Bahreyni, Maryam Sadat Nabavinia, Khalil Abnous & Seyed Mohammad Taghdisi
Pages: 603-610
Published online: 04 Feb 2019
AbstractforSmart aptamer-modified calcium carbonate nanoparticles for controlled release and targeted delivery of epirubicin and melittin into cancer cells in vitro and in vivo | Full Text | References | PDF (2.4 MB) | EPUB
  • 385 Views
  • 30 CrossRef citations
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Article
Design by optimization and comparative evaluation of vesicular gels of etodolac for transdermal delivery
Nimmathota Madhavi, Beeravelli Sudhakar, K. V. N Suresh Reddy & J. Vijaya Ratna
Pages: 611-628
Published online: 04 Feb 2019
AbstractforDesign by optimization and comparative evaluation of vesicular gels of etodolac for transdermal delivery | Full Text | References | PDF (3.9 MB) | EPUB
  • 161 Views
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Article
Development of novel pH-sensitive nanoparticles loaded hydrogel for transdermal drug delivery
Maimoona Qindeel, Naveed Ahmed, Fakhara Sabir, Samiullah Khan & Asim Ur-Rehman
Pages: 629-641
Published online: 28 Jan 2019
AbstractforDevelopment of novel pH-sensitive nanoparticles loaded hydrogel for transdermal drug delivery | Full Text | References | PDF (1.9 MB) | EPUB
  • 830 Views
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Article
Azelaic acid-loaded nanoemulsion with hyaluronic acid – a new strategy to treat hyperpigmentary skin disorders
Simone Jacobus Berlitz, Damiê De Villa, Luiz Augusto Maschmann Inácio, Samuel Davies, Kelly Cristine Zatta, Silvia Stanisçuaski Guterres & Irene Clemes Külkamp-Guerreiro
Pages: 642-650
Published online: 28 Jan 2019
AbstractforAzelaic acid-loaded nanoemulsion with hyaluronic acid – a new strategy to treat hyperpigmentary skin disorders | Full Text | References | PDF (1.3 MB) | EPUB
  • 719 Views
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Article
Formulation, optimization, and evaluation of raft-forming formulations containing Nizatidine
Manal K. M. Darwish, Amal S. M. Abu El-Enin & Kamilia H. A. Mohammed
Pages: 651-663
Published online: 07 Feb 2019
AbstractforFormulation, optimization, and evaluation of raft-forming formulations containing Nizatidine | Full Text | References | PDF (2.4 MB) | EPUB
  • 160 Views
  • 5 CrossRef citations
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Article
Bioanalytical method development and its application to pharmacokinetics studies on Simvastatin in the presence of piperine and two of its synthetic derivatives
Pratibha Auti, Satish Gabhe & Kakasaheb Mahadik
Pages: 664-668
Published online: 11 Feb 2019
AbstractforBioanalytical method development and its application to pharmacokinetics studies on Simvastatin in the presence of piperine and two of its synthetic derivatives | Full Text | References | PDF (568.9 KB) | EPUB
  • 108 Views
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Article
Effect of hydrophilic and hydrophobic polymers on permeation of S-amlodipine besylate through intercalated polymeric transdermal matrix: 3(2) designing, optimization and characterization
Vaibhav Rastogi, Pragya Yadav, Arif Husain & Anurag Verma
Pages: 669-682
Published online: 31 Jan 2019
AbstractforEffect of hydrophilic and hydrophobic polymers on permeation of S-amlodipine besylate through intercalated polymeric transdermal matrix: 3(2) designing, optimization and characterization | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 119 Views
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Article
In vitro activity of resorcinarene–chlorambucil conjugates for therapy in human chronic myelogenous leukemia cells
Sonia Mendoza-Cardozo, Luis D. Pedro-Hernández, Ulises Organista-Mateos, Luis Isaac Allende-Alarcón, Elena Martínez-Klimova, Teresa Ramírez-Ápan & Marcos Martínez-García
Pages: 683-688
Published online: 28 Jan 2019
AbstractforIn vitro activity of resorcinarene–chlorambucil conjugates for therapy in human chronic myelogenous leukemia cells | Full Text | References | PDF (1,011.1 KB) | EPUB | Supplemental
  • 163 Views
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Article
Effects of ketoconazole, voriconazole, and itraconazole on the pharmacokinetics of apatinib in rats
Dan Lou, Xiao Cui, Su-Su Bao, Wei Sun, Wen-He Pan, Meng-Chun Chen, Yao-Yao Dong, Guo-Xin Hu, Rui-Jie Chen & Zhe Wang
Pages: 689-693
Published online: 24 Jan 2019
AbstractforEffects of ketoconazole, voriconazole, and itraconazole on the pharmacokinetics of apatinib in rats | Full Text | References | PDF (670.1 KB) | EPUB
  • 219 Views
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