Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 31, Issue 5 (2016)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 31, Issue 5 (2016)

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Review Article

Review
A magnificent enzyme superfamily: carbonic anhydrases, their purification and characterization
Ozen Ozensoy Guler, Clemente Capasso & Claudiu T. Supuran
Pages: 689-694
Published online: 29 Jun 2015
AbstractforA magnificent enzyme superfamily: carbonic anhydrases, their purification and characterization | Full Text | References | PDF (148.6 KB)
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Research Article

Article
Resveratrol-salicylate derivatives as selective DNMT3 inhibitors and anticancer agents
Fahad S. Aldawsari, Rodrigo Aguayo-Ortiz, Kanishk Kapilashrami, Jakyung Yoo, Minkui Luo, José L. Medina-Franco & Carlos A. Velázquez-Martínez
Pages: 695-703
Published online: 29 Jun 2015
AbstractforResveratrol-salicylate derivatives as selective DNMT3 inhibitors and anticancer agents | Full Text | References | PDF (1.2 MB)
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Article
Design, green synthesis and pharmacological evaluation of novel 5,6-diaryl-1,2,4-triazines bearing 3-morpholinoethylamine moiety as potential antithrombotic agents
Riyaj S. Tamboli, Rajani Giridhar, Hardik P. Gandhi, Ashish M. Kanhed, Hemant M. Mande & Mange Ram Yadav
Pages: 704-713
Published online: 01 Jul 2015
AbstractforDesign, green synthesis and pharmacological evaluation of novel 5,6-diaryl-1,2,4-triazines bearing 3-morpholinoethylamine moiety as potential antithrombotic agents | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1092 Views
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Article
Synthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety
Leyla Yurttaş, Zafer Asım Kaplancıklı, Gamze Göger & Fatih Demirci
Pages: 714-720
Published online: 06 Aug 2015
AbstractforSynthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety | Full Text | References | PDF (214.7 KB) | Supplemental
  • 1127 Views
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Article
Synthesis, antitumor and antimicrobial activity of some new 6-methyl-3-phenyl-4(3H)-quinazolinone analogues: in silico studies
Amer M. Alanazi, Alaa A.-M. Abdel-Aziz, Taghreed Z. Shawer, Rezk R. Ayyad, Abdulrahman M. Al-Obaid, Mohamed H. M. Al-Agamy, Azza R. Maarouf & Adel S. El-Azab
Pages: 721-735
Published online: 10 Jul 2015
AbstractforSynthesis, antitumor and antimicrobial activity of some new 6-methyl-3-phenyl-4(3H)-quinazolinone analogues: in silico studies | Full Text | References | PDF (1.3 MB) | Supplemental
  • 2134 Views
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Article
Interaction exists between matriptase inhibitors and intestinal epithelial cells
Erzsebet Pászti-Gere, Réka Fanni Barna, Gabriella Ujhelyi & Torsten Steinmetzer
Pages: 736-741
Published online: 29 Jun 2015
AbstractforInteraction exists between matriptase inhibitors and intestinal epithelial cells | Full Text | References | PDF (363.6 KB)
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Article
Phenols displaying tyrosinase inhibition from Humulus lupulus
Dae Wook Kim, Hyun Sim Woo, Jeong Yoon Kim, Jin Ah Ryuk, Ki Hun Park & Byoung Seob Ko
Pages: 742-747
Published online: 10 Jul 2015
AbstractforPhenols displaying tyrosinase inhibition from Humulus lupulus | Full Text | References | PDF (422 KB) | Supplemental
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Article
New synthetic AICAR derivatives with enhanced AMPK and ACC activation
Olga Scudiero, Ersilia Nigro, Maria Ludovica Monaco, Giorgia Oliviero, Rita Polito, Nicola Borbone, Stefano D'Errico, Luciano Mayol, Aurora Daniele & Gennaro Piccialli
Pages: 748-753
Published online: 08 Oct 2015
AbstractforNew synthetic AICAR derivatives with enhanced AMPK and ACC activation | Full Text | References | PDF (426.6 KB)
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Article
Anthraquinone profile, antioxidant and enzyme inhibitory effect of root extracts of eight Asphodeline taxa from Turkey: can Asphodeline roots be considered as a new source of natural compounds?
Gokhan Zengin, Marcello Locatelli, Ramazan Ceylan & Abdurrahman Aktumsek
Pages: 754-759
Published online: 24 Jul 2015
AbstractforAnthraquinone profile, antioxidant and enzyme inhibitory effect of root extracts of eight Asphodeline taxa from Turkey: can Asphodeline roots be considered as a new source of natural compounds? | Full Text | References | PDF (276 KB) | Supplemental
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Article
Coumarin or benzoxazinone based novel carbonic anhydrase inhibitors: synthesis, molecular docking and anticonvulsant studies
Mert Olgun Karataş, Harun Uslu, Suat Sarı, Mehmet Abdullah Alagöz, Arzu Karakurt, Bülent Alıcı, Cigdem Bilen, Emre Yavuz, Nahit Gencer & Oktay Arslan
Pages: 760-772
Published online: 24 Jul 2015
AbstractforCoumarin or benzoxazinone based novel carbonic anhydrase inhibitors: synthesis, molecular docking and anticonvulsant studies | Full Text | References | PDF (1.2 MB)
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Article
The effects of some avermectins on bovine carbonic anhydrase enzyme
Leyla Polat Kose, İlhami Gülçin, Hasan Özdemir, Ali Atasever, Saleh H. Alwasel & Claudiu T. Supuran
Pages: 773-778
Published online: 24 Jul 2015
AbstractforThe effects of some avermectins on bovine carbonic anhydrase enzyme | Full Text | References | PDF (280.8 KB)
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Article
Sulfamate inhibitor S4 influences carbonic anhydrase IX ectodomain shedding in colorectal carcinoma cells
Helga Helseth Hektoen, Anne Hansen Ree, Kathrine Røe Redalen & Kjersti Flatmark
Pages: 779-786
Published online: 05 Aug 2015
AbstractforSulfamate inhibitor S4 influences carbonic anhydrase IX ectodomain shedding in colorectal carcinoma cells | Full Text | References | PDF (740.6 KB)
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Article
Synthesis, antiviral activity and structure–activity relationship of 1-(1-aryl-4,5-dihydro-1H-imidazoline)-3-chlorosulfonylureas and products of their cyclization
Marzena Rządkowska, Elżbieta Szacoń, Agnieszka A. Kaczor, Barbara Rajtar, Łukasz Świątek, Małgorzata Polz-Dacewicz & Dariusz Matosiuk
Pages: 787-795
Published online: 27 Jul 2015
AbstractforSynthesis, antiviral activity and structure–activity relationship of 1-(1-aryl-4,5-dihydro-1H-imidazoline)-3-chlorosulfonylureas and products of their cyclization | Full Text | References | PDF (788.3 KB)
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Article
Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: in silico studies
Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Amer M. Alanazi, Yousif A. Asiri, Ibrahim A. Al-Suwaidan, Azza R. Maarouf, Rezk R. Ayyad & Taghreed Z. Shawer
Pages: 796-809
Published online: 30 Jul 2015
AbstractforSynthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: in silico studies | Full Text | References | PDF (411.3 KB)
  • 1921 Views
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Article
Expression and characterization of a recombinant psychrophilic γ-carbonic anhydrase (NcoCA) identified in the genome of the Antarctic cyanobacteria belonging to the genus Nostoc
Viviana De Luca, Sonia Del Prete, Daniela Vullo, Vincenzo Carginale, Pietro Di Fonzo, Sameh M Osman, Zeid AlOthman, Claudiu T Supuran & Clemente Capasso
Pages: 810-817
Published online: 30 Jul 2015
AbstractforExpression and characterization of a recombinant psychrophilic γ-carbonic anhydrase (NcoCA) identified in the genome of the Antarctic cyanobacteria belonging to the genus Nostoc | Full Text | References | PDF (413.8 KB)
  • 837 Views
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Article
Synthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one and evaluation of their cytotoxicities
Mehtap Tugrak, Cem Yamali, Hiroshi Sakagami & Halise Inci Gul
Pages: 818-823
Published online: 06 Aug 2015
AbstractforSynthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one and evaluation of their cytotoxicities | Full Text | References | PDF (276.2 KB)
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Article
X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors
Lidia Ciccone, Susanna Nencetti, Armando Rossello, Livia Tepshi, Enrico A. Stura & Elisabetta Orlandini
Pages: 824-833
Published online: 03 Aug 2015
AbstractforX-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors | Full Text | References | PDF (2.7 MB) | Supplemental
  • 1086 Views
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Short Communication

Rapid Communication
Monocyclic β-lactam and unexpected oxazinone formation: synthesis, crystal structure, docking studies and antibacterial evaluation
Babita Aneja, Mohammad Irfan, Md. Imtaiyaz Hassan, Amresh Prakash, Umesh Yadava, Constantin G. Daniliuc, Md. Zafaryab, M. Moshahid A. Rizvi, Amir Azam & Mohammad Abid
Pages: 834-852
Published online: 01 Jul 2015
AbstractforMonocyclic β-lactam and unexpected oxazinone formation: synthesis, crystal structure, docking studies and antibacterial evaluation | Full Text | References | PDF (4.3 MB)
  • 2005 Views
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Rapid Communication
Synthesis and in vitro evaluation of 4-substituted furano[3,2-c] tetrahydroquinolines as potential anti-cancer agents
Can Chen, Sarah Zingales, Ting Wang, Mingyong Yuan, Dan Wang, Lulu Cai & Qinglin Jiang
Pages: 853-858
Published online: 24 Jul 2015
AbstractforSynthesis and in vitro evaluation of 4-substituted furano[3,2-c] tetrahydroquinolines as potential anti-cancer agents | Full Text | References | PDF (642.8 KB) | Supplemental
  • 960 Views
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