Leukemia & Lymphoma, Volume 61, Issue 5 (2020)

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Leukemia & Lymphoma, Volume 61, Issue 5 (2020)

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Commentaries

Article Commentary
Late relapses in diffuse large B-cell lymphoma: where to move next?
Marcel Nijland & Hanneke C. Kluin-Nelemans
Pages: 1005-1006
Published online: 04 Feb 2020
CitationforLate relapses in diffuse large B-cell lymphoma: where to move next? | Full Text | References | PDF (452.7 KB) | EPUB
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Article Commentary
The justification of vincristine dose capping: tradition, tradition…tradition!
Nancy L. Bartlett
Pages: 1007-1009
Published online: 26 Mar 2020
First Page PreviewforThe justification of vincristine dose capping: tradition, tradition…tradition! | Full Text | References | PDF (431 KB) | EPUB
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Article Commentary
Late and very late relapses in acute myeloid leukemia (AML)
Maximilian Stahl & Martin Stuart Tallman
Pages: 1010-1011
Published online: 14 Apr 2020
CitationforLate and very late relapses in acute myeloid leukemia (AML) | Full Text | References | PDF (246.9 KB) | EPUB
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Reviews

Review
Hypomethylating agent based combinations in higher risk myelodysplastic syndrome
Namrata S. Chandhok, Russell Lewis & Thomas Prebet
Pages: 1012-1027
Published online: 09 Dec 2019
AbstractforHypomethylating agent based combinations in higher risk myelodysplastic syndrome | Full Text | References | PDF (1.5 MB) | EPUB
  • 352 Views
  • 2 CrossRef citations
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Review
The potential role of glycogen metabolism in diffuse large B-cell lymphoma
Shahrzad Jalali & Stephen M. Ansell
Pages: 1028-1036
Published online: 17 Dec 2019
AbstractforThe potential role of glycogen metabolism in diffuse large B-cell lymphoma | Full Text | References | PDF (1.1 MB) | EPUB
  • 316 Views
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Review
Multiple B cell malignancies in patients with chronic lymphocytic leukemia: epidemiology, pathology, and clinical implications
Sameer A. Parikh, Philip J. Meacham, Clive S. Zent & Andrew G. Evans
Pages: 1037-1051
Published online: 11 Jan 2020
AbstractforMultiple B cell malignancies in patients with chronic lymphocytic leukemia: epidemiology, pathology, and clinical implications | Full Text | References | PDF (2.2 MB) | EPUB
  • 587 Views
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Review
A systematic review of outcomes after stem cell transplantation in acute lymphoblastic leukemia with or without measurable residual disease
Shweta Shah, Amber Martin, Monica Turner, Ze Cong, Faraz Zaman & Anthony Stein
Pages: 1052-1062
Published online: 21 Jan 2020
AbstractforA systematic review of outcomes after stem cell transplantation in acute lymphoblastic leukemia with or without measurable residual disease | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 302 Views
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Review
Checkpoint inhibition therapy as possible frontline therapy for Hodgkin lymphoma
Arushi Khurana, Philippe Armand & Stephen M. Ansell
Pages: 1063-1074
Published online: 08 Jan 2020
AbstractforCheckpoint inhibition therapy as possible frontline therapy for Hodgkin lymphoma | Full Text | References | PDF (888 KB) | EPUB
  • 435 Views
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Review report

Report
New developments in the field of mastocytosis and mast cell activation syndromes: a summary of the Annual Meeting of the European Competence Network on Mastocytosis (ECNM) 2019
Michel Arock, Karl Sotlar, Jason Gotlib, Wolfgang R. Sperr, Karin Hartmann, Lawrence B. Schwartz, Cem Akin, Hans-Peter Horny & Peter Valent
Pages: 1075-1083
Published online: 26 Dec 2019
AbstractforNew developments in the field of mastocytosis and mast cell activation syndromes: a summary of the Annual Meeting of the European Competence Network on Mastocytosis (ECNM) 2019 | Full Text | References | PDF (1.5 MB) | EPUB
  • 595 Views
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Original article

Article
Targeting of phospho-eIF4E by homoharringtonine eradicates a distinct subset of human acute myeloid leukemia
Hong Zhou, Rong Zhen Xu, Ying Gu, Peng Fei Shi & Shenxian Qian
Pages: 1084-1096
Published online: 15 Jan 2018
AbstractforTargeting of phospho-eIF4E by homoharringtonine eradicates a distinct subset of human acute myeloid leukemia | Full Text | References | PDF (3.6 MB) | EPUB
  • 281 Views
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Original Articles

Article
Cost-effectiveness analysis of rituximab with methotrexate, cytarabine and thiotepa for the treatment of patients with primary central nervous system lymphoma
Jaclyn M. Beca, Kaiwan Raza, Elena Mow, James Keech & C. Tom Kouroukis
Pages: 1097-1107
Published online: 13 Jan 2020
AbstractforCost-effectiveness analysis of rituximab with methotrexate, cytarabine and thiotepa for the treatment of patients with primary central nervous system lymphoma | Full Text | References | PDF (1.4 MB) | EPUB
  • 294 Views
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Article
Angioimmunoblastic T-cell lymphoma in Taiwan reveals worse progression-free survival for RHOA G17V mutated subtype
Ya-Ting Hsu, Yu-Chu Wang, Ruo-Yu Chen, Liang-Yi Hung, Sin-Syue Li, Chi-Chieh Yen, Tsai-Yun Chen, L. Jeffrey Medeiros & Kung-Chao Chang
Pages: 1108-1118
Published online: 23 Dec 2019
AbstractforAngioimmunoblastic T-cell lymphoma in Taiwan reveals worse progression-free survival for RHOA G17V mutated subtype | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 231 Views
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Article
Distinct clinical characteristics at diagnosis in patients with late relapses compared with early relapses of diffuse large B-cell lymphoma treated with R-CHOP
Junho Kang, Heejung Chae, Jung Yong Hong, Dok Hyun Yoon, Shin Kim, Jung Sun Park, Sang Wook Lee, Chan Sik Park, Jin-Sook Ryu, Jooryung Huh & Cheolwon Suh
Pages: 1119-1125
Published online: 06 Jan 2020
AbstractforDistinct clinical characteristics at diagnosis in patients with late relapses compared with early relapses of diffuse large B-cell lymphoma treated with R-CHOP | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 481 Views
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Article
Impact of a vincristine dose cap on the incidence of neuropathies with DA-EPOCH-R for the treatment of aggressive lymphomas
Taylor M. Weis, Bernard L. Marini, Victoria R. Nachar, Anna M. Brown, Tycel J. Phillips, Julia Brown, Ryan A. Wilcox, Mark S. Kaminski, Sumana Devata & Anthony J. Perissinotti
Pages: 1126-1132
Published online: 26 Dec 2019
AbstractforImpact of a vincristine dose cap on the incidence of neuropathies with DA-EPOCH-R for the treatment of aggressive lymphomas | Full Text | References | PDF (830.9 KB) | EPUB
  • 605 Views
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Article
The prognostic impact of monoclonal immune globulin and free light chain secretion in diffuse large B cell lymphoma (DLBCL)
Elena Maiolo, Eleonora Alma, Cecilia Napodano, Francesca Gulli, Silvia Bellesi, Annarosa Cuccaro, Krizia Pocino, Francesco D’Alo’, Marco Iachini, Maurizio Martini, Luigi Maria Larocca, Valerio De Stefano, Umberto Basile & Stefan Hohaus
Pages: 1133-1139
Published online: 31 Dec 2019
AbstractforThe prognostic impact of monoclonal immune globulin and free light chain secretion in diffuse large B cell lymphoma (DLBCL) | Full Text | References | PDF (1.5 MB) | EPUB
  • 149 Views
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Article
High plasma D-dimer level is a poor prognostic factor for patients with waldenström macroglobulinemia
Xin Cao, Yi-Lin Kong, Li Wang, Hua-Yuan Zhu, Jin-Hua Liang, Yi Xia, Lei Fan, Wen-Yu Shi, Hong Liu, Jian-yong Li & Wei Xu
Pages: 1140-1146
Published online: 13 Jan 2020
AbstractforHigh plasma D-dimer level is a poor prognostic factor for patients with waldenström macroglobulinemia | Full Text | References | PDF (776 KB) | EPUB
  • 117 Views
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Article
Cardiovascular mortality among chronic myeloid leukemia patients in the pre-tyrosine kinase inhibitor (TKI) and TKI eras: a surveillance, epidemiology and end results (SEER) analysis
Qian Wang, Changchuan Jiang, Yaning Zhang, Yu Zhang, Bing Yue, Binbin Zheng-Lin, Yang Zhao & Michael J. Mauro
Pages: 1147-1157
Published online: 27 Jan 2020
AbstractforCardiovascular mortality among chronic myeloid leukemia patients in the pre-tyrosine kinase inhibitor (TKI) and TKI eras: a surveillance, epidemiology and end results (SEER) analysis | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 425 Views
  • 5 CrossRef citations
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Article
Development and validation of the AML-QOL: a quality of life instrument for patients with acute myeloid leukemia
Sarah A. Buckley, Anna B. Halpern, Megan Othus, Diana Jimenez-Sahagun, Roland B. Walter & Stephanie J. Lee
Pages: 1158-1167
Published online: 07 Jan 2020
AbstractforDevelopment and validation of the AML-QOL: a quality of life instrument for patients with acute myeloid leukemia | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 486 Views
  • 10 CrossRef citations
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Article
Loss of X chromosome predicts favorable prognosis in female patients with t(8;21) acute myeloid leukemia
Guofeng Chen, Wei Zhou, Dan Gong, Yan Li, Sai Huang, Nan Wang, Qingyu Xu, Qian Xiong, Yu Jing, Na Lv, Lili Wang, Yonghui Li & Li Yu
Pages: 1168-1177
Published online: 09 Jan 2020
AbstractforLoss of X chromosome predicts favorable prognosis in female patients with t(8;21) acute myeloid leukemia | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 217 Views
  • 9 CrossRef citations
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Article
Hypomethylating agent (HMA) therapy use and survival in older adults with Refractory Anemia with Excess Blasts (RAEB) in the United States (USA): a large propensity score-matched population-based study
Amy J. Davidoff, Xin Hu, Jan Philipp Bewersdorf, Rong Wang, Nikolai A. Podoltsev, Scott F. Huntington, Steven D. Gore, Xiaomei Ma & Amer M. Zeidan
Pages: 1178-1187
Published online: 26 Dec 2019
AbstractforHypomethylating agent (HMA) therapy use and survival in older adults with Refractory Anemia with Excess Blasts (RAEB) in the United States (USA): a large propensity score-matched population-based study | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 248 Views
  • 15 CrossRef citations
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Article
Final safety and efficacy results from the CPX-351 early access program for older patients with high-risk or secondary acute myeloid leukemia
Gail J. Roboz, Melissa L. Larson, S. Eric Rubenstein, Scott R. Solomon, Gary J. Schiller, Qi An, Michael Chiarella, Arthur C. Louie & Tara L. Lin
Pages: 1188-1194
Published online: 26 Feb 2020
AbstractforFinal safety and efficacy results from the CPX-351 early access program for older patients with high-risk or secondary acute myeloid leukemia | Full Text | References | PDF (748.9 KB) | EPUB
  • 3170 Views
  • 7 CrossRef citations
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Open Access
Article
Marrow fibrosis is an independent predictor of hematological toxicity of tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia
Jing Ni, Jian Hong, Zhendong Zhang, Qingsheng Li, Ruixiang Xia, Qingshu Zeng & Guoping Sun
Pages: 1195-1200
Published online: 20 Dec 2019
AbstractforMarrow fibrosis is an independent predictor of hematological toxicity of tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia | Full Text | References | PDF (571 KB) | EPUB
  • 138 Views
  • 1 CrossRef citations
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Article
1q21 gain but not t(4;14) indicates inferior outcomes in multiple myeloma treated with bortezomib
Chenxing Du, Xuehan Mao, Yan Xu, Yuting Yan, Chenglu Yuan, Xin Du, Jiahui Liu, Huishou Fan, Qi Wang, Weiwei Sui, Shuhui Deng, Mingwei Fu, Zengjun Li, Chengwen Li, Jiawei Zhao, Shuhua Yi, Lanting Liu, Mu Hao, Dehui Zou, Yaozhong Zhao, Lugui Qiu & Gang An
Pages: 1201-1210
Published online: 16 Dec 2019
Abstractfor1q21 gain but not t(4;14) indicates inferior outcomes in multiple myeloma treated with bortezomib | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 579 Views
  • 12 CrossRef citations
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Article
A single-center retrospective cohort analysis of venetoclax in relapsed/refractory multiple myeloma
Swetha Kambhampati, Derek Galligan, Chiung-Yu Huang, Sandy Wong, Jeffrey Wolf, Thomas Martin & Nina Shah
Pages: 1211-1219
Published online: 11 Jan 2020
AbstractforA single-center retrospective cohort analysis of venetoclax in relapsed/refractory multiple myeloma | Full Text | References | PDF (1.2 MB) | EPUB
  • 406 Views
  • 5 CrossRef citations
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Letters to the Editor

Letter
Patterns of care and clinical outcomes of patients with newly diagnosed acute myeloid leukemia presenting with hyperleukocytosis who do not receive intensive chemotherapy
Rory M. Shallis, Maximilian Stahl, Wei Wei, Pau Montesinos, Etienne Lengline, Judith Neukirchen, Vijaya R. Bhatt, Mikkael A. Sekeres, Amir T. Fathi, Heiko Konig, Selina Luger, Irum Khan, Gail J. Roboz, Thomas Cluzeau, David Martínez-Cuadron, Emmanuel Raffoux, Ulrich Germing, Jayadev Manikkam Umakanthan, Sudipto Mukhereje, Andrew M. Brunner, Adam Miller, Christine M. McMahon, Ellen K. Ritchie, Rebeca Rodríguez-Veiga, Raphaël Itzykson, Blanca Boluda, Florence Rabian, Mar Tormo, Evelyn Acuña-Cruz, Emma Rabinovich, Brendan Yoo, Isabel Cano, Nikolai A. Podoltsev, Jan Philipp Bewersdorf, Steven Gore & Amer M. Zeidan
Pages: 1220-1225
Published online: 26 Feb 2020
First Page PreviewforPatterns of care and clinical outcomes of patients with newly diagnosed acute myeloid leukemia presenting with hyperleukocytosis who do not receive intensive chemotherapy | Full Text | References | PDF (1.2 MB) | EPUB
  • 320 Views
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Letter
More than ten percent of relapses occur after five years in AML patients with NPM1 mutation
Sarah Bertoli, Suzanne Tavitian, Emilie Bérard, Véronique Mansat-De Mas, Laetitia Largeaud, Noémie Gadaud, Jean-Baptiste Rieu, François Vergez, Isabelle Luquet, Françoise Huguet, Audrey Sarry, Eric Delabesse & Christian Récher
Pages: 1226-1229
Published online: 05 Feb 2020
First Page PreviewforMore than ten percent of relapses occur after five years in AML patients with NPM1 mutation | Full Text | References | PDF (432.5 KB) | EPUB
  • 156 Views
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Letter
Different sensitivity of CD19-positive bone marrow and lymph node lymphoblasts may cause resistance to blinatumomab in relapsed B-cell acute lymphoblastic leukemia/lymphoma
Vadim Ivanov, Laure Farnault, Cedric Mercier, Cecile Colavolpe, Geoffroy Venton, Julien Colle, Hubert Lepidi, Isabelle Arnoux, Corinne Nicolino-Brunet, Yael Berda-Haddad, Raphaelle Fanciullino, Gleb Ivanov & Regis Costello
Pages: 1230-1233
Published online: 03 Jan 2020
First Page PreviewforDifferent sensitivity of CD19-positive bone marrow and lymph node lymphoblasts may cause resistance to blinatumomab in relapsed B-cell acute lymphoblastic leukemia/lymphoma | Full Text | References | PDF (615.5 KB) | EPUB
  • 203 Views
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Letter
Phenotypical heterogeneity of acute myeloid leukemia in the elderly: a clue for a personalized therapy?
Giacomo Andreani, Sofia Camerlo, Marisa Pautasso, Matteo Dragani, Giovanna Carrà, Angelo Guerrasio, Daniela Cilloni & Alessandro Morotti
Pages: 1234-1237
Published online: 13 Jan 2020
First Page PreviewforPhenotypical heterogeneity of acute myeloid leukemia in the elderly: a clue for a personalized therapy? | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 117 Views
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Letter
Combining bortezomib to high dose melphalan as conditioning regimen results in the improvement of the response rate in newly diagnosed young multiple myeloma patients
Benedetta Dalla Palma, Fabrizio Accardi, Lucia Prezioso, Laura Notarfranchi & Nicola Giuliani
Pages: 1238-1241
Published online: 06 Jan 2020
First Page PreviewforCombining bortezomib to high dose melphalan as conditioning regimen results in the improvement of the response rate in newly diagnosed young multiple myeloma patients | Full Text | References | PDF (690.5 KB) | EPUB | Supplemental
  • 153 Views
  • 2 CrossRef citations
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Letter
Clonal dynamics of aplastic anemia/paroxysmal nocturnal hemoglobinuria
Bhumika J. Patel, Shimoli V. Barot, Madeline Waldron, Steven Billings, Alok Vij, Mikkael A. Sekeres, Jaroslaw P. Maciejewski & Hetty E. Carraway
Pages: 1242-1245
Published online: 28 Dec 2019
First Page PreviewforClonal dynamics of aplastic anemia/paroxysmal nocturnal hemoglobinuria | Full Text | References | PDF (988.7 KB) | EPUB
  • 244 Views
  • 1 CrossRef citations
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Letter
Use of allopurinol to reduce hepatotoxicity from 6-mercaptopurine (6-MP) in patients with acute lymphoblastic leukemia (ALL)
Austin J. Stuckert, Eric S. Schafer, M. Brooke Bernhardt, Patricia Baxter & Julienne Brackett
Pages: 1246-1249
Published online: 16 Dec 2019
First Page PreviewforUse of allopurinol to reduce hepatotoxicity from 6-mercaptopurine (6-MP) in patients with acute lymphoblastic leukemia (ALL) | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 1269 Views
  • 8 CrossRef citations
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Letter
Clinical effects of the CD13/CD33 ratio on the prognosis of myelodysplastic syndrome treated with azacitidine
Satoko Oka, Kazuo Ono & Masaharu Nohgawa
Pages: 1250-1253
Published online: 16 Jan 2020
First Page PreviewforClinical effects of the CD13/CD33 ratio on the prognosis of myelodysplastic syndrome treated with azacitidine | Full Text | References | PDF (396.1 KB) | EPUB
  • 118 Views
  • 2 CrossRef citations
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Letter
Inpatient hospitalization’s associated cost and mortality in myeloma patients undergoing autologous stem cell transplant: a 13-year analysis of the National Inpatient Sample
Saqib Abbasi, Alec Britt, Brian McClune, Leyla Shune, Suman Kambhampati & Ghulam Rehman Mohyuddin
Pages: 1254-1256
Published online: 07 Feb 2020
First Page PreviewforInpatient hospitalization’s associated cost and mortality in myeloma patients undergoing autologous stem cell transplant: a 13-year analysis of the National Inpatient Sample | Full Text | References | PDF (439.6 KB) | EPUB
  • 159 Views
  • 1 CrossRef citations
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Letter
Severe chemotherapy toxicity in a 10-year-old with T-acute lymphoblastic lymphoma harboring biallelic FANCM variants
Georgina L. Ryland, Lucy C. Fox, Virginia Wootton, Ella R. Thompson, Jennifer Lickiss, Alison H. Trainer, Paddy Barbaro, Morag Whyte, David Ritchie & Piers Blombery
Pages: 1257-1259
Published online: 16 Jan 2020
First Page PreviewforSevere chemotherapy toxicity in a 10-year-old with T-acute lymphoblastic lymphoma harboring biallelic FANCM variants | Full Text | References | PDF (483.3 KB) | EPUB
  • 215 Views
  • 2 CrossRef citations
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Letter
Low risk for viral reactivation during induction for acute myeloid leukemia in patients with resolved hepatitis B infection
Tsofia Inbar, Shehrban Sobeh Khalil, Ron Ram, Chezi Ganzel & Yishai Ofran
Pages: 1260-1262
Published online: 20 Dec 2019
First Page PreviewforLow risk for viral reactivation during induction for acute myeloid leukemia in patients with resolved hepatitis B infection | Full Text | References | PDF (458.7 KB) | EPUB
  • 86 Views
  • 0 CrossRef citations
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Letter
Haploidentical bone marrow transplantation in a child with fatal hepatic failure due to graft-versus-host disease after cord blood transplantation
Masataka Ito, Hiroshi Yagasaki, Erina Nakahara, Hirotsugu Okuma, Maiko Hirai, Motoaki Chin & Ichiro Morioka
Pages: 1263-1264
Published online: 26 Dec 2019
CitationforHaploidentical bone marrow transplantation in a child with fatal hepatic failure due to graft-versus-host disease after cord blood transplantation | Full Text | References | PDF (354 KB) | EPUB
  • 81 Views
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Letter
BCR-ABL1 positive lymphoblastic lymphoma – should it be treated like a B-lymphoblastic leukemia with t(9;22);BCR-ABL1?
Taro Takahashi, Satoshi Ichikawa, Ryo Ichinohasama & Hideo Harigae
Pages: 1265-1267
Published online: 26 Dec 2019
First Page PreviewforBCR-ABL1 positive lymphoblastic lymphoma – should it be treated like a B-lymphoblastic leukemia with t(9;22);BCR-ABL1? | Full Text | References | PDF (564 KB) | EPUB
  • 184 Views
  • 6 CrossRef citations
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