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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 3
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Research Article

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

Pages 297-310 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (31)

Siavosh Naji-Talakar, Sheena Sharma, Leslie A. Martin, Derek Barnhart & Bhagwat Prasad. (2021) Potential implications of DMET ontogeny on the disposition of commonly prescribed drugs in neonatal and pediatric intensive care units. Expert Opinion on Drug Metabolism & Toxicology 17:3, pages 273-289.
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Peng-fei Tang, Xiang Zheng, Xiao-xia Hu, Cheng-cheng Yang, Zhe Chen, Jian-chang Qian, Jian-ping Cai & Guo-xin Hu. (2020) Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism. Drug Design, Development and Therapy 14, pages 5129-5141.
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Hajime Tachikawa, Rei Nishiyama, Yoko Ichikawa-Kaji, Nozomi Uemura, Yasuhiro Takaku, Kiyoko Kishimoto, Yasushi Ono, Kuniaki Tayama, Toshinari Suzuki, Jin Suzuki & Takako Moriyasu. (2020) Structure elucidation of a PDE5 inhibitor detected as an illegal adulteration in a libido-boosting dietary supplement. Food Additives & Contaminants: Part A 37:12, pages 2023-2032.
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Wei Zhang, Yue-E Wu, Xiao-Yan Yang, Jing Shi, John van den Anker, Lin-Lin Song & Wei Zhao. (2020) Oral drugs used to treat persistent pulmonary hypertension of the newborn. Expert Review of Clinical Pharmacology 13:12, pages 1295-1308.
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Kishore K. Katyayan & Yu-Hua Hui. (2019) An evaluation of metabolite profiling of six drugs using dried blood spot. Xenobiotica 49:12, pages 1458-1469.
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Marike Visser, Matthew J. Zaya, Charles W. Locuson, Dawn M. Boothe & Dawn A. Merritt. (2019) Comparison of predicted intrinsic hepatic clearance of 30 pharmaceuticals in canine and feline liver microsomes. Xenobiotica 49:2, pages 177-186.
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Francesca M. Russo, Paola Mian, Elke H. Krekels, Kristel Van Calsteren, Dick Tibboel, Jan Deprest & Karel Allegaert. (2019) Pregnancy affects the pharmacokinetics of sildenafil and its metabolite in the rabbit. Xenobiotica 49:1, pages 98-105.
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Somchai Sawatdee, Apichart Atipairin, Attawadee Sae Yoon, Teerapol Srichana, Narumon Changsan, Tan Suwandecha, Wirot Chanthorn & Atchara Phoem. (2018) Oral bioavailability and pharmacokinetics of sildenafil citrate dry foam tablets in rats. Cogent Medicine 5:1.
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Khaled Mohamed Hosny, Khalid Mohamed El-say & Osama Abdelhakim Ahmed. (2016) Optimized sildenafil citrate fast orodissolvable film: a promising formula for overcoming the barriers hindering erectile dysfunction treatment. Drug Delivery 23:1, pages 355-361.
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Qian-Qian Liu & Zhi-Cheng Jing. (2015) The limits of oral therapy in pulmonary arterial hypertension management. Therapeutics and Clinical Risk Management 11, pages 1731-1741.
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Min Chul Cho & Jae-Seung Paick. (2014) Udenafil for the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management 10, pages 341-354.
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Srinivasan Shanmugam, Young-Hun Kim, Jeong-Hee Park, Ho Taek Im, Young Taek Sohn, Kyeong Soo Kim, Yong-Il Kim, Chul Soon Yong, Jong Oh Kim, Han-Gon Choi & Jong Soo Woo. (2014) Sildenafil vaginal suppositories: preparation, characterization, in vitro and in vivo evaluation. Drug Development and Industrial Pharmacy 40:6, pages 803-812.
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Marie-Camille Chaumais, Swanny Perrin, Olivier Sitbon, Gérald Simonneau, Marc Humbert & David Montani. (2013) Pharmacokinetic evaluation of sildenafil as a pulmonary hypertension treatment. Expert Opinion on Drug Metabolism & Toxicology 9:9, pages 1193-1205.
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Manar H. Arafa & Hebatallah H. Atteia. (2013) Sildenafil citrate attenuates the deleterious effects of elevated ammonia. Toxicology Mechanisms and Methods 23:6, pages 402-411.
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Ji-Hee Lee, Goeun Choi, Yeon-Ji Oh, Je Won Park, Young Bin Choy, Mung Chul Park, Yeo Joon Yoon, Hwa Jeong Lee, Hee Chul Chang & Jin-Ho Choy. (2012) A nanohybrid system for taste masking of sildenafil. International Journal of Nanomedicine 7, pages 1635-1649.
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Mohammad Amin Rezvanfar, Hamid Reza Rahimi & Mohammad Abdollahi. (2012) ADMET considerations for phosphodiesterase-5 inhibitors. Expert Opinion on Drug Metabolism & Toxicology 8:10, pages 1231-1245.
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Hsien-Tsung Lu, Ray-Neng Chen, Ming-Thau Sheu, Chung-Chiao Chang, Po-Yu Chou & Hsiu-O Ho. (2011) Rapid-onset sildenafil nasal spray carried by microemulsion systems: in vitro evaluation and in vivo pharmacokinetic studies in rabbits. Xenobiotica 41:7, pages 567-577.
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C.Y. Ahn, S.K. Bae, S.H. Bae, H.E. Kang, S.H. Kim, M.G. Lee & W.G. Shin. (2011) Pharmacokinetics of sildenafil and its metabolite, N-desmethylsildenafil, in rats with liver cirrhosis and diabetes mellitus, alone and in combination. Xenobiotica 41:2, pages 164-174.
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Samuel L Washington$suffix/text()$suffix/text() & Alan W Shindel. (2010) A once-daily dose of tadalafil for erectile dysfunction: compliance and efficacy. Drug Design, Development and Therapy 4, pages 159-171.
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Gordana Lazovic, Ubavka Radivojevic & Jelena Marinkovic. (2008) Tibolone: the way to beat many a postmenopausal ailments. Expert Opinion on Pharmacotherapy 9:6, pages 1039-1047.
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Ying-Ku Lin, Ming-Thau Sheu, Thau-Zong Tzen & Hsiu-O Ho. (2008) Biotransformation of Sildenafil in the Male Rat: Evaluation of Drug Interactions with Testosterone and Carbamazepine. Drug Development and Industrial Pharmacy 34:11, pages 1219-1226.
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Sharron H Francis & Jackie D Corbin. (2005) Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction. Expert Opinion on Drug Metabolism & Toxicology 1:2, pages 283-293.
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Eun-Joo Kim, Joung-Wook Seo, Ji-Yoon Hwang & Sang-Seop Han. (2005) Effects of Combined Treatment with Sildenafil and Itraconazole on the Cardiovascular System in Telemetered Conscious Dogs. Drug and Chemical Toxicology 28:2, pages 177-186.
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Alberto Briganti, Andrea Salonia, Andrea Gallina, Nazareno Suardi, Patrizio Rigatti & Francesco Montorsi. (2004) Emerging oral drugs for erectile dysfunction. Expert Opinion on Emerging Drugs 9:1, pages 179-189.
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Giuseppe Carlucci, Fabrizio Ruggieri, Giancarlo Palumbo & Pietro Mazzeo. (2004) Development of a Liquid Chromatographic Method for the Determination of Sildenafil in Seminal Plasma. Journal of Liquid Chromatography & Related Technologies 27:19, pages 3039-3050.
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Culley C Carson. (2003) Long-term use of sildenafil. Expert Opinion on Pharmacotherapy 4:3, pages 397-405.
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Andrea Salonia, Patrizio Rigatti & Francesco Montorsi. (2003) Sildenafil in erectile dysfunction: a critical review. Current Medical Research and Opinion 19:4, pages 241-262.
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RaymondC. Rosen & KevinE. McKenna. (2002) PDE-5 Inhibition and Sexual Response: Pharmacological Mechanisms and Clinical Outcomes. Annual Review of Sex Research 13:1, pages 36-88.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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D. K. Walker, K. C. Beaumont, P. Comby, K. M. Evans, J. I. Gedge, R. C. Halliday, S. J. Roffey & P. A. Wright. (2001) Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog. Xenobiotica 31:8-9, pages 651-664.
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