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Aerosol Science and Technology Volume 44, 2010 - Issue 6
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Original Articles

Characterization of Nanoaerosol Size Change During Enhanced Condensational Growth

P. Worth Longest Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA
,
James T. McLeskey Jr. Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA
&
Michael Hindle Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA
Pages 473-483 | Received 16 Oct 2009, Accepted 01 Mar 2010, Published online: 29 Apr 2010

Citations (39)

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M. N. Lavanya, R. Preethi, J. A. Moses & C. Anandharamakrishnan. (2022) Aerosol-based Pulmonary Delivery of Therapeutic Molecules from Food Sources: Delivery Mechanism, Research Trends, and the Way Forward. Food Reviews International 38:sup1, pages 753-788.
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Patrick T. O’Shaughnessy, Lawrence LeBlanc, Alessandra Pratt, Ralph Altmaier, Prathish K. Rajaraman, Ross Walenga & Ching-Long Lin. (2020) Assessment and validation of a hygroscopic growth model with different water activity estimation methods. Aerosol Science and Technology 54:10, pages 1169-1182.
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Xiaole Chen, Clement Kleinstreuer, Wenqi Zhong, Yu Feng & Xianguang Zhou. (2018) Effects of thermal airflow and mucus-layer interaction on hygroscopic droplet deposition in a simple mouth–throat model. Aerosol Science and Technology 52:8, pages 900-912.
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Geng Tian, Michael Hindle & P. Worth Longest. (2014) Targeted Lung Delivery of Nasally Administered Aerosols. Aerosol Science and Technology 48:4, pages 434-449.
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Xiaochen Tang, Zhongqing Zheng, HeejungS. Jung & Akua Asa-Awuku. (2012) The Effects of Mainstream and Sidestream Environmental Tobacco Smoke Composition for Enhanced Condensational Droplet Growth by Water Vapor. Aerosol Science and Technology 46:7, pages 760-766.
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P. Worth Longest & Michael Hindle. (2011) Numerical Model to Characterize the Size Increase of Combination Drug and Hygroscopic Excipient Nanoparticle Aerosols. Aerosol Science and Technology 45:7, pages 884-899.
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Articles from other publishers (33)

Y. Aghaei, B. Sajadi & G. Ahmadi. (2023) The effect of the mucus layer and the inhaled air conditions on the droplets fate in the human nasal cavity: A numerical study. Journal of Aerosol Science 171, pages 106163.
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Susyn Kelly, Matthew Valentine, Wei Hang Chua & Stanislav Tatkov. (2023) Impact of high- and low-flow nebulized saline on airway hydration and mucociliary transport. ERJ Open Research, pages 00724-2022.
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Yuan Zhang, Juhura G. Almazi, Hui Xin Ong, Matt D. Johansen, Scott Ledger, Daniela Traini, Philip M. Hansbro, Anthony D. Kelleher & Chantelle L. Ahlenstiel. (2022) Nanoparticle Delivery Platforms for RNAi Therapeutics Targeting COVID-19 Disease in the Respiratory Tract. International Journal of Molecular Sciences 23:5, pages 2408.
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Chang Xu, Xin Zheng & Shifei Shen. (2021) A numerical study of the effects of ambient temperature and humidity on the particle growth and deposition in the human airway. Environmental Research 200, pages 111751.
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Connor Howe, Mohammad A.M. Momin, Dale R. Farkas, Serena Bonasera, Michael Hindle & P. Worth Longest. (2021) Advancement of the Infant Air-Jet Dry Powder Inhaler (DPI): Evaluation of Different Positive-Pressure Air Sources and Flow Rates. Pharmaceutical Research 38:9, pages 1615-1632.
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Matus E. Diveky, Michael J. Gleichweit, Sandra Roy & Ruth Signorell. (2021) Shining New Light on the Kinetics of Water Uptake by Organic Aerosol Particles. The Journal of Physical Chemistry A 125:17, pages 3528-3548.
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Prathish K. Rajaraman, Jiwoong Choi, Eric A. Hoffman, Patrick T. O'Shaughnessy, Sanghun Choi, Renishkumar Delvadia, Andrew Babiskin, Ross Walenga & Ching-Long Lin. (2020) Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing. Journal of Aerosol Science 146, pages 105581.
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Alexander Ishmatov. (2020) Influence of weather and seasonal variations in temperature and humidity on supersaturation and enhanced deposition of submicron aerosols in the human respiratory tract. Atmospheric Environment 223, pages 117226.
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Sandra Roy, Matus E. Diveky & Ruth Signorell. (2019) Mass Accommodation Coefficients of Water on Organics from Complementary Photoacoustic and Light Scattering Measurements on Laser-Trapped Droplets. The Journal of Physical Chemistry C 124:4, pages 2481-2489.
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Xiaole Chen, Rui Ma, Wenqi Zhong, Baobin Sun & Xianguang Zhou. (2019) Numerical study of the effects of temperature and humidity on the transport and deposition of hygroscopic aerosols in a G3-G6 airway. International Journal of Heat and Mass Transfer 138, pages 545-552.
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Eleonore Fröhlich. (2019) Biological Obstacles for Identifying In Vitro-In Vivo Correlations of Orally Inhaled Formulations. Pharmaceutics 11:7, pages 316.
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Chaeho Moon, Hugh D. C. Smyth, Alan B. Watts & Robert O. WilliamsIIIIII. (2019) Delivery Technologies for Orally Inhaled Products: an Update. AAPS PharmSciTech 20:3.
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Xiaole Chen, Yu Feng, Wenqi Zhong & Clement Kleinstreuer. (2017) Numerical investigation of the interaction, transport and deposition of multicomponent droplets in a simple mouth-throat model. Journal of Aerosol Science 105, pages 108-127.
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Jeffry D. Schroeter, Bahman Asgharian, Owen T. Price, Julia S. Kimbell, Lambros Kromidas & Madhuri Singal. (2016) Simulation of the phase change and deposition of inhaled semi-volatile liquid droplets in the nasal passages of rats and humans. Journal of Aerosol Science 95, pages 15-29.
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Niels Grasmeijer, Henderik W. Frijlink & Wouter L.J. Hinrichs. (2016) An adaptable model for growth and/or shrinkage of droplets in the respiratory tract during inhalation of aqueous particles. Journal of Aerosol Science 93, pages 21-34.
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Daniel Z. Short, Diep Vu, Thomas D. Durbin, Georgios Karavalakis & Akua Asa-Awuku. (2015) Components of Particle Emissions from Light-Duty Spark-Ignition Vehicles with Varying Aromatic Content and Octane Rating in Gasoline. Environmental Science & Technology 49:17, pages 10682-10691.
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Daniel Short, Diep Vu, Thomas D. Durbin, Georgios Karavalakis & Akua Asa-Awuku. (2015) Particle speciation of emissions from iso-butanol and ethanol blended gasoline in light-duty vehicles. Journal of Aerosol Science 84, pages 39-52.
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Bhargava Kandala & Günther Hochhaus. 2014. Applied Pharmacometrics. Applied Pharmacometrics 349 382 .
Darragh Murnane, Victoria Hutter & Marie Harang. 2013. Aerosol Science. Aerosol Science 221 269 .
P. Worth LongestRoss L. WalengaYoen-Ju SonMichael Hindle. (2013) High-Efficiency Generation and Delivery of Aerosols Through Nasal Cannula During Noninvasive Ventilation. Journal of Aerosol Medicine and Pulmonary Drug Delivery 26:5, pages 266-279.
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Geng TianP. Worth LongestXiang LiMichael Hindle. (2013) Targeting Aerosol Deposition to and Within the Lung Airways Using Excipient Enhanced Growth. Journal of Aerosol Medicine and Pulmonary Drug Delivery 26:5, pages 248-265.
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Kamrun Nahar, Nilesh Gupta, Robert Gauvin, Shahriar Absar, Brijeshkumar Patel, Vivek Gupta, Ali Khademhosseini & Fakhrul Ahsan. (2013) In vitro, in vivo and ex vivo models for studying particle deposition and drug absorption of inhaled pharmaceuticals. European Journal of Pharmaceutical Sciences 49:5, pages 805-818.
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P. Worth Longest, Geng Tian, Xiang Li, Yoen-Ju Son & Michael Hindle. (2012) Performance of Combination Drug and Hygroscopic Excipient Submicrometer Particles from a Softmist Inhaler in a Characteristic Model of the Airways. Annals of Biomedical Engineering 40:12, pages 2596-2610.
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P. Worth Longest, Benjamin M. Spence, Landon T. Holbrook, Karla M. Mossi, Yoen-Ju Son & Michael Hindle. (2012) Production of inhalable submicrometer aerosols from conventional mesh nebulizers for improved respiratory drug delivery. Journal of Aerosol Science 51, pages 66-80.
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Michael Hindle & P Worth Longest. (2012) Condensational growth of combination drug-excipient submicrometer particles for targeted high-efficiency pulmonary delivery: evaluation of formulation and delivery device. Journal of Pharmacy and Pharmacology 64:9, pages 1254-1263.
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Ana Fernández Tena & Pere Casan Clarà. (2012) Depósito pulmonar de partículas inhaladas. Archivos de Bronconeumología 48:7, pages 240-246.
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Ana Fernández Tena & Pere Casan Clarà. (2012) Deposition of Inhaled Particles in the Lungs. Archivos de Bronconeumología (English Edition) 48:7, pages 240-246.
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P. Worth Longest & Landon T. Holbrook. (2012) In silico models of aerosol delivery to the respiratory tract — Development and applications. Advanced Drug Delivery Reviews 64:4, pages 296-311.
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P. Worth Longest & Michael Hindle. (2011) Condensational Growth of Combination Drug-Excipient Submicrometer Particles for Targeted High Efficiency Pulmonary Delivery: Comparison of CFD Predictions with Experimental Results. Pharmaceutical Research 29:3, pages 707-721.
Crossref
P. Worth LongestGeng TianMichael Hindle. (2011) Improving the Lung Delivery of Nasally Administered Aerosols During Noninvasive Ventilation—An Application of Enhanced Condensational Growth (ECG). Journal of Aerosol Medicine and Pulmonary Drug Delivery 24:2, pages 103-118.
Crossref
Geng Tian, Philip Worth Longest, Guoguang Su & Michael Hindle. (2010) Characterization of Respiratory Drug Delivery with Enhanced Condensational Growth using an Individual Path Model of the Entire Tracheobronchial Airways. Annals of Biomedical Engineering 39:3, pages 1136-1153.
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Michael Hindle & P. Worth Longest. (2010) Evaluation of Enhanced Condensational Growth (ECG) for Controlled Respiratory Drug Delivery in a Mouth-Throat and Upper Tracheobronchial Model. Pharmaceutical Research 27:9, pages 1800-1811.
Crossref
P. Worth Longest & Michael Hindle. (2010) CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery with comparisons to in vitro data. Journal of Aerosol Science 41:8, pages 805-820.
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