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Aerosol Science and Technology Volume 39, 2005 - Issue 2
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Original Articles

Computational Models for Simulating Multicomponent Aerosol Evaporation in the Upper Respiratory Airways

P. Worth Longest Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA
&
Clement Kleinstreuer Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA
Pages 124-138 | Received 01 Mar 2004, Accepted 01 Nov 2004, Published online: 17 Aug 2010

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Laurent Boudin & David Michel. (2021) Three-Dimensional Numerical Study of a Fluid-Kinetic Model for Respiratory Aerosols with Variable Size and Temperature. Journal of Computational and Theoretical Transport 50:5, pages 507-527.
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Pompy Patowary, Manash Pratim Pathak, Kamaruz Zaman, Sanjai Kumar Dwivedi & Pronobesh Chattopadhyay. (2020) Innate inflammatory response to acute inhalation exposure of riot control agent oleoresin capsicum in female rats: An interplay between neutrophil mobilization and inflammatory markers. Experimental Lung Research 46:3-4, pages 81-97.
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Xiaole Chen, Clement Kleinstreuer, Wenqi Zhong, Yu Feng & Xianguang Zhou. (2018) Effects of thermal airflow and mucus-layer interaction on hygroscopic droplet deposition in a simple mouth–throat model. Aerosol Science and Technology 52:8, pages 900-912.
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Geng Tian, Michael Hindle & P. Worth Longest. (2014) Targeted Lung Delivery of Nasally Administered Aerosols. Aerosol Science and Technology 48:4, pages 434-449.
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Jinxiang Xi, Jongwon Kim, XiuhuaA. Si & Yue Zhou. (2013) Hygroscopic aerosol deposition in the human upper respiratory tract under various thermo-humidity conditions. Journal of Environmental Science and Health, Part A 48:14, pages 1790-1805.
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Richard E. Jacob, Sean M. Colby, Senthil Kabilan, Daniel R. Einstein & James P. Carson. (2013) In situ casting and imaging of the rat airway tree for accurate 3D reconstruction. Experimental Lung Research 39:6, pages 249-257.
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P. Worth Longest & Michael Hindle. (2011) Numerical Model to Characterize the Size Increase of Combination Drug and Hygroscopic Excipient Nanoparticle Aerosols. Aerosol Science and Technology 45:7, pages 884-899.
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P. Worth Longest, JamesT. McLeskey$suffix/text()$suffix/text() & Michael Hindle. (2010) Characterization of Nanoaerosol Size Change During Enhanced Condensational Growth. Aerosol Science and Technology 44:6, pages 473-483.
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Benjamin Sutter, Denis Bémer, Jean-Christophe Appert-Collin, Dominique Thomas & Noël Midoux. (2010) Evaporation of Liquid Semi-Volatile Aerosols Collected on Fibrous Filters. Aerosol Science and Technology 44:5, pages 395-404.
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Ali A. Rostami. (2009) Computational Modeling of Aerosol Deposition in Respiratory Tract: A Review. Inhalation Toxicology 21:4, pages 262-290.
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P. Worth Longest & Jinxiang Xi. (2008) Condensational Growth May Contribute to the Enhanced Deposition of Cigarette Smoke Particles in the Upper Respiratory Tract. Aerosol Science and Technology 42:8, pages 579-602.
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P. Worth Longest, Michael Hindle, Suparna Das Choudhuri & PeterR. Byron. (2007) Numerical Simulations of Capillary Aerosol Generation: CFD Model Development and Comparisons with Experimental Data. Aerosol Science and Technology 41:10, pages 952-973.
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Articles from other publishers (32)

Sajad Eshaghi, Hassan Khaleghi & Reza Maddahian. (2024) In Silico Investigation of Inhalation Condition Impacts on Hygroscopic Growth and Deposition of Salbutamol Sulphate in Human Airways. Respiratory Physiology & Neurobiology, pages 104271.
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Wenxiu Gao, Xiaojian Xie, Yu Liu, Xiaole Chen & Chong Zhu. (2024) Numerical simulation of the transport of breath-exhaled aerosol from manikin with realistic nasal airway over short social distances. Powder Technology 437, pages 119543.
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Taha Sadeghi, Leila Pakzad & Pedram Fatehi. (2023) Evaluation of Soft Mist Inhaler Aerosol Velocity, Size, and Deposition Inside the Mouth—A Computational Fluid Dynamics Study. Journal of Biomechanical Engineering 145:6.
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Worth Longest, Amr Hassan, Dale Farkas & Michael Hindle. (2022) Computational Fluid Dynamics (CFD) Guided Spray Drying Recommendations for Improved Aerosol Performance of a Small-Particle Antibiotic Formulation. Pharmaceutical Research 39:2, pages 295-316.
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Hamideh Hayati, Yu Feng & Myron Hinsdale. (2021) Inter-species variabilities of droplet transport, size change, and deposition in human and rat respiratory systems: An in silico study. Journal of Aerosol Science 154, pages 105761.
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Xiaole Chen, Xianguang Zhou, Xueying Xia, Xiaojian Xie, Ping Lu & Yu Feng. (2021) Modeling of the transport, hygroscopic growth, and deposition of multi-component droplets in a simplified airway with realistic thermal boundary conditions. Journal of Aerosol Science 151, pages 105626.
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Prathish K. Rajaraman, Jiwoong Choi, Eric A. Hoffman, Patrick T. O'Shaughnessy, Sanghun Choi, Renishkumar Delvadia, Andrew Babiskin, Ross Walenga & Ching-Long Lin. (2020) Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing. Journal of Aerosol Science 146, pages 105581.
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P. Worth Longest, Dale Farkas, Amr Hassan & Michael Hindle. (2020) Computational Fluid Dynamics (CFD) Simulations of Spray Drying: Linking Drying Parameters with Experimental Aerosolization Performance. Pharmaceutical Research 37:6.
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Anika Singanayagam, Jie Zhou, Ruth A. Elderfield, Rebecca Frise, Jonathan Ashcroft, Monica Galiano, Shahjahan Miah, Laura Nicolaou & Wendy S. Barclay. (2020) Characterising viable virus from air exhaled by H1N1 influenza-infected ferrets reveals the importance of haemagglutinin stability for airborne infectivity. PLOS Pathogens 16:2, pages e1008362.
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Seyyed Morteza Javid, Christian Moreau & Javad Mostaghimi. (2019) Numerical Analysis of Buckling of a Single Suspension Droplet. Journal of Thermal Spray Technology 29:3, pages 344-357.
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Mahdi Asgari, Francesco Lucci & Arkadiusz K. Kuczaj. (2019) Multispecies aerosol evolution and deposition in a bent pipe. Journal of Aerosol Science 129, pages 53-70.
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M. Pirhadi, B. Sajadi, G. Ahmadi & D. Malekian. (2018) Phase change and deposition of inhaled droplets in the human nasal cavity under cyclic inspiratory airflow. Journal of Aerosol Science 118, pages 64-81.
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P. Worth Longest & Michael Hindle. (2017) Small Airway Absorption and Microdosimetry of Inhaled Corticosteroid Particles after Deposition. Pharmaceutical Research 34:10, pages 2049-2065.
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Kazunori Kadota, Takuro Nishimura, Yugo Nakatsuka, Kenji Kubo & Yuichi Tozuka. (2017) Assistance for Predicting Deposition of Tranilast Dry Powder in Pulmonary Airways by Computational Fluid Dynamics. Journal of Pharmaceutical Innovation 12:3, pages 249-259.
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Xiaole Chen, Yu Feng, Wenqi Zhong & Clement Kleinstreuer. (2017) Numerical investigation of the interaction, transport and deposition of multicomponent droplets in a simple mouth-throat model. Journal of Aerosol Science 105, pages 108-127.
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Jeffry D. Schroeter, Bahman Asgharian, Owen T. Price, Julia S. Kimbell, Lambros Kromidas & Madhuri Singal. (2016) Simulation of the phase change and deposition of inhaled semi-volatile liquid droplets in the nasal passages of rats and humans. Journal of Aerosol Science 95, pages 15-29.
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Jinxiang Xi, Xiuhua A. Si & Jong Won Kim. 2015. Heat Transfer and Fluid Flow in Biological Processes. Heat Transfer and Fluid Flow in Biological Processes 125 155 .
Lukas Pichelstorfer, Renate Winkler-Heil & Werner Hofmann. (2013) Lagrangian/Eulerian model of coagulation and deposition of inhaled particles in the human lung. Journal of Aerosol Science 64, pages 125-142.
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Jong Won KimJinxiang XiXiuhua A. Si. (2012) Dynamic growth and deposition of hygroscopic aerosols in the nasal airway of a 5‐year‐old child. International Journal for Numerical Methods in Biomedical Engineering 29:1, pages 17-39.
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P. Worth Longest, Geng Tian, Xiang Li, Yoen-Ju Son & Michael Hindle. (2012) Performance of Combination Drug and Hygroscopic Excipient Submicrometer Particles from a Softmist Inhaler in a Characteristic Model of the Airways. Annals of Biomedical Engineering 40:12, pages 2596-2610.
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Zhe Zhang, Clement Kleinstreuer & Sinjae Hyun. (2012) Size-change and deposition of conventional and composite cigarette smoke particles during inhalation in a subject-specific airway model. Journal of Aerosol Science 46, pages 34-52.
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P. Worth Longest & Landon T. Holbrook. (2012) In silico models of aerosol delivery to the respiratory tract — Development and applications. Advanced Drug Delivery Reviews 64:4, pages 296-311.
Crossref
P. Worth Longest & Michael Hindle. (2011) Condensational Growth of Combination Drug-Excipient Submicrometer Particles for Targeted High Efficiency Pulmonary Delivery: Comparison of CFD Predictions with Experimental Results. Pharmaceutical Research 29:3, pages 707-721.
Crossref
B. Asgharian, O. T. Price, J. D. Schroeter, J. S. Kimbell, L. Jones & M. Singal. (2011) Derivation of Mass Transfer Coefficients for Transient Uptake and Tissue Disposition of Soluble and Reactive Vapors in Lung Airways. Annals of Biomedical Engineering 39:6, pages 1788-1804.
Crossref
P. Worth LongestGeng TianMichael Hindle. (2011) Improving the Lung Delivery of Nasally Administered Aerosols During Noninvasive Ventilation—An Application of Enhanced Condensational Growth (ECG). Journal of Aerosol Medicine and Pulmonary Drug Delivery 24:2, pages 103-118.
Crossref
P. Worth Longest & Michael Hindle. (2010) CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery with comparisons to in vitro data. Journal of Aerosol Science 41:8, pages 805-820.
Crossref
P. Worth LongestMichael Hindle. (2009) Quantitative Analysis and Design of a Spray Aerosol Inhaler. Part 1: Effects of Dilution Air Inlets and Flow Paths. Journal of Aerosol Medicine and Pulmonary Drug Delivery 22:3, pages 271-283.
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P. Worth LongestMichael Hindle. (2009) Evaluation of the Respimat Soft Mist Inhaler using a Concurrent CFD and In Vitro Approach . Journal of Aerosol Medicine and Pulmonary Drug Delivery 22:2, pages 99-112.
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P. Worth LongestMichael HindleSuparna Das Choudhuri. (2009) Effects of Generation Time on Spray Aerosol Transport and Deposition in Models of the Mouth–Throat Geometry. Journal of Aerosol Medicine and Pulmonary Drug Delivery 22:2, pages 67-84.
Crossref
Laleh Golshahi & W. H. Finlay. 2009. Advances in Transport Phenomena. Advances in Transport Phenomena 1 30 .
P. Worth Longest, Michael Hindle, Suparna Das Choudhuri & Jinxiang Xi. (2008) Comparison of ambient and spray aerosol deposition in a standard induction port and more realistic mouth–throat geometry. Journal of Aerosol Science 39:7, pages 572-591.
Crossref
Kittisak Koombua & Ramana M. Pidaparti. (2008) Inhalation Induced Stresses and Flow Characteristics in Human Airways through Fluid-Structure Interaction Analysis. Modelling and Simulation in Engineering 2008, pages 1-8.
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