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Leukemia & Lymphoma Volume 43, 2002 - Issue 9
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Research Article

Indirubin and Meisoindigo in the Treatment of Chronic Myelogenous Leukemia in China

Zhijian Xiao Department of Clinical Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, People's Republic of China
,
Yushu Hao Department of Clinical Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, People's Republic of China
,
Bingcheng Liu Department of Clinical Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, People's Republic of China
&
Lingsheng Qian Department of Clinical Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, People's Republic of China
Pages 1763-1768 | Published online: 01 Jul 2009

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Lihong Chen, Jinhua Wang, Jianbo Wu, Qiaomei Zheng & Jifen Hu. (2018) Indirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathway. Drug Design, Development and Therapy 12, pages 3335-3342.
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Baixin Ye, Xiaoxing Xiong, Xu Deng, Lijuan Gu, Qiongyu Wang, Zhi Zeng, Xiang Gao, Qingping Gao & Yueying Wang. (2017) Meisoindigo, but not its core chemical structure indirubin, inhibits zebrafish interstitial leukocyte chemotactic migration. Pharmaceutical Biology 55:1, pages 673-679.
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Lucy Liu, Nicolas Gaboriaud, Konstantina Vougogianopoulou, Yan Tian, Jun Wu, Wei Wen, Leandros Skaltsounis & Richard Jove. (2014) MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells. Cancer Biology & Therapy 15:2, pages 178-184.
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Lucy Liu, Marina Kritsanida, Prokopios Magiatis, Nicolas Gaboriaud, Yan Wang, Jun Wu, Ralf Buettner, Fan Yang, Sangkil Nam, Leandros Skaltsounis & Richard Jove. (2012) A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling. Cancer Biology & Therapy 13:13, pages 1255-1261.
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Hyun Mi Kim, Yong-Chul Kim, Jae Il Kim, Yong Seok Choi & Yoon Gyoon Kim. (2012) DEVELOPMENT OF A LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY METHOD FOR THE DETERMINATION OF INDIRUBIN-5-NITRO-3′-MONOXIME, A NOVEL CDK INHIBITOR, IN RAT PLASMA. Journal of Liquid Chromatography & Related Technologies 35:15, pages 2175-2187.
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Aiying Zhang, Mingfeng Yu, Tian Lan, Zenglu Liu & Zhenmin Mao. (2010) Novel Synthesis of 4- or 6-Substituted Indirubin Derivatives. Synthetic Communications 40:21, pages 3125-3134.
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Chin-Cheng Lee, Che-Pin Lin, Yueh-Lun Lee, Giueng-Chueng Wang, Yuan-Chih Cheng & H. Eugene Liu. (2010) Meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. Leukemia & Lymphoma 51:5, pages 897-905.
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Amel Chebel, Sandrine Kagialis-Girard, Regine Catallo, Wei Wen Chien, Valérie Mialou, Carine Domenech, Cedric Badiou, Isabelle Tigaud & Martine Ffrench. (2009) Indirubin derivatives inhibit malignant lymphoid cell proliferation. Leukemia & Lymphoma 50:12, pages 2049-2060.
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Zuo Mingxin, Li Yan, Wang Hongbo, Zhou Jianhua, Li Hongyan, Liu He, Xin Hongqi, Zhang Sen & Chen Xiaoguang. (2008) The Antitumor Activity of Meisoindigo against Human Colorectal Cancer HT-29 Cells In Vitro and In Vivo . Journal of Chemotherapy 20:6, pages 728-733.
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Scott Miller, Jamie Stagl, Dawn B Wallerstedt, Mary Ryan & Patrick J Mansky. (2008) Botanicals used in complementary and alternative medicine treatment of cancer: clinical science and future perspectives. Expert Opinion on Investigational Drugs 17:9, pages 1353-1364.
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S. Kagialis-Girard, V. Mialou, A. Chebel, W. W. Chien, I. Tigaud, F. Mokdad, C. Badiou & M. Ffrench. (2007) Inhibition of normal lymphocyte proliferation by Indirubin-3′-monoxime: A multifactorial process. Leukemia & Lymphoma 48:3, pages 605-615.
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Peter M Fischer & Athos Gianella-Borradori. (2005) Recent progress in the discovery and development of cyclin-dependent kinase inhibitors. Expert Opinion on Investigational Drugs 14:4, pages 457-477.
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