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Pharmaceutical Development and Technology Volume 24, 2019 - Issue 5
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Research Article

Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line

Joana R. CamposDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Coimbra, Portugal; View further author information
,
Ana R. FernandesDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Coimbra, Portugal; View further author information
,
Raquel SousaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Coimbra, Portugal; View further author information
,
Joana F. FangueiroDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Coimbra, Portugal; View further author information
,
Prapaporn BoonmeDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand; ;Nanotec-PSU Center of Excellence on Drug Delivery System, Songkhla, Thailand; View further author information
,
Maria Luisa GarciaDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain; ;Institute of Nanoscience and Nanotechnology, University of Barcelona, Barcelona, Spain; View further author information
,
Amelia M. SilvaDepartment of Biology and Environment, University of Trás-os-Montes e Alto Douro, UTAD, Quinta de Prados, Vila Real, Portugal; ;Centre for Research and Technology of Agro-Environmental and Biological Sciences, CITAB, UTAD, Quinta de Prados, Vila Real, Portugal; View further author information
,
Beatriz C. NaverosDepartment of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Granada, Spain; View further author information
&
Eliana B. SoutoDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Coimbra, Portugal; ;CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar, Braga, PortugalCorrespondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0002-9737-6017View further author information
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Pages 616-622 | Received 13 Sep 2018, Accepted 13 Nov 2018, Published online: 04 Jan 2019

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Jafar Akbari, Majid Saeedi, Fatemeh Ahmadi, Seyyed Mohammad Hassan Hashemi, Amirhossein Babaei, Sadra Yaddollahi, Seyyed Sohrab Rostamkalaei, Kofi Asare-Addo & Ali Nokhodchi. (2022) Solid lipid nanoparticles and nanostructured lipid carriers: a review of the methods of manufacture and routes of administration. Pharmaceutical Development and Technology 27:5, pages 525-544.
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Marianne Joseph Naguib, Ibrahim Elsayed & Mahmoud Hassan Teaima. (2021) Simultaneous Optimization of Oral and Transdermal Nanovesicles for Bioavailability Enhancement of Ivabradine Hydrochloride. International Journal of Nanomedicine 16, pages 2917-2931.
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Aleksandra Zielińska, Nuno R. Ferreira, Agnieszka Feliczak-Guzik, Izabela Nowak & Eliana B. Souto. (2020) Loading, release profile and accelerated stability assessment of monoterpenes-loaded solid lipid nanoparticles (SLN). Pharmaceutical Development and Technology 25:7, pages 832-844.
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Eliana B. Souto, Iara Baldim, Wanderley P. Oliveira, Rekha Rao, Nitesh Yadav, Francisco M. Gama & Sheefali Mahant. (2020) SLN and NLC for topical, dermal, and transdermal drug delivery. Expert Opinion on Drug Delivery 17:3, pages 357-377.
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