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Research Article

Design, Development and Optimization of a Novel Time and pH-Dependent Colon Targeted Drug Delivery System

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Pages 65-72 | Received 24 May 2008, Accepted 25 Jun 2008, Published online: 16 Dec 2008

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Read on this site (11)

Preksha Vinchhi & Mayur M. Patel. (2021) Triumph against cancer: invading colorectal cancer with nanotechnology. Expert Opinion on Drug Delivery 18:9, pages 1169-1192.
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Somayeh Taymouri, Zoha Ahmadi, Mina Mirian & Naser Tavakoli. (2021) Simvastatin nanosuspensions prepared using a combination of pH-sensitive and timed-release approaches for potential treatment of colorectal cancer. Pharmaceutical Development and Technology 26:3, pages 335-348.
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Gurpreet Kaur Sinhmar, Neel N. Shah, Shruti U. Rawal, Nimitt V. Chokshi, Hiren N. Khatri, Bhoomika M. Patel & Mayur M. Patel. (2018) Surface engineered lipid nanoparticle-mediated site-specific drug delivery system for the treatment of inflammatory bowel disease. Artificial Cells, Nanomedicine, and Biotechnology 46:sup2, pages 565-578.
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Gurpreet Kaur Sinhmar, Neel N. Shah, Nimitt V. Chokshi, Hiren N. Khatri & Mayur M. Patel. (2018) Process, optimization, and characterization of budesonide-loaded nanostructured lipid carriers for the treatment of inflammatory bowel disease. Drug Development and Industrial Pharmacy 44:7, pages 1078-1089.
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Eskandar Moghimipour, Mohsen Rezaei, Maryam Kouchak, Jafar Fatahiasl, Kambiz Ahmadi Angali, Zahra Ramezani, Mohsen Amini, Farid Abedin Dorkoosh & Somayeh Handali. (2018) Effects of coating layer and release medium on release profile from coated capsules with Eudragit FS 30D: an in vitro and in vivo study. Drug Development and Industrial Pharmacy 44:5, pages 861-867.
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Makiko Fujii, Ayari Kawakami, Asumi Saito, Haruna Tuchiya, Naoya Koizumi & Yoshiteru Watanabe. (2016) Preparation and characterization of a powder containing an oily liquid drug with Eudragit EPO or L100 copolymer. Pharmaceutical Development and Technology 21:8, pages 1023-1028.
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Mayur M Patel. (2015) Colon: a gateway for chronotherapeutic drug delivery systems. Expert Opinion on Drug Delivery 12:9, pages 1389-1395.
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Mayur M. Patel & Avani F. Amin. (2013) Development of a novel tablet-in-capsule formulation of mesalamine for inflammatory bowel disease. Pharmaceutical Development and Technology 18:2, pages 390-400.
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Yellela S. R. Krishnaiah & Mansoor A. Khan. (2012) Strategies of targeting oral drug delivery systems to the colon and their potential use for the treatment of colorectal cancer. Pharmaceutical Development and Technology 17:5, pages 521-540.
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Mayur M Patel. (2011) Cutting-edge technologies in colon-targeted drug delivery systems. Expert Opinion on Drug Delivery 8:10, pages 1247-1258.
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Articles from other publishers (14)

Sadikalmahdi Abdella, Fatima Abid, Souha H. Youssef, Sangseo Kim, Franklin Afinjuomo, Constance Malinga, Yunmei Song & Sanjay Garg. (2023) pH and its applications in targeted drug delivery. Drug Discovery Today 28:1, pages 103414.
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Srinivasan Krishnamoorthy, Koka Zongo, J.A. Moses & C. Anandharamakrishnan. 2023. Industrial Application of Functional Foods, Ingredients and Nutraceuticals. Industrial Application of Functional Foods, Ingredients and Nutraceuticals 397 432 .
Nilesh Kulkarni, Priti Jain, Amol Shindikar, Pravin Suryawanshi & Nanasaheb Thorat. (2022) Advances in the colon-targeted chitosan based multiunit drug delivery systems for the treatment of inflammatory bowel disease. Carbohydrate Polymers 288, pages 119351.
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Syed Abdul Wasay, Syed Umer Jan, Muhammad Akhtar, Sobia Noreen & Rahman Gul. (2022) Developed meloxicam loaded microparticles for colon targeted delivery: Statistical optimization, physicochemical characterization, and in-vivo toxicity study. PLOS ONE 17:4, pages e0267306.
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Rijawan Rajjak PATHAN & Aquil-ur-rahim SIDDIQUI. (2022) Preparation, Optimization, and Evaluation of Pellets Containing Mesalamine With Natural Gums For Colon Drug Delivery System. Fabad Journal of Pharmaceutical Sciences, pages 35-56.
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Hossein Shahdadi Sardou, Abbas Akhgari, Hadi Afrasiabi Garekani & Fatemeh Sadeghi. (2019) Screening of different polysaccharides in a composite film based on Eudragit RS for subsequent use as a coating for delivery of 5-ASA to colon. International Journal of Pharmaceutics 568, pages 118527.
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Hossein Shahdadi Sardo, Farinaz Saremnejad, Sara Bagheri, Abbas Akhgari, Hadi Afrasiabi Garekani & Fatemeh Sadeghi. (2019) A review on 5-aminosalicylic acid colon-targeted oral drug delivery systems. International Journal of Pharmaceutics 558, pages 367-379.
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Somayeh Handali, Eskandar Moghimipour, Mohsen Rezaei, Maryam Kouchak, Zahra Ramezani & Farid Abedin Dorkoosh. (2018) In vitro and in vivo evaluation of coated capsules for colonic delivery. Journal of Drug Delivery Science and Technology 47, pages 492-498.
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Yassmin O. Samak, Magda El Massik & Allan G.A. Coombes. (2017) A Comparison of Aerosolization and Homogenization Techniques for Production of Alginate Microparticles for Delivery of Corticosteroids to the Colon. Journal of Pharmaceutical Sciences 106:1, pages 208-216.
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Laurent Simon & Juan Ospina. (2015) Three-dimensional analyses of a perforated cylindrical drug delivery device. International Journal of Pharmaceutics 481:1-2, pages 64-70.
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Kuldeep Singh, Rajat Suri, A.K. Tiwary & Vikas Rana. (2013) Exploiting the synergistic effect of chitosan–EDTA conjugate with MSA for the early recovery from colitis. International Journal of Biological Macromolecules 54, pages 186-196.
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Mayur M. Patel & Avani F. Amin. (2011) Process, optimization and characterization of mebeverine hydrochloride loaded guar gum microspheres for irritable bowel syndrome. Carbohydrate Polymers 86:2, pages 536-545.
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Mayur M. Patel & Avani F. Amin. (2011) Design and Optimization of Colon-Targeted System of Theophylline for Chronotherapy of Nocturnal Asthma. Journal of Pharmaceutical Sciences 100:5, pages 1760-1772.
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Kemper Talley & Emil Alexov. (2010) On the pH-optimum of activity and stability of proteins. Proteins: Structure, Function, and Bioinformatics, pages n/a-n/a.
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