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Original Articles

Toxicology of Nanomaterials Used in Nanomedicine

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Pages 593-632 | Published online: 18 Oct 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (71)

Regildo Márcio Gonçalves da Silva, Isabelly Do Nascimento Pereira, Laura Camargo Zibordi, Pedro Augusto Pereira Rosatto, Filipe Oliveira Granero, Célia Cristina Malaguti Figueiredo, Carlos José Leopoldo Constantino, Cibely da Silva Martin, Aldo Eloizo Job, Nilson Nicolau-Junior & Luciana Pereira Silva. (2024) Cytotoxic, antioxidant, and antiglycation activities, and tyrosinase inhibition using silver nanoparticles synthesized by leaf extract of Solanum aculeatissimum Jacq. Journal of Toxicology and Environmental Health, Part A 87:2, pages 57-76.
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Keita Djibril Sekou & Harshad Patel. (2023) A Review on the interaction between Nanoparticles and Toxic metals in Soil: Meta-analysis of their effects on soil, plants and human health. Soil and Sediment Contamination: An International Journal 32:4, pages 417-447.
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Maria João Bessa, Fátima Brandão, Fernanda Rosário, Luciana Moreira, Ana Teresa Reis, Vanessa Valdiglesias, Blanca Laffon, Sónia Fraga & João Paulo Teixeira. (2023) Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models. Journal of Toxicology and Environmental Health, Part B 26:2, pages 67-96.
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Sreejesh Sreedharan, Georgios Zouganelis, Samantha J Drake, Gyanendra Tripathi & Ali Kermanizadeh. (2023) Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions. Journal of Toxicology and Environmental Health, Part B 26:1, pages 1-27.
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Roland Vogt, Sarah Hartmann, Jan Kunze, Jonathan Frederik Jupke, Benedikt Steinhoff, Holger Schönherr, Klaus-Dieter Kuhnert, Klaudia Witte, Dunja Katharina Lamatsch & Josef Wanzenböck. (2022) Silver nanoparticles adversely affect the swimming behavior of European Whitefish (Coregonus lavaretus) larvae within the low µg/L range. Journal of Toxicology and Environmental Health, Part A 85:21, pages 867-880.
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Fatma Turna Demir. (2022) Protective effects of resveratrol against genotoxicity induced by nano and bulk hydroxyapatite in Drosophila melanogaster. Journal of Toxicology and Environmental Health, Part A 85:20, pages 850-865.
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Marlon Luiz Neves da Silva, Diego José Nogueira, Denice Schulz Vicentini, Rodrigo Costa Puerari, Paulo Roger Lopes Alves, Cristiane Funghetto Fuzinatto & William Gerson Matias. (2022) Rapid Communication: oxidative stress induced by mixed exposure to glyphosate and silver nanoparticles. Journal of Toxicology and Environmental Health, Part A 85:14, pages 586-590.
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Ricardo Andrade Furtado, Saulo Duarte Ozelin, Natália Helen Ferreira, Bárbara Ayumi Miura, Silvio Almeida Junior, Geórgia Modé Magalhães, Eduardo José Nassar, Mariza Abreu Miranda, Jairo Kenupp Bastos & Denise Crispim Tavares. (2022) Antitumor activity of solamargine in mouse melanoma model: relevance to clinical safety. Journal of Toxicology and Environmental Health, Part A 85:4, pages 131-142.
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Karine Cappuccio de Castro, Josiel Martins Costa & Maria Gabriela Nogueira Campos. (2022) Drug-loaded polymeric nanoparticles: a review. International Journal of Polymeric Materials and Polymeric Biomaterials 71:1, pages 1-13.
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Kyungeun Kim & Dongwoo Khang. (2020) Past, Present, and Future of Anticancer Nanomedicine. International Journal of Nanomedicine 15, pages 5719-5743.
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Ludiana Cardoso da Silva Cansian, Jessica Zablocki da Luz, Arandi Ginane Bezerra$suffix/text()$suffix/text(), Thiago Neves Machado, Michelle Thays Khun Santurio, Ciro Alberto de Oliveira Ribeiro & Francisco Filipak Neto. (2020) Malignancy and tumorigenicity of melanoma B16 cells are not affected by silver and gold nanoparticles. Toxicology Mechanisms and Methods 30:9, pages 635-645.
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Jéssica Schveitzer Köerich, Diego José Nogueira, Vitor Pereira Vaz, Carmen Simioni, Marlon Luiz Neves Da Silva, Luciane Cristina Ouriques, Denice Schulz Vicentini & William Gerson Matias. (2020) Toxicity of binary mixtures of Al2O3 and ZnO nanoparticles toward fibroblast and bronchial epithelium cells. Journal of Toxicology and Environmental Health, Part A 83:9, pages 363-377.
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Yuqiang Bi, Andrew K. Marcus, Hervé Robert, Rosa Krajmalnik-Brown, Bruce E. Rittmann, Paul Westerhoff, Marie-Hélène Ropers & Muriel Mercier-Bonin. (2020) The complex puzzle of dietary silver nanoparticles, mucus and microbiota in the gut. Journal of Toxicology and Environmental Health, Part B 23:2, pages 69-89.
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Sam Lekamge, Ana F. Miranda, Ben Pham, Andrew S. Ball, Ravi Shukla & Dayanthi Nugegoda. (2019) The toxicity of non-aged and aged coated silver nanoparticles to the freshwater shrimp Paratya australiensis. Journal of Toxicology and Environmental Health, Part A 82:23-24, pages 1207-1222.
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Firdos Alam Khan, Sultan Akhtar, Dana Almohazey, Munther Alomari, Sarah Ameen Almofty, Ibrahim Badr & Abdelhamid Elaissari. (2019) Targeted delivery of poly (methyl methacrylate) particles in colon cancer cells selectively attenuates cancer cell proliferation. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 1533-1542.
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Yang Liu, Jun Ji, Le Ji, Yuanyuan Li, Bowen Zhang, Tongwang Yang, Jing Yang, Liping Lv & Gang Wu. (2019) Translocation of intranasal (i.n.) instillation of different-sized cerium dioxide (CeO2) particles: potential adverse effects in mice. Journal of Toxicology and Environmental Health, Part A 82:20, pages 1069-1075.
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Bedanta Kumar Barik & Monalisa Mishra. (2019) Nanoparticles as a potential teratogen: a lesson learnt from fruit fly. Nanotoxicology 13:2, pages 258-284.
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Hong Su, Xin Song, Juan Li, Muhammad Zubair Iqbal, Samuel Selorm Fiati Kenston, Zhen Li, Aiguo Wu, Min Ding & Jinshun Zhao. (2018) Biosafety evaluation of Janus Fe3O4-TiO2 nanoparticles in Sprague Dawley rats after intravenous injection. International Journal of Nanomedicine 13, pages 6987-7001.
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Firdos Alam Khan, Dana Almohazey, Munthar Alomari & Sarah Ameen Almofty. (2018) Impact of nanoparticles on neuron biology: current research trends. International Journal of Nanomedicine 13, pages 2767-2776.
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Firdos Alam Khan, Sultan Akhtar, Dana Almohazey, Munthar Alomari, Sarah Ameen Almofty & Abdelhamid Eliassari. (2018) Fluorescent magnetic submicronic polymer (FMSP) nanoparticles induce cell death in human colorectal carcinoma cells. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 247-253.
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Christophe Bressot, Alexandra Aubry, Cécile Pagnoux, Olivier Aguerre-Chariol & Martin Morgeneyer. (2018) Assessment of functional nanomaterials in medical applications: can time mend public and occupational health risks related to the products’ fate?. Journal of Toxicology and Environmental Health, Part A 81:19, pages 957-973.
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Eşref Demir & Ricard Marcos. (2018) Toxic and genotoxic effects of graphene and multi-walled carbon nanotubes. Journal of Toxicology and Environmental Health, Part A 81:14, pages 645-660.
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Ding-Ping Bai, Xi-Feng Zhang, Guo-Liang Zhang, Yi-Fan Huang & Sangiliyandi Gurunathan. (2017) Zinc oxide nanoparticles induce apoptosis and autophagy in human ovarian cancer cells. International Journal of Nanomedicine 12, pages 6521-6535.
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Airton da Cunha Martins$suffix/text()$suffix/text(), Lara Ferreira Azevedo, Cecília Cristina de Souza Rocha, Maria Fernanda Hornos Carneiro, Vinicius Paula Venancio, Mara Ribeiro de Almeida, Lusânia Maria Greggi Antunes, Rodrigo de Carvalho Hott, Jairo Lisboa Rodrigues, Abayomi T. Ogunjimi, Joseph A. Adeyemi & Fernando Barbosa$suffix/text()$suffix/text(). (2017) Evaluation of distribution, redox parameters, and genotoxicity in Wistar rats co-exposed to silver and titanium dioxide nanoparticles. Journal of Toxicology and Environmental Health, Part A 80:19-21, pages 1156-1165.
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Bárbara Mesquita, Isabel Lopes, Susana Silva, Maria João Bessa, Maksim Starykevich, Jorge Carneiro, Tiago L. P. Galvão, Mário G. S. Ferreira, João Tedim, João Paulo Teixeira & Sónia Fraga. (2017) Gold nanorods induce early embryonic developmental delay and lethality in zebrafish (Danio rerio). Journal of Toxicology and Environmental Health, Part A 80:13-15, pages 672-687.
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Melisa Bunderson-Schelvan, Andrij Holian & Raymond F. Hamilton$suffix/text()$suffix/text(). (2017) Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents. Journal of Toxicology and Environmental Health, Part B 20:4, pages 230-248.
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Saud Alarifi, Daoud Ali & Saad Alkahtani. (2017) Involvement of mitochondrial dysfunction in nanosized lead oxide induced cellular damage in human lung alveolar epithelial cells. Toxicological & Environmental Chemistry 99:4, pages 680-690.
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Saud Alarifi, Daoud Ali, Mohammed A Al Gurabi & Saad Alkahtani. (2017) Determination of nephrotoxicity and genotoxic potential of silver nanoparticles in Swiss albino mice. Toxicological & Environmental Chemistry 99:2, pages 294-301.
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Saeed Alqahtani & Suliman Y Alomar. (2017) Induction of apoptosis and cytokine markers in colon cancer cells by magnesium oxide (MgO) nanoparticles. Toxicological & Environmental Chemistry 99:2, pages 302-314.
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Andrea L Armstead & Bingyun Li. (2016) Nanotoxicity: emerging concerns regarding nanomaterial safety and occupational hard metal (WC-Co) nanoparticle exposure. International Journal of Nanomedicine 11, pages 6421-6433.
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Franziska Schramm, Martina Lange, Pia Hoppmann & Astrid Heutelbeck. (2016) Cytotoxicity of carbon nanohorns in different human cells of the respiratory system. Journal of Toxicology and Environmental Health, Part A 79:22-23, pages 1085-1093.
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Yang Liu, Yuanyuan Li, Tongwang Yang, Jing Yang, He Wang & Gang Wu. (2016) Acute changes in murine hippocampus and olfactory bulb after nasal instillation of varying size cerium dioxide particles. Journal of Toxicology and Environmental Health, Part A 79:19, pages 869-877.
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Elizabeth B. Engler-Chiurazzi, Phoebe A. Stapleton, Jessica J. Stalnaker, Xuefang Ren, Heng Hu, Timothy R. Nurkiewicz, Carroll R. McBride, Jinghai Yi, Kevin Engels & James W. Simpkins. (2016) Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition. Journal of Toxicology and Environmental Health, Part A 79:11, pages 447-452.
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Maria Fernanda Hornos Carneiro & Fernando Barbosa$suffix/text()$suffix/text(). (2016) Gold nanoparticles: A critical review of therapeutic applications and toxicological aspects. Journal of Toxicology and Environmental Health, Part B 19:3-4, pages 129-148.
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Mohamed Alaraby, Balasubramanyam Annangi, Ricard Marcos & Alba Hernández. (2016) Drosophila melanogaster as a suitable in vivo model to determine potential side effects of nanomaterials: A review. Journal of Toxicology and Environmental Health, Part B 19:2, pages 65-104.
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Chavon R. Walters, Paul Cheng, Edmund Pool & Vernon Somerset. (2016) Effect of temperature on oxidative stress parameters and enzyme activity in tissues of Cape River crab (Potamanautes perlatus) following exposure to silver nanoparticles (AgNP). Journal of Toxicology and Environmental Health, Part A 79:2, pages 61-70.
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Jeongeun Kim, Sunay V. Chankeshwara, Frank Thielbeer, Jiyoung Jeong, Ken Donaldson, Mark Bradley & Wan-Seob Cho. (2016) Surface charge determines the lung inflammogenicity: A study with polystyrene nanoparticles. Nanotoxicology 10:1, pages 94-101.
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Ali Kermanizadeh, Ilse Gosens, Laura MacCalman, Helinor Johnston, Pernille H. Danielsen, Nicklas R. Jacobsen, Anke-Gabriele Lenz, Teresa Fernandes, Roel P. F. Schins, Flemming R. Cassee, Håkan Wallin, Wolfgang Kreyling, Tobias Stoeger, Steffen Loft, Peter Møller, Lang Tran & Vicki Stone. (2016) A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health—ENPRA Project—The Highlights, Limitations, and Current and Future Challenges. Journal of Toxicology and Environmental Health, Part B 19:1, pages 1-28.
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Abdullah A. Alkahtane. (2015) Indium tin oxide nanoparticles-mediated DNA fragmentation and cell death by apoptosis in human lung epithelial cells. Toxicological & Environmental Chemistry 97:8, pages 1086-1098.
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Daoud Ali & Huma Ali. (2015) Susceptibility of the freshwater pulmonate snail Lymnea luteola L. to copper oxide nanoparticle. Toxicological & Environmental Chemistry 97:5, pages 576-587.
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Günter Oberdörster, Vincent Castranova, Bahman Asgharian & Phil Sayre. (2015) Inhalation Exposure to Carbon Nanotubes (CNT) and Carbon Nanofibers (CNF): Methodology and Dosimetry. Journal of Toxicology and Environmental Health, Part B 18:3-4, pages 121-212.
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Sung Gu Han, Deborah Howatt, Alan Daugherty & Gary Gairola. (2015) Pulmonary and Atherogenic Effects of Multi-Walled Carbon Nanotubes (MWCNT) in Apolipoprotein-E-Deficient Mice. Journal of Toxicology and Environmental Health, Part A 78:4, pages 244-253.
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Ruth R Magaye, Xia Yue, Baobo Zou, Hongbo Shi, Hongsheng Yu, Kui Liu, Xialu Lin, Jin Xu, Cui Yang, Aiguo Wu & Jinshun Zhao. (2014) Acute toxicity of nickel nanoparticles in rats after intravenous injection. International Journal of Nanomedicine 9, pages 1393-1402.
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Nivedita Chatterjee, JiSu Yang, Hyun-Mi Kim, Eunhye Jo, Phil-Je Kim, Kyunghee Choi & Jinhee Choi. (2014) Potential Toxicity of Differential Functionalized Multiwalled Carbon Nanotubes (MWCNT) in Human Cell Line (BEAS2B) and Caenorhabditis elegans. Journal of Toxicology and Environmental Health, Part A 77:22-24, pages 1399-1408.
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Katherine M. Dunnick, Melissa A. Badding, Diane Schwegler-Berry, Jonathan M. Patete, Christopher Koenigsmann, Stanislaus S. Wong & Stephen S. Leonard. (2014) The Effect of Tungstate Nanoparticles on Reactive Oxygen Species and Cytotoxicity in Raw 264.7 Mouse Monocyte Macrophage Cells. Journal of Toxicology and Environmental Health, Part A 77:20, pages 1251-1268.
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Calvin C. Willhite, Nataliya A. Karyakina, Robert A. Yokel, Nagarajkumar Yenugadhati, Thomas M. Wisniewski, Ian M.F. Arnold, Franco Momoli & Daniel Krewski. (2014) Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts. Critical Reviews in Toxicology 44:sup4, pages 1-80.
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M. Almeida-Silva, S. M. Almeida, J. F. Gomes, P. C. Albuquerque & H. T. Wolterbeek. (2014) Determination of Airborne Nanoparticles in Elderly Care Centers. Journal of Toxicology and Environmental Health, Part A 77:14-16, pages 867-878.
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A. Rama Narsimha Reddy, D.R. Krishna, V. Himabindu & Y. Narsimha Reddy. (2014) Single walled carbon nanotubes induce cytotoxicity and oxidative stress in HEK293 cells. Toxicological & Environmental Chemistry 96:6, pages 931-940.
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Sujatha Purushothaman, Azhwar Raghunath, Vasanth Dhakshinamoorthy, Lakshmikanthan Panneerselvam & Ekambaram Perumal. (2014) Acute exposure to titanium dioxide (TiO2) induces oxidative stress in zebrafish gill tissues. Toxicological & Environmental Chemistry 96:6, pages 890-905.
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Devashri Sahu, G. M. Kannan & R. Vijayaraghavan. (2014) Size-Dependent Effect of Zinc Oxide on Toxicity and Inflammatory Potential of Human Monocytes. Journal of Toxicology and Environmental Health, Part A 77:4, pages 177-191.
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Kyeong-Nam Yu, Ji Eun Kim, Hwi Won Seo, Chanhee Chae & Myung-Haing Cho. (2013) Differential Toxic Responses Between Pristine and Functionalized Multiwall Nanotubes Involve Induction of Autophagy Accumulation in Murine Lung. Journal of Toxicology and Environmental Health, Part A 76:23, pages 1282-1292.
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Kui Liu, Xialu Lin & Jinshun Zhao. (2013) Toxic effects of the interaction of titanium dioxide nanoparticles with chemicals or physical factors. International Journal of Nanomedicine 8, pages 2509-2520.
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Kwangsik Park & Yeonjin Lee. (2013) The Stability of Citrate-Capped Silver Nanoparticles in Isotonic Glucose Solution for Intravenous Injection. Journal of Toxicology and Environmental Health, Part A 76:22, pages 1236-1245.
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Eşref Demir, Durmuş Burgucu, Fatma Turna, Sezgin Aksakal & Bülent Kaya. (2013) Determination of TiO2, ZrO2, and Al2O3 Nanoparticles on Genotoxic Responses in Human Peripheral Blood Lymphocytes and Cultured Embyronic Kidney Cells. Journal of Toxicology and Environmental Health, Part A 76:16, pages 990-1002.
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Tina M. Sager, Michael W. Wolfarth, Lori A. Battelli, Stephen S. Leonard, Michael Andrew, Thomas Steinbach, Morinobu Endo, Shuji Tsuruoka, Dale W. Porter & Vincent Castranova. (2013) Investigation of the Pulmonary Bioactivity of Double-Walled Carbon Nanotubes. Journal of Toxicology and Environmental Health, Part A 76:15, pages 922-936.
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Aaron D. Gilmour, Rylie A. Green & Christine E. Thomson. (2013) A low-maintenance, primary cell culture model for the assessment of carbon nanotube toxicity. Toxicological & Environmental Chemistry 95:7, pages 1129-1144.
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Venugopalan Kasturirangan, Bindu M. Nair, Muhammed T. S. Kariapper, Wojciech G. Lesniak, Wei Tan, Remy Bizimungu, Peter Kanter, Karoly Toth, Sandra Buitrago, Youcef M. Rustum, Alan Hutson, Lajos P. Balogh & Mohamed K. Khan. (2013) In vivo toxicity evaluation of gold-dendrimer composite nanodevices with different surface charges. Nanotoxicology 7:4, pages 441-451.
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Haico te Kulve & Arie Rip. (2013) Economic and societal dimensions of nanotechnology-enabled drug delivery. Expert Opinion on Drug Delivery 10:5, pages 611-622.
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Uday Burman, Mahesh Saini & Praveen- Kumar. (2013) Effect of zinc oxide nanoparticles on growth and antioxidant system of chickpea seedlings. Toxicological & Environmental Chemistry 95:4, pages 605-612.
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S. Syama, S.C. Reshma, P.J. Sreekanth, H.K. Varma & P.V. Mohanan. (2013) Effect of Zinc Oxide nanoparticles on cellular oxidative stress and antioxidant defense mechanisms in mouse liver. Toxicological & Environmental Chemistry 95:3, pages 495-503.
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J. Schneider, D. Walter, B. Brückel & K. Rödelsperger. (2013) Primary Particles and Their Agglomerate Formation as Modifying Risk Factors of Nonfibrous Nanosized Dust. Journal of Toxicology and Environmental Health, Part A 76:2, pages 131-141.
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Brandi N. Snyder-Talkington, Yong Qian, Vincent Castranova & Nancy L. Guo. (2012) New Perspectives for in Vitro Risk Assessment of Multiwalled Carbon Nanotubes: Application of Coculture and Bioinformatics. Journal of Toxicology and Environmental Health, Part B 15:7, pages 468-492.
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Shilpa Gantedi & Rama Narsimha Reddy Anreddy. (2012) Toxicological studies of zinc oxide nanomaterials in rats. Toxicological & Environmental Chemistry 94:9, pages 1768-1779.
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Nancy L. Guo, Ying-Wooi Wan, James Denvir, Dale W. Porter, Maricica Pacurari, Michael G. Wolfarth, Vincent Castranova & Yong Qian. (2012) Multiwalled Carbon Nanotube-Induced Gene Signatures in the Mouse Lung: Potential Predictive Value for Human Lung Cancer Risk and Prognosis. Journal of Toxicology and Environmental Health, Part A 75:18, pages 1129-1153.
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Priyanka Singh & Arun Nanda. (2012) Nanotechnology in cosmetics: a boon or bane?. Toxicological & Environmental Chemistry 94:8, pages 1467-1479.
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Zuzana Magdolenova, Yolanda Lorenzo, Andrew Collins & Maria Dusinska. (2012) Can Standard Genotoxicity Tests be Applied to Nanoparticles?. Journal of Toxicology and Environmental Health, Part A 75:13-15, pages 800-806.
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Camille Larue, Giulia Veronesi, Anne-Marie Flank, Suzy Surble, Nathalie Herlin-Boime & Marie Carrière. (2012) Comparative Uptake and Impact of TiO2 Nanoparticles in Wheat and Rapeseed. Journal of Toxicology and Environmental Health, Part A 75:13-15, pages 722-734.
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Changwei Hu, Mei Li, Weili Wang, Yibin Cui, Jun Chen & Liuyan Yang. (2012) Ecotoxicity of silver nanoparticles on earthworm Eisenia fetida: responses of the antioxidant system, acid phosphatase and ATPase. Toxicological & Environmental Chemistry 94:4, pages 732-741.
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