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Review

Carbonic anhydrase inhibitors: an update on experimental agents for the treatment and imaging of hypoxic tumors

Pages 1197-1208 | Received 19 Sep 2021, Accepted 02 Dec 2021, Published online: 13 Dec 2021

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (19)

Romeo Romagnoli, Tiziano De Ventura, Stefano Manfredini, Erika Baldini, Claudiu T. Supuran, Alessio Nocentini, Andrea Brancale, Roberta Bortolozzi, Lorenzo Manfreda & Giampietro Viola. (2023) Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Bo Yang, Yanni Quan, Wuli Zhao, Yingjie Ji, Xiaotang Yang, Jianrui Li, Yi Li, Xiujun Liu, Ying Wang & Yanping Li. (2023) Design, synthesis and biological evaluation of 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives as CDK inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Ashok Aspatwar, Alessandro Bonardi, Heidi Aisala, Ksenia Zueva, Craig R Primmer, Jaakko Lumme, Seppo Parkkila & Claudiu T. Supuran. (2023) Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Andrea Angeli & Claudiu T. Supuran. (2023) Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Morteza Abdoli, Alessandro Bonardi, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Morteza Abdoli, Alessandro Bonardi, Claudiu T. Supuran & Raivis Žalubovskis. (2023) 4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 156-165.
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Amina Merabti, Sébastien Richeter, Claudiu T. Supuran, Sébastien Clement & Jean-Yves Winum. (2023) Are tumour-associated carbonic anhydrases genuine therapeutic targets for photodynamic therapy?. Expert Opinion on Therapeutic Targets 0:0, pages 1-10.
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Claudiu T Supuran. (2023) Targeting carbonic anhydrases for the management of hypoxic metastatic tumors. Expert Opinion on Therapeutic Patents 0:0, pages 1-20.
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Viviana De Luca, Vincenzo Carginale, Claudiu T. Supuran & Clemente Capasso. (2022) The gram-negative bacterium Escherichia coli as a model for testing the effect of carbonic anhydrase inhibition on bacterial growth. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2092-2098.
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Francesco Liguori, Simone Carradori, Roberto Ronca, Sara Rezzola, Serena Filiberti, Fabrizio Carta, Marta Turati & Claudiu T. Supuran. (2022) Benzenesulfonamides with different rigidity-conferring linkers as carbonic anhydrase inhibitors: an insight into the antiproliferative effect on glioblastoma, pancreatic, and breast cancer cells. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1857-1869.
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Zainab Saad Yusuf, Tugba Kevser Uysal, Ender Simsek, Alessio Nocentini, Sameh Mohamed Osman, Claudiu T. Supuran & Özen Özensoy Güler. (2022) The inhibitory effect of boric acid on hypoxia-regulated tumour-associated carbonic anhydrase IX. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1340-1345.
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Haytham O. Tawfik, Moataz A. Shaldam, Alessio Nocentini, Rofaida Salem, Hadia Almahli, Sara T. Al-Rashood, Claudiu T. Supuran & Wagdy M. Eldehna. (2022) Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1043-1052.
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Alessandro Bonardi, Silvia Bua, Jacob Combs, Carrie Lomelino, Jacob Andring, Sameh Mohamed Osman, Alessandra Toti, Lorenzo Di Cesare Mannelli, Paola Gratteri, Carla Ghelardini, Robert McKenna, Alessio Nocentini & Claudiu T. Supuran. (2022) The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 930-939.
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Mateusz Kciuk, Adrianna Gielecińska, Somdutt Mujwar, Mariusz Mojzych, Beata Marciniak, Rafał Drozda & Renata Kontek. (2022) Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1278-1298.
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Mehmet Onyılmaz, Murat Koca, Alessandro Bonardi, Mustafa Degirmenci & Claudiu T. Supuran. (2022) Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 743-748.
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Mattia Mori & Claudiu T. Supuran. (2022) Acipimox inhibits human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 672-679.
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Simone Giovannuzzi, Viviana De Luca, Alessio Nocentini, Clemente Capasso & Claudiu T. Supuran. (2022) Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 680-685.
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Sridhar Goud Nerella, Priti Singh, Mohammed Arifuddin & Claudiu T Supuran. (2022) Anticancer carbonic anhydrase inhibitors: a patent and literature update 2018-2022. Expert Opinion on Therapeutic Patents 32:8, pages 833-847.
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Muhamad Mustafa & Jean-Yves Winum. (2022) The importance of sulfur-containing motifs in drug design and discovery. Expert Opinion on Drug Discovery 17:5, pages 501-512.
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Jekateri̅na Ivanova, Alessio Nocentini, Kaspars Ta̅rs, Ja̅nis Leita̅ns, Elviss Dvinskis, Andris Kazaks, Ilona Domračeva, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect. Journal of Medicinal Chemistry 66:8, pages 5703-5718.
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Sridhar Goud Nerella, Priti Singh, Pavitra S. Thacker, Mohammed Arifuddin & Claudiu T. Supuran. (2023) PET radiotracers and fluorescent probes for imaging human carbonic anhydrase IX and XII in hypoxic tumors. Bioorganic Chemistry 133, pages 106399.
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Claudiu T. Supuran. (2023) Progress of Section “Biochemistry” in 2022. International Journal of Molecular Sciences 24:6, pages 5873.
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Morteza Abdoli, Viviana De Luca, Clemente Capasso, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Inhibition Studies on Carbonic Anhydrase Isoforms I, II, IX, and XII with a Series of Sulfaguanidines. ChemMedChem 18:6.
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Ufuk Atmaca, Ruya Saglamtas, Yusuf Sert, Murat Çelik & İlhami Gülçin. (2023) Metal‐Free Synthesis via Intramolecular Cyclization, Enzyme Inhibition Properties and Molecular Docking of Novel Isoindolinones. ChemistrySelect 8:9.
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Mahmoud A. Ragab, Wagdy M. Eldehna, Alessio Nocentini, Alessandro Bonardi, Hazem E. Okda, Bahaa Elgendy, Tarek S. Ibrahim, Mohammad M. Abd-Alhaseeb, Paola Gratteri, Claudiu T. Supuran, Ahmed A. Al-Karmalawy & Mohamed Elagawany. (2023) 4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments. European Journal of Medicinal Chemistry 250, pages 115180.
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Toni C. Denner, Niels Heise, Julian Zacharias, Oliver Kraft, Sophie Hoenke & René Csuk. (2023) Small Structural Differences Govern the Carbonic Anhydrase II Inhibition Activity of Cytotoxic Triterpene Acetazolamide Conjugates. Molecules 28:3, pages 1009.
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Annachiara Sarnella, Ylenia Ferrara, Sandra Albanese, Daniela Omodei, Laura Cerchia, Giuseppina De Simone, Claudiu T. Supuran & Antonella Zannetti. (2023) Inhibition of Bone Marrow-Mesenchymal Stem Cell-Induced Carbonic Anhydrase IX Potentiates Chemotherapy Efficacy in Triple-Negative Breast Cancer Cells. Cells 12:2, pages 298.
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Claudiu T Supuran. (2023) Latest advances in specific inhibition of tumor-associated carbonic anhydrases. Future Medicinal Chemistry 15:1, pages 5-7.
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Wagdy M. Eldehna, Mahmoud A. El Hassab, Nahla A. Abdelshafi, Rana A. Eissa, Nadeen H. Diab, Ekram H. Mohamed, Mamdouh A. Oraby, Sara T. Al-Rashood, Rana G. Eissa, Zainab M. Elsayed, Alessio Nocentini, Claudiu T. Supuran, Mahmoud Elsabahy & Noura G. Eissa. (2023) Development of potent nanosized carbonic anhydrase inhibitor for targeted therapy of hypoxic solid tumors. International Journal of Pharmaceutics 631, pages 122537.
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Clemente Capasso, Alessio Nocentini & Claudiu T. Supuran. 2023.
Shoaib Manzoor, Andrea Angeli, Susi Zara, Simone Carradori, Md Ataur Rahman, Md Kausar Raza, Claudiu T. Supuran & Nasimul Hoda. (2022) Development of benzene and benzothiazole-sulfonamide analogues as selective inhibitors of the tumor-associated carbonic anhydrase IX. European Journal of Medicinal Chemistry 243, pages 114793.
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Pavitra S. Thacker, Vaishnavi Newaskar, Andrea Angeli, Dilep Kumar Sigalapalli, Nerella Sridhar Goud, Hepsibha Chirra, Afzal B. Shaik, Mohammed Arifuddin & Claudiu T. Supuran. (2022) Synthesis and biological evaluation of coumarin‐thiazole hybrids as selective carbonic anhydrase IX and XII inhibitors. Archiv der Pharmazie 355:12.
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Claudiu T. Supuran. (2022) Carbonic Anhydrase Inhibitors from Marine Natural Products. Marine Drugs 20:11, pages 721.
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Mariangela Agamennone, Marialuigia Fantacuzzi, Simone Carradori, Anél Petzer, Jacobus P. Petzer, Andrea Angeli, Claudiu T. Supuran & Grazia Luisi. (2022) Coumarin-Based Dual Inhibitors of Human Carbonic Anhydrases and Monoamine Oxidases Featuring Amino Acyl and (Pseudo)-Dipeptidyl Appendages: In Vitro and Computational Studies. Molecules 27:22, pages 7884.
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Viviana De Luca, Simone Giovannuzzi, Claudiu T. Supuran & Clemente Capasso. (2022) May Sulfonamide Inhibitors of Carbonic Anhydrases from Mammaliicoccus sciuri Prevent Antimicrobial Resistance Due to Gene Transfer to Other Harmful Staphylococci?. International Journal of Molecular Sciences 23:22, pages 13827.
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Divya Rai, Satyajit Khatua & Srabani Taraphder. (2022) Structure and Dynamics of the Isozymes II and IX of Human Carbonic Anhydrase. ACS Omega 7:35, pages 31149-31166.
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Ewies F. Ewies, Eman Sabry, Mohamed S. Bekheit, Marwa A. Fouad, Daniela Vullo & Claudiu T. Supuran. (2022) Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors. Drug Development Research 83:6, pages 1281-1291.
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Davide Moi, Alessandro Deplano, Andrea Angeli, Gianfranco Balboni, Claudiu T. Supuran & Valentina Onnis. (2022) Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity. Molecules 27:17, pages 5370.
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Krishna K. Chinchilli, Venkata N. Royyala, Pavitra S. Thacker, Andrea Angeli, Srikanth Danaboina, Priti Singh, Srinivas Nanduri, Claudiu T. Supuran & Mohammed Arifuddin. (2022) Design, synthesis, SAR, and biological evaluation of saccharin‐based hybrids as carbonic anhydrase inhibitors. Archiv der Pharmazie 355:8.
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Ashok Aspatwar, Martti E. E. Tolvanen, Harlan Barker, Leo Syrjänen, Susanna Valanne, Sami Purmonen, Abdul Waheed, William S. Sly & Seppo Parkkila. (2022) Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology. Physiological Reviews 102:3, pages 1327-1383.
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Luis Peña, Claudio Jiménez, Rodrigo Arancibia, Andrea Angeli & Claudiu T. Supuran. (2022) Heterobimetallic complexes containing organometallic acylhydrazone ligands as potential inhibitors of human carbonic anhydrases. Journal of Inorganic Biochemistry 232, pages 111814.
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Simone Giovannuzzi, Clemente Capasso, Alessio Nocentini & Claudiu T. Supuran. (2022) Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII. Molecules 27:13, pages 4076.
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Priti Singh, Dilep Kumar Sigalapalli, Nerella Sridhar Goud, Baijayantimala Swain, Santosh Kumar Sahoo, Andrea Angeli, Afzal B. Shaik, Venkata Madhavi Yaddanapudi, Claudiu T. Supuran & Mohammed Arifuddin. (2021) Ureidosulfocoumarin Derivatives As Selective and Potent Carbonic Anhydrase IX and XII Inhibitors. ChemMedChem 17:5.
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Toni C. Denner, Sophie Hoenke, Oliver Kraft, Hans-Peter Deigner, Ahmed Al-Harrasi & René Csuk. (2022) Hydroxyethylamide substituted triterpenoic acids hold good cytotoxicity for human tumor cells. Results in Chemistry 4, pages 100371.
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