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Original Article

Pharmacology of estrogens and progestogens: influence of different routes of administration

Pages 3-63 | Published online: 03 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (63)

Andrea R. Genazzani, Tiziana Fidecicchi, Domenico Arduini, Andrea Giannini & Tommaso Simoncini. (2023) Hormonal and natural contraceptives: a review on efficacy and risks of different methods for an informed choice. Gynecological Endocrinology 39:1.
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Erin Choi, John Buie, Jaime Camacho, Pranav Sharma & Werner T W de Riese. (2022) Evolution of Androgen Deprivation Therapy (ADT) and Its New Emerging Modalities in Prostate Cancer: An Update for Practicing Urologists, Clinicians and Medical Providers. Research and Reports in Urology 14, pages 87-108.
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Fanny Buckinx & Mylène Aubertin-Leheudre. (2022) Sarcopenia in Menopausal Women: Current Perspectives. International Journal of Women's Health 14, pages 805-819.
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Zofia Wicik, Pamela Czajka, Ceren Eyileten, Alex Fitas, Marta Wolska, Daniel Jakubik, Dirk von Lewinski, Harald Sourij, Jolanta M. Siller-Matula & Marek Postula. (2022) The role of miRNAs in regulation of platelet activity and related diseases - a bioinformatic analysis. Platelets 33:7, pages 1052-1064.
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Giulio Evangelisti, Fabio Barra, Umberto Perrone, Nadine Di Donato, Stefano Bogliolo, Marcello Ceccaroni & Simone Ferrero. (2022) Comparing the pharmacokinetic and pharmacodynamic qualities of current and future therapies for uterine fibroids. Expert Opinion on Drug Metabolism & Toxicology 18:7-8, pages 441-457.
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Buse Aysen Dundar & Metin Zora. (2022) A facile synthesis of a novel family of heterotricyclic hybrids: Spiro-pyrrolopyridazines. Synthetic Communications 52:3, pages 356-367.
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Santiago Palacios, Enrico Colli & Pedro A. Regidor. (2021) Metabolic and laboratory effects of a progestin-only pill containing drospirenone 4 mg in comparison to desogestrel 75 µg: a double-blind, double-dummy, prospective, randomised study. The European Journal of Contraception & Reproductive Health Care 26:6, pages 454-461.
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Andrea R. Genazzani, Patrizia Monteleone, Andrea Giannini & Tommaso Simoncini. (2021) Pharmacotherapeutic options for the treatment of menopausal symptoms. Expert Opinion on Pharmacotherapy 22:13, pages 1773-1791.
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H. A. Bimonte-Nelson, V. E. Bernaud & S. V. Koebele. (2021) Menopause, hormone therapy and cognition: maximizing translation from preclinical research. Climacteric 24:4, pages 373-381.
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Ning Zhang, Lili Zhuang, Shukun Gai, Yinghua Shan, Shuang Wang, Fenghua Li, Lili Chen, Dongmei Zhao & Xiaoyan Liu. (2021) Beneficial phytoestrogenic effects of resveratrol on polycystic ovary syndromein rat model. Gynecological Endocrinology 37:4, pages 337-341.
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I. Sriprasert, H. N. Hodis, B. Bernick, S. Mirkin & W. J. Mack. (2021) Determinants of attained estradiol levels in response to oral estradiol plus progesterone therapy. Climacteric 24:2, pages 194-199.
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Manuel Luque-Ramírez, Andrés E. Ortiz-Flores, Lia Nattero-Chávez & Héctor F. Escobar-Morreale. (2020) A safety evaluation of current medications for adult women with the polycystic ovarian syndrome not pursuing pregnancy. Expert Opinion on Drug Safety 19:12, pages 1559-1576.
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Miriam Giordano Imbroll & Mark Gruppetta. (2020) A current perspective into young female sex hormone replacement: a review. Expert Review of Endocrinology & Metabolism 15:6, pages 405-414.
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Birte Maria Hofmann, Dan Apter, Johannes Bitzer, Isabel Reinecke, Marco Serrani, Joachim Höchel & Martin Merz. (2020) Comparative pharmacokinetic analysis of levonorgestrel-releasing intrauterine systems and levonorgestrel-containing contraceptives with oral or subdermal administration route. The European Journal of Contraception & Reproductive Health Care 25:6, pages 417-426.
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Nagarajappa Hareesha & Jamballi G Manjunatha. (2020) Surfactant and polymer layered carbon composite electrochemical sensor for the analysis of estriol with ciprofloxacin. Materials Research Innovations 24:6, pages 349-362.
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Lauren R. Cirrincione, Tessa Senneker, Kimberly K. Scarsi & Alice Tseng. (2020) Drug Interactions with Gender-Affirming Hormone Therapy: Focus on Antiretrovirals and Direct Acting Antivirals. Expert Opinion on Drug Metabolism & Toxicology 16:7, pages 565-581.
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F. Fruzzetti, G. Palla, M. Gambacciani & T. Simoncini. (2020) Tailored hormonal approach in women with premature ovarian insufficiency. Climacteric 23:1, pages 3-8.
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Franca Fruzzetti, Anna Maria Paoletti, Tiziana Fidecicchi, Giulia Posar, Riccardo Giannini & Marco Gambacciani. (2019) Contraception with estradiol valerate and dienogest: adherence to the method. Open Access Journal of Contraception 10, pages 1-6.
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Rong Sun, Yuting Guo, Na Yin, Jiaojiao Yin, Tian Yin, Haibing He, Jingxin Gou, Yu Zhang & Xing Tang. (2019) Preparation of sterile long-acting injectable medroxyprogesterone acetate microcrystals based on anti-solvent precipitation and crystal habit control. Expert Opinion on Drug Delivery 16:10, pages 1133-1144.
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Vlatka Tomic, Miro Kasum & Katarina Vucic. (2019) The role of luteal support during IVF: a qualitative systematic review. Gynecological Endocrinology 35:10, pages 829-834.
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Bing Li, Jiaqing Hao, Xiaofang Yan, Maiying Kong & Edward R. Sauter. (2019) A-FABP and oestrogens are independently involved in the development of breast cancer. Adipocyte 8:1, pages 379-385.
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Franca Fruzzetti & Angelo Cagnacci. (2018) Venous thrombosis and hormonal contraception: what’s new with estradiol-based hormonal contraceptives?. Open Access Journal of Contraception 9, pages 75-79.
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Carlo Bastianelli, Manuela Farris, Elena Rosato, Ivo Brosens & Giuseppe Benagiano. (2018) Pharmacodynamics of combined estrogen-progestin oral contraceptives 3. Inhibition of ovulation. Expert Review of Clinical Pharmacology 11:11, pages 1085-1098.
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Peipei Jin & Yongyong Xie. (2018) Treatment strategies for women with polycystic ovary syndrome. Gynecological Endocrinology 34:4, pages 272-277.
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Chao Zhang, Haiyan Li, Xin Xiong, Suodi Zhai, Yudong Wei, Shuang Zhang, Yuanyuan Zhang, Lin Xu & Li Liu. (2017) An open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch. Drug Design, Development and Therapy 11, pages 725-731.
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Keli L. Beck, Michelle C. Anderson & Julienne K. Kirk. (2017) Transdermal estrogens in the changing landscape of hormone replacement therapy. Postgraduate Medicine 129:6, pages 632-636.
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T. S. Mikkola, H. Savolainen-Peltonen, M. Venetkoski & O. Ylikorkala. (2017) New evidence for cardiac benefit of postmenopausal hormone therapy. Climacteric 20:1, pages 5-10.
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Arne Reimers. (2016) Contraception for women with epilepsy: counseling, choices, and concerns. Open Access Journal of Contraception 7, pages 69-76.
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Franca Fruzzetti, Daria Perini, Lara Fornaciari, Marinella Russo, Fiorella Bucci & Angiolo Gadducci. (2016) Discontinuation of modern hormonal contraceptives: an Italian survey. The European Journal of Contraception & Reproductive Health Care 21:6, pages 449-454.
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Alexandre Goyon, Julia Zhenzhen Cai, Karin Kraehenbuehl, Christoph Hartmann, Bing Shao & Pascal Mottier. (2016) Determination of steroid hormones in bovine milk by LC-MS/MS and their levels in Swiss Holstein cow milk. Food Additives & Contaminants: Part A 33:5, pages 804-816.
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Hannat Akintomide & Sabeena Panicker. (2015) Nomegestrol acetate/17-beta estradiol: a review of efficacy, safety, and patient acceptability. Open Access Journal of Contraception 6, pages 77-86.
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Anita L Nelson. (2015) An update on new orally administered contraceptives for women. Expert Opinion on Pharmacotherapy 16:18, pages 2759-2772.
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Manuel Luque-Ramírez & Héctor Francisco Escobar-Morreale. (2015) Targets to treat androgen excess in polycystic ovary syndrome. Expert Opinion on Therapeutic Targets 19:11, pages 1545-1560.
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Anita L Nelson. (2015) Transdermal contraception methods: today’s patches and new options on the horizon. Expert Opinion on Pharmacotherapy 16:6, pages 863-873.
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Camil Castelo-Branco & Iris Soveral. (2014) Clinical efficacy of estradiol transdermal system in the treatment of hot flashes in postmenopausal women. Research and Reports in Transdermal Drug Delivery 3, pages 1-8.
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Donald R. Mattison, Nataliya Karyakina, Michael Goodman & Judy S. LaKind. (2014) Pharmaco- and toxicokinetics of selected exogenous and endogenous estrogens: A review of the data and identification of knowledge gaps. Critical Reviews in Toxicology 44:8, pages 696-724.
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Jeffrey T Jensen, Johannes Bitzer & Marco Serrani. (2013) Comparison of the pharmacologic and clinical profiles of new combined oral contraceptives containing estradiol. Open Access Journal of Contraception 4, pages 39-50.
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X. Ruan, H. Neubauer, Y. Yang, H. Schneck, S. Schultz, T. Fehm, M. A. Cahill, H. Seeger & A. O. Mueck. (2012) Progestogens and membrane-initiated effects on the proliferation of human breast cancer cells. Climacteric 15:5, pages 467-472.
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Franca Fruzzetti, Florence Trémollieres & Johannes Bitzer. (2012) An overview of the development of combined oral contraceptives containing estradiol: focus on estradiol valerate/dienogest. Gynecological Endocrinology 28:5, pages 400-408.
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V. Koskela-Niska, H. Lyytinen, A. Riska, E. Pukkala & O. Ylikorkala. (2012) Ovarian cancer risk in postmenopausal women using estradiol–progestin therapy – a nationwide study. Climacteric 16:1, pages 48-53.
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Diana Mansour, Carole Verhoeven, Werner Sommer, Edith Weisberg, Surasak Taneepanichskul, Gian Benedetto Melis, Inger Sundström-Poromaa & Tjeerd Korver. (2011) Efficacy and tolerability of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in a 24/4 regimen, in comparison to an oral contraceptive containing ethinylestradiol and drospirenone in a 21/7 regimen. The European Journal of Contraception & Reproductive Health Care 16:6, pages 430-443.
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Lee P Shulman & Jessica W Kiley. (2011) Oral contraception: from birth control to pregnancy prevention with noncontraceptive benefits. Expert Review of Obstetrics & Gynecology 6:5, pages 539-550.
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Nathalie Chabbert-Buffet, Didier Chassard, Edith Ochsenbein, Jean-Louis Thomas & Sophie Christin-Maitre. (2011) Inhibition of ovulation by NOMAC/E2, a novel monophasic oral contraceptive combining nomegestrol acetate and 17β-oestradiol: A double-blind, randomised, dose-finding pilot study. The European Journal of Contraception & Reproductive Health Care 16:2, pages 76-84.
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Alfred O Mueck. (2011) Dienogest: an oral progestogen for the treatment of endometriosis. Expert Review of Obstetrics & Gynecology 6:1, pages 5-15.
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Amy M Egras & Elena M Umland. (2010) The role of transdermal estrogen sprays and estradiol topical emulsion in the management of menopause-associated vasomotor symptoms. International Journal of General Medicine 3, pages 147-151.
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Ingrid J. M. Duijkers, Christine Klipping, Paul Grob & Tjeerd Korver. (2010) Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol on ovarian function in comparison to a monophasic combined oral contraceptive containing drospirenone and ethinylestradiol. The European Journal of Contraception & Reproductive Health Care 15:5, pages 314-325.
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Pauliina Tuomikoski, Petri Haapalahti, Seppo Sarna, Olavi Ylikorkala & Tomi S. Mikkola. (2010) Vasomotor hot flushes and 24-hour ambulatory blood pressure in normotensive women: A placebo-controlled trial on post-menopausal hormone therapy. Annals of Medicine 42:5, pages 334-343.
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Anita Nath & Regine Sitruk-Ware. (2009) Parenteral administration of progestins for hormonal replacement therapy. The European Journal of Contraception & Reproductive Health Care 14:2, pages 88-96.
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Stefano Lello, Grazia Primavera, Laura Colonna, Giorgio Vittori, Francesca Guardianelli, Roberto Sorge & Desanka Raskovic. (2008) Effects of two estroprogestins containing ethynilestradiol 30 mug and drospirenone 3 mg and ethynilestradiol 30 mug and chlormadinone 2 mg on skin and hormonal hyperandrogenic manifestations. Gynecological Endocrinology 24:12, pages 718-723.
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Thomas Dayspring & Gregory Pokrywka. (2007) Pharmacotherapeutic Decisions In Menopausal Women With Cardiovascular Risk. Future Lipidology 2:2, pages 197-210.
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Inka Wiegratz & Herbert Kuhl. (2007) High estrogenic impact on the liver by transdermal contraceptive patch. Expert Review of Obstetrics & Gynecology 2:1, pages 15-18.
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Tommaso Simoncini, Paolo Mannella, Nicola Pluchino & Andrea R. Genazzani. (2007) Comparative effects of dydrogesterone and medroxyprogesterone acetate in critical areas: The brain and the vessels. Gynecological Endocrinology 23:sup1, pages 9-16.
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Carlo Campagnoli, Chiara Abbà, Simona Ambroggio, Marie Rosa Lotano & Clementina Peris. (2007) Differential effects of various progestogens on metabolic risk factors for breast cancer. Gynecological Endocrinology 23:sup1, pages 22-31.
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Jean-Michel Foidart & Thomas Faustmann. (2007) Advances in hormone replacement therapy: Weight benefits of drospirenone, a 17α-spirolactone-derived progestogen. Gynecological Endocrinology 23:12, pages 692-699.
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Fernando Zegers-Hochschild, Juan-Enrique Schwarze & Claudia Borrero. (2006) Delivery routes of progesterone in assisted reproduction. Expert Review of Obstetrics & Gynecology 1:2, pages 173-182.
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Inka Wiegratz & Herbert Kuhl. (2006) Metabolic and clinical effects of progestogens. The European Journal of Contraception & Reproductive Health Care 11:3, pages 153-161.
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