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Romain Ollier, Aline Fuchs, Florence Gauye, Katarzyna Piorkowska, Sébastien Menant, Monisha Ratnam, Paolo Montanari, Florence Guilhot, Didier Phillipe, Mickael Audrain, Anne-Laure Egesipe, Damien Névoltris, Tamara Seredenina, Andrea Pfeifer, Marie Kosco-Vilbois & Tariq Afroz. (2023) Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework. mAbs 15:1.
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Karelle Ménochet, Hongbin Yu, Bonnie Wang, Jay Tibbitts, Cheng-Pang Hsu, Amrita V. Kamath, Wolfgang F. Richter & Andreas Baumann. (2022) Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper. mAbs 14:1.
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Eva Germovsek, Ming Cheng & Craig Giragossian. (2021) Allometric scaling of therapeutic monoclonal antibodies in preclinical and clinical settings. mAbs 13:1.
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Benjamin E. Low, Gregory J. Christianson, Emily Lowell, Wenning Qin & Michael V. Wiles. (2020) Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice. mAbs 12:1.
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Yingda Xu, Dongdong Wang, Bruce Mason, Tony Rossomando, Ning Li, Dingjiang Liu, Jason K Cheung, Wei Xu, Smita Raghava, Amit Katiyar, Christine Nowak, Tao Xiang, Diane D. Dong, Joanne Sun, Alain Beck & Hongcheng Liu. (2019) Structure, heterogeneity and developability assessment of therapeutic antibodies. mAbs 11:2, pages 239-264.
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Lindsay B. Avery, Jason Wade, Mengmeng Wang, Amy Tam, Amy King, Nicole Piche-Nicholas, Mania S. Kavosi, Steve Penn, David Cirelli, Jeffrey C. Kurz, Minlei Zhang, Orla Cunningham, Rhys Jones, Brian J. Fennell, Barry McDonnell, Paul Sakorafas, James Apgar, William J. Finlay, Laura Lin, Laird Bloom & Denise M. O'Hara. (2018) Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics. mAbs 10:2, pages 244-255.
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Articles from other publishers (21)
Hayli A. Larsen, William M. Atkins & Abhinav Nath. (2023)
The origins of nonideality exhibited by monoclonal antibodies and
Fab
fragments in human serum
. Protein Science 32:12.
Crossref
Crossref
Shufang Liu & Dhaval K. Shah. (2023) Physiologically Based Pharmacokinetic Modeling to Characterize the Effect of Molecular Charge on Whole-Body Disposition of Monoclonal Antibodies. The AAPS Journal 25:3.
Crossref
Crossref
Giuseppe Licari, Kyle P. Martin, Maureen Crames, Joseph Mozdzierz, Michael S. Marlow, Anne R. Karow-Zwick, Sandeep Kumar & Joschka Bauer. (2022) Embedding Dynamics in Intrinsic Physicochemical Profiles of Market-Stage Antibody-Based Biotherapeutics. Molecular Pharmaceutics 20:2, pages 1096-1111.
Crossref
Crossref
Hannes Ausserwöger, Matthias M. Schneider, Therese W. Herling, Paolo Arosio, Gaetano Invernizzi, Tuomas P. J. Knowles & Nikolai Lorenzen. (2022) Non-specificity as the sticky problem in therapeutic antibody development. Nature Reviews Chemistry 6:12, pages 844-861.
Crossref
Crossref
Kathryn Ball, Gerard Bruin, Enrique Escandón, Christoph Funk, Joao N.S. Pereira, Tong-Yuan Yang & Hongbin Yu. (2022) Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper. Drug Metabolism and Disposition 50:6, pages 858-866.
Crossref
Crossref
Nicolas Frances, Marina Bacac, Katharine Bray-French, François Christen, Heather Hinton, Elisabeth Husar, Elizabeth Quackenbush, Martin Schäfer, Eginhard Schick, Arthur Van De Vyver & Wolfgang F. Richter. (2022) Novel in Vivo and in Vitro Pharmacokinetic/Pharmacodynamic-Based Human Starting Dose Selection for Glofitamab. Journal of Pharmaceutical Sciences 111:4, pages 1208-1218.
Crossref
Crossref
Emily K Makowski, John S Schardt & Peter M Tessier. (2022) Improving antibody drug development using bionanotechnology. Current Opinion in Biotechnology 74, pages 137-145.
Crossref
Crossref
Robert S. Foti. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology
716
742
.
Valentin Dietlin-Auril, Maxime Lecerf, Stephanie Depinay, Rémi Noé & Jordan D. Dimitrov. (2021) Interaction with 2,4-dinitrophenol correlates with polyreactivity, self-binding, and stability of clinical-stage therapeutic antibodies. Molecular Immunology 140, pages 233-239.
Crossref
Crossref
Yuki Noguchi, Kazuhisa Ozeki, Hiroaki Takesue & Hidetaka Akita. (2021) A cell based assay for evaluating binding and uptake of an antibody using hepatic nonparenchymal cells. Scientific Reports 11:1.
Crossref
Crossref
Miho Nagayasu & Kazuhisa Ozeki. (2021) Combination of cassette-dosing and microsampling for reduced animal usage for antibody pharmacokinetics in cynomolgus monkeys, wild-type mice, and human FcRn transgenic mice. Pharmaceutical Research 38:4, pages 583-592.
Crossref
Crossref
Manali S. Sawant, Craig N. Streu, Lina Wu & Peter M. Tessier. (2020) Toward Drug-Like Multispecific Antibodies by Design. International Journal of Molecular Sciences 21:20, pages 7496.
Crossref
Crossref
Yuki Noguchi, Kazuhisa Ozeki & Hidetaka Akita. (2020) Pharmacokinetic prediction of an antibody in mice based on an in vitro cell-based approach using target receptor-expressing cells. Scientific Reports 10:1.
Crossref
Crossref
Jordan D. Dimitrov. (2020) Harnessing the Therapeutic Potential of ‘Rogue’ Antibodies. Trends in Pharmacological Sciences 41:6, pages 409-417.
Crossref
Crossref
Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin & Dan A. Rock. (2019) Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species. Drug Metabolism and Disposition 47:10, pages 1111-1121.
Crossref
Crossref
Hirotake Shiraiwa, Atsushi Narita, Mika Kamata-Sakurai, Takahiro Ishiguro, Yuji Sano, Naoka Hironiwa, Takashi Tsushima, Hiroaki Segawa, Toshiaki Tsunenari, Yosuke Ikeda, Yoko Kayukawa, Mizuho Noguchi, Tetsuya Wakabayashi, Akihisa Sakamoto, Hiroko Konishi, Taichi Kuramochi, Mika Endo, Kunihiro Hattori, Junichi Nezu & Tomoyuki Igawa. (2019) Engineering a bispecific antibody with a common light chain: Identification and optimization of an anti-CD3 epsilon and anti-GPC3 bispecific antibody, ERY974. Methods 154, pages 10-20.
Crossref
Crossref
Rong Deng, C. Andrew Boswell, Wendy S. Putnam, Meina T. Tang, Amit Garg, Chunze Li, Shan Chung & Sandhya Girish. 2019. Pharmaceutical Biotechnology. Pharmaceutical Biotechnology
151
190
.
Dennis R. Goulet, Michael J. Watson, Susan H. Tam, Adam Zwolak, Mark L. Chiu, William M. Atkins & Abhinav Nath. (2018) Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance. Drug Metabolism and Disposition 46:12, pages 1900-1907.
Crossref
Crossref
Meric Ovacik & Kedan Lin. (2018) Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development. Clinical and Translational Science 11:6, pages 540-552.
Crossref
Crossref
Lilia A. Rabia, Alec A. Desai, Harkamal S. Jhajj & Peter M. Tessier. (2018) Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility. Biochemical Engineering Journal 137, pages 365-374.
Crossref
Crossref
Paul J. Carter & Greg A. Lazar. (2017) Next generation antibody drugs: pursuit of the 'high-hanging fruit'. Nature Reviews Drug Discovery 17:3, pages 197-223.
Crossref
Crossref