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Invited Review

A Framework for Human Relevance Analysis of Information on Carcinogenic Modes of Action

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Pages 591-653 | Published online: 29 Sep 2008

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Gina M. Hilton, Catherine Adcock, Gregory Akerman, James Baldassari, Michael Battalora, Warren Casey, Amy J. Clippinger, Rhian Cope, Amber Goetz, A. Wallace Hayes, Sabitha Papineni, Richard C. Peffer, Deborah Ramsingh, Brandy Williamson Riffle, Mitscheli Sanches da Rocha, Natalia Ryan, Edward Scollon, Nicolo Visconti, Douglas C. Wolf, Zhongyu Yan & Anna Lowit. (2022) Rethinking chronic toxicity and carcinogenicity assessment for agrochemicals project (ReCAAP): A reporting framework to support a weight of evidence safety assessment without long-term rodent bioassays. Regulatory Toxicology and Pharmacology 131, pages 105160.
Crossref
H. Tinwell & R. Bars. (2022) Isoflucypram: Combining in vivo and NAMs data in a weight of evidence approach to demonstrate the human non-relevance of the mode of action leading to the subtle thyroid effects observed in the rat. Regulatory Toxicology and Pharmacology 131, pages 105154.
Crossref
C. Röhl, M. Batke, G. Damm, A. Freyberger, T. Gebel, U. Gundert-Remy, J. G. Hengstler, A. Mangerich, A. Matthiessen, F. Partosch, T. Schupp, K. M. Wollin & H. Foth. (2022) New aspects in deriving health-based guidance values for bromate in swimming pool water. Archives of Toxicology 96:6, pages 1623-1659.
Crossref
Nichole R. Vansell. (2022) Mechanisms by Which Inducers of Drug Metabolizing Enzymes Alter Thyroid Hormones in Rats. Drug Metabolism and Disposition 50:4, pages 508-517.
Crossref
Melvin E. Andersen. (2022) Assessing modes of action, measures of tissue dose and human relevance of rodent toxicity endpoints with octamethylcyclotetrasiloxane (D4). Toxicology Letters 357, pages 57-72.
Crossref
Emma Arnesdotter, Eva Gijbels, Bruna dos Santos Rodrigues, Vânia Vilas-Boas & Mathieu Vinken. 2022. In Silico Methods for Predicting Drug Toxicity. In Silico Methods for Predicting Drug Toxicity 521 535 .
. 2021. Mutagenic Impurities. Mutagenic Impurities 165 211 .
Lindsey Garnick, Caroline Gillie, Jordan Kozal, Andy Monnot, Pamela Spencer, Jordan Quinn & Andrew Maier. (2021) Hazard characterization of carcinogenicity, mutagenicity, and reproductive toxicity for short chain primary nitroalkanes. Journal of Applied Toxicology 41:12, pages 1910-1936.
Crossref
G. Craig Llewellyn, Marisa O. Rihner & Paul R. Hanlon. (2021) An evolution of risk assessment for potential carcinogens in food: Scientific session proceedings. Regulatory Toxicology and Pharmacology 126, pages 105047.
Crossref
Lynea Murphy, Matthew J. LeBaron, Kamin Johnson, Reza J. Rasoulpour, Xiujuan Wang & Jessica LaRocca. (2021) Bridging Sex-Specific Differences in the CAR-Mediated Hepatocarcinogenesis of Nitrapyrin Using Molecular and Apical Endpoints. Frontiers in Toxicology 3.
Crossref
Keiko Ogata, Yang Liu, Ayako Ohara, Kensuke Kawamoto, Miwa Kondo, Kumiko Kobayashi, Takako Fukuda, Hiroyuki Asano, Sachiko Kitamoto, Brian G Lake, Samuel M Cohen & Tomoya Yamada. (2021) Club Cells Are the Primary Target for Permethrin-Induced Mouse Lung Tumor Formation. Toxicological Sciences 184:1, pages 15-32.
Crossref
Caley B. CravenLindsay K. Jmaiff BlackstockJiaojiao XieJinhua LiChun-Gang YuanXing-Fang Li. (2021) Analytical discovery of water disinfection byproducts of toxicological relevance: highlighting halobenzoquinones. Canadian Journal of Chemistry 99:9, pages 715-724.
Crossref
Tyler P. Nicholas, William K. Boyes, David K. Scoville, Tomomi W. Workman, Terrance J. Kavanagh, William A. Altemeier & Elaine M. Faustman. (2021) The effects of gene × environment interactions on silver nanoparticle toxicity in the respiratory system: An adverse outcome pathway. WIREs Nanomedicine and Nanobiotechnology 13:5.
Crossref
Thomas J. Rosol & Raphael J. Witorsch. (2021) Ethyl acrylate (EA) exposure and thyroid carcinogenicity in rats and mice with relevance to human health. Regulatory Toxicology and Pharmacology 124, pages 104961.
Crossref
Carr J. Smith, Thomas A. Perfetti, A. Wallace Hayes, Sir Colin Berry, James E. Trosko, Judy A. King, Jay I. Goodman, C. Glenn Begley & Anthony Dayan. (2021) Categorizing the characteristics of human carcinogens: a need for specificity. Archives of Toxicology 95:8, pages 2883-2889.
Crossref
Jose D. Suarez-Torres, Camilo A. Orozco & Carlos E. Ciangherotti. (2021) The 2-year rodent bioassay in drug and chemical carcinogenicity testing: Performance, utility, and configuration for cancer hazard identification. Journal of Pharmacological and Toxicological Methods 110, pages 107070.
Crossref
Christine Kim & Brian P. Ceresa. (2021) Using In Vitro Models to Dissect the Molecular Effects of Arsenic Exposure in Skin and Lung Cell Lines . Applied In Vitro Toxicology 7:2, pages 71-88.
Crossref
Tomoya Yamada. (2021) Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Journal of Toxicologic Pathology 34:4, pages 283-297.
Crossref
Midori Yoshida. (2021) Chloroacetanilide herbicide-induced rat enterochromaffin cell tumors: a case study within the context of the IPCS framework, for analyzing the relevance of a cancer mode of action for humans. Journal of Toxicologic Pathology 34:3, pages 213-222.
Crossref
Simon Plummer, Bobby Beaumont, Matthew Elcombe, Stephanie Wallace, Jayne Wright, Elizabeth F Mcinnes, Richard A Currie & David Cowie. (2021) Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues. Toxicology Reports 8, pages 155-161.
Crossref
Enrica Bianchi, Eduardo Costa, Zhongyu (June) Yan, Lynea Murphy, Jessica Howell, Donna Anderson, Push Mukerji, Anand Venkatraman, Claire Terry & Kamin J. Johnson. (2021) A rat subchronic study transcriptional point of departure estimates a carcinogenicity study apical point of departure. Food and Chemical Toxicology 147, pages 111869.
Crossref
Maike Huisinga, Lise Bertrand, Ronnie Chamanza, Isabelle Damiani, Jeff Engelhardt, Sabine Francke, Alexius Freyberger, Takanori Harada, Johannes Harleman, Wolfgang Kaufmann, Kevin Keane, Josef Köhrle, Barbara Lenz, M. Sue Marty, Stephanie Melching-Kollmuss, Xavier Palazzi, Gabriele Pohlmeyer-Esch, Andreas Popp, Thomas J. Rosol, Volker Strauss, Hetty Van den Brink-Knol, Charles E. Wood & Midori Yoshida. (2020) Adversity Considerations for Thyroid Follicular Cell Hypertrophy and Hyperplasia in Nonclinical Toxicity Studies: Results From the 6th ESTP International Expert Workshop. Toxicologic Pathology 48:8, pages 920-938.
Crossref
Mirjam Luijten, Raffaella Corvi, Jyotigna Mehta, Marco Corvaro, Nathalie Delrue, Susan Felter, Bodo Haas, Nicola J. Hewitt, Gina Hilton, Thomas Holmes, Miriam N. Jacobs, Abigail Jacobs, Franz Lamplmair, Dick Lewis, Federica Madia, Irene Manou, Stephanie Melching-Kollmuss, Frederic Schorsch, Katrin Schütte, Fiona Sewell, Christian Strupp, Jan Willem van der Laan, Douglas C. Wolf, Gerrit Wolterink, Ruud Woutersen, Zvonimir Zvonar, Harm Heusinkveld & Hedwig Braakhuis. (2020) A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals. Regulatory Toxicology and Pharmacology 118, pages 104789.
Crossref
Thomas Colnot, Stephanie Melching-Kollmuß, Giovanna Semino & Wolfgang Dekant. (2020) A flow scheme for cumulative assessment of pesticides for adverse liver effects. Regulatory Toxicology and Pharmacology 116, pages 104694.
Crossref
Miwa Kondo, Hiroko Kikumoto, Thomas G Osimitz, Samuel M Cohen, Brian G Lake & Tomoya Yamada. (2020) An Evaluation of the Human Relevance of the Liver Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action. Toxicological Sciences 175:1, pages 50-63.
Crossref
Stanley T. Parish, Michael Aschner, Warren Casey, Marco Corvaro, Michelle R. Embry, Suzanne Fitzpatrick, Darren Kidd, Nicole C. Kleinstreuer, Beatriz Silva Lima, Raja S. Settivari, Douglas C. Wolf, Daiju Yamazaki & Alan Boobis. (2020) An evaluation framework for new approach methodologies (NAMs) for human health safety assessment. Regulatory Toxicology and Pharmacology 112, pages 104592.
Crossref
Leo T. M. van der Ven, Emiel Rorije, R. Corinne Sprong, Daniele Zink, Remco Derr, Giel Hendriks, Lit-Hsin Loo & Mirjam Luijten. (2020) A Case Study with Triazole Fungicides to Explore Practical Application of Next-Generation Hazard Assessment Methods for Human Health. Chemical Research in Toxicology 33:3, pages 834-848.
Crossref
R. Bevan, P.T.C. Harrison, B. Jeffery & D. Mitchell. (2020) Evaluating the risk to humans from mineral oils in foods: Current state of the evidence. Food and Chemical Toxicology 136, pages 110966.
Crossref
Jeremy A. Leonard, Mark Nelms, Evisabel Craig, Monique Perron, Hannah Pope-Varsalona, Sarah Dobreniecki, Anna Lowit & Yu-Mei Tan. (2019) A weight of evidence approach to investigate potential common mechanisms in pesticide groups to support cumulative risk assessment: A case study with dinitroaniline pesticides. Regulatory Toxicology and Pharmacology 107, pages 104419.
Crossref
Edward J. Perkins, Roman Ashauer, Lyle Burgoon, Rory Conolly, Brigitte Landesmann, Cameron Mackay, Cheryl A. Murphy, Nathan Pollesch, James R. Wheeler, Anze Zupanic & Stefan Scholz. (2019) Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment. Environmental Toxicology and Chemistry 38:9, pages 1850-1865.
Crossref
Jeremy A. Leonard. (2019) Supporting systems science through in silico applications: A focus on informing metabolic mechanisms. Current Opinion in Toxicology 16, pages 1-8.
Crossref
Antonenko A.M.Vavrinevych O.P.Korshun M.M.Omelchuk S.T.. (2019) Features of the modern pesticides modes of action on the thyroid gland functionality (review). Environment & Health:2 (91), pages 60-64.
Crossref
Miwa Kondo, Kaori Miyata, Hirohisa Nagahori, Kayo Sumida, Thomas G Osimitz, Samuel M Cohen, Brian G Lake & Tomoya Yamada. (2019) Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse. Toxicological Sciences 168:2, pages 572-596.
Crossref
Samuel M. Cohen, Alan R. Boobis, Vicki L. Dellarco, John E. Doe, Penelope A. Fenner-Crisp, Angelo Moretto, Timothy P. Pastoor, Rita S. Schoeny, Jennifer G. Seed & Douglas C. Wolf. (2019) Chemical carcinogenicity revisited 3: Risk assessment of carcinogenic potential based on the current state of knowledge of carcinogenesis in humans. Regulatory Toxicology and Pharmacology 103, pages 100-105.
Crossref
Samuel M. Cohen, Gerhard Eisenbrand, Shoji Fukushima, Nigel J. Gooderham, F. Peter Guengerich, Stephen S. Hecht, Ivonne M.C.M. Rietjens, Maria Bastaki, Jeanne M. Davidsen, Christie L. Harman, Margaret McGowen & Sean V. Taylor. (2019) FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients. Food and Chemical Toxicology 124, pages 192-218.
Crossref
Aida Sacaan, Stephane Thibault & K. Nasir Khan. (2019) Central nervous system tumors in 2-year rat carcinogenicity studies: perspectives on human risk assessment. The Journal of Toxicological Sciences 44:10, pages 643-655.
Crossref
Takafumi Yamaguchi, Minoru MaedaKeiko OgataJun AbeToru UtsumiKoji Kimura. (2019) The effects on the endocrine system under hepatotoxicity induction by phenobarbital and di(2-ethylhexyl)phthalate in intact juvenile male rats. The Journal of Toxicological Sciences 44:7, pages 459-469.
Crossref
Harm J. Heusinkveld, Paul F.K. Wackers, Willem G. Schoonen, Leo van der Ven, Jeroen L.A. Pennings & Mirjam Luijten. (2018) Application of the comparison approach to open TG-GATEs: A useful toxicogenomics tool for detecting modes of action in chemical risk assessment. Food and Chemical Toxicology 121, pages 115-123.
Crossref
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1932 1982 .
Ruediger Bartsch, Britta Brinkmann, Gunnar Jahnke, Britta Laube, Ruth Lohmann, Sandra Michaelsen, Ingrid Neumann & Helmut Greim. (2018) Human relevance of follicular thyroid tumors in rodents caused by non-genotoxic substances. Regulatory Toxicology and Pharmacology 98, pages 199-208.
Crossref
Cheryl A Murphy, Roger M Nisbet, Philipp Antczak, Natàlia Garcia‐Reyero, Andre Gergs, Konstadia Lika, Teresa Mathews, Erik B Muller, Diane Nacci, Angela Peace, Christopher H Remien, Irvin R Schultz, Louise M Stevenson & Karen H Watanabe. (2018) Incorporating Suborganismal Processes into Dynamic Energy Budget Models for Ecological Risk Assessment. Integrated Environmental Assessment and Management 14:5, pages 615-624.
Crossref
Pierre Martin, Claire Bladier, Bette Meek, Olivier Bruyere, Eve Feinblatt, Mathilde Touvier, Laurence Watier & David Makowski. (2018) Weight of Evidence for Hazard Identification: A Critical Review of the Literature. Environmental Health Perspectives 126:7.
Crossref
Brian G. Lake. (2018) Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators. Toxicology Research 7:4, pages 697-717.
Crossref
Tomoya Yamada. (2018) Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action. Toxicology Research 7:4, pages 681-696.
Crossref
Chad M. Thompson, Mina Suh, Deborah M. Proctor, Grace Chappell, Susan Borghoff, Robert Ellis-Hutchings, Karin Wiench & Lavorgie Finch. (2018) Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. Regulatory Toxicology and Pharmacology 96, pages 178-189.
Crossref
Deborah M. Proctor, Mina Suh, Grace Chappell, Susan J. Borghoff, Chad M. Thompson, Karin Wiench, Lavorgie Finch & Robert Ellis-Hutchings. (2018) An Adverse Outcome Pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regulatory Toxicology and Pharmacology 96, pages 30-40.
Crossref
Corinne Haines, Lynsey R. Chatham, Audrey Vardy, Clifford R. Elcombe, John R. Foster & Brian G. Lake. (2018) Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats. Toxicology 400-401, pages 20-27.
Crossref
Ivy Moffat, Nadia Martinova, Chad Seidel & Chad M. Thompson. (2018) Hexavalent Chromium in Drinking Water. Journal - American Water Works Association 110:5, pages E22-E35.
Crossref
Richard C Peffer, David E Cowie, Richard A Currie & Daniel J Minnema. (2018) Sedaxane—Use of Nuclear Receptor Transactivation Assays, Toxicogenomics, and Toxicokinetics as Part of a Mode of Action Framework for Rodent Liver Tumors. Toxicological Sciences 162:2, pages 582-598.
Crossref
Jaya Kumar, Srijit Das & Seong Lin Teoh. (2018) Dietary Acrylamide and the Risks of Developing Cancer: Facts to Ponder. Frontiers in Nutrition 5.
Crossref
Osama S. El Okle, Omnia I. El Euony, Asmaa F. Khafaga & Mohamed A. Lebda. (2017) Thiamethoxam induced hepatotoxicity and pro-carcinogenicity in rabbits via motivation of oxidative stress, inflammation, and anti-apoptotic pathway. Environmental Science and Pollution Research 25:5, pages 4678-4689.
Crossref
Samuel M. Cohen. (2018) Screening for human urinary bladder carcinogens: two-year bioassay is unnecessary. Toxicology Research 7:4, pages 565-575.
Crossref
R.L. Cooper & L.M. Zorrilla. 2018. Comprehensive Toxicology. Comprehensive Toxicology 230 275 .
S.M. Cohen. 2018. Comprehensive Toxicology. Comprehensive Toxicology 226 247 .
T Kobets & GM. Williams. 2018. Comprehensive Toxicology. Comprehensive Toxicology 409 442 .
Catherine Willett, Suzanne Fitzpatrick, Bette Meek & Carl Westmoreland. 2018. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment 349 378 .
Jeremy Leonard, Shannon Bell, Noffisat Oki, Mark Nelms, Yu-Mei Tan & Stephen Edwards. 2018. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment 235 261 .
Michael Waters & Claude HughesR. Brooks Robey. 2017. Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer. Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer 511 606 .
Juergen Funk, Martin Ebeling, Thomas Singer & Christian Landes. (2017) Image analysis for TSH mRNA in situ hybridization in pituitary glands from rats with thyroid follicular cell hypertrophy after treatment with three different test compounds. Research in Veterinary Science 114, pages 313-321.
Crossref
Nikolai L. Chepelev, Rémi Gagné, Timothy Maynor, Byron Kuo, Cheryl A. Hobbs, Leslie Recio & Carole L. Yauk. (2017) Transcriptional profiling of male F344 rats suggests the involvement of calcium signaling in the mode of action of acrylamide-induced thyroid cancer. Food and Chemical Toxicology 107, pages 186-200.
Crossref
Yu Okuda, Masahiko Kushida, Kayo Sumida, Hirohisa Nagahori, Yoshimasa Nakamura, Hashihiro Higuchi, Satoshi Kawamura, Brian G. Lake, Samuel M. Cohen & Tomoya Yamada. (2017) Editor’s Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes. Toxicological Sciences 158:2, pages 412-430.
Crossref
Tomoya Yamada, Miwa Kondo, Kaori Miyata, Keiko Ogata, Masahiko Kushida, Kayo Sumida, Satoshi Kawamura, Thomas G. Osimitz, Brian G. Lake & Samuel M. Cohen. (2017) An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action. Toxicological Sciences 157:2, pages 465-486.
Crossref
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 729 776 .
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 337 356 .
M.E. (Bette) Meek. (2017) AOPs in hazard characterization for human health. Current Opinion in Toxicology 3, pages 80-86.
Crossref
Samuel M. Cohen. (2017) The relevance of experimental carcinogenicity studies to human safety. Current Opinion in Toxicology 3, pages 6-11.
Crossref
Mugimane G. Manjanatha, Sharon D. Shelton, Ying Chen, Barbara L. Parsons, Meagan B. Myers, Karen L. McKim, B. Bhaskar Gollapudi, Nigel P. Moore, Lynne T. Haber, Bruce Allen & Martha M. Moore. (2017) Dose and temporal evaluation of ethylene oxide-induced mutagenicity in the lungs of male big blue mice following inhalation exposure to carcinogenic concentrations. Environmental and Molecular Mutagenesis 58:3, pages 122-134.
Crossref
Antonenko A.M.Korshun M.M.. (2017) Environmental factors as the reasons of thyroid gland pathology risk (analytical literary review, the second report). Environment & Health:1 (81), pages 59-64.
Crossref
Colin Ockleford, Paulien Adriaanse, Philippe Berny, Theodorus Brock, Sabine Duquesne, Sandro Grilli, Antonio F Hernandez‐Jerez, Susanne Hougaard Bennekou, Michael Klein, Thomas Kuhl, Ryszard Laskowski, Kyriaki Machera, Olavi Pelkonen, Silvia Pieper, Rob Smith, Michael Stemmer, Ingvar Sundh, Ivana Teodorovic, Aaldrik Tiktak, Chris J Topping, Gerrit Wolterink, Karine Angeli, Ellen Fritsche, Antonio F Hernandez‐Jerez, Marcel Leist, Alberto Mantovani, Pablo Menendez, Olavi Pelkonen, Anna Price, Barbara Viviani, Arianna Chiusolo, Federica Ruffo, Andrea Terron & Susanne Hougaard Bennekou. (2017) Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†. EFSA Journal 15:3.
Crossref
Julie Goodman & Heather Lynch. (2017) Improving the International Agency for Research on Cancer's consideration of mechanistic evidence. Toxicology and Applied Pharmacology 319, pages 39-46.
Crossref
Anna Bal-Price, Pamela J. Lein, Kimberly P. Keil, Sunjay Sethi, Timothy Shafer, Marta Barenys, Ellen Fritsche, Magdalini Sachana & M.E. (Bette) Meek. (2017) Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity. NeuroToxicology 59, pages 240-255.
Crossref
Tanwi Priya & Brijesh Kumar Mishra. (2016) Enzyme Mediated Chloroform Biotransformation and Quantitative Cancer Risk Analysis of Trihalomethanes Exposure in South East Asia. Exposure and Health 9:1, pages 61-75.
Crossref
Kirsten Gerloff, Brigitte Landesmann, Andrew Worth, Sharon Munn, Taina Palosaari & Maurice Whelan. (2017) The Adverse Outcome Pathway approach in nanotoxicology. Computational Toxicology 1, pages 3-11.
Crossref
Yu Okuda, Masahiko KushidaHiroko KikumotoYoshimasa Nakamura, Hashihiro HiguchiSatoshi KawamuraSamuel M. Cohen, Brian G. Lake & Tomoya Yamada. (2017) Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin. The Journal of Toxicological Sciences 42:6, pages 773-788.
Crossref
Jessica L. LaRocca, Reza J. Rasoulpour, B. Bhaskar Gollapudi, David L. Eisenbrandt, Lynea A. Murphy & Matthew J. LeBaron. (2017) Integration of novel approaches demonstrates simultaneous metabolic inactivation and CAR-mediated hepatocarcinogenesis of a nitrification inhibitor. Toxicology Reports 4, pages 586-597.
Crossref
E. Koch & S. Plassmann. 2017. A Comprehensive Guide to Toxicology in Nonclinical Drug Development. A Comprehensive Guide to Toxicology in Nonclinical Drug Development 7 38 .
Christian Strupp, Werner Bomann, Samuel M. Cohen & Klaus Weber. (2016) Relationship of Metabolism and Cell Proliferation to the Mode of Action of Fluensulfone-Induced Mouse Lung Tumors. II: Additional Mechanistic Studies. Toxicological Sciences 154:2, pages 296-308.
Crossref
Alan R. Boobis, Samuel M. Cohen, Vicki L. Dellarco, John E. Doe, Penelope A. Fenner-Crisp, Angelo Moretto, Timothy P. Pastoor, Rita S. Schoeny, Jennifer G. Seed & Douglas C. Wolf. (2016) Classification schemes for carcinogenicity based on hazard-identification have become outmoded and serve neither science nor society. Regulatory Toxicology and Pharmacology 82, pages 158-166.
Crossref
Penelope A. Fenner-Crisp & Vicki L. Dellarco. (2016) Key Elements for Judging the Quality of a Risk Assessment. Environmental Health Perspectives 124:8, pages 1127-1135.
Crossref
Richard Judson, Keith Houck, Matt Martin, Ann M. Richard, Thomas B. Knudsen, Imran Shah, Stephen Little, John Wambaugh, R. Woodrow Setzer, Parth Kothya, Jimmy Phuong, Dayne Filer, Doris Smith, David Reif, Daniel Rotroff, Nicole Kleinstreuer, Nisha Sipes, Menghang Xia, Ruili Huang, Kevin Crofton & Russell S. Thomas. (2016) Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space . Toxicological Sciences 152:2, pages 323-339.
Crossref
A.H. Heussner & T. Paget. (2016) Evaluation of renal in vitro models used in ochratoxin research . World Mycotoxin Journal 9:3, pages 435-454.
Crossref
D.S. Wikoff, J.E. Rager, L.C. Haws & S.J. Borghoff. (2016) A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regulatory Toxicology and Pharmacology 77, pages 143-159.
Crossref
Ann E. Bradley, Joanna L. Shoenfelt & Judi L. Durda. (2016) Carcinogenicity and mode of action evaluation for alpha-hexachlorocyclohexane: Implications for human health risk assessment. Regulatory Toxicology and Pharmacology 76, pages 152-173.
Crossref
Samuel M. Cohen & Lora L. Arnold. (2016) Critical role of toxicologic pathology in a short-term screen for carcinogenicity. Journal of Toxicologic Pathology 29:4, pages 215-227.
Crossref
Antonio F. Hernández & Fernando Gil. 2016. Nutraceuticals. Nutraceuticals 839 853 .
Masahiko Kushida, Tomoya Yamada & Yasuyoshi Okuno. 2016. Thresholds of Genotoxic Carcinogens. Thresholds of Genotoxic Carcinogens 193 203 .
T. Kobets & G.M. Williams. 2016. Thresholds of Genotoxic Carcinogens. Thresholds of Genotoxic Carcinogens 19 36 .
Mathieu Vinken. 2016. In Silico Methods for Predicting Drug Toxicity. In Silico Methods for Predicting Drug Toxicity 325 337 .
Kamin J. Johnson, Bethany R. Hannas, Sue Marty, Carol L. Zablotny, Jessica LaRocca, Nicholas Ball & Amanda K. Andrus. 2017. Developmental and Reproductive Toxicology. Developmental and Reproductive Toxicology 117 183 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 58 .
Brian G. Lake & Roger J. Price. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 309 332 .
Paul Harrison, Philip Holmes, Ruth Bevan, Klaus Kamps, Leonard Levy & Helmut Greim. (2015) Regulatory risk assessment approaches for synthetic mineral fibres. Regulatory Toxicology and Pharmacology 73:1, pages 425-441.
Crossref
Richard A. Becker, Grace Patlewicz, Ted W. Simon, J. Craig Rowlands & Robert A. Budinsky. (2015) The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor. Regulatory Toxicology and Pharmacology 73:1, pages 172-190.
Crossref
Charles E. Wood, Renee R. Hukkanen, Radhakrishna Sura, David Jacobson-Kram, Thomas Nolte, Marielle Odin & Samuel M. Cohen. (2015) Scientific and Regulatory Policy Committee (SRPC) Review*. Toxicologic Pathology 43:6, pages 760-775.
Crossref
Christopher J. Borgert, Kimberly Wise & Richard A. Becker. (2015) Modernizing problem formulation for risk assessment necessitates articulation of mode of action. Regulatory Toxicology and Pharmacology 72:3, pages 538-551.
Crossref
Reza J. Rasoulpour, Amanda K. Andrus, M. Sue Marty, Fagen Zhang, Johnson Thomas, Matthew J. LeBaron, Sabitha Papineni, Lynn H. Pottenger & David L. Eisenbrandt. (2015) Pronamide: Human relevance of liver-mediated rat leydig cell tumors. Regulatory Toxicology and Pharmacology 72:2, pages 394-404.
Crossref
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 18 .
Lorenz Rhomberg. (2014) Hypothesis‐Based Weight of Evidence: An Approach to Assessing Causation and its Application to Regulatory Toxicology. Risk Analysis 35:6, pages 1114-1124.
Crossref
William H. GoodsonIIIIII, Leroy Lowe, David O. Carpenter, Michael Gilbertson, Abdul Manaf Ali, Adela Lopez de Cerain Salsamendi, Ahmed Lasfar, Amancio Carnero, Amaya Azqueta, Amedeo Amedei, Amelia K. Charles, Andrew R. Collins, Andrew Ward, Anna C. Salzberg, Anna Maria Colacci, Ann-Karin Olsen, Arthur Berg, Barry J. Barclay, Binhua P. Zhou, Carmen Blanco-Aparicio, Carolyn J. Baglole, Chenfang Dong, Chiara Mondello, Chia-Wen Hsu, Christian C. Naus, Clement Yedjou, Colleen S. Curran, Dale W. Laird, Daniel C. Koch, Danielle J. Carlin, Dean W. Felsher, Debasish Roy, Dustin G. Brown, Edward Ratovitski, Elizabeth P. Ryan, Emanuela Corsini, Emilio Rojas, Eun-Yi Moon, Ezio Laconi, Fabio Marongiu, Fahd Al-Mulla, Ferdinando Chiaradonna, Firouz Darroudi, Francis L. Martin, Frederik J. Van Schooten, Gary S. Goldberg, Gerard Wagemaker, Gladys N. Nangami, Gloria M. Calaf, Graeme P. Williams, Gregory T. Wolf, Gudrun Koppen, Gunnar Brunborg, H. Kim Lyerly, Harini Krishnan, Hasiah Ab Hamid, Hemad Yasaei, Hideko Sone, Hiroshi Kondoh, Hosni K. Salem, Hsue-Yin Hsu, Hyun Ho Park, Igor Koturbash, Isabelle R. Miousse, A.Ivana Scovassi, James E. Klaunig, Jan Vondráček, Jayadev Raju, Jesse Roman, John Pierce WiseSr.Sr., Jonathan R. Whitfield, Jordan Woodrick, Joseph A. Christopher, Josiah Ochieng, Juan Fernando Martinez-Leal, Judith Weisz, Julia Kravchenko, Jun Sun, Kalan R. Prudhomme, Kannan Badri Narayanan, Karine A. Cohen-Solal, Kim Moorwood, Laetitia Gonzalez, Laura Soucek, Le Jian, Leandro S. D’Abronzo, Liang-Tzung Lin, Lin Li, Linda Gulliver, Lisa J. McCawley, Lorenzo Memeo, Louis Vermeulen, Luc Leyns, Luoping Zhang, Mahara Valverde, Mahin Khatami, Maria Fiammetta Romano, Marion Chapellier, Marc A. Williams, Mark Wade, Masoud H. Manjili, Matilde E. Lleonart, Menghang Xia, Michael J. Gonzalez Guzman, Michalis V. Karamouzis, Micheline Kirsch-Volders, Monica Vaccari, Nancy B. Kuemmerle, Neetu Singh, Nichola Cruickshanks, Nicole Kleinstreuer, Nik van Larebeke, Nuzhat Ahmed, Olugbemiga Ogunkua, P.K. Krishnakumar, Pankaj Vadgama, Paola A. Marignani, Paramita M. Ghosh, Patricia Ostrosky-Wegman, Patricia A. Thompson, Paul Dent, Petr Heneberg, Philippa Darbre, Po Sing Leung, Pratima Nangia-Makker, Qiang (Shawn) Cheng, R.Brooks Robey, Rabeah Al-Temaimi, Rabindra Roy, Rafaela Andrade-Vieira, Ranjeet K. Sinha, Rekha Mehta, Renza Vento, Riccardo Di Fiore, Richard Ponce-Cusi, Rita Dornetshuber-Fleiss, Rita Nahta, Robert C. Castellino, Roberta Palorini, Roslida A. Hamid, Sabine A.S. Langie, Sakina E. Eltom, Samira A. Brooks, Sandra Ryeom, Sandra S. Wise, Sarah N. Bay, Shelley A. Harris, Silvana Papagerakis, Simona Romano, Sofia Pavanello, Staffan Eriksson, Stefano Forte, Stephanie C. Casey, Sudjit Luanpitpong, Tae-Jin Lee, Takemi Otsuki, Tao Chen, Thierry Massfelder, Thomas Sanderson, Tiziana Guarnieri, Tove Hultman, Valérian Dormoy, Valerie Odero-Marah, Venkata Sabbisetti, Veronique Maguer-Satta, W.Kimryn Rathmell, Wilhelm Engström, William K. Decker, William H. Bisson, Yon Rojanasakul, Yunus Luqmani, Zhenbang Chen & Zhiwei Hu. (2015) Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis 36:Suppl 1, pages S254-S296.
Crossref
R.Brooks Robey, Judith Weisz, Nancy B. Kuemmerle, Anna C. Salzberg, Arthur Berg, Dustin G. Brown, Laura Kubik, Roberta Palorini, Fahd Al-Mulla, Rabeah Al-Temaimi, Anna Maria Colacci, Chiara Mondello, Jayadev Raju, Jordan Woodrick, A.Ivana Scovassi, Neetu Singh, Monica Vaccari, Rabindra Roy, Stefano Forte, Lorenzo Memeo, Hosni K. Salem, Amedeo Amedei, Roslida A. Hamid, Graeme P. Williams, Leroy Lowe, Joel Meyer, Francis L. Martin, William H. Bisson, Ferdinando Chiaradonna & Elizabeth P. Ryan. (2015) Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?. Carcinogenesis 36:Suppl 1, pages S203-S231.
Crossref
M.E. (Bette) Meek & John C. Lipscomb. (2015) Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment. Toxicology 332, pages 112-123.
Crossref
David Y. Lai, Sam Kacew & Wolfgang Dekant. (2015) Tetrabromobisphenol A (TBBPA): Possible modes of action of toxicity and carcinogenicity in rodents. Food and Chemical Toxicology 80, pages 206-214.
Crossref
Brian G Lake, Roger J Price & Thomas G Osimitz. (2014) Mode of action analysis for pesticide‐induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk. Pest Management Science 71:6, pages 829-834.
Crossref
Mandeep S. Sidhu, Karan P. Desai, Heather N. Lynch, Lorenz R. Rhomberg, Barbara D. Beck & Ferdinand J. Venditti. (2015) Mechanisms of action for arsenic in cardiovascular toxicity and implications for risk assessment. Toxicology 331, pages 78-99.
Crossref

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